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84,503 grants matching “bioinformatics”
The Colorado Building Interdisciplinary Research Careers in Women's Health Program
$647,601Judith G Regensteiner · University Of Colorado Denver · K12 · FY2024 · AR
Endocrinology of Tick Reproduction: A New Perspective
$647,534Richard M Roe · North Carolina State University · · FY2010 · BIO
HIV Viral Load Testing Using CRISPR Cascade Signal Amplification
$647,533Changchun Liu · University Of Connecticut Sch Of Med/Dnt · R01 · FY2025 · AI
Individual and social contextual factors in relation to DNA methylation, biological aging, and lung cancer risk
$647,413Qiuyin Cai · Vanderbilt University Medical Center · R01 · FY2021 · MD
Characterize the Landscape and Origin of Hybrid Peptides in Beta Cells
$647,409Thomas Delong · University Of Colorado Denver · R01 · FY2025 · DK
Professional Development Core (PDC)
$647,404Cynthia Madeline Perez · University Of Puerto Rico Med Sciences · P50 · FY2025 · GM
Multi-omic analysis of Myc-driven splicing for prostate cancer therapeutic development
$647,398Owen N Witte · University Of California Los Angeles · R01 · FY2020 · CA
Multi-omic analysis of Myc-driven splicing for prostate cancer therapeutic development
$647,398Owen N Witte · University Of California Los Angeles · R01 · FY2021 · CA
Genetic causes of developmental speech sound disorder in families
$647,376Sudha K Iyengar · Case Western Reserve University · R01 · FY2014 · DC
Individual and social contextual factors in relation to DNA methylation, biological aging, and lung cancer risk
$647,326Qiuyin Cai · Vanderbilt University Medical Center · R01 · FY2023 · MD
Social Factors, Epigenomics, and Lupus in African American women (SELA)
$647,310Paula Sofia Ramos · Medical University Of South Carolina · R01 · FY2023 · MD
Integrative approaches to identification and interpretation of genes underlying psychiatric disorders
$647,274Shizhong Han · Lieber Institute, Inc. · R01 · FY2020 · MH
Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung Cancer
$647,271Sandy A Napel · Stanford University · R01 · FY2011 · CA
Using CRISPR technology to study the function of paralogous genes
$647,246Norbert Perrimon · Harvard Medical School · R24 · FY2018 · OD
The UCLA - Boston University Lung Cancer Biomarker Development Laboratory
$647,222Steven M. Dubinett · University Of California Los Angeles · U01 · FY2012 · CA
Long-read single-molecule protein sequencing on an array of unfoldase-coupled nanopores
$647,138Jeffrey Matthew Nivala · University Of Washington · R01 · FY2022 · HG
A Community Effort to Translate Protein Data to Knowledge: An Integrated Platform
$647,114Peipei Ping · University Of California Los Angeles · U54 · FY2015 · GM
Clinical Core
$647,107Brian Wigdahl · Temple Univ Of The Commonwealth · P30 · FY2018 · MH
The role of osteoblast progenitors in response to bone anabolic agents
$647,103Henry M Kronenberg · Massachusetts General Hospital · P50 · FY2024 · AR
Melanoma Resistance Evolution Atlas (MREA) for identifying combinatorial targets to prevent and reverse MAPKi resistance
$647,072Roger S Lo · University Of California Los Angeles · R01 · FY2025 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** APPLES ARE THE MOST CONSUMED FRUIT IN AMERICA, AND AN APPLE A DAY KEEPS THE DOCTOR AWAY HAS BOTH ANECDOTAL AND SCIENTIFIC BACKING. THE COMMERCIAL IMPORTANCE OF APPLES HAS LED TO VARIETAL IMPROVEMENT; HOWEVER, PROGRESS IS LIMITED BY A LONG JUVENILE PERIOD, DELAYING FRUIT EVALUATION FOR TRAITS OF INTEREST. AS A RESULT, APPLE BREEDERS HAVE IMPLEMENTED GENOMICS APPROACHES TO ENHANCE SELECTION FOR SOME TRAITS, BUT STRATEGIES FOR NUTRITIONALLY RELEVANT PHYTOCHEMICALS ARE LACKING. WE HAVE DEVELOPED A PLATFORM FOR GENOME-METABOLOME INTEGRATION TO BETTER UNDERSTAND MARKER-METABOLITE RELATIONSHIPS IN APPLE FRUIT AND USED IT TO DISCOVER A STRONG ASSOCIATION BETWEEN CHLOROGENIC ACID CONTENT IN FRUIT AND A REGION ON CHROMOSOME 17. WE AIM TO CONDUCT THE FOUNDATIONAL PLANT SCIENCE NEEDED TO CREATE WELL CHARACTERIZED AND DIVERGENT APPLE GERMPLASM FOR FUTURE NUTRITIONAL TESTING IN ANIMAL STUDIES AND HUMAN CLINICAL TRIALS. IN OBJECTIVE 1, WE WILL SCREEN DIVERSE APPLE GERMPLASM TO UNDERSTAND VARIATION IN CHLOROGENIC ACID AND OTHER PHENOLICS ACROSS CULTIVATED AND WILD APPLES. IN OBJECTIVE 2, WE WILL REFINE OUR KNOWLEDGE ON GENETIC CONTROL OF CHLOROGENIC ACID AND PHENOLICS IN APPLE FRUIT BY COMBINING WHOLE GENOME SEQUENCING, TRANSCRIPTOMICS, AND PHYTOCHEMICAL QUANTITATIVE ANALYSIS. IN OBJECTIVE 3, WE WILL DEVELOP AN UNDERSTANDING OF THE INHERITANCE AND GENETIC COMPONENTS INVOLVED IN CHLOROGENIC ACID AND PHENOLIC CONTENT IN APPLE FRUITS USING TRANSGENIC APPLE GERMPLASM WITH REDUCED JUVENILITY. OUR INTERDISCIPLINARY TEAM WITH EXPERTISE IN APPLE DIVERSITY AND GERMPLASM EVALUATION, FRUIT GENETICS AND GENOMICS, PHYTOCHEMICAL ANALYSIS, BIOINFORMATICS, AND HUMAN NUTRITION HAS THE UNIQUE EXPERTISE TO COMPLETE THE PROJECT WE DESCRIBE.
$647,000Ohio State University, The · · FY2023 · National Institute of Food and Agriculture
In Vivo Base Editing for Precision Oncology Models
$646,960Lukas Edward Dow · Weill Medical Coll Of Cornell Univ · R01 · FY2019 · CA
Cartilage and Bone Development and Disease
$646,954Yoshihiko Yamada · National Institute Of Dental & Craniofacial Research · ZIA · FY2013 · DE
The Genetic and Genomic Study of MicroRNA in Bipolar and Schizophrenia
$646,924Chunyu Liu · University Of Chicago · R01 · FY2009 · MH
MBRS SCORE Program at Morehouse School of Medicine
$646,907Morehouse School Of Medicine · S06 · FY2003 · GM