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17,828 grants matching “crispr”
Cholesterol Regulation of Endothelial K+ Channels
$41,286Irena Levitan · University Of Illinois At Chicago · R01 · FY2024 · HL
Elucidating the role of circPMS1 in melanoma metastasis.
$41,251Nicol Mecozzi · University Of South Florida · F99 · FY2025 · CA
Investigating a rare pediatric enteropathy caused by ADAM17 loss of function using iPSC-derived human intestinal organoids
$41,197Shane Williams · University Of Colorado Denver · F31 · FY2025 · DK
Cellular and molecular mechanisms of vertebrate testis homeostasis
$41,167James Alan Gagnon · University Of Utah · R35 · FY2022 · GM
Discovering miRNA-Mediated Mechanisms of Interneuron Development
$41,165Jessica Xinyun Du · Scripps Research Institute, The · F31 · FY2022 · NS
Optimization of a massively parallel genome editing approach to link regulatory elements to their target genes during mouse germ layer formation
$41,159Samuel Regalado · University Of Washington · F31 · FY2021 · HG
Discovery of craniofacial genes capable of compensation through evolutionary mutant model
$41,152Hope M Healey · University Of Oregon · F31 · FY2022 · DE
Identification of a GABP Feedback Loop and its Role in Tumor Cell Immortality
$41,118Nicholas Oliver Stevers · University Of California, San Francisco · F31 · FY2020 · CA
DR. GRABBHAM WILL BE RESPONSIBLE FOR THE OVERALL COORDINATION SUPERVISION AND PARTICIPATION OF EXPERIMENTS FOR HIS COMPONENT OF THIS PROPOSAL. THIS INCLUDES HIRING TRAINING AND SUPERVISING STAFF/STUDENTS; SCHEDULING AND STAFF ASSIGNMENTS; AND DATA MANAGEMENT. IN ADDITION HE WILL BE PERFORMING AND PARTICIPATING IN THE MAJORITY OF THE EXPERIMENTS PROPOSED IN THIS GRANT INCLUDING BUT NOT LIMITED TO ALL THE GENETIC AND MOLECULAR MODIFICATION OF MIRNAS IN AIM I OF MULTIPLE CELL LINES FUNCTION ASSAYS IN AIM2 OR AIM 3 PROCESSING SAMPLES STATISTICAL ANALYSES AND WILL BE RESPONSIBLE FOR ASSISTING WITH REPORTING THE STUDY'S FINDINGS. DR. GRABBHAM HAS PREVIOUSLY USED RETROVIRAL AND LENTIVIRAL DELIVERY SYSTEMS TO OVEREXPRESS TARGETS OF INTEREST AS WELL AS SUCCESSFULLY ESTABLISHED THE USE OF THE CRISPR-CAS9 GENETIC ENGINEERING TOOLS TO KNOCK-OUT TARGETS OF INTEREST. THESE TOOLS AND TECHNIQUES WILL BE UTILIZED TO FULLY EXECUTE THE RELEVANT RESEARCH AIMS DESCRIBED IN THE RESEARCH PROPOSAL.
$41,101The Trustees Of Columbia University In The City Of New York · · FY2020 · National Aeronautics and Space Administration
âÂÂNp53 as a Regulator of p53 Biology
$41,096Cecilia Blair Levandowski · University Of Colorado · F30 · FY2019 · AG
Elucidating the role of Scribble in angiogenic symmetry breaking and adherens junction remodeling
$41,081Lakyn Nicole Mayo · University Of California, San Francisco · F31 · FY2024 · HL
Characterization of Altered Fatty Acid Trafficking in Triple-Negative Breast Cancer
$41,081Jeremy Williams · University Of California, San Francisco · F31 · FY2021 · CA
Identification and Characterization of the Antiviral Response to RSV Infection: A Single Cell Approach
$41,081Sara Sunshine · University Of California, San Francisco · F31 · FY2021 · AI
Molecular mechanisms of synapse loss in Alzheimerâs disease
$41,081Kunal Shroff · University Of California, San Francisco · F30 · FY2024 · AG
Gene Regulation and Cell Proliferation Program
$41,077David L Spector · Cold Spring Harbor Laboratory · P30 · FY2018 · CA
Gene Regulation and Cell Proliferation Program
$41,074David L Spector · Cold Spring Harbor Laboratory · P30 · FY2017 · CA
Gene Regulation and Cell Proliferation Program
$41,073David L Spector · Cold Spring Harbor Laboratory · P30 · FY2020 · CA
Gene Regulation and Cell Proliferation Program
$41,073David L Spector · Cold Spring Harbor Laboratory · P30 · FY2019 · CA
Regulation and retention of extrachromosomal oncogene amplifications in cancer
$41,065King L. Hung · Stanford University · F99 · FY2022 · CA
Mechanisms of neural compensation in the retina and dysfunction in congenital stationary night blindness
$41,062Jacob Omar Khoussine · University Of Wisconsin-Madison · F30 · FY2023 · EY
Impact of the Placenta Barrier on Fetal Nutrition and Growth Restriction
$41,032Danielle Kozlosky · Rutgers, The State Univ Of N.J. · F31 · FY2021 · ES
Elucidating the Mechanisms of Lipid Droplet Protein Degradation
$40,987Melissa Roberts · University Of California Berkeley · F31 · FY2020 · DK
Raf-1 As a Regulator of Glutamine Metabolism
$40,920Ronald Leslie Shanderson · Stanford University · F31 · FY2022 · CA
Elucidating the impact of FIC-1/FICD-mediated AMPylation on polyglutamine aggregation dynamics and toxicity
$40,911Kate Matthys Van Pelt · University Of Michigan At Ann Arbor · F31 · FY2023 · NS
Identification and Characterization of Novel Cis-Regulatory Elements Controlling PTEN Expression
$40,892Christian Gonzalo Cerda-Smith · Duke University · F30 · FY2022 · CA