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91,797 grants matching “obesity”
Park, Rx, Physical Activity and other Health Benefits for Low Income Children
$633,200Deborah A Cohen · Kaiser Foundation Research Institute · R01 · FY2021 · HL
Impact of a Community Care Intervention to Address Inequities in COVID-19 and Influenza Vaccination Among Adults Suffering from Disproportionate Chronic Disease
$633,199Marielena Lara · Rand Corporation · R01 · FY2023 · MD
Interventions to Control Obesity in Colleges
$633,146Laura A Linnan · Univ Of North Carolina Chapel Hill · R01 · FY2007 · HL
REAL HEALTH-Diabetes: REach Ahead for Lifestyle and Health-Diabetes
$633,139Deborah J Wexler · Massachusetts General Hospital · R18 · FY2017 · DK
Dynamic Sustainment of Evidence-Based Health Promotion Interventions in Mental Health
$633,127Kelly A Aschbrenner · Dartmouth-Hitchcock Clinic · R01 · FY2025 · MH
Project Title: PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends
$633,120Josiemer Mattei · Harvard School Of Public Health · R01 · FY2019 · HL
Role of Environmental Exposures on the Infant Gut Bacterial Microbiome and Virome
$633,101Lori R Holtz · Washington University · R01 · FY2020 · DK
Recurrent circadian disruption & pancreatic B-cell responsiveness in older people
$633,096Charles A Czeisler · Brigham And Women'S Hospital · P01 · FY2016 · AG
SWAN: Study of Women's Health Across the Nation
$633,058Joel S Finkelstein · Massachusetts General Hospital · U01 · FY2012 · AG
Non-viral gene therapy for sickle cell anemia
$633,051Robert P Hebbel · University Of Minnesota · R33 · FY2012 · HL
Learning Theory to Improve Obesity Treatments
$633,001Kerri N Boutelle · University Of California, San Diego · R01 · FY2014 · DK
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECTRESPONDS TO USDA-NIFA AFRI FOUNDATION PROGRAM FOR FOOD SAFETY, NUTRITION AND HEALTH IN THE PROGRAM AREA OF FOOD AND HUMAN HEALTH (A1343). WE WILL EXAMINE INTERACTIONS BETWEEN BRASSICA, GUT MICROBIOME (GM) AND GLP-1 SECRETION. BRASSICA VEGETABLES ARE A RICH SOURCE OF GLUCOSINOLATES (GSLS), A GROUP OF SULFUR COMPOUNDS THAT ARE UNIQUE TO THESE VEGETABLES (BROCCOLI, KALE, AND OTHERS). UPON HYDROLYSIS, GSLS ARE CONVERTED TO BIOACTIVE ISOTHIOCYANATES (ITCS). WHEN CONSUMED RAW, GSLS CAN BE CONVERTED TO ITCS BY THE PLANT ENZYME MYROSINASE. HEAT (COOKING) INACTIVATES MYROSINASE, THEN GUT MICROBIOTA (GM) BECOME RESPONSIBLE FOR ANY GSL CONVERSION TO ITCS. WE HYPOTHESIZE THAT NON-ITC PRODUCING PATHWAYS PRESENT IN THE GM ARE COMPETING FOR GSLS AND THUS EXPLAIN THE DRAMATIC INTER-INDIVIDUAL DIFFERENCES SEEN IN ITC PRODUCTION (AIM 1). ONCE THOUGHT TO BE ONLY PRESENT IN THE MOUTH, BITTER-TASTE RECEPTORS (T2RS) ARE NOW FOUND TO BE PRESENT IN MANY TISSUES INCLUDING THE GUT. SINCE GUT T2RS CAN TRIGGER GLP-1 SECRETION AND ITCS CAN SERVE AS T2R AGONISTS, WE HYPOTHESIZE THAT ITCS PRODUCED BY THE GM BIND INTESTINAL T2R(S) TO TRIGGER GLP-1-DEPENDENT CONTROL OF OBESITY AND GLUCOSE HOMEOSTASIS (AIM 2). OPTIMIZING ITC PRODUCTION IN THE GUT, BOTH AMOUNT AND LOCATION, HAS THE POTENTIAL TO REVERSE GLUCOSE INTOLERANCE AND OBESITY IN HUMANS. OUR FINDINGS WILL INFORM THE PUBLIC ABOUT THE HEALTH PROMOTING PROPERTIES OF BRASSICA, EXPLAIN THE VARIATION IN GSL BIOACTIVATION SEEN IN HUMAN STUDIES, WHERE NON-ITC METABOLISM OF GSLS BY GM HAVE BEEN LITTLE CONSIDERED, AND WILL FURTHER INCREASE BRASSICA INTAKE WORLDWIDE.
$633,000University Of Illinois · · FY2023 · National Institute of Food and Agriculture
Effect of an integrated nutrition-math curriculum to improve food-purchasing behavior of children
$632,999Olajide Williams · Columbia University Health Sciences · R01 · FY2020 · NR
EAT: A Reliable Eating Assessment Technology for Free-living Individuals.
$632,985Nabil Alshurafa · Northwestern University At Chicago · R01 · FY2025 · DK
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics - Supplement
$632,968Michael I Goran · Children'S Hospital Of Los Angeles · R01 · FY2019 · MD
A Novel Diet-Phenotype Interaction Affecting Body Weight
$632,965David S Ludwig · Boston Children'S Hospital · R01 · FY2011 · DK
Osteoporotic Fractures in Men (MrOS) Renewal - Portland
$632,944Eric S. Orwoll · Oregon Health & Science University · U01 · FY2010 · AR
Neurodevelopmental, Health, and Economic Outcomes at Preschool Age in Former Very Preterm Infants Randomized to An Economic Intervention to Support Mother's Own Milk
$632,928Aloka Lahoti Patel · Rush University Medical Center · R01 · FY2025 · HD
Enhancing the Diabetes Prevention Program to promote weight loss among non-responders in a community based lifestyle intervention
$632,910Lovoria B Williams · University Of Kentucky · R01 · FY2020 · DK
Healthy Environments Partnership: Lean &Green in Motown
$632,899University Of Michigan At Ann Arbor · R01 · FY2005 · ES
Hepatic Rap1a in cholesterol homeostasis
$632,897Lale Ozcan · Columbia University Health Sciences · R01 · FY2024 · HL
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in Utero
$632,883Nina T Holland · University Of California Berkeley · R01 · FY2013 · ES
Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among Women
$632,883Yiqing Song · Indiana University Indianapolis · R01 · FY2015 · HL
Changes in neural response to eating after bariatric surgery: MRI results
$632,876Thomas A. Wadden · University Of Pennsylvania · R01 · FY2010 · DK
Structure and mechanism of mammalian stearoyl-CoA desaturases
$632,860Ming Zhou · Baylor College Of Medicine · R01 · FY2022 · DK