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24,576 grants matching “microbiome”
Drugs, Germs, and Joints: Antibiotics, Gut Microbiota, and Juvenile Idiopathic Arthritis
$189,886Daniel Benjamin Horton · Rbhs-Robert Wood Johnson Medical School · K23 · FY2018 · AR
Molecular Signatures of Early-Onset Neonatal Sepsis in Umbilical Cord Blood
$189,864Leena Bhattacharya Mithal · Lurie Children'S Hospital Of Chicago · K23 · FY2022 · AI
Administrative Core
$189,845Linda S Mansfield · Michigan State University · U19 · FY2010 · AI
Ex vivo skin wound infection model for Vibrio vulnificus pathogenesis
$189,699Julia C. Van Kessel · Trustees Of Indiana University · R21 · FY2025 · AI
The microbiome as a risk factor for periprosthetic joint infection
$189,616Mathias P.g. Bostrom · Hospital For Special Surgery · R21 · FY2018 · AR
Studies on the virulence of Fillifactor alocis
$189,600Hansel M. Fletcher · Loma Linda University · R21 · FY2013 · DE
Response of the Gut Microbiome and Circulating Metabolome to Diet Intervention in Young Children: Ancillary Study to the Keeping Ideal Cardiovascular Health Family Intervention Trial (KIDFIT)
$189,594Amanda K Marma · Lurie Children'S Hospital Of Chicago · K23 · FY2023 · HL
Employing smart underwear to measure gut microbial hydrogen sulfide production
$189,585Andrew Brantley Hall · Univ Of Maryland, College Park · R21 · FY2023 · DK
Impacts of antiretroviral therapy on oral cavity homeostasis in an FIV animal model
$189,550Sue Vandewoude · Colorado State University · R21 · FY2021 · DE
The IU/JAX Alzheimer's Disease Precision Models Center: Microbiome
$189,547Bruce T Lamb · Indiana University Indianapolis · U54 · FY2019 · AG
Elucidating racial and ethnic differences in functional effects of the vaginal microbiome in ovarian cancer
$189,540Oyomoare L Osazuwa-Peters · Duke University · K22 · FY2024 · CA
Taking a Breath after the Disaster: Homes, Mold and Health in Puerto Rico after Hurricane Maria
$189,480Humberto Cavallin · University Of Puerto Rico Rio Piedras · R21 · FY2018 · ES
THE NUMBER OF RECENT FOODBORNE ILLNESSES ASSOCIATED WITH FRESH PRODUCE IS CONCERNING. ALTHOUGH FOOD SAFETY SYSTEMSFOR FOOD PROCESSING INDUSTRIES ARE USUALLY IN PLACE, OUTBREAKS CONTINUE. ONE POSSIBLE OVERLOOKED SCENARIO FOR WHY OR HOW FOODBORNE PATHOGENS ARE PRESENT IN INFECTIOUS DOSE LEVELS IN PACKAGED AND BULK PRODUCE MAY BE THAT ONCE PATHOGENS HAVE ENTERED THE PRODUCTION CHAIN, THEY ARE PROTECTED OR GO UNDETECTED BY BEING SEQUESTERED WITHIN PROTOZOA OR PROTOZOAN CYSTS THAT MAY BE RESISTANT TO SANITIZERS IN THE PRODUCE INDUSTRY. WE HYPOTHESIZE THAT CYST-FORMING PROTOZOA ARE PRESENT IN THE FOOD PACKAGING ENVIRONMENT AND ON PRODUCE AND MAY ENTRAP AND PROTECT FOODBORNE PATHOGENS.TO DETERMINE WHETHER THESE PROTOZOA ARE IMPORTANT IN THE PROTECTION OF FOODBORNE PATHOGENS, WE WILL 1) ISOLATE AND CULTURE CYST-FORMING PROTOZOA FROM PRODUCE AND TEST ENTRAPMENT OF THE FOODBORNE PATHOGENS, E. COLI O157:H7, LISTERIA, AND SALMONELLA, IN CYSTS OF AMOEBAE AND CILIATES. WE WILL THEN USE THE CONDITIONS FOUND IN PRODUCE PACKAGING PLANTS TO TEST RELEASE OF VIABLE FOODBORNE PATHOGENS FROM PROTOZOAN CYSTS. THE CONDITIONS USED WILL INCLUDE EXPOSURE TO SANITIZERS AND MODIFIED ATMOSPHERE PACKAGING (CONDITIONS IN THE BAGS OF PRE-PACKAGED LEAFY GREENS FOUND IN GROCERY STORES). WE WILL ALSO TEST WHETHER SANITIZERS AND MODIFIED ATMOSPHERE PACKAGING CAN INDUCE PROTOZOA TO FORM CYSTS AND TRAP PATHOGENS. LASTLY, WE WILL CHARACTERIZE THE PROTOZOAN MICROBIOME OF FRESH PRODUCE AND IN PACKAGING WASH WATER TO DETERMINE THE DIVERSITY OF PROTOZOA THAT MIGHT BE PRESENT ON THE PRODUCEAND COULDENTRAP AND PROTECT BACTERIA. THIS PROJECTWILL HELP TO DETERMINE THE SIGNIFICANCE OF AND ROLES FOR PROTOZOA IN OUTBREAKS ASSOCIATED WITH PACKAGED PRODUCE, SUCH THAT UNDERSTANDING THE ROLES FOR THESE ORGANISMS MAY LEAD TO NEWINTERVENTIONS FOR REDUCING PROTOZOA ON PRODUCE, THEREBY REDUCING THE RISK FOR FOODBORNE ILLNESS.
$189,469Middle Tennessee State University · · FY2019 · National Institute of Food and Agriculture
Molecular Signatures of Early-Onset Neonatal Sepsis in Umbilical Cord Blood
$189,432Leena Bhattacharya Mithal · Lurie Children'S Hospital Of Chicago · K23 · FY2019 · AI
Molecular Signatures of Early-Onset Neonatal Sepsis in Umbilical Cord Blood
$189,432Leena Bhattacharya Mithal · Lurie Children'S Hospital Of Chicago · K23 · FY2021 · AI
Microbial provision of essential amino acids: protein conservation in hibernation
$189,413Khrystyne Duddleston · University Of Alaska Fairbanks · P20 · FY2020 · GM
Genetic screen for fungal triggers of the NLRP-3-inflammasone in macrophages
$189,381Damian J Krysan · University Of Rochester · R21 · FY2016 · AI
Microbiota and Neural Circuits controlling Social Behavior
$189,375Geert J De Vries · Georgia State University · R21 · FY2017 · MH
Viral Categorization and Discovery in Acute Liver Failure with Unknown Etiology
$189,375Xiaofeng Fan · Saint Louis University · R21 · FY2018 · AI
Point of care diagnostics for home monitoring of Inflammatory Bowel Disease
$189,375Suri Saranathan Iyer · Georgia State University · R21 · FY2017 · EB
BCM/TCH CHOLESTATIC LIVER DISEASE CONSORTIUM
$189,332Benjamin L. Shneider · Baylor College Of Medicine · U01 · FY2019 · DK
Deciphering the Pathogenesis of EHEC Infection and the Effects of Bacteria-Based Therapies Using Comparative Gut-on-a-Chip
$189,331Yoko Miyamoto Ambrosini · Washington State University · R21 · FY2022 · OD
Molecular Signatures of Early-Onset Neonatal Sepsis in Umbilical Cord Blood
$189,324Leena Bhattacharya Mithal · Lurie Children'S Hospital Of Chicago · K23 · FY2023 · AI
Development of humanized TLR4 SNP mouse models
$189,262Adeline M Hajjar · University Of Washington · R21 · FY2015 · OD
Functional Genomics & Microbiome Core
$189,256James Versalovic · Baylor College Of Medicine · P30 · FY2020 · DK