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24,576 grants matching “microbiome”
Modulation of respiratory melioidosis inflammation
$225,223Jonathan Mark Warawa · University Of Louisville · P20 · FY2020 · GM
Accessing molecular communication via synthetic biology and microelectronics â gut on a chip model
$225,209William E. Bentley · Univ Of Maryland, College Park · R21 · FY2017 · EB
Logistics Coordinating Core
$225,150Kimberly A. Dukes · University Of Texas Med Br Galveston · U54 · FY2017 · HD
Logistics Coordinating Core
$225,150Kimberly A. Dukes · University Of Texas Med Br Galveston · U54 · FY2018 · HD
Investigating role of maternal gut microbiome in microglia-neuron dynamics and development of somatosensory circuits
$225,038Helen Vuong · University Of Minnesota · R00 · FY2023 · HD
Novel Approach for Characterizing Exposure and Response to Engineered Nanomaterials in the Gut
$225,000Seyoum Ayehunie · Mattek Corporation · R43 · FY2019 · ES
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PREVALENCE OF CARDIOMETABOLIC DISEASE RISK FACTORS IS REACHING AN EPIDEMIC WITH THE HIGHEST RISK AMONG INDIVIDUALS WITH NUTRIENT INSECURITY. TO COMBAT THIS, TRADITIONAL PLANT BREEDING HAS BEGUN TO SHIFT FROM A CALORIE-CENTRIC APPROACH TO IMPROVING NUTRIENTS IN CROPS. POTATOES ARE AN IDEAL CROP TO BEGIN THIS SHIFT DUE TO THEIR HIGH CONSUMPTION, AFFORDABILITY, ACCESSIBILITY, AND HIGH NUTRITIONAL VALUE. FURTHERMORE, POTATOES' GENE POOL PROVIDES A UNIQUE OPPORTUNITY TO USE THEIR NOVEL TRAITS IN DEVELOPING CULTIVARS.THE LONG-TERM GOAL OF THIS RESEARCH IS TO IMPROVE ACCESS TO A HEALTHY AND SUSTAINABLE SOURCE OF NUTRIENTS FOR DIFFERENT SOCIOECONOMIC GROUPS WHILE BOOSTING ECONOMIC VIABILITY FOR GROWERS AND STAKEHOLDERS. I HYPOTHESIZE THAT POTATO CARBOHYDRATES AND ASSOCIATED PHYTOCHEMICALS (PCAP) PROVIDE A HIGH-QUALITY SOURCE OF NUTRIENTS THAT IMPROVE GUT HEALTH BY SUPPLYING PREBIOTICS TO THE GUT MICROBIOTA. THE FIELD OF POTATOES' MATRICES IN THE CONTEXT OF GUT HEALTH IS UNDERSTUDIED. WE HAVE TWO GOALS; 1) TO DEVELOP A STANDARD PROFILE OF PCAP, AND 2) TO DETERMINE THE EFFECT OF PCAP ON GUT HEALTH, USING A MULTI-OMICS APPROACH.THIS RIGOROUS TRAINING WILL PROVIDE ME WITH A DIVERSE SKILLSET, SETTING ME APART AS A DYNAMIC RESEARCHER, WITH A UNIQUE VISION OF FUSION OF FOOD-OMICS, METAGENOMICS, AND PRECLINICAL RESEARCH TO BETTER UNDERSTAND HOW CROP VARIATION AND THEIR DIETARY COMPONENT AND GUT MICROBIOME INTERACT.WITH ITS FOCUS ON SOLVING CURRENT CHALLENGES IN HUMAN NUTRITION AND HEALTH IN THE UNITED STATES, THIS PROJECT IS WELL ALIGNED WITH THE GOALS OF AFRI NIFA FELLOWSHIP GRANT PROGRAM.
$225,000Colorado State University · · FY2024 · National Institute of Food and Agriculture
Skin Microbiome Editing with Fermentation Initiator
$225,000Chun-Ming Huang · Surface Bioadvances, Inc. · R41 · FY2017 · AR
High Resolution Microbiome Profiling System
$225,000Mark David Driscoll · Intus Biosciences Llc · R43 · FY2017 · DA
SBIR Phase I: Development of a Miniaturized Multiwell Plate Reader
$225,000Kevin P Seitter · Cerillo, Inc · · FY2016 · TIP
SBIR Phase I: Enhancing the skin microbiome for mosquito repellency: Next generation mosquito repellent derived from big data analysis
$225,000Nicole M Scott · Cybele Microbiome Inc · · FY2019 · TIP
SBIR Phase I: Harnessing Untapped Food-borne Microbial Diversity to Rationally Engineer Novel Healthy Foods
$225,000Ravi U Sheth · Imvela Corp. · · FY2020 · TIP
SBIR Phase I: A Microbial Enrichment Device to Reduce the Cost of Sequencing Metagenomes
$225,000Lorenzo Damico · Aincobio Llc · · FY2019 · TIP
SBIR Phase I: Novel Probiotic-Based Feed Additive Formulation for Enteric Methane Mitigation
$225,000Elizabeth L Sheets · Bezoar Laboratories, Llc · · FY2019 · TIP
SBIR Phase I: Establishing a Synthetic Niche to Reliably Colonize the Human Gut with Engineered Bacterial Therapeutics
$225,000Weston Whitaker · Novome Biotechnologies, Inc. · · FY2016 · TIP
MODERN PLANT BREEDING HAS SIGNIFICANTLY IMPROVED CROP YIELDS AND TRAITS LIKE GROWTH AND PRODUCTIVITY. HOWEVER, AS CLIMATE CHANGE INTRODUCES NEW CHALLENGES, THERE IS A NEED TO EXPLORE OVERLOOKED AREAS, SUCH AS THE PLANT MICROBIOME--THE COMMUNITY OF BACTERIA, FUNGI, AND VIRUSES LIVING IN AND AROUND PLANT ROOTS AND LEAVES. THESE MICROBES PLAYKEY ROLES IN HELPING PLANTS ABSORB NUTRIENTS AND RESIST ENVIRONMENTAL STRESSLIKE HEAT AND DROUGHT.MODERN MAIZE BREEDING HAS BEEN CONDUCTED UNDERIDEAL GROWING CONDITIONS WITH EXCESS NUTRIENTS GRANTED BY FERTILIZATION, WHICH MAY HAVE UNINTENTIONALLY REDUCED THE PLANT'S ABILITY TO REGULATE ITS MICROBIOME TO USE THE AVAILABLE RESOURCES MOST EFFICIENTLY. BY STUDYING MAIZE ALONGSIDE ITS WILD ANCESTOR, TEOSINTE, AND A RELATED CROP, SORGHUM, WE CAN TAP INTO THEIR NATURAL MECHANISMS OF MICROBIOME REGULATION TO CONFER STRESS TOLERANCE AND IDENTIFY WAYS TO STRENGTHEN MAIZE'S MICROBIOME. THIS RESEARCH AIMS TO UNDERSTAND HOW THE GENETIC MAKEUP OF THESE PLANTS INFLUENCES THEIR MICROBIOMES AND HELPS THEM ADAPT TO CHALLENGING CONDITIONS.BY INVESTIGATING THE GENETICS OF MAIZE AND ITS RELATIVES, THIS WORK WILL HELP DEVELOP FUTURE CROPVARIETIES THAT ARE MORE RESILIENT TO HEAT AND NUTRIENT STRESS. IT ALSO ALIGNS WITH EFFORTS TO USE AGRICULTURAL MICROBIOMES TO SUPPORT SUSTAINABLE FARMING AND CLIMATE-RESILIENT CROPS.
$225,000North Carolina State University · · FY2025 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OUTBREAKS OF FOODBORNE ILLNESS DUE TO CONTAMINATED LEAFY GREENS REMAINS A SERIOUS PUBLIC HEALTH CONCERN. MECHANICAL DAMAGE OF PROCESSED LEAF TISSUE OFFERS NEW OPPORTUNITIES FOR THE PROLIFERATION OF E. COLI O157:H7 (ECO157), THE MAIN CAUSAL BACTERIAL AGENT OF NUMEROUS LETTUCE-LINKED FOODBORNE OUTBREAKS. ECO157 WITHIN DAMAGED TISSUE IS PROTECTED FROM SANITIZATION, THEREFORE ALTERNATE MITIGATIONS MUST BE DEVELOPED TO MINIMIZE LETTUCE CONTAMINATION. JASMONIC ACID (JA)-MEDIATED PLANT DEFENSES ELICITED IN RESPONSE TO MECHANICAL INJURY OF LEAF TISSUE MAY SERVE AS A FIRST HURDLE TO WOUND COLONIZATION BY ENTERIC PATHOGENS. GIVEN KNOWN CULTIVAR-DEPENDENT DIFFERENCES IN JA-BASED LETTUCE RESISTANCE TO BIOTIC STRESSES, WE HYPOTHESIZE THAT CERTAIN LETTUCE GENOTYPES CAN MOUNT JA-MEDIATED RESPONSES TO LEAF INJURY THAT ARE INHIBITORY TO ECO157. ECO157 SURVIVAL WILL BE COMPARED ON SHREDDED AND INTACT LETTUCE OF CULTIVARS SELECTED BASED ON THEIR RESISTANCE TO NECROTROPHIC PATHOGENS AND INSECTS. THE MOST INHIBITORY CULTIVARS WILL BE ASSESSED FOR CALLOSE DEPOSITION, PRODUCTION OF JA, PHENOLICS, AND ROS, AND JA-DEPENDENT GENE EXPRESSION UPON WOUNDING. LETTUCE MICROBIOME AND TRANSCRIPTOME DATA WILL BE ACQUIRED IN COLLABORATION WITH THE FDA AND UC DAVIS, RESPECTIVELY, TO DETERMINE THE FACTORS THAT INFLUENCE ECO157 SURVIVAL ON CANDIDATE CULTIVARS. THE NOVEL RESULTS WILL CONTRIBUTE KNOWLEDGE FOR PLANT BREEDING TO INCREASE PRODUCE SAFETY, AND THUS TO THE AFRI EWD GOAL OF ADVANCING SCIENCE
$225,000Agricultural Research Service · · FY2022 · National Institute of Food and Agriculture
Development of a rapid point of care diagnostic,to monitor MucoCept-CVN, an HIV-targeted biotherapy,
$225,000Laurel A. Lagenaur · Osel, Inc. · R43 · FY2016 · AI
SBIR Phase I: Polyvalent Bacteriophages as Livestock Feed Additives and Alternatives to Antibiotics for Pathogen Control and Improved Animal Performance
$225,000Jacques M Mathieu · Sentinel Environmental Group Llc · · FY2018 · TIP
STTR Phase I: Use of Hydroxycinnamic Acids and Their Oligomers as Substitutes for Synthetic Growth Promoting Supplements in Livestock Feeds
$225,000Rajai H Atalla · Cellulose Sciences International · · FY2020 · TIP
SBIR Phase I: Culture-independent Rapid Bacterial Isolation and Identification
$225,000Rajesh Krishnamurthy · 3i Diagnostics, Inc. · · FY2018 · TIP
The Impact of the Intrauterine and Early Childhood Environments on Neurocognitive and Metabolic Development in African American Youth: Focus on the Gut-Brain Axis
$225,000Anne Lang Dunlop · Emory University · UH3 · FY2020 · OD
An Agent-Based Modeling Platform for Environmental Biotechnology
$225,000Fatemeh Shirazi · Microvi Biotech, Inc. · R41 · FY2016 · ES
Improving chemotherapy outcomes with proprietary molecules targeting the human mi
$225,000Ward Peterson · Symberix, Inc. · R43 · FY2014 · CA
Development of a kit for the targeted depletion of abundant sequencesfrom DNA/RNA libraries
$225,000Meredith Lauren Carpenter · Arc Bio, Llc · R43 · FY2016 · AI