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38,696 grants matching “als”
RUI: Expanding the Atomic Database for Nebular and Stellar Neutron-Capture Element Abundance Determinations
$320,399Nicholas C Sterling · University Of West Georgia · · FY2014 · MPS
LEVODOPA DYSKINESIAS: IMPACT OF DOPAMINE NEURONS
$320,396Kathy Steece Steece-Collier · University Of Cincinnati · R01 · FY2006 · NS
Dissolved trace elements in the tropical Northwest Pacific Ocean
$320,393Christopher T Hayes · University Of Southern Mississippi · · FY2019 · GEO
Power and Sample-Size Methodology for Radiology Research
$320,384Stephen Lawrence Hillis · University Of Iowa · R01 · FY2013 · EB
Hippocampal neurogenesis, pattern separation & age-related cognitive impairments.
$320,350Rene Hen · Columbia University Health Sciences · R01 · FY2014 · AG
Defining the role of FUS phosphorylation in neurodegeneration
$320,347Thomas L Kukar · Emory University · R01 · FY2015 · NS
Novel CatSper3 and CatSper4 Ion Channel Genes in Sperm
$320,340David E. Clapham · Boston Children'S Hospital · R01 · FY2006 · HD
G PROTEIN COUPLED RECEPTORS AND HIV DEMENTIA
$320,338University Of Pennsylvania · R01 · FY2001 · MH
The ALS Gene Family of Candida albicans
$320,318Lois L. Hoyer · University Of Illinois At Urbana-Champaign · R01 · FY2007 · DE
Randomized Controlled Trial Computer-Base Intervention to Augment Drug Counseling
$320,315M. Zachary Rosenthal · Duke University · R01 · FY2013 · DA
Hormonal Effects on Behavior and Spinal Cord Morphology
$320,315S Marc Breedlove · Michigan State University · R01 · FY2015 · NS
Genomic Correlates with Differential Virulence in Melioidosis Animal Models
$320,303Paul Stephen Keim · University Of California-Irvine · U54 · FY2012 · AI
Pathobiology of HMG-CoA reductase inhibitors in diabetes
$320,298Northwestern University · R01 · FY2005 · DK
Pathobiology of HMG-CoA reductase inhibitors in diabetes
$320,298Northwestern University · R01 · FY2004 · DK
THE GREAT LAKES BASIN (GLB) HAS BEEN A REGIONAL HOTSPOT OF CLIMATE CHANGE IMPACTS INCLUDING LAKE WARMING DECLINING ICE COVER AND INCREASED LAKE-EFFECT SNOWFALL. MODELING STUDIES HAVE DEMONSTRATED THE SUBSTANTIAL CONTRIBUTION OF LAKE-ATMOSPHERE INTERACTIONS AND UNCERTAINTY IN LAKE-EFFECT SNOWFALL PROJECTIONS. DESPITE THE VAST SOCIO-ECONOMIC IMPACTS OF LAKE-EFFECT SNOWSTORMS (LES) THESE EXTREME EVENTS HAVE RECEIVED MINIMAL ATTENTION FROM IPCC AND NATIONAL CLIMATE ASSESSMENT. THE INSUFFICIENT INVESTIGATION OF PROJECTED CHANGES IN THESE COLD SEASON EXTREMES IS PARTLY DUE TO THE GENERAL LACK OF APPROPRIATE MODELING TOOLS THAT PROPERLY REPRESENT THE GREAT LAKES AND LAKE-ATMOSPHERE INTERACTIONS. THERE HAVE BEEN RECENT ADVANCES IN THE REPRESENTATION OF LAKE-ATMOSPHERE INTERACTIONS AMONG REGIONAL CLIMATE MODELS THROUGH 2-WAY COUPLING WITH 1D LAKE MODELS PERMITTING THE SIMULATION OF BROAD-SCALE LAKE-EFFECT SNOW FEATURES. HOWEVER SUCH LAKE MODELS ARE INAPPROPRIATE FOR DEEP LAKES LEADING TO LARGE BIASES IN LAKE SURFACE TEMPERATURE (LST) ICE COVER AND EVAPORATION. XUE ET AL. EMPLOYED OFFLINE AND 2-WAY COUPLING OF THE 3D FINITE VOLUME COMMUNITY OCEAN MODEL (FVCOM) TO WRF AND REGCM4 AND DEMONSTRATED THE BENEFITS OF INCORPORATING 3D MODELS TO REPRESENT GREAT LAKES HYDRODYNAMICS INCLUDING DRAMATIC BIAS REDUCTIONS AND ACCURATE TURBULENT FLUX REPRESENTATION WITH IMPLICATIONS FOR LES. RECENT ADVANCES IN DATA COLLECTION INCLUDING OVER-LAKE FLUX MEASUREMENTS THROUGH THE GREAT LAKES EVAPORATION NETWORK (GLEN) AND ONTARIO WINTER LAKE- EFFECT SYSTEMS FIELD CAMPAIGN ALONG WITH IMPROVED SPACEBORNE COLD SEASON CLOUD/PRECIPITATION DETECTION BY CLOUDSAT AND GLOBAL PRECIPITATION MEASUREMENT (GPM) PLATFORMS HAVE DEEPENED THE UNDERSTANDING OF LAKE-ATMOSPHERE INTERACTIONS LES DYNAMICS AND SHALLOW CUMULIFORM SNOW MICROPHYSICS. WE PROPOSED TO EVALUATE AND ADVANCE THE REPRESENTATION OF LAKE-ATMOSPHERE INTERACTIONS AND HEAVY LES IN THE GLB BY NU-WRF. NUWRF PERMITS 2 CRUDE LAKE TREATMENTS: REMOTELY-SENSED LSTS ARE PROVIDED AS BOUNDARY CONDITIONS OR THE ATMOSPHERE IS 2-WAY COUPLED TO THE 1D FLAKE MODEL. IN ADDITION TO EXPLORING LSTS TURBULENT FLUXES CLOUDS AND LES IN THESE CONFIGURATIONS WE WILL ENHANCE THE REPRESENTATION OF 3D LAKE PROCESSES AND LAKE-ATMOSPHERE INTERCONNECTIONS BY DEVELOPING A 2-WAY COUPLED LAKE-ATMOSPHERE-LAND MODEL NU-WRF/FVCOM WHICH PERMITS THE DEVELOPMENT OF DYNAMICALLY DOWNSCALED LES PROJECTIONS. HISTORICAL NU-WRF RUNS WILL BE PRODUCED FOR THE AFOREMENTIONED LAKE TREATMENTS AND EVALUATED AGAINST OBSERVATIONS TO QUANTIFY ADDED VALUE TO OVER-LAKE TURBULENT FLUXES AND LES FREQUENCY/INTENSITY FROM INCORPORATING 3D LAKE PROCESSES AND ADVANCED LAKE-ATMOSPHERE COUPLING. GLEN MEASUREMENTS WILL BE USED TO EVALUATE TURBULENT FLUX RESPONSES TO ICE COVER AND TEMPORAL DISTRIBUTION OF EVAPORATION EVENTS. FOR A SET OF OBSERVED LES WE WILL CREATE A NU-WRF/FVCOM ENSEMBLE EXPLORING THE IMPACT OF MICROPHYSICAL BOUNDARY LAYER CONVECTIVE AND RADIATION SCHEMES; VERTICAL RESOLUTION; AND GRID SPACING ON MORPHOLOGIES OF LAKE-INDUCED MESOSCALE CIRCULATIONS. BY VARYING PARAMETERIZATIONS AND PERFORMING RUNS WITH IMPOSED LAKE TEMPERATURE ANOMALIES THE SENSITIVITY OF SPATIO-TEMPORAL PATTERNS OF LAKEEFFECT SNOWFALL AND RESULTING SNOWFALL BIASES CAN BE ATTRIBUTED TO LST OR MICROPHYSICS BIASES. EVALUATING THE REPRESENTATION OF HEAVY LES IN NU-WRF WILL BE GROUNDED IN CLOUDSAT/GPM PRODUCTS. WE WILL EVALUATE CLOUDSAT/GPM SNOWFALL RETRIEVALS AGAINST STATION OBSERVATIONS. IN ADDITION TO EVALUATING NU-WRF AGAINST CLOUDSAT/GPM VERTICAL RADAR REFLECTIVITY TRANSECTS FOR CASE STUDIES WE WILL EXAMINE THE SPECTRUM OF SNOW EVENTS THROUGH DENSITY FUNCTIONS OF RADAR REFLECTIVITY-BASED ESTIMATES OF SNOWFALL INTENSITY/FREQUENCY AND CLOUD ATTRIBUTES ALLOWING FOR THE EVALUATION OF THE MODEL S MICROPHYSICS. RADAR SIMULATORS WILL BE APPLIED TO MODEL OUTPUT TO COMPARE RADAR REFLECTIVITY DISTRIBUTIONS AND CHARACTERISTICS BETWEEN SIMULATED AND OBSERVED LES DATASETS.
$320,294University Of Wisconsin System · · FY2020 · National Aeronautics and Space Administration
Tau-mediated regulation of axonal transport
$320,250Christopher L. Berger · University Of Vermont & St Agric College · R01 · FY2013 · GM
Temporal and Spatial Processing in the Lateral Belt of Auditory Cortex
$320,233Gregg Howard Recanzone · University Of California At Davis · R01 · FY2020 · DC
Understanding speech in noise_The roles of aging and attentional entrainment
$320,213Gary R Kidd · Trustees Of Indiana University · R01 · FY2017 · DC
Synaptic modulation in neural circuits
$320,212Jing W Wang · University Of California, San Diego · R01 · FY2013 · DC
Radiation-Induced Crosstalk of Immune and Glioma Stem Cells
$320,209Ichiro Nakano · University Of Alabama At Birmingham · R01 · FY2019 · NS
NAD metabolsim and mitochondrial dysfunction in ALS models
$320,188Marcelo R Vargas · Medical University Of South Carolina · R01 · FY2015 · NS
Analysis of Multi-Voxel Patterns of Activity in fMRI data
$320,177James V Haxby · Dartmouth College · R01 · FY2007 · MH
Ocular Disposition of Antimicrobial Agents
$320,175Ashim K Mitra · University Of Missouri Kansas City · R01 · FY2006 · EY
Copper Proteins In Metal and Oxidant Stress Responses
$320,175Northwestern University · R01 · FY2001 · GM
Regulation of mitochondrial oxidative stress by Bcl-2 family proteins
$320,141Daniel A Linseman · University Of Denver (Colorado Seminary) · R01 · FY2008 · NS