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17,054 grants matching “genome editing”
New Mechanisms of the Pseudouridine Synthase Module in Mitoribosome Assembly
$1Monica Pillon · Baylor College Of Medicine · R35 · FY2024 · GM
Mouse Biology Shared Resource
$1Kc Kent Lloyd · University Of California At Davis · P30 · FY2021 · CA
Informatics Platform for Mammalian Gene Regulation at Isoform-level
$1Ramana V Davuluri · Northwestern University At Chicago · R01 · FY2020 · LM
Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic Engineering
$1Yi Lu · University Of Illinois At Urbana-Champaign · R35 · FY2021 · GM
Mechanistic studies of RNA-targeting CRISPR systems
$1Patrick Hsu · University Of California Berkeley · R01 · FY2022 · GM
Functional Genomics Shared Resource
$1Richard D Schulick · University Of Colorado Denver · P30 · FY2023 · CA
Cell migration and wound repair
$1Anna Huttenlocher · University Of Wisconsin-Madison · R35 · FY2025 · GM
Transgenic and Chimeric Mouse Facility
$1Stephen Aaron Liebhaber · University Of Pennsylvania · P30 · FY2023 · CA
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
$1Ping Mu · Ut Southwestern Medical Center · R37 · FY2024 · CA
CSHL 2020 Systems Biology Conference: Global Regulation of Gene Expression
$1David J. Stewart · Cold Spring Harbor Laboratory · R13 · FY2022 · HG
Development of 211Astatine-Conjugated Anti-CD45 Antibody-Based Conditioning for Hematopoietic Stem Cell Gene Therapy and Editing
$1Roland Bruno Walter · Fred Hutchinson Cancer Research Center · R01 · FY2021 · HL
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency
$1Pietro Genovese · Dana-Farber Cancer Inst · R01 · FY2023 · AI
Mouse Biology Shared Resource
$1Kc Kent Lloyd · University Of California At Davis · P30 · FY2023 · CA
2022 Human Genetic Variation and Disease GRC and GRS
$1Olivier Lichtarge · Gordon Research Conferences · R13 · FY2022 · HG
Mouse Engineering Core
$1Arlene H Sharpe · Dana-Farber Cancer Inst · P30 · FY2022 · CA
Cellular and molecular transport in mucus
$1W Mark Saltzman · Yale University · R01 · FY2016 · EB
Mouse Biology Shared Resource
$1Kc Kent Lloyd · University Of California At Davis · P30 · FY2024 · CA
Elucidation of mutant p53-medidated mechanisms in promoting metastatic esophageal cancer
$1Gizem Efe · Columbia University Health Sciences · F31 · FY2024 · CA
MolQTL: A comprehensive resource for molecular quantitative trait loci in human cancer.
$1Leng Han · Texas A&M University Health Science Ctr · R01 · FY2023 · HG
Mental Health Conferences: Comparative & Primate Studies
$1Judy L Cameron · University Of Pittsburgh At Pittsburgh · U13 · FY2008 · MH
A biochemical approach to patterning molecules in regeneration
$1Kathryn Elizabeth Malecek · Whitehead Institute For Biomedical Res · F32 · FY2018 · GM
AFLATOXINS ARE POTENT CARCINOGENS AND POSE A SERIOUS THREAT TO GLOBAL FOOD SAFETY. EXTENSIVE RESEARCH ON HOST PLANT RESISTANCE TO AFLATOXIN CONTAMINATION HAS BEEN PERFORMED, BUT PROGRESS HAS BEEN LIMITED BY ENVIRONMENTAL INTERACTIONS AND THE QUANTITATIVE NATURE OF RESISTANCE. BECAUSE OF THIS, NOVEL METHODS ARE NEEDED TO ENHANCE HOST RESISTANCE. OUR RESEARCH HAS SHOWN THAT RESISTANCE TO AFLATOXIN CONTAMINATION IS CORRELATED WITH DROUGHT TOLERANCE, AND KERNEL SIMPLE SUGAR, OXYLIPIN, AND REACTIVE OXYGEN SPECIES (ROS) CONTENTS. WE HAVE ALSO DEMONSTRATED THAT ROS STIMULATE AFLATOXIN PRODUCTION BY ASPERGILLUS FLAVUS, AND REGULATE DEVELOPMENTAL AND PATHOGENICITY-RELATED MECHANISMS. THEREFORE, THE MANIPULATION OF THE ROS CONTENT OF HOST KERNELS USING GENETIC ENGINEERING MAY PROVIDE A NOVEL AND EFFECTIVE MEANS OF MITIGATING AFLATOXIN CONTAMINATION. IN THIS PROPOSED PROJECT, THIS HYPOTHESIS WILL BE EXPLORED THROUGH TWO OBJECTIVES. OBJECTIVE 1 WILL BE TO TEST WHETHER THE OVEREXPRESSION OF ANTIOXIDANT ENZYMES IN MAIZE AND PEANUT SEED TISSUES RESULTS IN REDUCED ROS CONTENT AND ENHANCED AFLATOXIN RESISTANCE UNDER DROUGHT STRESS. OBJECTIVE 2 WILL BE TO TEST THE HYPOTHESIS USING GENOME EDITING THROUGH CRISPR/CAS9 TECHNOLOGY TO SILENCE THE FUNCTION OF ANTIOXIDANT GENES RESULTING IN INCREASED ROS CONTENT, COMPROMISED DROUGHT TOLERANCE, AND GREATER SUSCEPTIBILITY TO AFLATOXIN CONTAMINATION. SUCCESSFUL CHARACTERIZATION OF THE RELATIONSHIP BETWEEN HOST TISSUE ROS CONTENT AND AFLATOXIN CONTAMINATION RESISTANCE WILL PROVIDE GREATER INSIGHT INTO THIS DISEASE, AND A NOVEL METHOD OF REDUCING AFLATOXIN EXPOSURE IN THE FOOD CHAIN. AS SUCH, THIS PROPOSED PROJECT IS IN LINE WITH THE AFRI CHALLENGE AND FY 2017 FOUNDATIONAL PRIORITY AREA: FOOD SAFETY, NUTRITION, AND HEALTH.
$0Mississippi State University · · FY2021 · National Institute of Food and Agriculture
DEVELOPMENT OF METHODS FOR KNOCKOUT CHICKENS: CRISPR-CAS GENOME EDITING TO UNDERSTAND FOODBORNE PATHOGEN-HOST INTERACTIONS IN POULTRY
$-0North Carolina State University · · FY2018 · National Institute of Food and Agriculture
THIS STANDARD RESEARCH PROPOSAL ADDRESSES MOLECULAR, CELLULAR AND WHOLE-PLANT APPROACHES TO UNDERSTANDING HOW GROWTH AND DEVELOPMENT AFFECT PLANT PRODUCTIVITY. THIS RESEARCH FOCUSES ON RHIZOMES, VEGETATIVE/REPRODUCTIVE STRUCTURES THAT ARE A VALUABLE ASSET IN PRODUCTIVITY OF BIOMASS, FORAGE, AND TURFGRASSES CULTIVATED ON >60 MILLION US ACRES AND LIKELY TO INCREASE. RHIZOMES ALSO ENHANCE 'WEEDINESS' OF UNDESIRABLE PLANTS THAT INFEST MILLIONS OF ACRES, REDUCING CROP PRODUCTIVITY AND HINDERING UTILIZATION OF POTENTIALLY VALUABLE GENES IN BREEDING. INFORMATION ABOUT RHIZOMATOUSNESS FROM BOTANICAL MODELS EXTRAPOLATES WELL. RELATIVES OF SORGHUM, A MODEL FOR RHIZOMATOUSNESS, WILL BE STUDIED. COMPARATIVE AND ASSOCIATION GENETICS WILL CLARIFY THE GENETIC CONTROL OF RHIZOMATOUSNESS FROM SORGHUM HALEPENSE, DISCERN NOVEL QTLS FROM THOSE SHARED WITH S. PROPINQUUM, AND INVESTIGATE CANDIDATE GENES BY SEVERAL APPROACHES. EXPRESSION PROFILING DURING EARLY STAGES OF RHIZOME DEVELOPMENT AND INGENOTYPES WITH DIFFERENT QTLS FOR RHIZOMATOUSNESS WILL REVEAL GENE NETWORKS, FUNCTIONAL GROUPS AND SPECIFIC GENES ASSOCIATED WITH SPECIFIC S. HALEPENSE QTLS FOR ENHANCED RHIZOMATOUSNESS. AT THE INTERSECTION OF POSITIONAL, EXPRESSION, FUNCTIONAL, COMPARATIVE AND ASSOCIATION GENETIC EVIDENCE, A TRACTABLE NUMBER OF CANDIDATE GENES ARE EXPECTED TO BE STRONGLY IMPLICATED IN THE GENETIC AND DEVELOPMENTAL CONTROL OF RHIZOME GROWTH, PERHAPS INITIATING FUNCTIONAL TESTS BY MEANS SUCH AS CRISPR/CAS GENOME EDITING. THESE APPROACHES WILL ALSO PROVIDE NEW INFORMATION ON GENETIC CONTROL OF TILLERING, ANOTHER IMPORTANT DETERMINANT OF PLANT PRODUCTIVITY. FINDINGS ARE EXPECTED TO ADVANCE KNOWLEDGE TOWARD DEVELOPMENT OF NOVEL METHODS TO ENHANCE PRODUCTIVITY OF DESIRABLE PLANTS AND CONTROL UNDESIRABLE ONES, ALSO TRAINING YOUNG SCIENTISTS IN INTEGRATIVE CONTEMPORARY APPROACHES TO ADDRESSING AGRICULTURAL CHALLENGES.
$-1University Of Georgia Research Foundation, Inc. · · FY2023 · National Institute of Food and Agriculture
INFLUENZA OR FLU IS ONE OF TOP 3 ECONOMIC DISEASES AFFECTING THE PORK INDUSTRY. IN HUMANS, IT CAUSES UP TO 41,000 HUMAN FATALITIES IN UNITED STATES AND UPWARDS OF 500,000 CASUALTIES WORLDWIDE. PIGS SERVE AS RESERVOIRS FOR SWINE, AVIAN, AND HUMAN VIRUSES AND PRODUCE NOVEL HIGH POTENCY STRAINS, SIMILAR TO THE SWINE FLU PANDEMIC H1N1 STRAIN. OUR HYPOTHESIS IS THAT ELIMINATING RECEPTORS FOR VIRAL ENTRY AND INTERFERING WITH VIRAL REPLICATION WILL SERVES AS A DUAL MECHANISM FOR PROTECTING THE PIGS FROM VIRAL INFECTION, AND TRANSMISSION OF FLU TO HUMAN AND PIG HOSTS. THERE ARE THREE OBJECTIVES IN THE PROPOSAL: 1) ASSEMBLE AND VALIDATE GENOME EDITING TOOLS TO DELETE THE RECEPTOR FOR FLU VIRUS ENTRY, AND PREVENT VIRAL PROPAGATION; 2) GENERATE RECOMBINANT PIGS; AND 3) TEST THE RECOMBINANT PIGS FOR SUSCEPTIBILITY TO INFECTION BY SWINE AND HUMAN TYPE ADAPTED VIRUSES TO INFECTION AND DISSEMINATION. WE EXPECT TO DEVELOP A PIG MODEL OF INFLUENZA RESEARCH AND IDENTIFY DRUGGABLE TARGETS. FROM AGRICULTURAL STAND POINT, WE ANTICIPATE ELIMINATION OF FLU FROM COMMERCIAL SWINE HERDS.
$-4University Of Maryland, College Park · · FY2023 · National Institute of Food and Agriculture