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59,101 grants matching “hypertension”
Mechanisms of CLC Transporters and Channels
$473,494Merritt C Maduke · Stanford University · R01 · FY2024 · GM
Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular Behaviors
$473,457Franklin D Costantini · Columbia University Health Sciences · R01 · FY2010 · DK
Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo Probes
$473,430Adam R Renslo · University Of California, San Francisco · R01 · FY2020 · MH
Novel Genome Editing for the Treatment of Glaucoma
$473,396Val C Sheffield · University Of Iowa · R01 · FY2023 · EY
Postpartum Remote Blood Pressure Monitoring Program: Study of Reducing Severe Maternal Morbidity among Black and Latina Women by Incorporating Patient Experiences and Systems Science
$473,377Samantha Parker Kelleher · Boston University Medical Campus · R01 · FY2025 · HL
Gender Differences in Experimental Aortic Aneurysms
$473,353Gilbert Rivers Upchurch · University Of Virginia · R01 · FY2012 · HL
Mechanisms of Aldosterone Induced Cardiovascular Damage
$473,345Brigham And Women'S Hospital · R01 · FY2003 · HL
Air pollution and risk of incident hypertension and diabetes in U.S. black women
$473,208Patricia F Coogan · Boston University Medical Campus · R01 · FY2014 · ES
Optimizing Linkage and Retention to Hypertension Care in Rural Kenya
$473,199Valentin Fuster · Icahn School Of Medicine At Mount Sinai · U01 · FY2014 · HL
PROFITS FROM BEEF PRODUCTION IN GREAT PLAINS FEEDLOTS ARE INCREASINGLY OFFSET BY HEALTH ISSUES. IN THE PAST DECADE, IT WAS OBSERVED THAT FAT-CATTLE CAN SUFFER FROM PULMONARY HYPERTENSION, A BUILDUP IN BLOOD PRESSURE BETWEEN THE HEART AND LUNGS. ALSO, IT IS VERY CONCERNING THAT THIS CONDITION MAY BE MADE WORSE IF AN ANIMAL CONTRACTS A RESPIRATORY DISEASE, ESPECIALLY LATE IN THE FATTENING PHASE. THE PROJECT WILL FOCUS STUDY ON FATTENING ANGUS STEERS, WITH AND WITHOUT PULMONARY HYPERTENSION, AND THEN EVALUATE THE IMPACT OF VIRAL INFECTION IN THE CATTLE SUFFERING FROM THE CONDITION. MORE SPECIFICALLY, THESE STUDIES WILL EVALUATE HOW HIGH-PRESSURE BETWEEN THE HEART AND LUNGS IN FATTENING STEERS INFLUENCES HEART AND LUNG TISSUES, THE IMMUNE SYSTEM, AND OVERALL BEHAVIOR; SPECIFICALLY, ELECTRONIC DATA SYSTEMS WILL RECORD ACTIVITY AND FEED INTAKE OF HEALTHY AND CATTLE SUFFERING FROM HIGH-PRESSURE BETWEEN THE HEART AND LUNGS AND INFECTED WITH A RESPIRATORY VIRUS.PULMONARY HYPERTENSION (PH) APPEARS TO BE RESPONSIBLE FOR FATTENING-INDUCED CHANGES IN THE LEFT-SIDE OF THE HEART, WHICH IS A SLIGHTLY DIFFERENT OUTCOME THAN OBSERVED IN CATTLE SUFFERING FROM LACK OF OXYGEN BECAUSE OF HIGH MOUNTAIN (I.E., BRISKET-RIGHT HEART) DISEASE. WE HYPOTHESIZE THAT INFLAMMATION COMBINED WITH ELEVATED METABOLIC DEMAND FROM FATTENING CONTRIBUTE TO LOW OXYGEN IN BLOOD AND DEVELOPMENT OF PH IN FEEDLOT CATTLE AT LOW ELEVATION. USING FATTENED ANGUS STEERS WEANED FROM LOW ELEVATION COW-CALF OPERATIONS, WE WILL EXECUTE THESE SPECIFIC AIMS: 1) UTILIZE MARKER MOLECULES IN BLOOD TO EVALUATE THE CONSEQUENCES OF PH; 2) UTILIZE THESE MARKER MOLECULES TO ASSESS INFLAMMATION AND LOW OXYGEN DELIVERY IN HEART AND LUNGS; AND 3) DETERMINE THE INFLUENCE OF PH ON (A) CATTLE BEHAVIOR AND PERFORMANCE CHARACTERISTICS, AND (B) THE RESPONSE TO EXPERIMENTAL INFECTION WITH BOVINE RESPIRATORY SYNCYTIAL VIRUS, A COMMON PATHOGEN OF CATTLE THAT CAUSES RESPIRATORY DISEASE. THIS RESEARCH WILL IDENTIFY BLOOD MARKERS THAT PREDICT DISEASE RISK TO BENEFIT SELECTIVE BREEDING, PRE-CONDITIONING, AND FATTENING PROGRAMS, LEADING TO IMPROVED CATTLE HEALTH.
$473,196Colorado State University · · FY2018 · National Institute of Food and Agriculture
Assessing Health Impacts of Extreme Weather on American Indian, Rural Populations with Multisystem Electronic Health Records
$473,180Jesse David Berman · University Of Minnesota · P20 · FY2024 · MD
Community Engagement Core
$473,166Monica L. Baskin · University Of Alabama At Birmingham · P50 · FY2024 · MD
Ambulatory Arteriovenous Carbon Dioxide Removal
$473,141Mc3, Inc. · R42 · FY2004 · HL
Macrophages and Biosensor Function in Vivo
$473,134Don L Kreutzer · University Of Connecticut Sch Of Med/Dnt · R01 · FY2009 · DK
Role of Chromosome Y gene, Uty, in protecting against Pulmonary Hypertension
$473,094Mansoureh Eghbali · University Of California Los Angeles · R01 · FY2023 · HL
Role of Chromosome Y gene, Uty, in protecting against Pulmonary Hypertension
$473,094Mansoureh Eghbali · University Of California Los Angeles · R01 · FY2021 · HL
Role of Chromosome Y gene, Uty, in protecting against Pulmonary Hypertension
$473,094Mansoureh Eghbali · University Of California Los Angeles · R01 · FY2022 · HL
Protein activated Receptor-4 in Cardiac Rupture after Myocardial Infarction
$473,053Abdelkarim Sabri · Temple Univ Of The Commonwealth · R01 · FY2021 · HL
Protein activated Receptor-4 in Cardiac Rupture after Myocardial Infarction
$473,053Abdelkarim Sabri · Temple Univ Of The Commonwealth · R01 · FY2019 · HL
Protein activated Receptor-4 in Cardiac Rupture after Myocardial Infarction
$473,053Abdelkarim Sabri · Temple Univ Of The Commonwealth · R01 · FY2018 · HL
Protein activated Receptor-4 in Cardiac Rupture after Myocardial Infarction
$473,053Abdelkarim Sabri · Temple Univ Of The Commonwealth · R01 · FY2020 · HL
Glomerular Cell-Cell Crosstalk and Injury
$473,040Ilse Sofia Daehn · Icahn School Of Medicine At Mount Sinai · R01 · FY2019 · DK
Genetics of Chronic Kidney Disease
$473,017Stephen T Turner · Mayo Clinic Rochester · R01 · FY2008 · DK
RISK FACTORS FOR DIABETIC RETINOPATHY IN BLACK AMERICANS
$473,006Univ Of Med/Dent Of Nj-Nj Medical School · R01 · FY2003 · EY
New CVD risk factors for lowered congitive functioning
$472,968University Of Maine Orono · R01 · FY2004 · HL