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24,576 grants matching “microbiome”
Administrative Core
$198,477Eric Ravussin · Lsu Pennington Biomedical Research Ctr · P30 · FY2019 · DK
CANCAN - Cambridge
$198,412Giulia Biffi · University Of Cambridge · OT2 · FY2024 · CA
MICROBIAL (BACTERIA AND FUNGI) BEHAVIOR HAS BEEN OBSERVED TO CHANGE IN MICROGRAVITY: ENHANCED BACTERIAL GROWTH IMPROVED CELL AGGREGATION INCREASED VIRULENCE AND REDUCED SUSCEPTIBILITY TO ANTIBIOTICS HAVE BEEN REPORTED ON SPACEFLIGHT EXPERIMENTS. HOWEVER THESE PARAMETERS HAVE NOT BEEN SYSTEMATICALLY ASSESSED AND EVEN LESS SO AT PARTIAL GRAVITIES: 1/6 (LUNAR) AND 1/3 G (MARS). THIS PROJECT AIMS TO CHARACTERIZE CHANGES ON CELL GROWTH DYNAMICS AND CELL AGGREGATION AS A FUNCTION OF THESE GRAVITATIONAL REGIMES (SIMULATED MICRO- 1/6 AND 1/3 G). THIS WILL BE COMPLEMENTED BY GENE EXPRESSION ANALYSES FOCUSED ON THE DRUG-RESISTANCE-ASSOCIATED GENES (RESISTOME) AS WELL AS THOSE RESPONSIBLE FOR BACTERIAL VIRULENCE. THIS SYSTEMATIC MICROBIAL STUDY WILL INCLUDE TEN COMMENSAL OPPORTUNISTIC AND PATHOGENIC BACTERIAL AND FUNGAL STRAINS (OF ESCHERICHIA COLI PSEUDOMONAS AERUGINOSA METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) CANDIDA ALBICANS BACILLUS CEREUS STAPHYLOCOCCUS HAEMOLYTICUS SALMONELLA TYPHIMURIUM AND SHEWANELLA ONEIDENSIS). THIS STUDY HAS A SECOND COMPONENT THAT FOCUSES ON DETERMINING IF THERE ARE CHANGES ON THE CONCENTRATIONS OF DRUGS NEEDED TO INHIBIT MICROBIAL GROWTH AT DIFFERENT GRAVITATIONAL REGIMES LIKE THE ONES EXPECTED TO BE EXPERIENCED DURING DEEP SPACE MISSIONS THE MOON AND MARS. FOR THIS STUDY FOUR DIFFERENT ANTIMICROBIALS (EACH REPRESENTING DISTINCT MECHANISMS OF ACTION) ARE PLANNED TO BE USED: GENTAMICIN SULFATE (AMINOGLYCOSIDE CLASS) WHICH HAS BEEN USED FOR THREE DIFFERENT SPACE-BASED EXPERIMENTS; CIPROFLOXACIN (FLUOROQUINOLONE CLASS) THE MOST COMMONLY PRESCRIBED DRUG FOR URINARY TRACT INFECTIONS (UTI); CEFTOLOZANE/TAZOBACTAM (-LACTAM/-LACTAM COMBINATION ANTIBIOTIC USED ON DRUG-RESISTANT INFECTIONS); AND FLUCONAZOLE (AN AZOLE-CLASS ANTIFUNGAL). THE USE OF SPACEFLIGHT HARDWARE INCLINED CLINOSTATS TO SIMULATE PARTIAL- AND MICRO-GRAVITY AND HUMAN MICROBIOME-ASSOCIATED BACTERIAL AND FUNGAL MODELS WILL ENABLE THIS PROJECT TO ADDRESS RISKS AND GAPS OF NASA#S HUMAN RESEARCH ROADMAP AS WELL AS TO EXPAND OUR UNDERSTANDING OF FUNDAMENTAL CELLULAR AND MOLECULAR MECHANISMS BEHIND MICROBIAL RESPONSES TO CHANGES IN GRAVITY. KNOWLEDGE PRODUCED FROM THIS PROJECT MAY HELP US BETTER PREPARE FOR HUMAN SPACE EXPLORATION OF OTHER CELESTIAL BODIES.
$198,354The Regents Of The University Of Colorado · · FY2020 · National Aeronautics and Space Administration
The Production of Uremic Solutes by Colon Microbes
$198,323Timothy W Meyer · Palo Alto Veterans Instit For Research · R21 · FY2010 · DK
Exploring Mechanisms of Changes in Glucose Homeostasis After Bariatric Surgery: Comparing Vertical Sleeve Gastrectomy and Roux-en-Y Gastric Bypass
$198,305Clare Jung Eun Lee · Johns Hopkins University · K23 · FY2017 · DK
Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular Transplantation
$198,298Matthew Scott Zinter · University Of California, San Francisco · K23 · FY2020 · HL
Microbiome and Transcriptomics Core (MTC)
$198,297David W. Dyer · University Of Oklahoma Hlth Sciences Ctr · P20 · FY2023 · GM
Hyposalivation and the Human Oral Microbiome
$198,260David A Relman · Palo Alto Veterans Instit For Research · R01 · FY2015 · DE
Vaginal Microbiome and Metabolites in Preterm Birth
$198,180Anna Maya Powell · Johns Hopkins University · K23 · FY2025 · AI
Vaginal Microbiome and Metabolites in Preterm Birth
$198,180Anna Maya Powell · Johns Hopkins University · K23 · FY2021 · AI
Vaginal Microbiome and Metabolites in Preterm Birth
$198,180Anna Maya Powell · Johns Hopkins University · K23 · FY2023 · AI
Vaginal Microbiome and Metabolites in Preterm Birth
$198,180Anna Maya Powell · Johns Hopkins University · K23 · FY2024 · AI
Understanding protection against norovirus at the maternal-child interface
$198,174Sylvia Irene Becker-Dreps · Univ Of North Carolina Chapel Hill · K24 · FY2025 · AI
Alterations in the intrauterine environment with prenatal stress: Novel role for commensal microbes
$198,157Tamar Gur · Ohio State University · R21 · FY2019 · MH
Cerebral small vessel disease, obstructive sleep apnea, and the gastrointestinal system
$198,125Robert M Bryan · Baylor College Of Medicine · R21 · FY2016 · NS
The Role of FimH in ExPEC Translocation
$198,125Anthony W Maresso · Baylor College Of Medicine · R21 · FY2017 · AI
Impact of Hurricane Harvey on the Maternal and Infant Microbiome and Birth Outcomes
$198,125Kjersti Marie Aagaard-Tillery · Baylor College Of Medicine · R21 · FY2019 · ES
Treatment and Prevention of Systemic Candidiasis
$198,125Suzanne M Noble · University Of California, San Francisco · R21 · FY2017 · AI
Fecal microbial transplantation to reduce HIV-associated inflammation
$198,125Ma Somsouk · University Of California, San Francisco · R21 · FY2016 · DK
Genome amplification and dysbiosis in tongue cancer
$198,125Donna G Albertson · New York University · R21 · FY2017 · DE
Tetraacylated lipid A enhancement of checkpoint blocking cancer immunotherapy
$198,103Dennis L. Kasper · Harvard Medical School · R21 · FY2025 · CA
Discovery of immunomodulatory gut microbes with MAGIC
$198,073Ivaylo Ivanov Ivanov · Columbia University Health Sciences · R21 · FY2019 · AI
Research Pathology
$198,039Stanley R Hamilton · Beckman Research Institute/City Of Hope · P30 · FY2024 · CA
OPUS: CRS: Synthesizing microbial ecology of fungus-growing ants
$198,031Ulrich G Mueller · University Of Texas At Austin · · FY2019 · BIO
Integrating population-wide oral microbiome data to better understand health differences in the United States
$198,000Laura S Weyrich · Pennsylvania State University, The · R21 · FY2025 · DE