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141,003 grants matching “cytokine”
Phase II study to evaluate the efficacy and safety of baricitinib for reduction of HIV in the central nervous system
$638,381Christina Gavegnano · Emory University · R01 · FY2024 · MH
Biodefense Proteomics Collaboratory
$638,375David G. Gorenstein · University Of Texas Hlth Sci Ctr Houston · U01 · FY2007 · AI
Culturally Adapted Cognitive Behavioral Stress and Self-Management (C-CBSM) Intervention for PC
$638,319Frank J Penedo · Northwestern University At Chicago · R01 · FY2017 · CA
Mechanisms and therapeutic implications of human clonal hematopoiesis (CH) mutations
$638,281Eirini Papapetrou · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · CA
Nano immunoconjugates to treat primary and metastatic HER2 positive breast cancer
$638,279Julia Y Ljubimova · Cedars-Sinai Medical Center · R01 · FY2019 · CA
Diversity of Host Pathogen Interactions
$638,258Samuel I. Miller · University Of Washington · U54 · FY2012 · AI
Study of Tumor Pathogenesis and Development of Therapies for AIDS Malignancies
$638,233Robert Yarchoan · Division Of Basic Sciences - Nci · ZIA · FY2021 · CA
Plasma-based therapies for bone infection: A tripartite USA/Northern Ireland/Republic of Ireland consortium
$638,200Theresa A Freeman · Thomas Jefferson University · R01 · FY2025 · AR
Modulation of pain mechanisms by cannabis-derived phytochemicals.
$638,190Reinhold Penner · Queen'S Medical Center · R01 · FY2023 · AT
Project 2: : Systematic discovery of cell-extrinsic mechanisms of cancer drug resistance
$638,188Alex K Shalek · Massachusetts Institute Of Technology · U54 · FY2018 · CA
Pathogenesis of renal injury and hypertension in HIV+ children
$638,157Patricio Ernesto Ray · University Of Virginia · R01 · FY2024 · DK
Renal & Cellular Studies in Type 1 Diabetic Patients
$638,129S Michael Mauer · University Of Minnesota · R01 · FY2007 · DK
Mesothelin-targeted immunotoxins in Pancreatic Cancer
$638,124Christine Alewine · Division Of Basic Sciences - Nci · ZIA · FY2016 · CA
Molecular and Structural Basis for T Cell Costimulation
$638,122Stanley G Nathenson · Albert Einstein College Of Medicine · R01 · FY2006 · AI
Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis
$638,095Timothy L Smith · Oregon Health & Science University · R01 · FY2017 · DC
Who are the Ultra-positive, culture-negative? Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum
$638,033Emily A Kendall · Johns Hopkins University · R01 · FY2022 · HL
(PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune Responses
$638,007Gerald S Shadel · Salk Institute For Biological Studies · R01 · FY2022 · CA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** MATERNAL OBESITY (MO) ASSOCIATED WITH THE DEVELOPMENT OF MATERNAL GUT DYSBIOSIS WITH INCREASED GRAM NEGATIVE BACTERIA, INTESTINAL BARRIER DYSFUNCTION RESULTING RELEASE OF LIPOPOLYSACCHARIDE (LPS) FROM A LEAKY GUT, WHICH CAN CAUSE MATERNAL SYSTEMIC INFLAMMATION AND ENHANCE LIPOTOXICITY TO PLACENTA AND FETAL LIVER. OUR PRELIMINARY DATA SHOWED INCREASED LIPID DROPLETS AND TROPHOBLAST APOPTOSIS IN THE PLACENTA OF ANIMALS FED WITH HIGH FAT/HIGH SUCROSE (HFHS) DIET-INDUCED MO. SUPPLEMENTATION OF MACADAMIA NUT-CONTAINING HFHS DIET TO PREGNANT MICE SHOWED DECREASED PROINFLAMMATORY CYTOKINE LEVELS IN THE PLACENTA AND FETAL LIVER COMPARED TO HFHS DIET ALONE FED OBESE PREGNANT MICE. WE ALSO OBSERVED THAT CO-TREATMENT OF TROPHOBLAST WITH PALMITATE AND LPS EXACERBATED PALMITATE-INDUCED TROPHOBLAST LIPOAPOPTOSIS. TREATMENT OF TROPHOBLASTS WITH MONOUNSATURATED FATTY ACIDS (MUFA) DRAMATICALLY PREVENTED PALMITATE-INDUCED TROPHOBLAST LIPOAPOPTOSIS. MUFAS ALSO PREVENTED LPS-INDUCED INFLAMMATION BY BLOCKING INFLAMMASOME ACTIVATION. WE HYPOTHESIZE THAT SUPPLEMENTATION OF MACADAMIA NUTS (CONTAINS HIGH MUFAS, PHYTOSTEROL, AND INSOLUBLE FIBER), AS A WHOLE FOOD APPROACH, PREVENTS MO-INDUCED MATERNAL INTESTINAL BARRIER DYSFUNCTION, AND GUT DYSBIOSIS; LIPOTOXICITY AND INFLAMMATION TO THE PLACENTA AND FETAL LIVER. PROPOSED HYPOTHESIS WILL BE TESTED IN THE FOLLOWING OBJECTIVES: 1) DETERMINE THE PROTECTIVE ROLE OF DIETARY MACADAMIA NUT AGAINST PLACENTAL LIPOTOXICITY AND INFLAMMATION DURING MO; 2) ASCERTAIN THE PROTECTIVE ROLE OF MACADAMIA NUT SUPPLEMENTATION AGAINST MO-INDUCED FETAL FATTY LIVER AND INFLAMMATION; 3) DETERMINE THE PREVENTIVE ROLE OF MACADAMIA NUT AGAINST MATERNAL INTESTINAL BARRIER DYSFUNCTION AND GUT DYSBIOSIS DURING MO. THE PROPOSED OBJECTIVES WILL CONTRIBUTE TO THE MECHANISTIC INSIGHTS ON THE WHOLE FOOD-DERIVED BIOACTIVE COMPONENTS PRESENT IN THE MACADAMIA NUT TO PREVENT MO-INDUCED COMPLICATIONS.
$638,000Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis
$637,975Timothy L Smith · Oregon Health & Science University · R01 · FY2018 · DC
Study to establish safety, tolerability and feasibility of LM11A-31 as a neuroprotective agent in aging people living with HIV and neurocognitive impairment on antiretroviral therapy
$637,932Rick B Meeker · Univ Of North Carolina Chapel Hill · R01 · FY2025 · AG
Mapping novel subdominant B*5701 epitopes in conserved regions of the HIV proteom
$637,928June Kan-Mitchell · University Of Texas El Paso · R01 · FY2010 · AI
Nano immunoconjugates to treat primary and metastatic HER2 positive breast cancer
$637,908Julia Y Ljubimova · Cedars-Sinai Medical Center · R01 · FY2020 · CA
New strategies for treating septic vasculopathy, inflammation and thrombosis
$637,840Xiaoping Du · University Of Illinois At Chicago · R01 · FY2015 · HL
Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging
$637,833Beshay Zordoky · University Of Minnesota · R01 · FY2022 · HL
Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging
$637,833Beshay Zordoky · University Of Minnesota · R01 · FY2020 · HL