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17,828 grants matching “crispr”
Understanding the regulation of ER GPATs to control glycerolipid synthesis in disease
$69,500Timothy Cole Kenny · Rockefeller University · F32 · FY2023 · DK
Nicotine & Nodose: A Neural Basis for Peripheral Control over Nicotine Intake
$69,500Kevin Braunscheidel · Icahn School Of Medicine At Mount Sinai · F32 · FY2023 · DA
Assessing the generality of sexual conflict in new gene evolution in Drosophila
$69,500Deanna Arsala · University Of Chicago · F32 · FY2023 · GM
The Role of eIF4G1 and eIF4G2 in Translational Control of Adipogenesis and Obesity
$69,500Rachel Elizabeth Turn · Stanford University · F32 · FY2023 · GM
Defining synthetic lethal relationships with loss of the homologous recombination factor Rad52
$69,500Beth Anne Osia · Beckman Research Institute/City Of Hope · F32 · FY2023 · CA
Deciphering Translational Control in Stem Cells
$69,500Julia Joung · Whitehead Institute For Biomedical Res · F32 · FY2023 · GM
Elucidating the Quality Control Pathways that Cope with Mutant Ribosomal RNA in Mammalian Cells
$69,500Zachary Stolp · Carnegie Institution Of Washington, D.C. · F32 · FY2023 · GM
The critical ciliary role of ARL13B in kidney cystogenesis
$69,426Robert E Van Sciver · Emory University · F32 · FY2020 · DK
ADVANCEMENTS IN GENOMICS HAVE SHIFTED THE PARADIGM OF LIVESTOCK BREEDING BY USING HIGH THROUGHPUT TECHNOLOGIES. HOWEVER, UNDERSTANDING THE BIOLOGICAL CONTEXT OF MARKERS USED IN GENOMIC BREEDING IS A MAJOR CHALLENGE ESPECIALLY DUE TO THE INTERGENIC LOCATION OF THE MARKERS (> 80%) ASSOCIATED WITH COMPLEX TRAITS. THE OVERALL GOAL OF THIS PROJECT IS TO UNDERSTAND THE BIOLOGICAL CONTEXT OF GENOMIC MARKERS IN THE INTERGENIC REGULATORY ELEMENTS (ENHANCERS/PROMOTERS) OF THE MUSCLE AND FAT SINCE TRANSCRIPTIONAL REGULATION SUCH AS HORMONE RESPONSE, IS THE MAJOR MECHANISM BEHIND COMPLEX TRAITS. AN INTERNATIONAL CONSORTIUM WITHIN THE LIVESTOCK GENOMICS COMMUNITY CALLED FAANG (FUNCTIONAL ANNOTATION OF ANIMAL GENOMES) HAS BEEN GENERATING DATA FROM MULTIPLE TISSUES THAT WE CAN TAKE ADVANTAGE OF FOR THIS PROJECT TO IDENTIFY AND ANNOTATE TISSUE SPECIFIC REGULATORY ELEMENTS IN MUSCLE AND ADIPOSE. ONCE WE IDENTIFY THE INTERGENIC REGULATORY REGIONS IN MUSCLE AND ADIPOSE, WE WILL INCORPORATE THE GENOMIC VARIANT MARKER DATA FROM PUBLIC DATABASES AND/OR FROM BREEDER COMPANIES TO SELECT THE CANDIDATE REGIONS TO TEST THEIR FUNCTIONS. WE WILL DEVELOP EPIGENOMIC MODIFICATION SYSTEMS USING CRISPR TO VALIDATE THE FUNCTION OF MUSCLE AND FAT SPECIFIC REGULATORY ELEMENTS WE ANNOTATED.
$69,375The Pennsylvania State University · · FY2021 · National Institute of Food and Agriculture
Molecular Mechanisms of Synapse Coordination
$69,306Elizabeth Anne Martin · University Of Oregon · F32 · FY2020 · HD
Functions of translation regulation in host susceptibility to virus infection
$69,306Alison Whitney Ashbrook · Rockefeller University · F32 · FY2020 · AI
Effect of Pre- and Peri-Implantation Zika Virus Infection on Fetal Development
$69,306Lauretta A. Lacko · Weill Medical Coll Of Cornell Univ · F32 · FY2020 · HD
Characterization of a Novel lncRNA in Breast Cancer
$69,306Kirsten Tracy · University Of Vermont & St Agric College · F32 · FY2020 · CA
IDH1 is a novel therapeutic target in pancreatic cancer
$69,306Ali Vaziri-Gohar · Case Western Reserve University · F32 · FY2020 · CA
Investigating the role of KAT6A in MLL-rearranged acute myeloid leukemia
$69,113Mario Andres Blanco · University Of Pennsylvania · R01 · FY2024 · CA
How does the ubiquitously expressed ZFX mediate cell type-specific transcriptional regulation
$69,080Emily Hsu · University Of Southern California · F32 · FY2023 · CA
Cellular perturbations to enhance precise therapeutic genome editing to treat FTD/ALS
$69,080Bria Macklin · J. David Gladstone Institutes · F32 · FY2023 · AG
Targeting the cancer neo-genome for destruction with CRISPR-Cas enzymes
$69,080Mitchell L Leibowitz · Dana-Farber Cancer Inst · F32 · FY2023 · CA
Evaluating the mechanism by which the DYNLL1-MRE11 complex regulates DNA end resection and genome stability.
$69,080Michelle Swift · Dana-Farber Cancer Inst · F32 · FY2023 · GM
Parkinson's and Prokaryotes: roles of bacteria, gut permeability, innate immunity, and genetics in C. elegans dopaminergic neurodegeneration
$69,080Graham Redweik · University Of Colorado · F32 · FY2023 · NS
Transcriptomics compendia for the study of strain-level genetic diversity of the human skin microbiome
$69,080Georgia Doing · Jackson Laboratory · F32 · FY2023 · GM
Interplay between macroautophagy and secretory autophagy in neurons.
$69,080Sierra Danielle Palumbos · University Of Pennsylvania · F32 · FY2023 · NS
Administrative supplement to promote diversity in health-related research: Melisa Gonzalez
$68,960Rebecca A Butcher · University Of Florida · R35 · FY2025 · GM
Molecular Mechanisms of HIV Latency
$68,909Eric M Verdin · Buck Institute For Research On Aging · R01 · FY2021 · DA
Dissecting the non-growing-but-active state of a hybrid bacteria-material microdevice
$68,839Cheemeng Tan · University Of California At Davis · R35 · FY2025 · GM