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17,054 grants matching “genome editing”
Core Center for Stem Cell and Transplantation Biology
$57,000Beverly J Torok-Storb · Fred Hutchinson Cancer Research Center · U54 · FY2016 · DK
Optimization of a massively parallel genome editing approach to link regulatory elements to their target genes during mouse germ layer formation
$56,974Samuel Regalado · University Of Washington · F31 · FY2024 · HG
Cancer Genomics and Epigenomics
$56,909Zhenghe Wang · Case Western Reserve University · P30 · FY2025 · CA
Animal Models of Disease Core
$56,836Wenhao Xu · University Of Virginia · P30 · FY2017 · CA
The Role of DHCR7 in Endotoxemia
$56,700Vinitha Jacob · University Of Michigan At Ann Arbor · K08 · FY2025 · GM
Regulation of Hepatic Lipogenesis by a Mitochondrial Pyruvate Carrier-Citrate Carrier Axis
$56,694Ryan Douglas Sheldon · University Of Iowa · F32 · FY2017 · DK
GPR56/ADGRG1 in peripheral nerve development and repair
$56,694Mitchell R D'rozario · Washington University · F32 · FY2017 · NS
Understanding metabolic pathways that support redox homeostasis in cancer
$56,694Alexander Muir · Massachusetts Institute Of Technology · F32 · FY2017 · CA
Context-Specific Functional Annotation of EGFR Mutations in Glioblastoma
$56,694Kathleen Kong · Baylor College Of Medicine · F32 · FY2017 · CA
DNA damage response and repair of a broken chromosome
$56,672James E Haber · Brandeis University · R35 · FY2018 · GM
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
$56,376Paula M Vertino · University Of Rochester · R01 · FY2024 · CA
Characterization of genetic modifiers of bioenergetic rescue in mitochondrial disease cell lines
$56,334Christopher F. Bennett · Dana-Farber Cancer Inst · F32 · FY2017 · GM
SCLEROTINIA SCLEROTIORUM, OR WHITE MOLD, IS A DEVASTATING PATHOGEN OF A NUMBER OF CROPS THAT THREATENS FOOD SECURITY AROUND THE WORLD. PREVIOUS RESEARCH HAS SHOWN THAT SOME PLANTS CAN SUCCESSFULLY DEFEND AGAINST WHITE MOLD BY PRODUCING A LARGE AMOUNT OF CERTAIN COMPOUNDS WHICH ARE SAFE FOR HUMAN CONSUMPTION, BUT ARE TOXIC TO THE PATHOGEN. GIVEN THE SUCCESS OF THIS PATHOGEN IN INFECTING CROPS, WE KNOW THAT IT IS CAPABLE OF DETOXIFYING THESE COMPOUNDS AT LOW LEVELS, BUT THE MECHANISM OF THIS DETOXIFICATION IS CURRENTLY UNKNOWN. THIS PROJCT AIMS TO CHARACTERIZE THE MECHANISMS BEING USED BYWHITE MOLD TO DETOXIFY PLANT DEFENSE COMPOUNDS AND POTENTIALLY ASSIST IN EFFORTS TO DEVELOP MORE RESISTANT PLANT VARIETIES IN THE FUTURE.TO ADDRESS THIS, OUR LAB HAS IDENTIFIED TWO GENES IN THE WHITE MOLD GENOME WHICH HAVE A LIKELY ROLE IN THIS DETOXIFICATION ACTIVITY. USING A COMBINATION OF APPROACHES, WE WILL WORK TO PROVE THAT THESE GENES ARE DRIVERS OF THIS ACTIVITYAS WELL AS IDENTIFYING WHICH PLANTDEFENSE COMPOUNDS THEY ARE MOST IMPORTANT IN DETOXIFYING. FURTHERMORE, AS THESE GENES APPEAR TO BE IMPORTANT VIRULENCE FACTORS FOR THE PATHOGEN, WE WILL ASSESS THEIR VALUE AS TARGETS IN THE DEVELOPMENT OF NEW, GENE EDITED PLANT VARIETIES WITH ROBUST RESISTANCE TO WHITE MOLD.
$56,176University Of Wisconsin System · · FY2021 · National Institute of Food and Agriculture
Investigating the role of diazepam binding inhibitor (DBI) in astrocytes and neural circuit maturation
$56,160Dongeun Heo · Oregon Health & Science University · F32 · FY2025 · NS
Correcting the beta-globin mutation in iPS cells for treatment of sickle cell disease.
$56,118Jeffrey A Mosenson · University Of Illinois At Chicago · F32 · FY2016 · DK
Elucidating the architecture of native multiprotein complexes involved in ER-associated degradation
$56,118Christopher Paul Walczak · Stanford University · F32 · FY2016 · GM
Patterning the cell: role of the PAR-1 kinase
$56,118Andrew William Folkmann · Johns Hopkins University · F32 · FY2016 · GM
Spatial and Temporal Resolution of the Plasticity in Mitochondrial Proteomes
$56,118Nan Xin · University Of California Berkeley · F32 · FY2016 · AG
Investigating the role of Retrotransposon muERV-L reactivation in Tumorigenesis
$56,118Andrew Joseph Modzelewski · University Of California Berkeley · F32 · FY2016 · CA
Modeling Familial Dilated Cardiomyopathy Using Patient-derived Induced Pluripotent Stem Cells
$56,118Cassandra Lynn Happe · University Of California, San Diego · F32 · FY2016 · HL
Elucidating the complex genetic and molecular basis of Plasmodium falciparum artemisinin resistance.
$56,118Leila Saxby Ross · Columbia University Health Sciences · F32 · FY2016 · AI
RNA that prevents RNase activity: Biochemical and biophysical studies of the ciRNA-RNase L complex
$56,118Daniel R Eiler · University Of Colorado Denver · F32 · FY2016 · GM
A role for Hox-dependent chromatin architecture in defining cell-fate
$56,118Rebecca Kyle Delker · Columbia University Health Sciences · F32 · FY2016 · GM
Modeling Familial Dilated Cardiomyopathy Using Patient-derived Induced Pluripotent Stem Cells
$56,091Cassandra Lynn Happe · University Of California, San Diego · F32 · FY2017 · HL
Elucidating molecular mechanisms mediating cellular responses to touch and pain
$56,066Elizabeth A. Heath-Heckman · University Of California Berkeley · F32 · FY2017 · NS