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84,503 grants matching “bioinformatics”
Biostatistics and Bioinformatics Core
$687,148Christine A. Stidley · University Of New Mexico Health Scis Ctr · U19 · FY2013 · AI
The impact of traumatic stress on the methylome: implications for PTSD
$687,095Alicia K Smith · Emory University · R01 · FY2016 · MH
Core-001
$687,093David H. Ellison · Oregon Health & Science University · UL1 · FY2021 · TR
Project 1. Nanolipoprotein-supported multi-subunit vaccine for Chlamydia trachomatis
$687,086Matthew Adrian Coleman · University Of Calif-Lawrnc Lvrmr Nat Lab · U19 · FY2021 · AI
New tools for tick-borne pathogen surveillance
$687,043Jonathan D Oliver · University Of Minnesota · R01 · FY2025 · AI
Heterogeneity of Forebrain Neural Precursors
$687,018Tarik F Haydar · Boston University Medical Campus · R01 · FY2015 · NS
THE WORLD NEEDS TO PRODUCE MORE FOOD WITH FEWER RESOURCES IN THE COMING DECADES. PART OF SOLVING THIS PUZZLE RELATES TO UNDERSTANDING AND CONTROLLING PLANT PATHOGENS. PLANT PATHOGENS INCLUDE BACTERIA, NEMATODES, FUNGI AND VIRUSES THAT INFECT PLANTS AND ANNUALLY THREATEN FOOD SECURITY AND IMPOSE ECONOMIC LOSSES BOTH DOMESTICALLY AND INTERNATIONALLY. AGRICULTURAL SCIENTISTS MUST CONTINUE TO DEVELOP INNOVATIVE IDEAS AND TECHNIQUES TO ADDRESS THE CURRENT AND FUTURE CHALLENGES POSED BY PLANT PATHOGENS. OUR PROJECT WILL ADDRESS THESE ISSUES BY DEVELOPING NEW METHODS AND CONCEPTUAL FRAMEWORKS TO UNDERSTAND HOW FUNGI CAUSE DISEASE. FUNGAL PLANT PATHOGENS MUST GROW DIFFERENTLY AND USE SPECIAL 'TOOLS' TO INFECT PLANTS AND OVERCOME THE PLANT IMMUNE SYSTEM. WE KNOW THAT FUNGI AND OTHER PLANT PATHOGENS HAVE THESE 'TOOLS', BUT WE DO NOT UNDERSTAND HOW THEY USE THE INFORMATION IN THEIR DNA TO REGULATE WHEN AND HOW TO USE THEM DURING INFECTION. ONE LIMITATION IS THAT IT IS CURRENTLY DIFFICULT TO GATHER DATA FROM FUNGI AND OTHER PLANT PATHOGENS WHEN THEY ARE INFECTING THE PLANT. TO OVERCOME THIS, OUR PROJECT AIMS TO DEVELOP A NEW METHOD TO ISOLATE FUNGI FROM INFECTED PLANTS, ENABLING BETTER DATA COLLECTION AND EXPANDING THE TYPES OF DATA THAT CAN BE COLLECTED. THIS WILL IMPACT OTHER AREAS OF PLANT PATHOLOGY AND CAN PROVIDE A GENERAL APPROACH TO HELP OTHER RESEARCHERS ADDRESS SIMILAR QUESTIONS. WE ARE ALSO ADDRESSING HOW PARTICULAR PIECES OF DNA, ONCE THOUGHT TO BE 'JUNK' PARTS OF THE GENOME, MAY BE PLAYING ANACTIVE ROLE IN REGULATING FUNGAL INFECTION. UNDERSTANDING HOW THESE TYPES OF DNA IMPACT FUNGAL GROWTH AND DEVELOPMENT CAN INFORM MANY TYPES OF SCIENTISTS WORKING TO UNDERSTAND HOW THE INFORMATION IN OUR DNA IS USED. LASTLY, THE PROJECT AIMS TO DEVELOP NEW APPROACHES TO DIRECTLY MANIPULATE THE INFORMATION IN FUNGAL DNA, ALLOWING RESEARCHERS TO MORE DIRECTLY TEST THE CAUSAL RELATIONSHIP BETWEEN INFORMATION IN THE DNA AND THE PROCESS OF FUNGI INFECTING PLANTS. THIS PROJECT WILL TRAIN STUDENTS IN THE AREAS OF PLANT BIOLOGY, MYCOLOGY, PLANT PATHOLOGY, BIOINFORMATICS AND MOLECULAR GENETICS TO CONTINUE DEVELOPING THE NEEDED WORK-FORCE TO MEET SOCIETAL CHALLENGES RELATED TO FOOD PRODUCTION AND PLANT HEALTH. KNOWLEDGE FROM THE PROJECT WILL IMPACT THE GENERAL PUBLIC THROUGH OUTREACH AND COMMUNICATION EFFORTS, AND THROUGH DEVELOPING NEW APPROACHES TO SOLVE CURRENT AND FUTURE AGRICULTURAL CHALLENGES.
$687,000Kansas State University · · FY2018 · National Institute of Food and Agriculture
Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)
$686,972Jason A Wertheim · University Of Arizona · R01 · FY2025 · DK
EFS-ADA Lentiviral Vector Transduction of Bone Marrow CD34+ Cells for ADA-SCID
$686,892Donald B Kohn · University Of California Los Angeles · U01 · FY2014 · AI
GLYCOSYLATION MUTANTS OF LEISHMANIA
$686,835Stephen M Beverley · Washington University · R01 · FY2007 · AI
PROTEOMICS CORE
$686,824Richard Daniel Carliss · University Of Washington · P30 · FY2010 · DA
Epigenetic mechanisms of sustained transcription across cocaine abstinence
$686,803Elizabeth A Heller · University Of Pennsylvania · R01 · FY2022 · DA
Mechanisms of Disparities in Adverse Neurocognitive Outcomes among Hispanics Aging with HIV
$686,665Maria Marquine · University Of California, San Diego · R01 · FY2020 · MD
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders
$686,631Aparna Bhaduri · University Of California Los Angeles · R01 · FY2025 · MH
Mapping Drug Resistance Genes in Plasmodium falciparum
$686,592Tim J Anderson · Texas Biomedical Research Institute · R37 · FY2014 · AI
CAREER: Dynamics and Diversity of Bone Morphogenetic Protein Signaling in Epithelial Cells
$686,544Nir Yakoby · Rutgers University Camden · · FY2012 · BIO
Redefining Tuberculosis Meningitis with Metagenomics and Host Transciptomics
$686,519Michael R Wilson · University Of California, San Francisco · R01 · FY2020 · AI
Defining Sjögrenâs pathogenesis by endotype: maladaptive responses of endogenous salivary gland mesenchymal stromal cells
$686,512Sara McCoy · University Of Wisconsin-Madison · R01 · FY2025 · DE
DEVELOPMENTAL FUNDS
$686,500Stanton L Gerson · Case Western Reserve University · P30 · FY2013 · CA
Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopy
$686,499Jon Clardy · Harvard Medical School · R01 · FY2017 · AT
Collaborative Research: BEE: Bridging the ecology and evolution of East African Acacias across time and space: genomics, ecosystem, and diversification.
$686,486Todd M Anderson · Wake Forest University · · FY2021 · BIO
Clinical Core
$686,484Brian Wigdahl · Temple Univ Of The Commonwealth · P30 · FY2016 · MH
Genomic Epidemiology of Cardiovascular Disease
$686,448Christopher O'Donnell · National Heart, Lung, And Blood Institute · ZIA · FY2015 · HL
Functional Genetic Variation Underlying Cardiovascular Genomic Epidemiology
$686,448Christopher O'Donnell · National Heart, Lung, And Blood Institute · ZIA · FY2015 · HL
Cincinnati Rheumatic Diseases Resource Center
$686,406Leah Claire Kottyan · Cincinnati Childrens Hosp Med Ctr · P30 · FY2025 · AR