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38,696 grants matching “als”
Telepsychiatry & Culturally Sensitive Treatment of Depressed Asian Americans
$354,841Albert S. Yeung · Massachusetts General Hospital · R01 · FY2011 · MH
Role of Oligodendroglia in the Pathogenesis of ALS
$354,797Shin H Kang · Temple Univ Of The Commonwealth · R01 · FY2019 · NS
Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
$354,791Tore Eid · Yale University · R01 · FY2012 · NS
Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
$354,791Tore Eid · Yale University · R01 · FY2011 · NS
Neurocognition, Nicotine and Polysubstance Abuse
$354,784University Of Oklahoma Hlth Sciences Ctr · R01 · FY2002 · DA
CNS Mechanisms that Modulate Reward
$354,784Kenneth D Carr · New York University School Of Medicine · R01 · FY2015 · DA
The Aging Genome Association Study "AGE-GAIN"
$354,743Luigi Ferrucci · National Institute On Aging · ZIA · FY2009 · AG
Changes in V2 topography after V1 lesions: Impact of microstimulation on behavior
$354,717Stelios Manolis Smirnakis · Baylor College Of Medicine · R01 · FY2011 · EY
Structural Changes in BKCa Channels During Gating
$354,699Riccardo Olcese · University Of California Los Angeles · R01 · FY2011 · GM
The role of estrogen receptors in Alzheimer?s disease
$354,650Rena Li · Banner Sun Health Research Institute · R01 · FY2009 · AG
Post-transcriptional gene regulation in Alzheimer's Disease
$354,616Myriam Gorospe · National Institute On Aging · ZIA · FY2012 · AG
MicroRNAs Regulating Gene Expression during Cellular Senescence and Aging
$354,616Myriam Gorospe · National Institute On Aging · ZIA · FY2012 · AG
PRE-B CELL RECEPTOR SIGNALING IN ACUTE LYMPHOBLASTIC LEUKEMIA
$354,563Markus Mãschen · University Of California, San Francisco · R01 · FY2014 · CA
Multi-Scale Cortical Dynamics in Human Epilepsy
$354,558Wilson Truccolo · Brown University · R01 · FY2020 · NS
Thermodynamics of Interfaces: Theory to Atomistic Modeling
$354,527Yuri Mishin · George Mason University · · FY2021 · MPS
TOTAL SOLAR IRRADIANCE (TSI) HAS BEEN MEASURED FROM SPACE SINCE 1978 PROVIDING THE BEST DATA RECORD OF THE NET ENERGY POWERING THE EARTH'S CLIMATE SYSTEM. VARIATIONS IN THE TSI OVER LONG PERIODS OF TIME CAN CAUSE CLIMATE CHANGES THAT MUST BE DISTINGUISHED FROM ANTHROPOGENIC INFLUENCES FOR UNDERSTANDING CLIMATE VARIABILITY. CLIMATE STUDIES RELY ON MODELED TSI RECONSTRUCTIONS THAT EXTEND THE SPACE-BORNE TSI MEASUREMENTS BACK THOUSANDS OF YEARS. THE TWO MOST PROMINENT TSI MODELS ARE THE NRLTSI AND THE SATIRE MODELS. WITH THE PROPOSED EFFORTS WE WILL IMPROVE THE HISTORICAL TSI RECONSTRUCTIONS FROM BOTH THE NRLTSI AND SATIRE MODELS BOTH FORWARD IN TIME AND BACK TO THE YEAR 1610 BY INCORPORATING THREE PRIMARY IMPROVEMENTS TO THE MODELS' INPUTS. IN PARTICULAR VIA THIS PROPOSAL WE WILL: 1. UPDATE THE 400-YEAR SUNSPOT RECORD USED IN TSI MODELS FOR HISTORICAL RECONSTRUCTIONS 2. RE-COMPUTE FLUX-TRANSPORT RESULTS TO IMPROVE HISTORICAL SOLAR-VARIABILITY ESTIMATES 3. IMPROVE THE TSI-MEASUREMENT COMPOSITE PROVIDING A REFERENCE FOR TSI MODELS IMPROVE SUNSPOT RECORDS: THE TSI MODELS RELY ON SUNSPOT RECORDS REEVALUATIONS OF WHICH THUS AFFECT HISTORICAL TSI RECONSTRUCTIONS. PRELIMINARY SUCH EFFECTS WERE DESCRIBED BY KOPP ET AL. [9] USING THE FIRST RELEASE (V.2) OF AN UPDATED SUNSPOT RECORD BY THE SUNSPOT INDEX AND LONG-TERM SOLAR OBSERVATIONS (SILSO) PROJECT. REFINEMENTS TO THIS RECORD VIA SEVERAL COMPLEMENTARY OR INDEPENDENT METHODS ARE BEING CONSIDERED BY AN INTERNATIONAL SPACE STUDIES INSTITUTE (ISSI) TEAM WITH TWO MEETINGS PLANNED IN 2018 TO RECOMMEND UPDATES TO THIS RECORD. PI KOPP AND COLLABORATOR DUDOK DE WIT ARE MEMBERS OF THIS ISSI TEAM. OUR TEAM WILL HELP CREATE A FUTURE VERSION (V.3) OF THE SILSO SUNSPOT RECORDS AND ESTIMATE HISTORICAL TSI RECONSTRUCTIONS BASED ON THESE NEW RECORDS. RE-COMPUTE FLUX-TRANSPORT MODEL RESULTS: FLUX-TRANSPORT MODELS HELP DISTINGUISH THE AMOUNT OF OPEN VS. CLOSED MAGNETIC FIELDS ON THE SUN. THE LATTER MORE DIRECTLY AFFECT THE TSI BUT THE FORMER BETTER PROVIDE A LONG-TERM INDICATOR OF HISTORICAL SOLAR ACTIVITY VIA SOLAR MODULATION OF GALACTIC COSMIC RAYS AND THUS COSMOGENIC-ISOTOPE RECORDS. WE WILL USE THE IMPROVED SUNSPOT RECORD AS SOURCE DATA IN THE ADVECTIVE FLUX TRANSPORT MODEL [22 23] TO GIVE BETTER ESTIMATES OF SECULAR VARIABILITY FROM THOSE IN THE PRIOR FLUX-TRANSPORT-BASED VERSION OF THE NRLTSI MODEL [24]. THIS NEWER STATE-OF-THE-ART SURFACE FLUX-TRANSPORT MODEL INCORPORATES MANY ADVANCES MADE OVER THE LAST DECADE. CONTINUE TSI COMPOSITE: AN IMPROVED TSI COMPOSITE IS BEING CREATED BY A 2014 SIST TEAM LED BY PI KOPP. THAT PROJECT UTILIZES A STATISTICALLY-DRIVEN METHOD FOR COMBINING DATA FROM THE 39-YEAR RECORD OF SPACE-BORNE INSTRUMENTS INTO A SINGLE TIME-SERIES [5]. SPECIFIC IMPROVEMENTS OVER PRIOR COMPOSITES INCLUDE: THE USE OF DATA FROM ALL AVAILABLE INSTRUMENTS WEIGHTING EACH BY ITS INTRINSIC NOISE BASED ON A DATA-DRIVEN METHODOLOGY; AN UNBIASED STATISTICALLY-DRIVEN SCALE-WISE SELECTION OF INSTRUMENT DATA; SMOOTHING TEMPORAL TRANSITIONS BETWEEN INSTRUMENTS; SYSTEMATIC ESTIMATION OF THE TIME-DEPENDENT UNCERTAINTY ASSOCIATED WITH EACH TSI RECORD AND THE FINAL TSI COMPOSITE. THE RESULTING COMPOSITE PROVIDES CLIMATE MODELERS AND RESEARCHERS STUDYING SOLAR VARIABILITY A FOURDECADE RECORD OF VARIABILITY AND UNCERTAINTIES IN THE NET ENERGY DRIVING THE EARTH'S CLIMATE SYSTEM. WE WILL UPDATE AND IMPROVE THIS TSI COMPOSITE BY INCORPORATING NEW SPACECRAFT DATA FROM UPCOMING INSTRUMENTS SUCH AS NASA'S TSIS/TIM AND BY IMPLEMENTING REFINEMENTS TO THE COMPOSITE-CREATION METHODOLOGY. THESE THREE INDEPENDENT AND COMPLEMENTARY EFFORTS WILL PROVIDE IMPROVED SOLAR FORCINGS AND UNCERTAINTIES FOR GLOBAL-CLIMATE MODELS. WITH THESE ADVANCES WE WILL COMPUTE THE TSI RECONSTRUCTIONS FROM THE SATIRE AND THE NRLTSI MODELS TO ESTIMATE THE VARIABILITY IN THE LONG-TERM TSI RECORD AND THE RANGE OF HISTORICAL SOLAR FORCING AS NEEDED FOR CLIMATE STUDIES.
$354,506The Regents Of The University Of Colorado · · FY2020 · National Aeronautics and Space Administration
Opening the Doors for Diverse Populations to Health Disparities Research
$354,495Ingrid Alisa Bowleg · Drexel University · R25 · FY2011 · MD
Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults
$354,478Tiffany Lashaun Carson · H. Lee Moffitt Cancer Ctr & Res Inst · R01 · FY2024 · CA
Changes in V2 topography after V1 lesions: Impact of microstimulation on behavior
$354,478Stelios Manolis Smirnakis · Baylor College Of Medicine · R01 · FY2012 · EY
Multimeric Peptide Copolymer Formulations for Targeted Drug Delivery to Treat Nervous System Disorders
$354,462Drew L Sellers · University Of Washington · R01 · FY2024 · NS
THE VISUALLY DEFECTIVE PHENOTYPE OF RBP-DEFICIENT MICE
$354,458Columbia University Health Sciences · R01 · FY2002 · EY
Intracellular chloride regulation in olfactory neurons
$354,454Rona J Delay · University Of Vermont & St Agric College · R01 · FY2008 · DC
Neurofilaments, SOD1 and Motor Neuron Diseases
$354,386Ludwig Institute For Cancer Research · R01 · FY2001 · NS
Animal testing of RNA aptamers as ALS drug candidate
$354,385Li Niu · State University Of New York At Albany · R01 · FY2024 · NS
Behavioral and Physiological Mechanisms of Olfaction
$354,382Brian H. Smith · Arizona State University-Tempe Campus · R01 · FY2007 · RR