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24,576 grants matching “microbiome”
Microbiome Induced Epigenetic Changes in Intestinal Inflammation and Necrotizing Enterocolitis
$190,762Mohan Pammi · Baylor College Of Medicine · R21 · FY2021 · HD
Identifying non-human primate models for specific human microbiome traits
$190,727Katherine Ryan Amato · Northwestern University · R21 · FY2025 · OD
Discovery of Antibiotics from Soil Microbiomes Using Metagenomics
$190,688Sean F Brady · Rockefeller University · R35 · FY2017 · GM
Appetite regulation with DTG based ART in postpartum women living with HIV and their infants (Ar-DART)
$190,679Jim Aizire · Johns Hopkins University · R21 · FY2025 · HD
Stanford Training Program in Lung Biology
$190,662Mark Robert Nicolls · Stanford University · T32 · FY2020 · HL
POSTMENOPAUSAL BONE LOSS IS A PRIMARY CONTRIBUTOR TO OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES IN ADULT WOMEN. THE OVERALL GOAL OF THIS PROJECT IS TO EVALUATE THE EFFECTS OF BC SUPPLEMENTATION ON CHANGES IN GUT MICROBIOME AND BONE MASS IN ADULT WOMEN. FOR THIS PURPOSE, WE WILL CONDUCT A PILOT RANDOMIZED PLACEBO-CONTROLLED CLINICAL TRIAL WITH BLACKCURRANT SUPPLEMENTATION FOR 6 MONTHS IN PERI- AND EARLY POSTMENOPAUSAL WOMEN AGED 45-60 YEARS. THE PRIMARY ENDPOINT WILL BE LUMBAR SPINE BMD; SECONDARY ENDPOINTS WILL BE GUT MICROBIAL FIRMICUTES/BACTEROIDETES (F/B) RATIO. TO DELINEATE THE UNDERLYING MECHANISMS OF THE ACTION, CHANGES IN BIOMARKERS FOR BONE METABOLISM, BONE-RELATED IMMUNE AND ENDOCRINE SYSTEMIC BIOMARKERS BY BC SUPPLEMENTATION WILL BE MEASURED IN PLASMA AND PERIPHERAL BLOOD DERIVED MONONUCLEAR CELLS. THE SPECIFIC OBJECTIVES OF THE STUDY ARE TO INVESTIGATE THE EFFECTS OF BLACKCURRANT EXTRACT ON: 1) BONE MASS AND BONE REMODELING MARKERS; 2) CHANGES IN THE GUT MICROBIOTA ABUNDANCEAND COMPOSITION, IMMUNE AND ENDOCRINE BIOMARKERS AND THEIR RELATIONSHIPS WITH CHANGES IN BONE MASS. THE PROPOSED STUDY WILL PROVIDE NOVEL INSIGHT INTO WHETHER AND HOW BLACKCURRANT CONSUMPTION REDUCES THE RISK OF POSTMENOPAUSAL BONE LOSS IN ADULT WOMEN AND WILL IMPROVE UNDERSTANDING OF THE CLINICAL ROLES OF GUT MICROBIOME IN POSTMENOPAUSAL BONE LOSS. FINDINGS FROM THIS STUDY WILL HELP INCREASE AWARENESS OF THE BONE HEALTH PROMOTING EFFECT OF BC AND MOTIVATE INCREASED PRODUCTION OF BC AND BERRY PRODUCTS IN RESPONSE TO THE INCREASING CONSUMER DEMAND. THUS, THIS STUDY IS CONSISTENT WITH THE USDA NIFA PROGRAM AREA PRIORITY OF FOOD AND HUMAN HEALTH (A1343).
$190,643University Of Connecticut · · FY2020 · National Institute of Food and Agriculture
CYCLIC PEPTIDE INHIBITORS OF BACTERIAL TYPE IV SECRETION SYSTEMS
$190,625Joseph P Vogel · Washington University · R21 · FY2015 · AI
Antibiotic Effects on the Developing Microbiome Metabolome and Morbidites in Preterm Neonates.
$190,625Josef Neu · University Of Florida · R21 · FY2018 · HD
Gut-brain axis: functional link between microbial metabolites and neurogenic hypertension
$190,625Christopher Joseph Martyniuk · University Of Florida · R21 · FY2020 · AT
Biology of Aging Oral Health and Anti-aging Intervention in a Non-human Primate Model
$190,625Chih-Ko Yeh · University Of Texas Hlth Science Center · R21 · FY2018 · DE
CYCLIC PEPTIDE INHIBITORS OF BACTERIAL TYPE IV SECRETION SYSTEMS
$190,625Joseph P Vogel · Washington University · R21 · FY2016 · AI
Periodontal bacteria and Alzheimer?s disease
$190,625Kesavalu Naidu Lakshmyya · University Of Florida · R21 · FY2017 · NS
Metgagenomic Analysis of the Human Oral Viral Microbiome
$190,603Derrick E Fouts · Institute For Genomic Research · R21 · FY2007 · DE
Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children
$190,493Jennifer F Friedman · Rhode Island Hospital · K24 · FY2023 · AI
Desiccation-based microbial sample preservation in remote regions
$190,467Stilianos Louca · University Of Oregon Eugene · · FY2023 · BIO
Dietary Rice Bran Phytochemicals and Microbial Metabolites for Colon Chemoprevent
$190,441Tiffany L Weir · Colorado State University · R21 · FY2012 · CA
Microbiome / Gnotobiotic Shared Facility
$190,412Casey D Morrow · University Of Alabama At Birmingham · P30 · FY2017 · CA
Interspecies interactions among oral Streptococci: ecology through air
$190,387Slava Simon Epstein · Northeastern University · R21 · FY2017 · DE
Gut Microbiome, Acute Rejection, and Tacrolimus Dosing in Kidney Transplantation
$190,358John Richard Lee · Weill Medical Coll Of Cornell Univ · K23 · FY2019 · AI
Biologic Specimen Bank for Early Lung Cancer Markers
$190,334Christian Abnet · Division Of Cancer Epidemiology And Genetics · ZIA · FY2025 · CA
THE HUMAN COLON HARBORS TRILLIONS OF MICROORGANISMS, AND THE INTERACTIONS OF THESE MICROORGANISMS WITH THE HOST INFLUENCES HEALTH. ALTHOUGH IT IS KNOWN THAT DIETARY FIBER BROADLY AFFECTS THE MICROBIOME, THERE IS INSUFFICIENT KNOWLEDGE REGARDING HOW INSOLUBLE FIBERS WITH SPECIFIC PHYSICAL STRUCTURES INFLUENCE THE TAXONOMIC COMPOSITION OF THIS COMPLEX ENVIRONMENT. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DETERMINE THE IMPACT OF DIETARY FIBER PHYSICAL STRUCTURE, INVESTIGATED THROUGH CROSS-LINKING ARABINOXYLANS WITH DIFFERENT FERULIC ACID CONTENT AND ARABINOSE TO XYLOSE RATIOS, ON TAXONOMIC SHIFTS IN THE COLONIC MICROBIOME. THE CENTRAL HYPOTHESIS IS THAT FIBERS WITH GREATER DEGREE OF PHYSICAL STRUCTURE (CROSS-LINKING) WILL INCREASE THE POPULATIONS OF BUTYROGENIC BACTERIA IN THE COLONIC MICROBIOME AS THESE MICROORGANISMS HAVE A COMPETITIVE ADVANTAGE TO METABOLIZE SUCH FIBERS. RESULTS OF THIS PROJECT WILL LEAD TO GREATER UNDERSTANDING OF FIBER UTILIZATION BY BACTERIA IN THE COLONIC MICROBIOME BY INTEGRATING MICROBIAL METABOLISM, A NOVEL APPROACH TO SYSTEMATICALLY MODIFY THE DEGREE OF CROSS-LINKING OF ARABINOXYLANS, AND MATHEMATICAL MODELING. THIS APPROACH WILL BE USED TO DEVELOP A PREDICTIVE RELATIONSHIP BETWEEN FIBER STRUCTURE AND TAXONOMIC SHIFTS OF THE MICROBIOME. THIS COULD HELP ENABLE TARGETED SHIFTS IN THE GUT MICROBIOME, ADVANCING THE AFRI PRIORITY AREA OF FOOD SAFETY, NUTRITION, AND HEALTH. THE PROJECT SUPPORTS THE CAREER DEVELOPMENT OF THE PROJECT DIRECTOR THROUGH A SPECIFIC PLAN TO STRENGTHEN RESEARCH, COMMUNICATION, AND LEADERSHIP SKILLS AND FOSTER A TRANSITION TO CAREER INDEPENDENCE. THIS PROJECT MEETS THE AFRI-EWD GOALS OF ADVANCING SCIENTIFIC KNOWLEDGE AND DEVELOPMENT OF THE PROJECT DIRECTOR AS A FUTURE LEADER IN THE AGRICULTURAL RESEARCH WORKFORCE.
$190,320Purdue University · · FY2022 · National Institute of Food and Agriculture
Development of probiotic-based and Clostridioides difficile-targeted therapeutics
$190,313Xingmin Sun · University Of South Florida · R21 · FY2025 · AI
The gut microbiome and susceptibility to Vibrio cholerae
$190,188Ana A Weil · University Of Washington · K08 · FY2020 · AI
The gut microbiome and susceptibility to Vibrio cholerae
$190,188Ana A Weil · University Of Washington · K08 · FY2019 · AI
Core A: Human Metabolism
$190,171Alka M Kanaya · University Of California, San Francisco · P30 · FY2023 · DK