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24,576 grants matching “microbiome”
Ozone, inflammation and respiratory microbiome
$232,500Andrew J Gow · Rutgers, The State Univ Of N.J. · R21 · FY2018 · ES
Characterizing the Respiratory Microbiome Via a Novel, Non-Invasive Technique
$232,500Sara Adar · University Of Michigan At Ann Arbor · R21 · FY2016 · AI
Host genetic variation affecting the microbiome in rhesus macaques
$232,500Eric J. Vallender · University Of Mississippi Med Ctr · R21 · FY2022 · OD
Defining the role of the early infant microbiome in mediating allergic outcomes associated with asthma in a mouse model
$232,500Linda S Mansfield · Michigan State University · R21 · FY2017 · AI
Age-Related Changes in Intestinal Function and Sarcopenia in Monkeys
$232,500Kylie Kavanagh · Wake Forest University Health Sciences · R21 · FY2016 · AG
Surgical site infections and the microbiome: Understanding the pathogenesis of surgical site infections
$232,500Jennifer L Rickard · University Of Minnesota · R21 · FY2024 · AI
Host and Microbial Biomarkers Related to the Development of Complicated Clostridium difficile Infection
$232,500Vincent B Young · University Of Michigan At Ann Arbor · R21 · FY2015 · AI
Biology of hypervirulent Klebsiella pneumoniae translocation from the gastrointestinal tract
$232,500Muhammad Ammar Zafar · Wake Forest University Health Sciences · R21 · FY2022 · AI
Bacterial Mast cell conditioning modulates skin allergic reactions
$232,500Anna Di Nardo · University Of California, San Diego · R21 · FY2017 · AI
The Influence of Physical Activity on the Gut Microbiome of Pre-Diabetic Adults
$232,500Mark A Pereira · University Of Minnesota · R21 · FY2021 · DK
Role of B cells in controlling Klebsiella pneumoniae associated disease states
$232,500Karen M Haas · Wake Forest University Health Sciences · R21 · FY2024 · AI
Extracellular RNA carrier subclasses in processes relevant to Substance Use Disorders or HIV infection
$232,410Sabita Roy · University Of Miami School Of Medicine · R21 · FY2025 · DA
Device for Preservation of Cell Free RNA in Saliva
$232,400Shivani Nautiyal · Prime Genomics, Inc. · R21 · FY2021 · CA
TODAY'S SWINE DIETS CONTAIN HIGH AMOUNTS OF CORN-BASED FIBER (CBF) DUE TO THE INCREASED UTILIZATION OF INDUSTRIAL CORN CO- PRODUCTS IN FEED. THIS FIBER TYPE IS POORLY UTILIZED BY PIGS FOR ENERGY AS IT CONTRIBUTES LESS THAN 5% OF THE CALORIES IN A PIG'S DIET. IMPROVING ITS UTILIZATION IS IMPERATIVE BECAUSE MEETING THE CALORIC SPECIFICATION OF A SWINE DIET ACCOUNTS FOR MORE THAN 60% OF THE TOTAL COST OF PORK PRODUCTION. PIGS RELY ON THEIR GASTROINTESTINAL MICROBIOME TO FERMENT FIBER FOR ENERGY. IT IS POORLY UNDERSTOOD HOW CBF INFLUENCES THE METABOLISM OF GASTROINTESTINAL MICROBIOTA, AND HOW THE PIG'S UTILIZE THESE MICROBIAL METABOLITES. THIS GAP IN OUR KNOWLEDGE IS LIMITING THE DEVELOPMENT OF TECHNOLOGIES THAT IMPROVE THE UTILIZATION OF CBF IN SWINE. THE RATIONALE IS THAT ONCE WE UNDERSTAND HOW CBF IMPACTS MICROBIAL METABOLISM AND THE ABILITY OF THE GUT TO UPTAKE MICROBIAL METABOLITES, WE WILL BE BETTER POSITIONED TO DEVELOP NOVEL SCIENCE-BASED TECHNOLOGIES TO IMPROVE ITS CONTRIBUTION TO ENERGY. WE HYPOTHESIS THAT BY UNDERSTANDING THE INFLUENCE OF CBF ON MICROBIAL METABOLISM AND THE PIG'S EFFICACY FOR ABSORBING AND UTILIZING SUBSEQUENT METABOLITES, WILL LEAD TO NOVEL TECHNOLOGIES AND STRATEGIES THAT IMPROVE CBF FERMENTATION. OUR OVERALL OBJECTIVE IS TO OBTAIN PRELIMINARY EVIDENCE ON THE METABOLIC CAPACITY OF GASTROINTESTINAL MICROBIOTA, AND PHYSIOLOGICAL MECHANISMS ALONG THE GASTROINTESTINAL TRACT TO ABSORB AND TRANSPORT MICROBIAL METABOLITES IN PIGS FED CBF. OUR SPECIFIC OBJECTIVES ARE TO 1) DETERMINE THE INFLUENCE OF CBF ON MICROBIAL METABOLISM AND COMPOSITION ALONG THE GUT OF GROWING PIGS USING METAGENOMIC RECONSTRUCTION; AND 2) INVESTIGATE THE CAPACITY OF THE GUT TO ABSORB, TRANSPORT, AND UTILIZE MICROBIAL METABOLITES DERIVED FROM THE FERMENTATION OF CBF USING TARGETED TRANSCRIPTOMICS. THE EXPECTED OUTCOME OF THIS RESEARCH IS A FUNDAMENTAL KNOWLEDGE FRAMEWORK FOR HOW PIGS, IN SYMBIOSIS WITH ITS MICROBIOTA, UTILIZE CBF FROM CORN CO-PRODUCTS. THE ANTICIPATED IMPACT OF THIS RESEARCH IS THAT FROM THE DERIVED KNOWLEDGE FRAMEWORK, TAILORED AND MORE EFFECTIVE TECHNOLOGIES CAN BE DEVELOPED TO IMPROVE THE FEEDING VALUE OF INDUSTRIAL CORN CO-PRODUCTS IN SWINE DIETS. ULTIMATELY, THIS RESEARCH HAS THE POTENTIAL TO IMPROVE FEED EFFICIENCY, NUTRIENT AND ENERGY UTILIZATION, AND THE SUSTAINABILITY OF SWINE PRODUCTION.
$232,232University Of Missouri System · · FY2023 · National Institute of Food and Agriculture
Biomarker Core
$232,219Robert A Rissman · University Of California, San Diego · P30 · FY2023 · AG
Pets. House Dust and GI Microbiota and Infant Allergy
$232,206Susan Veronica Lynch · Henry Ford Health System · P01 · FY2016 · AI
Metgagenomic Analysis of the Human Oral Viral Microbiome
$232,160Derrick E Fouts · J. Craig Venter Institute, Inc. · R21 · FY2008 · DE
Bacteria-Virus interactions in genital herpes infections
$232,073Smita Gopinath · Harvard University D/B/A Harvard School Of Public Health · R21 · FY2025 · AI
Alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism
$232,073Peter Belenky · Brown University · R21 · FY2025 · AI
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in Adolescence
$232,043Tanya Lynn Alderete · University Of Colorado · R00 · FY2020 · ES
The Role of the Microbiome in the Development/Prevention of Food Allergies
$232,000Gary B. Huffnagle · University Of Michigan At Ann Arbor · R21 · FY2010 · AI
Pets and the Infant's Microbiome Exposures: Impac on Childhood Allergic Asthma
$231,991Christine C Johnson · Henry Ford Health System · P01 · FY2016 · AI
Impact of HSV-2 shedding on the vaginal microbiome in the female genital tract
$231,989Christine Michelle Johnston · University Of Washington · U19 · FY2017 · AI
RC1: Pre-Clinical Research Core
$231,988Adam Salmon · University Of Texas Hlth Science Center · P30 · FY2021 · AG
Evaluation of Novel Interferon Epsilon across Human Pregnancy
$231,971Brandie Depaoli Taylor · Temple Univ Of The Commonwealth · R21 · FY2018 · AI