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21,281 grants matching “influenza”
A New Method for Biomembrane Simulations
$147,020Gregory A. Voth · University Of Utah · R01 · FY2009 · GM
Data-driven Computational Modeling of the Growth and Spread of Viruses
$147,000John Yin · University Of Wisconsin-Madison · R21 · FY2006 · AI
Immuno-modulatory Effects of Parenteral Nutrition After Intestinal Failure
$147,000Mary E Hise · University Of Kansas Medical Center · R21 · FY2006 · DK
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** RECENT RESEARCH HAS DEMONSTRATED THE IMPORTANCE OF HOST PROTEINS FOR AVIAN INFLUENZA VIRUS (AIV) TRANSMISSION INTO OTHER SPECIES AND THE UNIQUE ABILITY OF SWINE TO PROMOTE AIV INFECTION COMPARED TO OTHER MAMMALS. DESPITE EXTENSIVE CHARACTERIZATION OF DIFFERENCES WITHIN CORRESPONDING HOST PROTEINS BETWEEN MAMMALIAN SPECIES, NO STUDIES HAVE BEEN REPORTED THAT FOCUS SPECIFICALLY ON NATURAL HOST VARIATION PRESENT WITHIN SWINE AND THE IMPACT ON AIV INFECTIVITY. GIVEN THE IMMENSE ROLE THAT DOMESTIC PIGS PLAY IN THE ADAPTATION OF AIV FOR MAMMALIAN HOSTS, IDENTIFICATION OF GENE VARIANTS THAT AFFECT SWINE SUSCEPTIBILITY TO AIV WOULD PROVIDE A PLAUSIBLE AVENUE FOR LIMITING THE EMERGENCE OF NOVEL INFLUENZA STRAINS. THEREFORE, THE OVERALL GOAL OF THIS RESEARCH IS TO IDENTIFY GENETIC VARIANTS WITHIN SWINE THAT AFFECT AIV REPLICATION FOLLOWING INFECTION. SPECIFICALLY, THIS STUDY WILL FOCUS ON TWO HOST PROTEINS BELONGING TO THE ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 (ANP32) GENE FAMILY, ANP32A AND ANP32B. FIRST, WE WILL OBTAIN SEQUENCES FROM ~1,000 PIGS TO UNCOVER GENE VARIANTS PRESENT ACROSS DIVERSE DOMESTIC POPULATIONS. SECOND, WE WILL USE GENE EDITING TO GENERATE VARIANT CELL LINES IN COMBINATION WITH FLUORESCENCE-BASED ASSAYS TO QUANTIFY THE EFFECT OF EACH GENE VARIANT ON VIRAL REPLICATION FOR DIFFERENT AVIAN INFLUENZA STRAINS. THE OUTCOMES OF THIS RESEARCH WILL DIRECTLY BENEFIT SWINE PRODUCERS BY INCREASING ANIMAL WELFARE THROUGH POTENTIAL GENETICS-BASED PREVENTION STRATEGIES AND ALTERNATIVE SOLUTIONS TO SUBOPTIMAL VACCINATION REGIMES. ADDITIONALLY, THIS RESEARCH HAS THE POTENTIAL TO REACH BEYOND SWINE AND INTO THE REALM OF HUMAN HEALTH. AS SWINE ARE KNOWN RESERVOIRS AND SUSPECTED MIXING VESSELS FOR DIVERSE INFLUENZA SUBTYPES, DECREASING THE ABILITY FOR AIV TO SURVIVE AND ADAPT WITHIN SWINE WOULD LIKELY REDUCE THE EMERGENCE OF NOVEL PATHOGENIC STRAINS WITH POTENTIAL FOR HUMAN INFECTION AND/OR PANDEMIC TRANSMISSION.
$146,974Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
Development of small near-infrared laser system capable of improving immune respo
$146,905John James Callahan · Seminex Corporation · R41 · FY2014 · AI
Core--Animal resources
$146,889Trudeau Institute, Inc. · P01 · FY2004 · HL
RAPID: A comparison of the 1918 influenza pandemic and COVID-19 in Missouri: implications for current mitigation strategies in rural versus urban locations
$146,794Lisa Sattenspiel · University Of Missouri-Columbia · · FY2020 · SBE
Administrative Core
$146,789Monica Kraft · University Of Arizona · U19 · FY2021 · AI
VIRAL MEMBRANE AND GLYCOPROTEIN STRUCTURE
$146,700Harvard University · R01 · FY2002 · AI
NIAID Centers of Excellence for Influenza Research and Response
$146,648Stephan Bour · Digital Infuzion, Inc. · N01 · FY2024 · AI
Rape-related PTSD and immune functioning
$146,621Elizabeth A Mundy · University Of Pittsburgh At Pittsburgh · K23 · FY2009 · MH
Structure and Function of Viral Fusion Domains
$146,513California State Poly U Pomona · S06 · FY2005 · GM
The Effectiveness of Vaccines in Clinical Practice
$146,477Eugene David Shapiro · Yale University · K24 · FY2006 · RR
Structure and Function of Viral Fusion Domains
$146,420California State Poly U Pomona · S06 · FY2004 · GM
Core A: Administrative
$146,280Stuart C. Sealfon · Icahn School Of Medicine At Mount Sinai · U19 · FY2017 · AI
Does Dengue Virus Suppress RNA Interference in its Mosquito Vector?
$146,200Kathryn Alyce Hanley · New Mexico State University Las Cruces · R21 · FY2010 · AI
Administrative Core
$146,159Gr Scott Budinger · Northwestern University At Chicago · P01 · FY2017 · AG
Assessing mechanisms for the persistence of RNA viruses in bats using a captive and wild Eidolon helium colonies
$146,125Osbourne Quaye · University Of Ghana · R01 · FY2025 · AI
High-throughput droplet qRT-PCR microfluidic platform for quantification of virus from single cells
$146,021Connie B Chang · Montana State University - Bozeman · R56 · FY2021 · AI
Adapting Natural Language Processing Tools for Biosurveillance
$145,926Debbie A Travers · Univ Of North Carolina Chapel Hill · G08 · FY2009 · LM
Role of miR-181a-5p in Adenovirus 14p1 induced Acute Lung Injury
$145,875Jay R Radke · Idaho Veterans Research / Education Fdn · R21 · FY2023 · AI
New Nasal Spray Influenza Vaccine for Children (Research Supplement for Post Baccalaureate Diversity Candidate)
$145,772Mingtao Zeng · Texas Tech University Health Sciences Center At El Paso · R15 · FY2023 · HD
New Bioinformatics Tools For Analyzing Immunological Data
$145,724Atul J Butte · Stanford University · U19 · FY2012 · AI
Pathogenesis of myalgia and fatigue after SARS-CoV-2 infection
$145,723Sachiko Homma · Boston University Medical Campus · R21 · FY2023 · AR
Regulation of alveolar epithelial homeostasis in acute lung injury
$145,715Jieru Wang · University Of California Los Angeles · R01 · FY2016 · HL