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91,797 grants matching “obesity”
Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's Disease
$638,400Prasad V Katakam · Tulane University Of Louisiana · R01 · FY2021 · AG
Assessing and Preventing Obesity Among New Immigrants
$638,395Christina D Economos · Tufts University Boston · R01 · FY2008 · HD
Antipsychotic Medication
$638,378Washington University · R01 · FY2002 · MH
A Screening Library for Peptide-Activated GPCR's
$638,359Neurocrine Biosciences, Inc. · R44 · FY2003 · GM
Structural, Biochemical and Functional Connectivity in Osteoarthritis using Quantitative Magnetic Resonance Imaging and Skeletal Biomechanics
$638,348Sharmila Majumdar · University Of California, San Francisco · R01 · FY2025 · AR
Healthy Homes/Healthy Kids: Pediatric Primary Care-based Obesity Prevention
$638,348Nancy E Sherwood · Healthpartners Institute · R01 · FY2013 · DK
Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD
$638,277David E Cohen · Brigham And Women'S Hospital · R01 · FY2015 · DK
Biopsychosocial determinants of sleep and wellbeing for teens in Fragile Families
$638,219Lauren Hale · State University New York Stony Brook · R01 · FY2017 · HD
Healthy Sleep Intervention for Preschool Children
$638,181Michelle Marian Garrison · Seattle Children'S Hospital · R01 · FY2014 · HD
Project 2 - The Frontotemporal Lobar Degeneration Clinical Research Consortium
$638,169Adam L Boxer · University Of California, San Francisco · U54 · FY2018 · NS
Project 2 - The Frontotemporal Lobar Degeneration Clinical Research Consortium
$638,168Adam L Boxer · University Of California, San Francisco · U54 · FY2017 · NS
Childhood Origins for Cardiac Structure and Function
$638,138Shumei S Sun · Virginia Commonwealth University · R01 · FY2014 · HL
Coordinating Unit for the National Centers for Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD)
$638,127Richard A McIndoe · Augusta University · U24 · FY2023 · DK
Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals
$638,117Vaia Lida Chatzi · University Of Southern California · R01 · FY2021 · ES
Longitudinal mixed method investigation of social networks and affective states as determinants of smoking behavior among cancer patient
$638,088Hermine Poghosyan · Yale University · R01 · FY2021 · CA
The eXtraordinarY Babies Study: Natural History of Health and Neurodevelopment in Infants with Sex Chromosome Trisomy
$638,062Nicole Renee Tartaglia · University Of Colorado Denver · R01 · FY2024 · HD
Mechanism of Gdf3 action to limit insulin sensitivity in obesity
$638,001Alexander Banks · Beth Israel Deaconess Medical Center · R01 · FY2022 · DK
Mechanism of Gdf3 action to limit insulin sensitivity in obesity
$638,001Alexander Banks · Beth Israel Deaconess Medical Center · R01 · FY2023 · DK
West Philadelphia Asthma Care Implementation Plan
$638,000Tyra C Bryant-Stephens · Children'S Hosp Of Philadelphia · U01 · FY2021 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** MATERNAL OBESITY (MO) ASSOCIATED WITH THE DEVELOPMENT OF MATERNAL GUT DYSBIOSIS WITH INCREASED GRAM NEGATIVE BACTERIA, INTESTINAL BARRIER DYSFUNCTION RESULTING RELEASE OF LIPOPOLYSACCHARIDE (LPS) FROM A LEAKY GUT, WHICH CAN CAUSE MATERNAL SYSTEMIC INFLAMMATION AND ENHANCE LIPOTOXICITY TO PLACENTA AND FETAL LIVER. OUR PRELIMINARY DATA SHOWED INCREASED LIPID DROPLETS AND TROPHOBLAST APOPTOSIS IN THE PLACENTA OF ANIMALS FED WITH HIGH FAT/HIGH SUCROSE (HFHS) DIET-INDUCED MO. SUPPLEMENTATION OF MACADAMIA NUT-CONTAINING HFHS DIET TO PREGNANT MICE SHOWED DECREASED PROINFLAMMATORY CYTOKINE LEVELS IN THE PLACENTA AND FETAL LIVER COMPARED TO HFHS DIET ALONE FED OBESE PREGNANT MICE. WE ALSO OBSERVED THAT CO-TREATMENT OF TROPHOBLAST WITH PALMITATE AND LPS EXACERBATED PALMITATE-INDUCED TROPHOBLAST LIPOAPOPTOSIS. TREATMENT OF TROPHOBLASTS WITH MONOUNSATURATED FATTY ACIDS (MUFA) DRAMATICALLY PREVENTED PALMITATE-INDUCED TROPHOBLAST LIPOAPOPTOSIS. MUFAS ALSO PREVENTED LPS-INDUCED INFLAMMATION BY BLOCKING INFLAMMASOME ACTIVATION. WE HYPOTHESIZE THAT SUPPLEMENTATION OF MACADAMIA NUTS (CONTAINS HIGH MUFAS, PHYTOSTEROL, AND INSOLUBLE FIBER), AS A WHOLE FOOD APPROACH, PREVENTS MO-INDUCED MATERNAL INTESTINAL BARRIER DYSFUNCTION, AND GUT DYSBIOSIS; LIPOTOXICITY AND INFLAMMATION TO THE PLACENTA AND FETAL LIVER. PROPOSED HYPOTHESIS WILL BE TESTED IN THE FOLLOWING OBJECTIVES: 1) DETERMINE THE PROTECTIVE ROLE OF DIETARY MACADAMIA NUT AGAINST PLACENTAL LIPOTOXICITY AND INFLAMMATION DURING MO; 2) ASCERTAIN THE PROTECTIVE ROLE OF MACADAMIA NUT SUPPLEMENTATION AGAINST MO-INDUCED FETAL FATTY LIVER AND INFLAMMATION; 3) DETERMINE THE PREVENTIVE ROLE OF MACADAMIA NUT AGAINST MATERNAL INTESTINAL BARRIER DYSFUNCTION AND GUT DYSBIOSIS DURING MO. THE PROPOSED OBJECTIVES WILL CONTRIBUTE TO THE MECHANISTIC INSIGHTS ON THE WHOLE FOOD-DERIVED BIOACTIVE COMPONENTS PRESENT IN THE MACADAMIA NUT TO PREVENT MO-INDUCED COMPLICATIONS.
$638,000Board Of Regents Of The University Of Nebraska · · FY2023 · National Institute of Food and Agriculture
Health Professionals Education Partnership Initiative Ethiopia
$638,000Miliard Derbew · Addis Ababa University · R25 · FY2018 · TW
Teen School-Night Sleep Extension: An Intervention Targeting the Circadian System
$637,961Stephanie Crowley McWilliam · Rush University Medical Center · R01 · FY2016 · HL
Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth (MIGHTY-Fiber)
$637,949Stephanie Therese Chung · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2023 · DK
Racial Disparities in Ischemic Stroke &Atherosclerotic Risk Factors In the Young
$637,914Heather J Fullerton · Kaiser Foundation Research Institute · U54 · FY2016 · NS
Prenatal stress and diet, and the fetal epigenome
$637,896Cathrine Hoyo · North Carolina State University Raleigh · R01 · FY2023 · MD