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17,054 grants matching “genome editing”
Roles and Regulation of the bZip Transcription Factor CEBP-1 in Stress Response Pathways
$37,891Rose Malinow · University Of California, San Diego · F31 · FY2019 · GM
Genetic Strategies for the Treatment of Usher Syndrome in Mice
$37,889Katelyn N Robillard · Lsu Health Sciences Center · F30 · FY2021 · EY
Impact of mtDNA Mutations and Transfer on Tumor Growth Dynamics
$37,853Amy Katherine Yu · University Of California Los Angeles · F30 · FY2021 · CA
Supplement: Acquisition of a Multi-Mode Microplate Reader
$37,827Peter Z Qin · University Of Southern California · R01 · FY2021 · GM
Interactions between Mitochondria, ER, and Amyloid
$37,827Taylor A. Strope · University Of Kansas Medical Center · F31 · FY2024 · AG
Regulation of thermogenesis by the novel brown adipose-specific protein BASIC
$37,808Kevin Qian · University Of California Los Angeles · F30 · FY2021 · DK
Signal Transduction in B cell Activation
$37,800John C. Cambier · University Of Colorado Denver · R01 · FY2007 · AG
Genome editing to determine functional consequences of thousands of potentially pathogenic variants
$37,795Gregory Findlay · University Of Washington · F30 · FY2017 · CA
Understanding the Mechanisms of Ventricular Dysfunction in Hypoplastic Left Heart Syndrome
$37,792Francisco Xavier Galdos · Stanford University · F30 · FY2019 · HL
Signaling at the Uterine Placental Interface
$37,752Mikaela Elizabeth Simon · University Of Kansas Medical Center · F31 · FY2024 · HD
Establishment of the Uterine-Placental Interface
$37,710Regan Leigh Scott · University Of Kansas Medical Center · F31 · FY2024 · HD
Mechanisms of TGFb in prostaglandin metabolism and fertilization
$37,692Muhan Hu · University Of Alabama At Birmingham · F30 · FY2019 · HD
Base Editing Gene Correction of Pathogenic MYH7 Mutations in Models of Hypertrophic Cardiomyopathy
$37,674Andreas C Chai · Ut Southwestern Medical Center · F30 · FY2022 · HL
Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics
$37,665Blair Willette · Duke University · F31 · FY2022 · NS
Molecular Mechanisms of Invader Silencing in Type III CRISPR-Cas Systems
$37,644Kawanda A Foster · University Of Georgia · F31 · FY2017 · GM
Using CRISPR/Cas9 to dissect the role of FUS-CHOP in tumor response to radiation therapy
$37,644Mark Shuo Chen · Duke University · F30 · FY2017 · CA
Regulation of hematopoiesis by epigenetic timing control
$37,596Nicholas Pease · University Of Washington · F31 · FY2020 · HL
Decoding Alzheimer's disease-related enhancers in microglia
$37,592Bethany Rose Fixsen · University Of California, San Diego · F30 · FY2018 · AG
Elucidating KRAS-specific vulnerabilities in pancreatic cancer
$37,557Mandar Deepak Muzumdar · Dana-Farber Cancer Inst · K08 · FY2017 · CA
High-resolution functional mapping of non-coding sequences regulating fetal hemoglobin
$37,547Basheer Becerra · Harvard Medical School · F31 · FY2025 · DK
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
$37,542Matthew Jared Stevenson · Univ Of North Carolina Chapel Hill · F31 · FY2021 · CA
Using genome engineering to study mosquito biology and combat malaria
$37,524Andrea Lynelle Smidler · Harvard School Of Public Health · F31 · FY2018 · AI
A-Z junction formation drives recognition of Alu RNAs by ADAR1 and supports viral infectivity and replication
$37,498Parker J Nichols · University Of Colorado Denver · F31 · FY2024 · AI
How a cell cycle kinase, Aurora A, regulates polarity proteins organization
$37,472Nadia Ingabire Manzi · University Of Texas At Austin · F31 · FY2022 · HD
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** MANY CROPS, INCLUDING MAIZE, SORGHUM, AND MANY MILLETS, OCCUR IN A SUB-FAMILY OF GRASSES CALLED THE PANICOIDEAE. ALL PANICOIDS SHARE A FLORAL TRAIT THAT CONSTRAINS THEIR POTENTIAL PRODUCTIVITY. GRASS FLOWERS OCCUR IN STRUCTURES CALLED SPIKELETS. PANICOIDEAE SPIKELETS CONTAIN TWO FLOWERS, BUT USUALLY ONLY ONE FLOWER (THE UPPER FLOWER) IS FERTILE AND PRODUCES A GRAIN AFTER POLLINATION. THIS IS BECAUSE THE FLORAL ORGANS (CALLED CARPELS) THAT GO ON TO FORM THE GRAIN ARE SUPPRESSED IN LOWER FLOWERS, LEADING TO STERILE FLOWERS. THUS, POTENTIAL CROP PRODUCTIVITY IS CONSTRAINED BY CARPEL SUPPRESSION. IN THIS ERA OF GENOME ENGINEERING, CARPEL SUPPRESSION GENES COULD BE TRANSFORMATIVE TARGETS FOR GENOME EDITING AND YIELD IMPROVEMENT. HOWEVER, ONLY A FEW GENES ARE KNOWN TO REGULATE CARPEL SUPPRESSION IN MAIZE AND ITS RELATIVES. FURTHERMORE, HOW THESE GENES INTERACT IN PATHWAYS, AND WHETHER THESE GENES HAVE CONSERVED FUNCTIONS IN MANY GRASS SPECIES REMAINS UNKNOWN. HERE, WE WILL (1) EXPAND THE LIST OF GENES WITH KNOWN ROLES IN CARPEL SUPPRESSION, (2) DETERMINE HOW CARPEL SUPPRESSION GENES ARE ORDERED INTO GENETIC NETWORKS AND PATHWAYS IN MAIZE, AND (3) TEST THE HYPOTHESIS THAT A COMMON GENETIC MECHANISM REGULATES CARPEL SUPPRESSION IN THE PANICOIDEAE. TO ACHIEVE THESE OBJECTIVES, WE WILL USE STATE-OF-THE-ART METHODS IN GENETICS, GENOMICS, COMPUTER VISION, AND QUANTITATIVE PHENOTYPING.THIS PROJECT WILL PROVIDE FUNDAMENTAL KNOWLEDGE FOR ENSURING RESILIENT AND PROSPEROUS AGRICULTURAL SYSTEMS IN THE U.S. CARPEL SUPPRESSION GENES REPRESENT PROMISING TARGETS TO INCREASE YIELD IN MAIZE, AN IMPORTANT CROP IN THE U.S., AND IN ITS CLIMATE RESILIENT RELATIVES IN THE PANICOIDEAE. OUR RESULTS WILL REPRESENT AN IMPORTANT FIRST STEP IN DETERMINING THE GENETIC ARCHITECTURE OF CARPEL SUPPRESSION AND WILL ALLOW US TO EVALUATE THE POTENTIAL FOR THE GENES WE IDENTIFY TO AFFECT PRODUCTIVITY IN MAIZE AND THE MODEL PANICOID SETARIA VIRIDIS AT SMALL SCALES. GIVEN THE RELATIVE EASE OF GENOME EDITING IN MANY GRASSES, THE DISCOVERIES WE MAKE CAN BE TRANSLATED TO OTHER CROPS, TO BE RIGOROUSLY EVALUATED IN YIELD TRIALS. THERE IS A GROWING INTEREST WORLDWIDE IN CLIMATE-RESILIENT PANICOID CROPS, INCLUDING SORGHUM AND PROSO MILLET. HOWEVER, WHILE MANY MILLETS ARE DROUGHT, SALT AND HEAT TOLERANT, MOST ARE NOT HIGH-YIELDING, AND HAVE NOT BEEN SUBJECT TO THE INTENSIVE BREEDING THAT HAS SO DRAMATICALLY IMPROVED U.S. MAIZE YIELD IN THE 20TH CENTURY. SELECTIVE BREEDING, TOGETHER WITH TARGETED MODIFICATIONS TO KEY DEVELOPMENTAL GENES, SUCH AS CARPEL SUPPRESSION GENES, COULD DRAMATICALLY ACCELERATE YIELD IMPROVEMENTS. THUS, IDENTIFYING THE GENES THAT CONTROL PANICOID CROP PRODUCTIVITY COULD ACCELERATE THE PRODUCTION OF HIGH-YIELDING, CLIMATE-RESILIENT CROPS THAT WOULD ENHANCE THE LONG-TERM SUSTAINABILITY OF U.S. FOOD PRODUCTION SYSTEMS.
$37,465University Of Massachusetts · · FY2023 · National Institute of Food and Agriculture