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91,797 grants matching “obesity”
Longitudinal examination of DNA methylation in maltreated children
$599,132Stephanie Hart Parade · Emma Pendleton Bradley Hospital · R01 · FY2018 · HD
Long-term function and health effects of intentional weight loss in obese elders
$599,089Denise Kathryn Houston · Wake Forest University Health Sciences · R01 · FY2017 · AG
Epigenetic Mechanisms and Developmental Actions of Leptin in the Hypothalamus
$599,088Richard B Simerly · Vanderbilt University · R01 · FY2019 · DK
Reducing disparities in colorectal cancer screening in Vietnamese Americans
$599,078Bang H Nguyen · Cancer Prevention Instit Of California · R01 · FY2008 · CA
The Louisiana Center for Advancing Uplifting Scientists Careers in Health, Nutrition, Obesity, and Diabetes Research (LAUNCHED)
$599,045Robert Lee Newton · Lsu Pennington Biomedical Research Ctr · U24 · FY2025 · DK
Upstream Contributors to Downstream Disparities in Type 2 Diabetes
$599,042John B McKinlay · New England Research Institutes, Inc. · R01 · FY2012 · DK
The broad impact of environmental exposures on repetitive element expression in cellular biology
$599,041Richard Woychik · National Institute Of Environmental Health Sciences · ZIA · FY2016 · ES
Focal segmental glomerulosclerosis: Treatment
$599,015Jeffrey Burnett Kopp · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2014 · DK
Cardiovascular Molecular/Cellular Biology
$599,000M Harold Laughlin · University Of Missouri-Columbia · P30 · FY2009 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A HIGH INTAKE OF FATS, PARTICULARLY SATURATED FATTY ACIDS, IS CLOSELY ASSOCIATED WITH HEALTH RISKS SUCH AS OBESITY, TYPE 2 DIABETES, CERTAIN CANCERS, AND CARDIOVASCULAR DISEASES. RECENT NATIONAL STUDIES ON US ADULT CONSUMERS SHOWED THAT THE INTAKE OF SATURATED FATTY ACIDS REMAINED ABOVE 10% OF ENERGY, WHICH IS HIGHER THAN THE RECOMMENDED LEVEL BY WHO AND FAO. IT IS ESSENTIAL TO PROVIDE LOW-FAT OR FAT-FREE FOOD PRODUCTS TO KEEP CONSUMERS HEALTHY. FAT TEXTURIZING AGENTS CAN ACT LIKE FAT BUT SUPPLY FEWER CALORIES AND POSE NO OR LITTLE HEALTH RISKS. IN THE FOOD INDUSTRY, FAT TEXTURIZING AGENTS ARE ADDED TO PROCESSED FOOD PRODUCTS, INCLUDING PROCESSED MEAT, MEAT ANALOGUES, FRIED FOODS, BAKED FOODS, DAIRY PRODUCTS, FROZEN AND REFRIGERATED FOODS, AND SNACKS TO PROVIDE CONSUMERS WITH THE DESIRED MOUTHFEEL. TRADITIONAL FAT TEXTURIZING AGENTS RECEIVE AN INCREASING EXPRESSION OF CONCERNS ABOUT NUTRITION, HEALTH, AND FOOD SUSTAINABILITY AS THEY ARE PRODUCED USING CARBOHYDRATES, FATTY ACIDS, OR VEGETABLE OILS. PROTEIN-BASED FAT TEXTURIZING AGENTS IS THE NEW TREND, BUT THEY ALSO CARRY DRAWBACKS THAT LIMIT THEIR DEVELOPMENT AND APPLICATIONS. THE PRIMARY DISADVANTAGE IS THAT PLANT-BASED FAT TEXTURIZERS CANNOT TOLERATE COLD-TEMPERATURE AND HIGH-TEMPERATURE PROCESSING. THE SECOND DRAWBACK IS THEIR LOW FLEXIBILITY IN THE COMPLEX FOOD MATRIX WHERE POLAR AND NON-POLAR COMPONENTS CO-EXIST. THERE ARE ALSO LIMITED TECHNIQUES FOR PRODUCING HIGH-QUALITY PROTEIN-BASED FAT TEXTURIZING AGENTS, CONSIDERING THAT THE CURRENT TECHNIQUES RELY HEAVILY ON MECHANICAL PROCESSING. UNLIKE MECHANICAL PROCESSING, ENZYMES CATALYZE CHEMICAL REACTIONS WITH HIGH SPECIFICITY UNDER MILD REACTION CONDITIONS WITH LOW ENERGY CONSUMPTION. THUS, WE FORESEE THE URGENT NEED TO DISCOVER NOVEL PROTEIN-BASED FAT TEXTURIZING AGENTS WITH SUPERIOR QUALITIES VIA NOVEL AND CLEAN ENZYMATIC MANUFACTURING TECHNIQUES.WE PROPOSE TO USE PROTEINS FROM PULSE CROPS, E.G., DRY PEAS, LENTILS, AND CHICKPEAS, TO CREATE NOVEL FAT TEXTURIZING AGENTS. PULSES ARE MASSIVELY PRODUCED IN THE US AND ARE EXPECTED TO PLAY A VITAL ROLE IN ADDRESSING FOOD SECURITY, NUTRITION, HEALTH, AND SUSTAINABILITY IN THE IMMEDIATE AND FORESEEABLE FUTURE. PULSE PROTEINS WILL BE MODIFIED BY PROTEASE ENZYMES TO IMPROVE THEIR FUNCTIONALITIES TO ENABLE THEM TO FUNCTION AS FAT TEXTURIZING AGENTS. TO IMPROVE THEIR TOLERANCE TO COLD-TEMPERATURE AND HIGH-TEMPERATURE PROCESSING, WE ARE INSPIRED BY NATURE, WHERE NATURALLY OCCURRING TRANSGLUTAMINASE ENZYMES CAN ACT TO COMBINE DIFFERENT PROTEINS IN LIVING ORGANISMS FOR A PLETHORA OF BIOLOGICAL FUNCTIONS, AND THE CROSS-LINKED PROTEINS SHOW IMPROVED STABILITY. WE, THEREFORE, WILL FURTHER MODIFY THE PROTEINS VIA TRANSGLUTAMINASE CATALYSIS. THE NOVEL PULSE PROTEIN-BASED HYDROGELS WILL BE INVESTIGATED FOR THEIR COLD-/HEAT-TOLERANCE AS FAT TEXTURIZING AGENTS IN A CASE STUDY IN MEAT ANALOGUE PRODUCTS. OVERALL, THIS PROJECT IS BIOINSPIRED BY BIOCATALYSIS IN NATURE, AIMING TO DISCOVER NOVEL PROTEIN-BASED HYDROGELS A,S NEW FAT TEXTURIZING AGENTS FOR HEALTHY PROCESSED FOODS. THE PULSE PROTEIN HYDROGELS DISCOVERED IN THIS PROJECT AS NEW TEXTURIZING AGENTS WILL MEET THE CURRENT NEEDS OF LOW-FAT, LOW-CALORIE FOODS AND GOOD TEXTURE FOR FROZEN AND THERMALLY PROCESSED FOODS. IN ADDITION, THE NEW MANUFACTURING TECHNIQUE IS CONSISTENT WITH THE CLEAN PRODUCTION AND SUSTAINABILITY OF AGRI-FOOD SYSTEMS.
$599,000The Pennsylvania State University · · FY2023 · National Institute of Food and Agriculture
Gene-Environment Interactions and Weight Gain
$598,988Penny Gordon-Larsen · Univ Of North Carolina Chapel Hill · R01 · FY2009 · HD
Genes and Gene Networks Associated with Obesity and Diabetes
$598,977Alan D Attie · University Of Wisconsin-Madison · R01 · FY2012 · DK
Genes and Gene Networks Associated with Obesity and Diabetes
$598,977Alan D Attie · University Of Wisconsin-Madison · R01 · FY2011 · DK
Maternal metabolic and molecular changes induced by preconception weight loss and their effects on birth outcomes
$598,970Charles F Burant · University Of Michigan At Ann Arbor · R01 · FY2021 · DK
Maternal metabolic and molecular changes induced by preconception weight loss and their effects on birth outcomes
$598,970Charles F Burant · University Of Michigan At Ann Arbor · R01 · FY2020 · DK
Impact of Park Renovations on Physical Activity and Community Health in NYC
$598,964Terry T-K Huang · Graduate School Of Public Health And Health Policy · R01 · FY2017 · CA
Stand Up for Your Health: A Randomized Study
$598,956Jacquelyn P Kulinski · Medical College Of Wisconsin · R01 · FY2023 · HL
Effect of intensity and health coaches on the translation of DPP to worksites
$598,947Mark G. Wilson · University Of Georgia · R18 · FY2014 · DK
ARKANSAS NUTRITION, PHYSICAL AND OBESITY PROGRAM
$598,933Becky Adams · Arkansas State Department Of Health · U58 · FY2011 · DP
Neighborhood Environments and Cardiometabolic Disorders in Hispanic/Latinos
$598,928Matthew A Allison · University Of California, San Diego · R01 · FY2017 · DK
Pilot Projects Program
$598,921Celso Enrique Gomez-Sanchez · University Of Mississippi Med Ctr · U54 · FY2017 · GM
Pilot Projects Program
$598,920Celso Enrique Gomez-Sanchez · University Of Mississippi Med Ctr · U54 · FY2019 · GM
Pilot Projects Program
$598,920Celso Enrique Gomez-Sanchez · University Of Mississippi Med Ctr · U54 · FY2020 · GM
Genetic Instability & Risk for Esophageal Carcinoma
$598,914Xifeng Wu · University Of Tx Md Anderson Can Ctr · R01 · FY2010 · CA
Implementing Sustainable Diabetes Prevention and Self-Management in Primary Care
$598,904Jodi Summers Holtrop · Michigan State University · R18 · FY2010 · DK