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24,576 grants matching “microbiome”
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis
$199,800Maureen Michelle Leonard · Massachusetts General Hospital · K23 · FY2023 · DK
Systems approach to elucidate the microbiome's influence on the development of food allergies early in life
$199,800Victoria Mackenzie Martin · Massachusetts General Hospital · K23 · FY2025 · AI
New Tools for Understanding the Composition and Dynamics of Microbial Communities
$199,774Robin Knight · University Of Colorado · R01 · FY2012 · HG
INFLAMMATORY BOWEL DISEASE (IBD) IS A GLOBAL DISEASE THAT HAS RAPIDLY EXPANDED IN BOTH WESTERN CIVILIZATIONS AND NEWLY INDUSTRIALIZED NATIONS IN THE 21ST CENTURY. IN NORTH AMERICA, OVER 1.5 MILLION PEOPLE SUFFER FROM IBD, WHICH INCLUDES ULCERATIVE COLITIS (UC) AND CROHN'S DISEASE (CD). CHANGES IN ENVIRONMENTAL AND LIFESTYLE FACTORS COINCIDING WITH WESTERNIZATION HAS DRIVEN A RAPID ACCELERATION IN IBD PREVALENCE WORLDWIDE. THE GUT MICROBIOME AS WELL AS HOST IMMUNE RESPONSE AND GUT BARRIER FUNCTION APPEAR TO CONTRIBUTE TO IBD, VIA INCREASING INTESTINAL INFLAMMATION AND COLITIS. THUS, THERE IS A CRITICAL NEED TO IDENTIFY THERAPEUTIC STRATEGIES AIMED AT IMPROVING GUT HEALTH AND HOST-MICROBIOTA INTERACTIONS IN THE MANAGEMENT OF IBD. THE EFFECTS OF DAIRY LIPIDS ON IBD IS CONTROVERSIAL, AS SOME EVIDENCE SUGGESTS MILK FAT EXACERBATES COLITIS IN MICE, WHILE MILK SPHINGOMYELIN (SM) (A TYPE OF MILK POLAR LIPID) PROTECTS AGAINST COLITIS. A RECENT OBSERVATIONAL STUDY FAILED TO FIND ANY NEGATIVE IMPACT OF DAIRY PRODUCTS ON IBD INCIDENCE, WITH MILK CONSUMPTION ACTUALLY BEING PROTECTIVE AGAINST CD. MILK FAT GLOBULES ARE NATURALLY ENCASED IN MILK FAT GLOBULE MEMBRANE (MFGM), A STRUCTURE RICH IN POLAR LIPIDS, LIKE SM. HOWEVER, DAIRY PRODUCTION PROCESSES RESULT IN VARIABLE MILK POLAR LIPID (MPL) CONTENT OF DAIRY PRODUCTS, WITH SOME UNDERUTILIZED DAIRY CO-PRODUCTS, SUCH AS BUTTER SERUM AND BUTTERMILK, BEING RICH SOURCES OF MPLS. WE HAVE REPORTED THAT MILK SM BENEFICIALLY MODULATES GUT MICROBIOTA AND IS ANTI-INFLAMMATORY. PRELIMINARY DATA FROM OUR RESEARCH GROUP ALSO SHOWS MPL-FED MICE HAVE INCREASES IN GUT MICROBIOTA DIVERSITY AND BENEFICIAL GUT MICROBE POPULATIONS. THUS, DAIRY LIPIDS APPEAR TO HAVE DIFFERENTIAL EFFECTS ON COLITIS; HOWEVER, THE UNDERLYING MECHANISMS, INTERACTIONS BETWEEN LIPIDS, AND THE ROLE OF GUT MICROBIOTA ARE UNCLEAR. IN THIS PROJECT, WE PLAN TO 1) DETERMINE THE EFFECTS OF MPLS AND MILK FAT ON COLITIS DEVELOPMENT IN MICE AND THE DEPENDENCE ON GUT BACTERIA, AND 2) EVALUATE THE UNDERLYING MECHANISMS AT PLAY. THERE IS A CLEAR GAP IN THE SCIENTIFIC KNOWLEDGE REGARDING THE ROLE THAT DAIRY LIPIDS MAY PLAY IN COLITIS DEVELOPMENT, ESPECIALLY IN REGARDS TO INTERACTIONS OF MPLS AND MILK FAT IN THE DIET, UNDERLYING MECHANISMS INVOLVED, AND DEPENDENCE ON GUT MICROBIOTA. THIS PROJECT SERVES AS THE FIRST ATTEMPT AT UNDERSTANDING HOW DAIRY LIPIDS INTERACT WITH GUT MICROBIOTA TO INFLUENCE COLON HEALTH, AS WELL AS PROVIDE NOVEL INSIGHT INTO MECHANISMS INVOLVED VIA EMPLOYING TRANSCRIPTOMICS ANALYSIS. SUCH BASIC SCIENCE RESEARCH MAY PROVIDE THE IMPETUS FOR CLINICAL TRIALS INVESTIGATING MPLS IN IBD PATIENTS AND PROMOTE THE CONSUMPTION OF MPL-RICH MILK AND DAIRY PRODUCTS. FURTHERMORE, INEXPENSIVE DAIRY CO-PRODUCTS RICH IN MPLS, SUCH AS BUTTER SERUM OR BUTTERMILK, COULD BE PROMOTED AND UTILIZED AS VALUE-ADDED SOURCES OF THESE BIOACTIVE LIPIDS.
$199,748University Of Connecticut · · FY2020 · National Institute of Food and Agriculture
Genetics, glycemic control and the microbiome in cystic fibrosis
$199,745Laura N Brenner · Massachusetts General Hospital · K23 · FY2023 · DK
Genetics, glycemic control and the microbiome in cystic fibrosis
$199,745Laura N Brenner · Massachusetts General Hospital · K23 · FY2022 · DK
Genetics, glycemic control and the microbiome in cystic fibrosis
$199,745Laura N Brenner · Massachusetts General Hospital · K23 · FY2024 · DK
DMPA use and vaginal bacterial diversity among African women
$199,726Alison Christina Roxby · University Of Washington · R21 · FY2018 · AI
Effects of cardiac ICU practice variation on intestinal epithelial barrier function and microbiome diversity
$199,692Katri Vanamo Typpo · University Of Arizona · K23 · FY2018 · DK
Effects of cardiac ICU practice variation on intestinal epithelial barrier function and microbiome diversity
$199,692Katri Vanamo Typpo · University Of Arizona · K23 · FY2019 · DK
Effects of cardiac ICU practice variation on intestinal epithelial barrier function and microbiome diversity
$199,692Katri Vanamo Typpo · University Of Arizona · K23 · FY2017 · DK
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis
$199,682Maureen Michelle Leonard · Massachusetts General Hospital · K23 · FY2021 · DK
NIDDK Diabetic Foot Consortium Clinical Research Unit
$199,680Rodica Pop-Busui · University Of Michigan At Ann Arbor · U01 · FY2023 · DK
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
$199,648Jeffrey H Samet · Boston Medical Center · R01 · FY2018 · AA
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
$199,648Jeffrey H Samet · Boston Medical Center · R01 · FY2019 · AA
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
$199,648Jeffrey H Samet · Boston Medical Center · R01 · FY2017 · AA
Systems approach to elucidate the microbiome's influence on the development of food allergies early in life
$199,640Victoria Mackenzie Martin · Massachusetts General Hospital · K23 · FY2021 · AI
Milk Analytics Core
$199,631Lars Bode · University Of California, San Diego · P50 · FY2025 · HD
Systems approach to elucidate the microbiome's influence on the development of food allergies early in life
$199,600Victoria Mackenzie Martin · Massachusetts General Hospital · K23 · FY2024 · AI
Systems approach to elucidate the microbiome's influence on the development of food allergies early in life
$199,600Victoria Mackenzie Martin · Massachusetts General Hospital · K23 · FY2023 · AI
Systems approach to elucidate the microbiome's influence on the development of food allergies early in life
$199,600Victoria Mackenzie Martin · Massachusetts General Hospital · K23 · FY2022 · AI
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis
$199,560Maureen Michelle Leonard · Massachusetts General Hospital · K23 · FY2019 · DK
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis
$199,560Maureen Michelle Leonard · Massachusetts General Hospital · K23 · FY2020 · DK
ANTHOCYANIN (ACN)-RICH FUNCTIONAL FOODS ARE THOUGHT TO SUPPRESS GUT INFLAMMATION AND MAY REDUCE RISK OF COLITIS-ASSOCIATED COLORECTAL CANCER VIA DIRECT ACTION AT THE GUT EPITHELIUM OR VIA MODULATION OF THE GUT MICROBIOME. HOWEVER, PRE-CLINICAL STUDIES INVESTIGATING THESE ACNS ARE TYPICALLY IDEALIZED IN THEIR DESIGN, EMPLOYING LONG-TERM, CONSISTENT DIETARY EXPOSURES AND RARELY CONSIDERING DYNAMIC SHIFTS IN THE GUT MICROBIOME. THUS, THERE REMAINS A CRITICAL KNOWLEDGE GAP REGARDING THE DYNAMIC RESPONSE OF THE GUT MICROBIOME TO DIETARY INTERVENTIONS WITH ACN-RICH FOODS WITH EXPERIMENT DESIGNS THAT MORE APPROPRIATELY EMULATE COMMON WAYS IN WHICH HUMANS CONSUME THESE FOOD ITEMS. IN THIS SEED GRANT PROPOSAL, OUR PRIMARY OBJECTIVE IS TO MAP THE DYNAMIC RESPONSE OF THE MOUSE GUT MICROBIOME TO VARYING-LENGTH DIETARY SUPPLEMENTATION WITH FUNCTIONAL FOODS WITH DIVERSE ACN PROFILES. OUR EXPERIMENTAL APPROACH WILL ADDRESS THESE IMPORTANT RESEARCH QUESTIONS: 1) HOW QUICKLY WILL THE GUT MICROBIOME RESPOND TO DIETARY INTERVENTION WITH ACN-RICH FOODS AS DEFINED BY A SHIFT IN RELATIVE ABUNDANCE OF SPECIFIC TAXA OR CHANGES IN A- OR B-DIVERSITY? 2) HOW LONG WILL SHIFTS IN MICROBIOME COMPOSITION PERSIST AFTER CONSUMPTION OF THE ACN-RICH FOOD CEASES? 3) IS THE STRUCTURE OF THE DOMINANT ACNS IN THESE FOODS DETER­MINATIVE OF SHIFTS IN MICROBIOME COMPOSITION? SUCCESSFUL COMPLETION OF THIS SEED PROJECT WILL GENERATE ROBUST DATA IN SUPPORT OF OUR PLANNED AFRI STANDARD PROPOSAL TO COMPARE THE EFFICACY OF VARIED DIETARY INTERVENTION STRATEGIES (CONSISTENT, VARYING BY SOURCE, OR VARYING BY DURATION) WITH INDIVIDUAL OR MIXTURES OF ACN-RICH FOODS IN BOTH MOUSE AND HUMAN DISEASE MODELS.
$199,559Utah State University · · FY2021 · National Institute of Food and Agriculture
Translational Epigenomics in Gastrointestinal Cancer
$199,549Ming Yu · Fred Hutchinson Cancer Research Center · R50 · FY2019 · CA