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38,696 grants matching “als”
Complex Neurodegenerative Disorders Clinic
$336,313Mary Kay Floeter · National Institute Of Neurological Disorders And Stroke · ZID · FY2018 · NS
Research Training in the Language Sciences
$336,255Michael Kehas Tanenhaus · University Of Rochester · T32 · FY2013 · DC
Riluzole Prodrugs for Melanoma and ALS
$336,255Allen Bernard Reitz · Fox Chase Chemical Diversity Center, Inc · R43 · FY2011 · CA
Regulation of Synaptic Dysfunction and Maintenance with age using Drosophila
$336,239Daniel T. Babcock · Lehigh University · R01 · FY2022 · NS
POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
$336,188Kathleen C Light · University Of Utah · R01 · FY2012 · AR
Autoregulation of Glomerular Filtration Rate
$336,174Roland C Blantz · Veterans Medical Research Fdn/San Diego · R01 · FY2010 · DK
The Miner Suite: State of the Art Bioinformatic Tools and Data Resources
$336,151John N Weinstein · Division Of Basic Sciences - Nci · Z01 · FY2008 · CA
Programmed Cell Death and DNA Damage Signals
$336,148Wesleyan University · R01 · FY2002 · NS
Functional Analysis of the BAP1 Metastasis Suppressor Gene in Uveal Melanoma
$336,136Frank J. Rauscher · Wistar Institute · R01 · FY2013 · CA
Potential therapeutic implications of targeting miR-150 in acute myeloid leukemia
$336,114Jianjun Chen · University Of Cincinnati · R01 · FY2017 · CA
Potential therapeutic implications of targeting miR-150 in acute myeloid leukemia
$336,114Jianjun Chen · University Of Cincinnati · R01 · FY2016 · CA
IN THIS PROPOSAL WE WILL EXPLORE THE INTERTWINED DYNAMICS OF THE PLANETS THEIR SATELLITES AND SMALL BODIES IN THE INNER SOLAR SYSTEM. OUR GOAL IS TO PRODUCE A SELF-CONSISTENT PICTURE OF THE INNER SOLAR SYSTEM'S EVOLUTION IN THE FIRST FEW TENS AND HUNDREDS OF MYR BEFORE IT REACHED ITS PRESENT DYNAMICAL CONFIGURATION. HUNGARIA ASTEROID GROUP IS A SLOWLY ERODING REMNANT OF A MUCH-LARGER INITIAL POPULATION WHICH WAS LIKELY RESPONSIBLE FOR THE LATE HEAVY BOMBARDMENT OF THE MOON (CUK 2012 BOTTKE ET AL. 2012). HOWEVER THERE IS STILL A FACTOR OF A FEW SHORTFALL BETWEEN THE PROJECTED NUMBERS OF PROTO-HUNGARIAS COMPARED TO LUNAR IMPACTORS 3.9 GYR AGO. HERE WE PROPOSE TO USE RECENT RESULTS OF CUK&NESVORNY (2018) ON THE SENSITIVE DEPENDENCE OF HUNGARIAS' STABILITY ON MARTIAN ECCENTRICITY AND TEST IF AN EXCESS OF LATE LUNAR IMPACTS COULD BE DUE TO LOW INITIAL ECCENTRICITY OF MARS WHICH RELAXED TO THE PRESENT STATE OVER THE FIRST FEW HUNDREDS OF MYR AFTER MARS' FORMATION. IN TASK 1 WE WILL USE NUMERICAL SIMULATIONS TO STUDY THE EVOLUTION OF A PRIMORDIAL MARS-CROSSER POPULATION THAT EVOLVES INTO HUNGARIAS IN THE PRESENCE OF CHAOTICALLY CHANGING ORBIT OF MARS. IN TASK 2 WE WILL COMPARE DIFFERENT REALIZATIONS OF THE EARLY SOLAR SYSTEM WITH VARYING TIME-HISTORIES OF MARS IN TERMS HOW THEY WOULD BE REFLECTED IN THE EARLY LUNAR RECORD. WE WILL BUILD ON RECENT WORK OF CO-I MINTON AND HIS COLLABORATORS AT PURDUE WHO HAVE DEVELOPED NEW MODELS THAT START WITH AN IMPACTOR POPULATION AND SHOW A VARIETY OF IMPACTS RECORDS THAT CAN RESULT FROM STOCHASTIC BOMBARDMENT BY THIS POPULATION. OUR GOAL IS TO IDENTIFY MODELS OF EARLY DYNAMICS OF TERRESTRIAL PLANETS AND PROTO-HUNGARIAS THAT ARE CONSISTENT WITH THE AVAILABLE CONSTRAINTS FROM THE MOON INCLUDING BASIN AND CRATER NUMBERS THEIR RELATIVE CHRONOLOGY AS WELL AS FORMATION TIME FOR THE IMBRIUM BASIN 3.9 GYA. IN TASK 3 WE WILL MODEL THE 2-DEGREE ORBITAL INCLINATION THAT THE MARTIAN MOON DEIMOS SHOULD HAVE OBTAINED FROM ENCOUNTERS WITH PASSING PLANETESIMALS A MECHANISM PREVIOUSLY PROPOSED FOR IAPETUS (NESVORNY ET AL. 2014) AND THE MOON (PAHLEVAN&MORBIDELLI 2015). USING DIRECT NUMERICAL METHODS AND A REALISTIC MODEL OF THE LATE PLANETESIMAL POPULATION WE WILL QUANTIFY THE AMOUNT OF ORBITAL EXCITATION THAT CAN BE EXPECTED FOR DEIMOS FROM PASSING PLANETESIMALS THAT WOULD NOT AT THE SAME TIME DISRUPT DEIMOS AND ERASE THE ORBITAL INCLINATION. WE WILL USE THE LUNAR CRATERING RECORD TO CONSTRAIN THE SIZE-DISTRIBUTION OF PLANETESIMALS AND THEIR FRAGMENTS. PAHLEVAN AND MORBIDELLI (2015) HAVE SHOWN THAT PLANETESIMAL ENCOUNTERS CAN IN SOME CASES PRODUCE THE OBSERVED LUNAR INCLINATION. HOWEVER THEIR LUNAR ORBITAL EVOLUTION MODEL WAS NOT SELF-CONSISTENT AND MAY VIOLATE CONSTRAINTS FROM LUNAR ECCENTRICITY. IN TASK 4 WE WILL REVISIT THIS ISSUE AND WE WILL ALSO INTRODUCE FLY-BYS INTO THE TIDAL EVOLUTION SCENARIOS OF CUK&STEWART(2012) TIAN&WISDOM(2016) AND CUK ET AL.(2016) WHICH ALL ACHIEVE ANGULAR MOMENTUM (AM) LOSS BY THE MOON SPENDING SOME TIME IN RESONANT NEAR-RESONANT OR EQUILIBRIUM-STATE ORBITS WHICH MAY BE UNSTABLE AGAINST "KICKS" FROM PLANETESIMAL FLYBYS. VENUS IS IN A VERY SLOW RETROGRADE ROTATION AND MODELS REQUIRE AN INITIAL ROTATION PERIOD>40 HR IF VENUS WAS SPUN DOWN BY SOLAR TIDES. IN TASK 5 WE WILL EXPLORE A POSSIBILITY THAT VENUS HAD A SATELLITE AND A HIGH OBLIQUITY (80-100 DEGREES) WHICH WOULD LEAD TO A RAPID EARLY AM TRANSFER TO HELIOCENTRIC ORBIT DUE TO LAPLACE PLANE INSTABILITY (TREMAINE ET AL. 2009 CUK ET AL. 2016). WE WILL ALSO EXPLORE LARGE SWINGS IN OBLIQUITY THAT ARE EXPECTED FROM PLANETARY PERTURBATIONS ONCE VENUS HAS BEEN PARTIALLY DESPUN AND A RELATIVELY SMALL MOON HAS EVOLVED OUTWARD. RESULTING LARGE AND CHAOTICALLY CHANGING MUTUAL INCLINATION BETWEEN THE MOON AND THE PLANET'S SPIN WOULD LEAD TO FURTHER AM DRAIN. WE WILL EXPLORE A RANGE OF INITIAL CONDITIONS TO DETERMINE IF THE DRASTIC AM LOSS AS OBSERVED FOR VENUS IS A COMMON DYNAMICAL OUTCOME.
$336,104Seti Institute · · FY2020 · National Aeronautics and Space Administration
Genetic Factors in Birth Defects
$336,104James Mills · Eunice Kennedy Shriver National Institute Of Child Health & Human Development · ZIA · FY2015 · HD
PATHWAYS AND PARTNERS OF P66SHC: FUNCTIONAL GENOMICS
$336,063Gino A Cortopassi · University Of California At Davis · P01 · FY2011 · AG
CORTICAL REPRESENTATION OF AUDITORY SPACE
$336,050University Of Michigan At Ann Arbor · R01 · FY2005 · DC
CORTICAL REPRESENTATION OF AUDITORY SPACE
$336,050University Of Michigan At Ann Arbor · R01 · FY2004 · DC
CORTICAL REPRESENTATION OF AUDITORY SPACE
$336,050University Of Michigan At Ann Arbor · R01 · FY2003 · DC
A cluster-randomized trial of a behavioral activation intervention administered in a college freshman orientation course
$336,040Tera L Fazzino · University Of Kansas Lawrence · R01 · FY2019 · AA
Mechanisms of Altered Gastrointestinal Dysfunction
$336,038Qiqi Zhou · University Of Texas Med Br Galveston · R01 · FY2013 · DK
SIGNALING IN INTESTINAL CANCER
$336,030Leonard H. Augenlicht · Montefiore Medical Center (Bronx, Ny) · R01 · FY2010 · CA
CLONING THE MCRD1 GENE--NORTH CAROLINA MACULAR DYSTROPHY
$336,020University Of California Los Angeles · R01 · FY2001 · EY
Collaborative Research: Density and structure of s
$336,000Yanbin Wang · University Of Chicago · · FY2016 · GEO
MAP Kinase Signaling in Lymphoma: A Novel Therapeutic Paradigm
$335,991Andrew M Evens · Tufts Medical Center · R01 · FY2014 · CA
CORNEAL HSV-1: A NOVEL VIRULENCE/REACTIVATION GENE
$335,977Cedars-Sinai Medical Center · R01 · FY2001 · EY
Attacking anthrax action by blocking receptor signaling
$335,965Dana-Farber Cancer Institute · R21 · FY2003 · AI