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24,576 grants matching “microbiome”
The Wake Forest Nonhuman Primate Radiation Survivor Cohort
$200,000J. Mark Cline · Wake Forest University Health Sciences · U01 · FY2021 · AI
COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT
$200,000Edward E Partridge · University Of Alabama At Birmingham · P30 · FY2017 · CA
Identification of Pathogenic Bacteria in Crohn's Disease
$200,000Alexander Rodriguez-Palacios · Case Western Reserve University · R21 · FY2018 · DK
GUT MICROBIOME DYSBIOSIS IS ONE OF THE KEY CONTRIBUTORS IN TRIGGERING HOST METABOLIC DYSFUNCTION, LEADING TO DIABETES. DIETARY INTERVENTIONS HAVE BEEN SHOWN TO REBALANCE THE GUT MICROBIOME AND RESCUE RELATED METABOLIC DISORDERS EFFECTIVELY. WATERMELON IS A COMMONLY CONSUMED FRUIT RICH IN NUTRIENTS, SUCH AS LYCOPENE, A NON-PRO-VITAMIN A CAROTENOID METABOLIZED BY Β-CAROTENE OXYGENASE 2 (BCO2). THE HEALTH BENEFITS OF WATERMELON ARE SIGNIFICANT IN, FOR INSTANCE, BOOSTING IMMUNITY AND SCAVENGING OF FREE RADICALS. HOWEVER, DIABETIC PATIENTS ARE RECOMMENDED TO MODERATE THEIR WATERMELON CONSUMPTION DUE TO ITS HIGH GLYCEMIC INDEX VALUE. THUS, THERE IS A SIGNIFICANT KNOWLEDGE GAP IN UNDERSTANDING THE EXTENT TO WHICH WATERMELON EXERTS ROLES IN PROMOTING THE GUT MICROBIOME HOMEOSTASIS IN HEALTH AND DIABETES. IN THIS PROJECT, WE HYPOTHESIZE THAT THE CONSUMPTION OF WATERMELON AS A WHOLE FRUIT WILL PROMOTE GUT HEALTH IN DIABETIC MICE. WE WILL ASSESS THE ROLE OF WATERMELON IN THE MAINTENANCE OF GUT MICROBIOME HOMEOSTASIS AND DETERMINE THE MECHANISM UNDERLYING ITS LYCOPENE EXERTS A ROLE AS A BIOACTIVE COMPOUND IN REGULATION OF GUT MICROBIOME HOMEOSTASIS AND HEALTH IN DIABETIC MICE. WE EXPECT THAT WATERMELON WILL SIGNIFICANTLY IMPROVE THE DIVERSITY OF THE COMMENSAL BACTERIA AND ENHANCE THE INTEGRITY OF GUT EPITHELIAL CELL LAYERS THROUGH THE STIMULATOR OF INTERFERON GENES (STING) SIGNALING IN DIABETIC MICE. DEFICIENCY OF LYCOPENE METABOLISM BY BCO2 DEPLETION WILL AT LEAST PARTIALLY ABOLISH THE PROTECTIVE EFFECT OF WATERMELON. THEREFORE, THIS RESEARCH WILL FUNDAMENTALLY ADVANCE OUR UNDERSTANDING OF WATERMELON AS A WHOLE FOOD, TO PROMOTE GUT HEALTH IN HUMANS, ESPECIALLY IN HIGH-RISK POPULATIONS.
$200,000Oklahoma State University · · FY2021 · National Institute of Food and Agriculture
EAGER: Tick-host interactions and the role of host blood meal in pathogen transmission
$200,000Andrea Swei · San Francisco State University · · FY2017 · BIO
Collaborative Research: Topology and Infection Dynamics of Bacteriophage Viruses
$200,000Maria-Carme T Calderer · University Of Minnesota-Twin Cities · · FY2023 · MPS
Characterization of novel virulence factors in Candida
$200,000Michael C Lorenz · University Of Texas Hlth Sci Ctr Houston · R01 · FY2024 · AI
Investigating the role of intestinal-derived oxytocin in social behavior and gut inflammation.
$200,000Robert A Britton · Baylor College Of Medicine · R21 · FY2025 · HD
Collaborative Research: Topology and Infection Dynamics of Bacteriophage Viruses
$200,000Javier Arsuaga · University Of California-Davis · · FY2023 · MPS
RAPID: Modeling the Host-Microbiome-Virome Interactions and their Impact on COVID-19 Severity.
$200,000Gregory A Buck · Virginia Commonwealth University · · FY2020 · ENG
COMPREHENSIVE CANCER CENTER CORE SUPPORT GRANT
$200,000Barry P Sleckman · University Of Alabama At Birmingham · P30 · FY2019 · CA
A Quality Assurance, Coordination and Analysis Center for HMP
$200,000Owen R White · University Of Maryland Baltimore · U01 · FY2012 · HG
Advancing Clinical Science in Pediatric Gastroparesis
$200,000Robert Shulman · Baylor College Of Medicine · U01 · FY2017 · DK
A Quality Assurance, Coordination and Analysis Center for HMP
$200,000Owen R White · University Of Maryland Baltimore · U01 · FY2009 · HG
ODF: Support infrastructure for NextGen sequence storage analysis and mgt
$200,000Owen R White · University Of Maryland Baltimore · U01 · FY2012 · HG
Knockoff Feature Selection Techniques for Robust Inference in Supervised and Unsupervised Learning
$200,000Yushu Shi · Joan And Sanford I. Weill Medical College Of Cornell University · · FY2023 · MPS
Isolation Selection and Polony Amplification of Single Cells in a Gel Matrix
$200,000Ronald Wayne Davis · Stanford University · R21 · FY2010 · HG
Characterizing the Contribution of Gut Microbiota to Metabolic Phenotypes: Alteration by Antibiotics and Transmission using Fecal Microbial Transplantation
$200,000David H Wasserman · Vanderbilt University · U2C · FY2020 · DK
RAPID: Coral robustness: lessons from an "improbable" reef
$200,000Monica Medina · Pennsylvania State Univ University Park · · FY2016 · GEO
Vibrio colonization determinants in symbiosis
$200,000Edward G Ruby · Carnegie Institution Of Washington, D.C. · R01 · FY2023 · GM
Fluorescence Lifetime Imaging (FLIm): a method to evaluate colon inflammation in vivo
$200,000Alba Alfonso-Garcia · University Of California At Davis · R21 · FY2023 · DK
RAPID: Improving QIIME 2 and UniFrac for Viruses to Respond to COVID-19
$199,999Rob Knight · University Of California-San Diego · · FY2020 · BIO
Responses to variation in nutritional environments
$199,996Jessica Rothman · Cuny Hunter College · · FY2022 · SBE
EAGER: Testing the Host-Microbiome Specificity Paradigm in Birds
$199,995Sarah Hird · University Of Connecticut · · FY2021 · BIO
ANTIMICROBIAL FEEDS ARE ESSENTIAL FOR CONTROL OF FISH DISEASES AND FOR SUSTAINING PROFITABILITY IN THE AQUACULTURE SECTOR. UNFORTUNATELY, MULTIDRUG-RESISTANT (MDR) PLASMIDS HAVE BEEN REPORTED AMONG BACTERIAL STRAINS IN CATFISH FARMS IN THE UNITED STATES. THE POTENTIAL SPREAD OF THESE PLASMIDS COULD ADD CONSIDERABLE AND AVOIDABLE COSTS TO THE CATFISH INDUSTRY BY INCREASING THE FREQUENCY OF TREATMENT FAILURES. HOWEVER, FACTORS THAT FOSTER THE TRANSFER AND PERSISTENCE OF THESE PLASMIDS IN THE AQUATIC ENVIRONMENT REMAIN UNCLEAR AND UNINVESTIGATED. THE OBJECTIVE OF THE CURRENT PROPOSAL IS TO UNDERSTAND THE FATE, MOBILITY, AND DISSEMINATION OF THESE PLASMIDS IN THE AQUATIC ENVIRONMENT. CURTAILING THE SPREAD OF MDR-PLASMIDS REQUIRES A COMPREHENSIVE UNDERSTANDING OF WHEN, WHERE, AND HOW RESISTANCE WAS ACQUIRED, AND HOW PLASMIDS MOVE AMONG AND WITHIN ENVIRONMENTS. THE TWO SPECIFIC AIMS OF THIS PROPOSAL ARE TO: 1) EXAMINE THE TRANSMISSION DYNAMICS AND FATE OF MDR-PLASMIDS IN CATFISH MICROBIOTA.; 2) DETERMINE THE IMPACT OF ANTIMICROBIAL USE ON TRANSFER OF MDR-PLASMIDS.DATA GENERATED FROM THIS STUDY WILL PROVIDE A COMPREHENSIVE UNDERSTANDING OF THE FATE AND PREVALENCE OF MDR-PLASMIDS IN THE AQUACULTURE ENVIRONMENT, AND EFFECTS OF ANTIMICROBIAL USE ON THE PERSISTENCE OF THESE PLASMIDS IN CATFISH GUT MICROBIOME. THE PROPOSED QPCR ASSAY WOULD PROVIDE ADDITIONAL DIAGNOSTIC AND MANAGEMENT TOOLS FOR CATFISH PRODUCERS TO DETECT AND QUANTIFY THESE MDR-PLASMIDS IN THE AQUATIC ENVIRONMENT. A BETTER UNDERSTANDING OF THE TRANSMISSION OF MDR-PLASMIDS IS ESSENTIAL TO DEVELOP MANAGEMENT OPTIONS FOR REDUCING THE SPREAD OF AMR DETERMINANTS IN AQUACULTURE PONDS.
$199,994Mississippi State University · · FY2021 · National Institute of Food and Agriculture