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166,118 grants matching “stem cells”
Cilia in Heart Development and Disease
$750,315Martina Brueckner · Yale University · R35 · FY2023 · HL
Regulatory T Cells in Allogeneic Transplantation
$750,258Robert S Negrin · Stanford University · RC2 · FY2010 · HL
Mechanisms of Cross-talk Between EphrinB and Alternate Signaling Pathways
$750,245Ira Daar · Division Of Basic Sciences - Nci · ZIA · FY2019 · CA
Predicting Tissue Specific Gli3 Regulatory Activity Using Hand2
$750,186Kevin Anthony Peterson · Jackson Laboratory · R01 · FY2024 · DE
Mechanisms of Cross-talk Between EphrinB and Alternate Signaling Pathways
$750,182Ira Daar · Division Of Basic Sciences - Nci · ZIA · FY2023 · CA
Regulating hematopoietic stem cells and hematopoiesis for clinical efficacy
$750,151Hal E. Broxmeyer · Indiana University Indianapolis · P30 · FY2012 · DK
An Automated Platform for High-throughput Network Electrophysiology
$750,099James Ross · Axion Biosystems, Llc · R44 · FY2014 · NS
In Vivo And In Vitro Studies Of Hepatitis E Virus
$750,057Suzanne U Emerson · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
SPORE: Developing New Rationale, Personalized Medicine for Lung Cancer
$750,052John D Minna · Ut Southwestern Medical Center · P50 · FY2016 · CA
Collaborative Research: Ideas Lab: Rational Design of Noncoding RNA for Epigenetic Signal Amplification
$750,032Alisha N Jones · New York University · · FY2023 · BIO
Enhance human ENCODE by function comparisons to mouse
$750,003Ross C Hardison · Pennsylvania State University, The · RC2 · FY2009 · HG
Validation of a single cell multiplexed in-situ biomarker analysis platform for p
$750,002Michael Gerdes · General Electric Global Research Ctr · R01 · FY2014 · CA
The Epigenetics of Alzheimer's Disease
$750,001Li-Huei Tsai · Massachusetts Institute Of Technology · R01 · FY2015 · NS
Validation of a single cell multiplexed in-situ biomarker analysis platform for p
$750,001Michael Gerdes · General Electric Global Research Ctr · R01 · FY2016 · CA
THE GOALS OF THIS RESEARCH PROPOSAL ALIGN WITH NASA S EMPHASIS ON ANIMAL BIOLOGY (VERTEBRATES) IN SUPPORT OF HUMAN SPACE EXPLORATION AND THE CELL AND MOLECULAR BIOLOGY GUIDING QUESTIONS 1 5 AND 8 (TO DEFINE THE UNDERLYING MECHANISMS OF THE CELLS THAT ARE INFLUENCED BY GRAVITATIONAL CHANGES CAUSING TISSUE/ORGAN DYSFUNCTION AND AFFECT STEM CELL FUNCTION RESPECTIVELY) AS DESCRIBED AT THE SPACE BIOLOGY SCIENCE PLAN 2016-2025. THIS WORK IS HIGHLY RELEVANT TO THE CARE OF ASTRONAUTS SINCE WE ANTICIPATE THAT OUR RESULTS WILL HELP UNDERSTAND THE IMPORTANCE OF TELOMERE LENGTH ALTERATIONS IN STEM CELLS DURING SKELETAL MUSCLE ATROPHY THAT HAVE NOT BEEN STUDIED BEFORE. OUR STUDY WILL BENEFIT NASA AND ASTRONAUTS HEALTH BY 1) EVALUATING THE COMBINED EFFECT OF WEIGHTLESSNESS AND RADIATION EXPOSURE ON TELOMERE LENGTH IN MUSCLE ATROPHY AND 2) ASSESSING THE MOLECULAR PATHWAYS AFFECTED DURING THIS PROCESS. OVERALL BY COMBINING UNIQUE MOLECULAR AND CELLULAR BIOLOGY APPROACHES AS WELL AS GENETICALLY ENGINEERED MICE THAT OUR LAB HAS DEVELOPED WE WILL DETERMINE THE MOLECULAR MECHANISMS OF TELOMERE DEFECTS IN MUSCS OF ATROPHIED MUSCLES THAT CAN TRANSLATE INTO BENEFITS FOR NASA EXPLORATION MISSION. THE REGULATORY MECHANISMS THAT WE WILL EXPLORE IN THIS PROPOSAL USING PROVEN ANALOGS SUCH AS MOUSE HIND LIMB UNLOADING THAT INDUCE BIOLOGICAL EFFECTS SIMILAR TO SPACEFLIGHT WILL BE FUNDAMENTAL FOR FUTURE STUDIES TO INVESTIGATE MUSCLE SPECIFIC TELOMERE LENGTH CHANGES IN TRANSITIONS FROM ONE GRAVITY TO ANOTHER. ADDITIONALLY SUCCESS IN OUR EXPERIMENTS WILL INFORM SIMILAR MECHANISMS IN MUSCULOSKELETAL APPLICATIONS WITH STEM CELL DYSFUNCTION SUCH AS MUSCLE INJURIES AFTER REPEATED EXERCISES PROVIDING BENEFITS TO THE HEALTH AND WELL BEING TO BOTH ASTRONAUTS IN SPACE AND THOSE ON EARTH.
$750,000Trustees Of The University Of Pennsylvania, The · · FY2020 · National Aeronautics and Space Administration
SpecEES: Spectrally-Efficient Near-Zero-Power IoT Connectivity with Existing Wi-Fi Infrastructure
$750,000Dinesh Bharadia · University Of California-San Diego · · FY2019 · CSE
The Epigenetics of Alzheimer's Disease
$750,000Li-Huei Tsai · Massachusetts Institute Of Technology · R01 · FY2012 · NS
Sickle Cell post Transplantation Long Term and Late Effects Registry ( STELLAR)
$750,000Lakshmanan Krishnamurti · Emory University · OT2 · FY2019 · HL
An interactive, digital platform to transform biological learning
$750,000Kelly Puzio · Squid Books, Llc · R44 · FY2021 · GM
Web Software for Drug Targeting Signaling Networks in Primary Cell Subsets
$750,000Nikesh Kotecha · Cytobank, Inc. · R44 · FY2014 · GM
CAREER: Enabling nanodisc native mass spectrometry to study membrane active compounds
$750,000Michael T Marty · University Of Arizona · · FY2019 · MPS
Dissecting the Sphingolipid Metabolic and Regulatory Network
$750,000Edgar B Cahoon · University Of Nebraska-Lincoln · · FY2018 · BIO
AN INNOVATIVE SYSTEM FOR CORD BLOOD STEM CELL ISOLATION
$750,000Zhiyong Wang · Diagnologix, Llc · R44 · FY2018 · HL
Web Software for Drug Targeting Signaling Networks in Primary Cell Subsets
$750,000David Craford · Cytobank, Inc. · R44 · FY2015 · GM
Program Project,Restoration of Endocrine Pancreas Funct*
$750,000Massachusetts General Hospital · U19 · FY2004 · DK