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91,797 grants matching “obesity”
Neurosteroid Regulation of Adiposity, Glucose Homeostasis and Energy Expenditure in Primates
$597,950Jon E Levine · University Of Wisconsin-Madison · R01 · FY2023 · DK
Neurosteroid Regulation of Adiposity, Glucose Homeostasis and Energy Expenditure in Primates
$597,950Jon E Levine · University Of Wisconsin-Madison · R01 · FY2021 · DK
Clinical Research Network in Non Alcoholic Steatohepati*
$597,913Kris Kowdley · University Of Washington · U01 · FY2006 · DK
Glycemic reduction approaches in polycystic ovary syndrome: a comparative effectiveness study
$597,901Laura Saslow · University Of Michigan At Ann Arbor · R01 · FY2024 · DK
Morehouse-Emory Partnership to Reduce CV Disparities
$597,889Morehouse School Of Medicine · U01 · FY2005 · HL
A Targeted Self-Management Intervention for Reducing Stroke Risk Factors in High Risk Ugandans
$597,855Martha X Sajatovic · Case Western Reserve University · R01 · FY2023 · NS
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT ADDRESSES AN IMPORTANT CHALLENGE AREA OF NANOTOXICOLOGY- A DETAILED UNDERSTANDING OF THE MODE OF ACTIONS BY WHICH ENGINEERED NANOPARTICLES (NPS) INDUCE HEALTH RISKS. A LARGE NUMBER OF FOOD PRODUCTS CONTAIN ENGINEERED INORGANIC NPS, SUCH AS SILICON DIOXIDE NPS, DUE TO BOTH UNINTENTIONAL AND INTENTIONAL ADDITION. HOWEVER, A DETAILED UNDERSTANDING OF THE POTENTIAL ADVERSE EFFECTS OF FOODBORNE SILICON DIOXIDE NPS AND THE MOLECULAR MECHANISM INVOLVED IS NOT CURRENTLY AVAILABLE. OUR PRELIMINARY STUDIES DEMONSTRATED THAT ORAL INTAKE OF SILICON DIOXIDE NPS IN MICE RESULTED IN ACCUMULATION OF THE NPS IN THE LIVER AND KIDNEY, ADVERSE EFFECTS ON LIVER AND KIDNEY, TOXICITY IN REPRODUCTIVE SYSTEMS, AND DISRUPTION OF GUT MICROBIOTA. THESE ADVERSE EFFECTS OF SILICON DIOXIDE NPS TENDED TO BE STRONGER IN THE OBESE MICE THAN NON-OBESE MICE. THESE FINDINGS ARE CRITICALLY IMPORTANT BECAUSE THEY SUGGESTED A MODE OF ACTION BY WHICH FOODBORNE SILICON DIOXIDE NPS INDUCED ADVERSE HEALTH EFFECTS, AND IT ALSO DEMONSTRATED THAT CERTAIN POPULATIONS (SUCH AS THOSE WHO WERE OBESE) WERE MORE SUSCEPTIBLE TO THE SILICON DIOXIDE NPS-INDUCED ADVERSE EFFECTS. TO ADDRESS THE LACK OF KNOWLEDGE ON THE HEALTH RISKS OF FOODBORNE SILICON DIOXIDE NPS, BASED ON OUR PRELIMINARY DATA, THE OVERALL OBJECTIVE OF THIS PROJECT IS TO SYSTEMATICALLY DETERMINE THE ADVERSE EFFECTS OF FOODBORNE SILICON DIOXIDE NPS AND ELUCIDATE THE MOLECULAR MECHANISMS INVOLVED IN DIFFERENT POPULATIONS INCLUDING THOSE POTENTIALLY MORE SUSCEPTIBLE TO THE ADVERSE EFFECTS OF SILICON DIOXIDE NPS, SUCH AS CHILDREN AND OBESE INDIVIDUALS. THE KNOWLEDGE GAINED FROM THIS PROJECT IS CRITICALLY IMPORTANT FOR ENSURING THE SAFETY OF A WIDE RANGE OF FOOD PRODUCTS THAT MAY CONTAIN SILICON DIOXIDE NPS.
$597,845University Of Massachusetts · · FY2022 · National Institute of Food and Agriculture
War of Attrition: Predicting Dropout from Pediatric Weight Management
$597,843Joseph Arnold Skelton · Wake Forest University Health Sciences · R01 · FY2021 · NR
TrkB Neurons in the Control of Body Weight
$597,842Baoji Xu · Scripps Florida · R01 · FY2019 · DK
Neuroimmune Mechanisms of Depressive-Like Behavior During Aging
$597,835Keith W. Kelley · University Of Illinois At Urbana-Champaign · R01 · FY2011 · AG
The Impact of Environmental Stressors on Chronic Disease Disparities in Women
$597,822Edward S Peters · University Of Nebraska Medical Center · R01 · FY2023 · AG
Administrative Core
$597,820Janos Zempleni · University Of Nebraska Lincoln · P20 · FY2014 · GM
Impact of the gut microbiome and diet on change in insulin homeostasis and cardiometabolic risk
$597,787Mark Goodarzi · Cedars-Sinai Medical Center · R01 · FY2019 · DK
The immune contexture of colorectal adenomas and serrated polyps
$597,781Kristin Wallace · Medical University Of South Carolina · R01 · FY2021 · CA
Study of Women's Health Across the NationIV: Chicago Site
$597,750Howard M Kravitz · Rush University Medical Center · U01 · FY2011 · AG
Obestiy Reduction Black Intervention Trial (ORBIT)
$597,707Marian L Fitzgibbon · University Of Illinois At Chicago · R01 · FY2006 · CA
Childhood Secondhand Smoke and Longitudinal Cardiovascular Risk Profile
$597,704Wei Chen · Tulane University Of Louisiana · R01 · FY2014 · ES
Role of the Macrophage in Developmentally Programmed NAFLD
$597,694Jacob E Friedman · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2021 · DK
Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
$597,677Susan L Hughes · University Of Illinois At Chicago · R01 · FY2014 · AG
PQA - 3: Neural predictors of receptivity to health communication and behavior ch
$597,628Emily Falk · University Of Pennsylvania · R01 · FY2013 · CA
Calorie Restriction & Changes in Body Composition, Disease, Function, & QoL in Ol
$597,593Julie L Locher · University Of Alabama At Birmingham · R01 · FY2009 · AG
A4: MULTI ETHNIC HLTH: GENETICS OF INSULIN RESIST IN HAWAIIANS: CVD RISK FACTORS
$597,580University Of Hawaii At Manoa · G12 · FY2000 · RR
Cook For Your Life: Maintaining diet and physical activity changes in Latina breast cancer survivors
$597,551Heather A Greenlee · Columbia University Health Sciences · R01 · FY2017 · CA
Define conserved and variable elements of the pan-genomes of members of the adult
$597,541Claire M Fraser-Liggett · Washington University · P01 · FY2009 · DK
Hoarding disorder in older adults: cognition, etiology and functional impact
$597,529Carol A. Mathews · University Of Florida · R01 · FY2020 · MH