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38,696 grants matching “als”
Role of a novel neuropeptide (p5/Tp5/TFp5) derived from a neuronal cell cycle kinase (Cdk5),p35 activator protein, in neurobiology
$1,556,991Harish C Pant · National Institute Of Neurological Disorders And Stroke · ZIA · FY2018 · NS
Family Study of Affective and Anxiety Spectrum Disorders
$1,556,721Kathleen R Merikangas · National Institute Of Mental Health · ZIA · FY2013 · MH
Restoring Communication with an Intracortical Neural Interface System
$1,556,196Leigh R Hochberg · Massachusetts General Hospital · R01 · FY2012 · DC
Section on High Resolution Optical Imaging
$1,555,754Hari Shroff · National Institute Of Biomedical Imaging And Bioengineering · ZIA · FY2017 · EB
Environmental and Genetic Risk Factors For Breast Cancer: The Sister Study
$1,555,730Dale P Sandler · National Institute Of Environmental Health Sciences · ZIA · FY2022 · ES
Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)
$1,555,588Michael Benatar · University Of Miami School Of Medicine · U54 · FY2021 · NS
Clinical and Informatics Research on Large Clinical Databases
$1,554,491Clement McDonald · National Library Of Medicine · ZIA · FY2021 · LM
THE DEVELOPMENT OF AN ASTROCYTE HEMICHANNEL BLOCKER TO DELAY SPATIAL AND TEMPORAL PROGRESSION IN ALS
$1,553,737The Johns Hopkins University · · FY2020 · Defense Health Agency
Immunoglobulin Light Chain Fibrillogenesis
$1,553,421Boston University Medical Campus · P01 · FY2004 · HL
Discovery And Functional Genomics Of Environmental Response Genes
$1,552,896Douglas Bell · National Institute Of Environmental Health Sciences · ZIA · FY2009 · ES
Center for Alzheimer's and Related Dementias: Detection of cryptic exons (splicing differences) in TDP-43 as biomarkers for frontotemporal dementia and Alzheimer's disease
$1,552,521Mark Cookson · National Institute On Aging · ZIA · FY2025 · AG
Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance
$1,552,021Ann M Chahroudi · Emory University · P01 · FY2025 · HD
Technical Development of Diagnostic Cardiovascular MRI
$1,550,551Andrew Arai · National Heart, Lung, And Blood Institute · ZIA · FY2012 · HL
Synaptic Mechanisms in the Mammalian Retina
$1,550,292Jeffrey Diamond · Neurological Disorders And Stroke · Z01 · FY2007 · NS
Exploiting DNA Replicative Stress for Novel Small Cell Lung Cancer Therapies
$1,548,129Anish Thomas · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
IGF-I/ALS Trial
$1,547,356Mayo Clinic Coll Of Medicine, Rochester · R01 · FY2002 · NS
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
$1,544,813Matthew Wayne Johnson · Johns Hopkins University · U01 · FY2022 · DA
Axonal transport regulates synaptic function and axonal homeostasis
$1,544,570Zu-Hang Sheng · National Institute Of Neurological Disorders And Stroke · ZIA · FY2017 · NS
What determines the location of meiotic crossovers in the mammalian genome?
$1,544,128Rafael Camerini-Otero · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2017 · DK
Clonal analysis of in vivo hematopoiesis
$1,543,957Cynthia E Dunbar · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
Optimization of gene transfer and gene editing safety and efficacy focusing on the NHP model
$1,543,957Cynthia E Dunbar · National Heart, Lung, And Blood Institute · ZIA · FY2019 · HL
AFTER MORE THAN A CENTURY OF RESEARCH ON ENVIRONMENTAL MICROBES IT IS BROADLY RECOGNIZED THAT MICROBES ARE THE PRIMARY MEDIATORS OF PLANETARY BIOGEOCHEMICAL CYCLES. THERE IS A PAUCITY OF TOOLS AVAILABLE TO THE SCIENTIFIC COMMUNITY THAT ENABLES THE SIMULTANEOUS COLLECTION OF SAMPLES FOR MICROBIAL AND GEOCHEMICAL ANALYSES AT AN APPROPRIATE RANGE OF SPATIAL AND TEMPORAL SCALES. IT IS A FOREGONE CONCLUSION THAT DEVELOPING THE TECHNOLOGIES TO DETECT LIFE AND QUANTIFY ITS METABOLIC ACTIVITY IN OUR OWN BIOSPHERE IS REQUIRED TO PAVE THE WAY FOR SUCH EFFORTS ON OTHER PLANETS. TO ADDRESS THIS ISSUE WE PROPOSE TO DEVELOP AN OPEN SOURCE AUTONOMOUS VEHICLE LANDER (AVL) THAT ENABLES USERS TO COLLECT SAMPLES AND IN SITU DATA FOR ALLYING MICROBIAL DIVERSITY AND GENE EXPRESSION (VIA DNA AND RNA ANALYSES) TO MICROBIAL ACTIVITY (VIA STABLE ISOTOPIC TRACERS AND ANALYSES) AND GEOCHEMISTRY (VIA IN SITU AND LAB-BASED GEOCHEMICAL MEASUREMENTS). THE ABISS WILL BE THE MOST TECHNOLOGICALLY ADVANCED AVL TO DATE. ADVANCES IN SUCH TECHNOLOGIES HAVE LONG BEEN INCREMENTAL AND IT IS OUR HOPE THAT THE PROPOSED EFFORT WILL HELP PUT SUCH BIOGEOCHEMICAL OBSERVATORY TECHNOLOGIES ON PAR WITH EXISTING SPACE SYSTEM TECHNOLOGIES SO THAT FUTURE MISSIONS CAN INCORPORATE SIMILARLY INTEGRATED SYSTEM TO MORE COMPREHENSIVELY RELATE THE GEOCHEMICAL SETTING TO POTENTIAL INDICATIONS OF LIFE. HIGHLIGHTS OF THE ABISS SYSTEM INCLUDE: 1) A STATE-OF-THE ART OPTICAL MODEM WITH>10 MB/S TRANSMISSION RATES FOR SENDING DATA IMAGES AND VIDEO FROM THE ABISS TO THE USER DURING ANY STAGE OF ABISS OPERATIONS. THIS WILL BE THE FIRST IMPLEMENTATION OF THIS NEW TECHNOLOGY ON AN AVL. THIS LEVERAGES OFF ~ $3.5M OF SUPPORT FROM NSF. 2) OUR IN SITU MASS SPECTROMETER (ISMS) TO MEASURE DISSOLVED VOLATILES. IT HAS BEEN DEPLOYED ON ~130 DIVES AND FEATURED IN NUMEROUS ARTICLES IN NATURE AND NATURE GEOSCIENCES (PETERSEN ET AL. 2011; WANKEL ET AL. 2011) AMONG OTHERS. IT CAN RUN CONTINUOUSLY FOR ~2 YEARS IN SITU. WHEN USED WITH STABLE ISOTOPIC TRACERS IT CAN BE USED TO CONDUCT RATE MEASUREMENTS IN SITU. THIS IMPLEMENTATION LEVERAGES OFF ~$1.5 MILLION DOLLARS TO HARVARD FROM NSF NASA &THE MOORE FOUNDATION. 3) A NOVEL 3-DEGREE-OF-FREEDOM POSITIONABLE SEDIMENT PROBE EQUIPPED WITH AN ARRAY OF SIX THERMISTORS LOCATED ALONG THE LENGTH OF THE SEDIMENT PROBE THAT WILL PROVIDE CRITICALLY NEEDED TEMPERATURES FOR HEAT AND GEOCHEMICAL FLUX. THIS IS A MAJOR ADVANCE IN AVL TECHNOLOGY. 4) SIX IN SITU TITANIUM HIGH-PRESSURE VESSELS TO ALLOW FOR IN SITU EXPERIMENTS AND RECOVERY AT PRESSURE. IMPACT AND VALUE: THE ABISS IS DESIGNED TO ADDRESS THE LONG-STANDING CHALLENGE OF BETTER UNDERSTANDING THE RELATIONSHIPS AMONG MICROBES AND BIOGEOCHEMICAL PROCESSES. DEVELOPING THIS SYSTEM FOR STUDYING LOW-ENERGY EARTH SYSTEMS SUCH AS THE RATES OF MICROBIAL ACTIVITY AND BIOGEOCHEMICAL CYCLING WITHIN OLIGOTROPHIC WATERS AND OCEAN GYRES AFFORDS US THE OPPORTUNITY TO BETTER UNDERSTAND "HOW" TO ALLY SUCH SYSTEMS TO DETECT LIFE BUT PRIMARILY TO QUANTIFY ITS ACTIVITY.OPERATIONAL UTILITY ASSESSMENT PLAN: BRIEFLY TWO MAJOR DEPLOYMENTS OF THE ABISS ARE PLANNED OFF THE CALIFORNIA COAST: ONE IN AN ANOXIC BASIN AND THE OTHER IN OLIGOTROPHIC WATERS. COMPARING THESE TWO SITES VIA THE ABISS TO DETERMINE RATES OF PRIMARY AND SECONDARY PRODUCTION DISSOLVED CARBON AND NITROGEN FLUXES AND STABLE ISOTOPIC COMPOSITION TOGETHER WITH RECORDS OF MICROBIAL ABUNDANCE AND MRNA EXPRESSION VIA ILLUMINA SEQUENCING WILL PROVIDE A VALIDATION OF THE TECHNOLOGY AS WELL A RICH DATASET THAT PROVIDES A RELEVANT FRAMEWORK FOR QUANTIFYING THE IMPACT THAT MARINE MICROBES HAVE ON BIOGEOCHEMICAL CYCLING IN TWO DISPARATE BUT HIGHLY RELEVANT TO ASTROBIOLOGY ECOSYSTEMS.
$1,542,792President And Fellows Of Harvard College · · FY2017 · National Aeronautics and Space Administration
Adaptive changes of the ground squirrel retina during hibernation
$1,542,259Wei Li · National Eye Institute · ZIA · FY2019 · EY
Novel DNA encoded monoclonal antibodies (DMAbs) for control of Antimicrobial Resistant (AMR) Pseudomonas aeruginosa infection
$1,541,486David B. Weiner · Wistar Institute · R01 · FY2019 · AI
Development of new antibody-based cancer therapies
$1,541,067Mitchell Ho · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA