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91,797 grants matching “obesity”
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PREGNANCY AND LACTATION IMPOSE SUBSTANTIAL ADDITIONAL NUTRIENT DEMANDS TO MODERN SHEEP AND DAIRY COWS.THESE HIGHLY PRODUCTIVE ANIMALS FACE THIS CHALLENGE BY BECOMING SOMEWHAT UNRESPONSIVE TO THE HORMONE INSULIN.ALTHOUGH THIS ADAPTATION IS GENERALLY BENEFICIAL, IT BECOMES EXCESSIVE IN SOME OF THESE ANIMALS LEADING TO DISEASES AND REDUCED PRODUCTIVITY.A MAJOR LIMITATION IN ADDRESSING THIS PROBLEM IS OUR INCOMPLETE UNDERSTANDING OF FACTORS REGULATING INSULIN ACTION IN SHEEP AND DAIRY COWS.THE OVERALL GOAL OF THIS PROJECT IS TO ASSESS THE ROLE OF NOVEL, TISSUE-DERIVED SIGNALS KNOWN AS EXOSOMES IN REGULATING INSULIN ACTION.THIS GOAL WILL BE ACHIEVED BY PURSUING 3 RELATED AIMS: FIRST, BY DESCRIBING CHANGES IN EXOSOMAL VARIABLES IN THE SHEEP DURING STATES OF REDUCED INSULIN RESPONSE, SUCH AS PREGNANCY AND OBESITY, SECOND, BY ASSESSING THE ABILITY OF THESE EXOSOMES TO ATTENUATE INSULIN ACTION IN ISOLATED CELLS AND FINALLY, BY ASSESSING THE ROLE OF BIOACTIVE CIRCULATING LIPIDS AS PRIMARY FACTORS DRIVING CHANGES IN EXOSOMAL VARIABLES.WE EXPECT TO SHOW THAT EXOSOMES INCREASE IN ABUNDANCE WHEN ANIMALS BECOME SOMEWHAT UNRESPONSIVE TO INSULIN AND THAT THEY REPRESS INSULIN ACTION BY ACTING DIRECTLY ON CELLS AND TISSUES. IDENTIFICATION OF EXOSOMES AS REGULATORS OF INSULIN RESPONSES WILL ALLOW DEPLOYMENT OF NEW APPROACHES TO COUNTER EXCESSIVE ATTENUATION OF INSULIN ACTION AND THEREFORE TO IMPROVE THE HEALTH AND WELL-BEING OF HIGHLY PRODUCTIVE ANIMALS AND THE OVERALL PROFITABILITY OF US SHEEP AND DAIRY FARMS.
$640,000Cornell University · · FY2022 · National Institute of Food and Agriculture
Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain
$639,997Janet E Audrain-McGovern · University Of Pennsylvania · R01 · FY2016 · CA
A life course perspective on gut microbiome aging and health in a non-human primate model
$639,997Elizabeth Archie · University Of Notre Dame · R01 · FY2024 · AG
Epidemiology of BMI Rebound
$639,968Children'S Hospital Med Ctr (Cincinnati) · M01 · FY2004 · RR
Low Intensity Weight Loss for Young Adults: Autonomous vs. Extrinsic Motivation
$639,965Jessica Gokee Larose · Virginia Commonwealth University · R01 · FY2015 · DK
Microbiota-immune interactions that promote intestinal homeostasis
$639,963June Louise Round · University Of Utah · R01 · FY2024 · AT
Family Inclusive Childhood Obesity Treatment designed for Low Income and Hispanic Families
$639,956Matthew A. Haemer · University Of Colorado Denver · R01 · FY2022 · DK
Obesity risk in African American women is determined by a diet-by-phenotype interaction
$639,953Barbara A. Gower · University Of Alabama At Birmingham · R01 · FY2021 · DK
Community Based Obesity Prevention Among Black Women
$639,941Gary G Bennett · Duke University · R01 · FY2008 · DK
Neuroscience of human food perception and eating behavior
$639,874Kevin Hall · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2023 · DK
LEPTIN-- SIGNALING, TARGETS AND RESISTANCE
$639,855Jeffrey S Flier · Beth Israel Deaconess Medical Center · R37 · FY2007 · DK
Glycemic reduction approaches in polycystic ovary syndrome: a comparative effectiveness study
$639,848Laura Saslow · University Of Michigan At Ann Arbor · R01 · FY2022 · DK
Determinants of Leukocyte Telomere Length at Birth
$639,820Ezra S. Susser · Columbia University Health Sciences · R01 · FY2015 · HD
Mediators of Atherosclerosis in South Asians Living in America
$639,789Alka M Kanaya · University Of California, San Francisco · R01 · FY2012 · HL
Healthy Hearts Across Generations
$639,780Karina Lynn Walters · University Of Washington · U01 · FY2007 · HL
Treatment of Obesity and Binge Eating: Behavioral weight Loss versus Stepped Care
$639,773Carlos M Grilo · Yale University · R01 · FY2010 · DK
Maternal and Paternal Preconception Environmental Exposures and Children's Health
$639,769Russ B Hauser · Harvard School Of Public Health · R01 · FY2018 · ES
Early life exposure to the natural, built, and social environments and incident hypertension
$639,755Francine Laden · Brigham And Women'S Hospital · R01 · FY2021 · ES
A Follow-up Study for Causes of Cancer in Black Women
$639,740Lynn Rosenberg · Boston University Medical Campus · UM1 · FY2017 · CA
Longitudinal Impact of Fluoride on Neurodevelopment and Neuroimaging Outcomes During Childhood and Adolescence in the United States and Mexico
$639,686Kelly J Brunst · University Of Cincinnati · R56 · FY2024 · ES
Brain Health Across the Metabolic Continuum in Youth at Risk for T2D
$639,677Tamara G Hershey · Washington University · R01 · FY2025 · DK
Parent training program to improve outcomes in childhood obesity treatment
$639,656Kyung E Rhee · University Of California, San Diego · R01 · FY2019 · DK
Impacts of Discriminatory Mortgage Lending Practices on Obesity
$639,646Andrea Richardson · Rand Corporation · R01 · FY2024 · HL
Cutaneous biomarkers of pediatric non-alcoholic fatty liver disease
$639,629Marialena Mouzaki · Cincinnati Childrens Hosp Med Ctr · R01 · FY2025 · DK
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
$639,619Lauren Berger Shomaker · Colorado State University · R01 · FY2025 · DK