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38,696 grants matching “als”
CRCNS: Extracting Dynamical Structure Embedded in Motor Preparatory Activity
$353,407Krishna V Shenoy · Stanford University · R01 · FY2007 · NS
Mechanisms of Als vaccine protection against S. aureus
$353,406Brad J Spellberg · Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center · R01 · FY2007 · AI
Imaging Brain Signal Transduction In Vivo With Radiolabeled Arachidonic Acid
$353,337Stanley I Rapoport · National Institute On Aging · ZIA · FY2010 · AG
Drosophila SK channels: ICS and the mammalian Islow AHP
$353,311Oregon Health And Science University · R01 · FY2003 · GM
Voltage-Gated Proton Channels in Human Neutrophils
$353,285Thomas E Decoursey · Rush University Medical Center · R01 · FY2007 · HL
Delineating Physiologic Mechanisms of Swallowing impairment and Decline in ALS
$353,265Emily Kate Plowman · University Of Florida · R01 · FY2017 · NS
Regulatory role of iron transport in stress and ineffective erythropoiesis
$353,260Yelena Ginzburg · Icahn School Of Medicine At Mount Sinai · R01 · FY2016 · DK
Astrocytes and ischemic brain injury
$353,257Rona G Giffard · Stanford University · R01 · FY2013 · NS
Amyloid-like Interactions in Yeast Cell Adhesion
$353,250Peter N Lipke · Brooklyn College · SC1 · FY2009 · GM
Amyloid-like Interactions in Yeast Cell Adhesion
$353,250Peter N Lipke · Brooklyn College · SC1 · FY2008 · GM
Effects of environmental estrogen exposure on the heart
$353,250Hong-Sheng Wang · University Of Cincinnati · R01 · FY2009 · ES
Amyloid-like Interactions in Yeast Cell Adhesion
$353,250Peter N Lipke · Brooklyn College · SC1 · FY2010 · GM
The Vascular Chymase-Angiotensin II System
$353,201Ahsan Husain · University Of Alabama At Birmingham · R01 · FY2007 · HL
BACE1 regulation and TNFR Type II receptor in Alzheimers disease
$353,116Yong Shen · Roskamp Institute, Inc. · R01 · FY2013 · AG
INSIGHT IS THE FIRST PLANETARY MISSION SINCE THE APOLLO MISSION DEDICATED TO ACQUIRING GEO- PHYSICAL DATA FROM SURFACE-INSTALLED INSTRUMENTS INCLUDING A SHORT-PERIOD AND A BROAD-BAND SEISMOMETER TO EXPLORE THE INTERNAL STRUCTURE AND DYNAMICS OF A SOLAR SYSTEM OBJECT OTHER THAN THE EARTH AND THE MOON. OUR GOAL IS TO CHARACTERIZE SEISMIC SIGNALS WHICH WE EXPECT TO RECEIVE FROM A SINGLE BROADBAND INSTRUMENT ONBOARD INSIGHT BY NUMERICAL SIMULATIONS OF SEISMIC WAVE PROPAGATION IN CONJUNCTION WITH 3D (AN)ELASTIC MODELS. SUCH 3D WAVE SIMULATIONS WILL PLAY A CRUCIAL ROLE FOR INTERPRETING THE REAL MARTIAN DATA SPECIFICALLY THE COMPLEX WAVEFORMS THAT CANNOT BE EXPLAINED BY APPROXIMATIONS TO THE WAVE EQUATION. WE WILL INVESTIGATE THE EFFECT OF TOPOGRAPHY AND DISTINCT CRUSTAL DICHOTOMY SIZE OF THE CORE AS WELL AS THE 3D VARIATIONS IN CRUST AND MANTLE ON SEISMIC WAVEFORMS AT REGIONAL AND GLOBAL SCALES. THE SPECTRAL-ELEMENT METHOD IS PARTICULARLY WELL-SUITED FOR SIMULATIONS OF WAVE PROPAGATION IN TERMS OF ITS ACCURACY AND FLEXIBILITY TO CAPTURE COMPLEX STRUCTURES (E.G. KOMATITSCH AND TROMP 2002; CHALJUB ET AL. 2003; CAPDEVILLE ET AL. 2003; CHALJUB AND VALETTE 2004; PETER ET AL. 2011). AS PART OF INSIGHT WE HAVE STARTED EXAMINING THE EFFECT OF 3D MARTIAN CRUST ON WAVEFORMS PERFORMING 3D SPECTRAL-ELEMENT SIMULATIONS (BOZDAG ET AL. 2017) FOR INITIALLY SELECTED REFERENCE MARS MODELS. WE NOW PROPOSE A THOROUGH INVESTIGATION OF MARS INTERNAL STRUCTURE SPECIFICALLY THE CRUST USING THE GLOBAL AND REGIONAL VERSIONS OF THE SPECTRAL-ELEMENT WAVE SIMULATION PACKAGE SPECFEM3D (KOMATITSCH AND TROMP 2002). ATTENUATION ELLIPTICITY ROTATION AND GRAVITY (COWLING APPROXIMATION) CAN ALL BE INCORPORATED IN SIMULATIONS. WE WILL ADDRESS THE FOLLOWING QUESTIONS: 1- GLOBAL SIMULATIONS: WE WILL IMPLEMENT A SET OF 1D/3D MARS MODELS AND OPTIMISE THE 3D NUMERICAL SOLVER. THE 3D MANTLE STRUCTURE DERIVED FROM THE CURRENT THERMOCHEMICAL AND MIN- ERALOGICAL MODELS WILL ALSO BE USED IN SIMULATIONS TO BETTER ASSESS 3D CRUSTAL EFFECTS ON BODY AND SURFACE WAVES. IN ADDITION THE DEEP INTERIOR WILL BE STUDIED BY ANALYSING MANTLE AND CORE PHASES. 2- REGIONAL SIMULATIONS: HIGHER-RESOLUTION SIMULATIONS WILL BE PERFORMED USING THE CUR- RENT HIGH-RESOLUTION TOPOGRAPHY REGOLITH THICKNESS MODELS ETC. TO INVESTIGATE FOR INSTANCE THE EFFECT OF THE EJECTA AND THE SHAPE OF CRATERS ON BODY AND SURFACE WAVEFORMS. 3- BLIND TESTS: USING THE GLOBAL VERSION OF SPECFEM3D SYNTHETICS WILL BE GENERATED FOR A CHOSEN 3D CRUST AND MANTLE MODEL USING VARIOUS SEISMIC SOURCES (MARSQUAKES METEORITE IMPACTS) AND DIS- SEMINATED FOR BLIND TESTS TO THE OTHER INSIGHT RESEARCHERS TO VALIDATE HOW FAR THE SOURCE AND STRUCTURE CAN BE INFERRED WITH DATA FROM A SINGLE SEISMOMETER. BOZDAG ET AL. (2017) DEMONSTRATED GLOBAL SIMULATIONS DOWN TO 9 S. WE AIM TO TAKE IT FURTHER TO ULTIMATELY GO DOWN TO 1 S. 4- WE WILL ALSO USE 3D SIMULATIONS TO DEFINE THE SOURCE OF COMPLEX WAVEFORMS TO BE OBSERVED IN REAL MARTIAN DATA WHICH MAY NOT BE EXPLAINED BY 1D SIMULATIONS AND SIMPLIFIED INVERSIONS. WE WILL ULTIMATELY EMPLOY MACHINE-LEARNING ALGORITHMS TO DETECT AND DISCRIMINATE PHASES IN COM- PARISON WITH THE OBSERVED DATA FROM MARS BASED ON OUR EXPERIENCE AND TOOLS BEING DEVELOPED FOR EARTH'S IMAGING PROBLEMS. THE RESEARCH WILL BE CARRIED OUT IN CLOSE COLLABORATION WITH THE INSIGHT TEAM.
$353,078Trustees Of The Colorado School Of Mines · · FY2020 · National Aeronautics and Space Administration
Research Project 2
$353,063Paul F Worley · Johns Hopkins University · P50 · FY2015 · DA
Primary cilia as mechanotransducers in bone
$353,057Christopher Rae Jacobs · Columbia Univ New York Morningside · R01 · FY2012 · AR
Copper Proteins In Metal and Oxidant Stress Responses
$353,044Northwestern University · R01 · FY2002 · GM
Tau-mediated regulation of axonal transport
$353,041Christopher L. Berger · University Of Vermont & St Agric College · R01 · FY2016 · GM
Tau-mediated regulation of axonal transport
$353,041Christopher L. Berger · University Of Vermont & St Agric College · R01 · FY2015 · GM
Bayesian methods for cortical surface neuroimaging data
$353,033Amanda Mejia · Trustees Of Indiana University · R01 · FY2022 · EB
Impact of Allostatic Load and Neighborhood Contextual Factors on Breast Cancer in the Women's Health Initiative
$353,011Adana A. M. Llanos · Columbia University Health Sciences · R01 · FY2024 · CA
Voltage-sensitive dye imaging from the nervous system
$353,003Dejan P Zecevic · Yale University · R01 · FY2010 · NS
DETECTING SUBTLE SIGNALS IN GENOMIC SEQUENCE
$353,003Brown University · R01 · FY2004 · HG
Population-Based Study of Environmental Risk Factors for ALS
$352,942Marc G Weisskopf · Harvard School Of Public Health · R01 · FY2012 · ES