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172,184 grants matching “inflammation”
Attenuating Inflammation to Restore GI Tract Integrity and Reduce Viral Reservoirs During cART
$771,835Jacob D Estes · Oregon Health & Science University · R01 · FY2021 · DK
Stem Cell Bioreactor for Cardiac Care
$771,827Arno W Tilles · Sentien Biotechnologies, Inc. · R44 · FY2016 · HL
Framingham: Inflammation, Genes & Cardiovascular Disease
$771,807Emelia J. Benjamin · Boston University Medical Campus · R01 · FY2008 · HL
Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
$771,805Cora E Lewis · University Of Alabama At Birmingham · N01 · FY2012 · HL
Biobehavioral mechanisms linking personality to health in midlife
$771,761Stephen B Manuck · University Of Pittsburgh At Pittsburgh · R01 · FY2017 · AG
Pathogenic monocyte response to chronic lung inflammation in cystic fibrosis
$771,679Emanuela Marina Bruscia · Yale University · R01 · FY2025 · HL
Pathogenic monocyte response to chronic lung inflammation in cystic fibrosis
$771,679Emanuela Marina Bruscia · Yale University · R01 · FY2023 · HL
Persistent HIV expression induced type I IFN responses and inflammaging
$771,666Suryaram Gummuluru · Boston University Medical Campus · R01 · FY2022 · AG
GBS mediated in utero fetal injury
$771,648Lakshmi Rajagopal · Seattle Children'S Hospital · R01 · FY2014 · AI
Effects of SGLT2 Inhibition on Coronary Flow Reserve and Other Key Indices Relevant to Type 2 Myocardial Infarction Risk among Women with HIV
$771,613Markella V. Zanni · Massachusetts General Hospital · R01 · FY2024 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WILDFIRES ARE BECOMING AN INCREASING PROBLEM ACROSS THE GLOBE. LANDSCAPE CHANGES AND A DRIER, HOTTER CLIMATE ARE CONTRIBUTING TO AN INCREASE IN THE NUMBER AND SEVERITY OF WILDFIRES. OVER THE PAST DECADE IN THE U.S., THERE HAS BEEN AN AVERAGE OF 63,000 WILDFIRES PER YEAR THAT BURNED 7.5 MILLION ACRES ANNUALLY. EXPERTS ARE PREDICTING FURTHER INCREASES OVER THE NEXT CENTURY IN THE DURATION OF THE WILDFIRE SEASON AND IN THE NUMBER OF LARGE, CATASTROPHIC WILDFIRES IN THE U.S. WILDFIRES OCCUR FREQUENTLY IN THE WESTERN U.S., WHERE THERE ARE MORE THAN THREE MILLION DAIRY COWS THAT PRODUCE ALMOST 40% OF THE MILK IN THE U.S. THESE ANIMALS MAY BE LOCATED IN THE DIRECT BURN AREAS OR MAY BE EXPOSED TO THE SMOKE EMITTED FROM WILDFIRES, WHICH CONTAINS TOXIC GASES AND PARTICLES. INHALATION OF POLLUTANTS FROM WILDFIRE SMOKE CONTRIBUTES TO ILLNESS AND MORTALITY IN HUMANS AND RECENT RESEARCH INDICATES THAT WHEN DAIRY CATTLE ARE EXPOSED TO WILDFIRE SMOKE THEY HAVE ALTERED IMMUNE RESPONSES, LOWER MILK PRODUCTION, AND ADVERSE HEALTH OUTCOMES DURING AND IN THE WEEK FOLLOWING EXPOSURE. BEYOND THESE LIMITED STUDIES, THERE ARE CURRENTLY NO PUBLISHED DATA REGARDING IMPACTS OF WILDFIRE SMOKE INHALATION IN DAIRY CATTLE. GIVEN THAT WILDFIRES ARE EXPECTED TO CONTINUE TO WORSEN, IT IS IMPORTANT THAT WE UNDERSTAND HOW WILDFIRES IMPACT CATTLE AND CONSEQUENTLY HOW WE CAN MITIGATE OR PREVENT THOSE RISKS.OUR GOALS IN THE PROPOSED WORK ARE TO 1) DETERMINE HOW WILDFIRES CONTRIBUTE TO DISEASE AND IMPEDE OPTIMAL PERFORMANCE IN LACTATING DAIRY COWS IN THE SHORT AND LONG-TERM; 2) INVESTIGATE SHORT- AND LONG-TERM EFFECTS ON CALVES WHEN THEY ARE EXPOSED TO WILDFIRE SMOKE EARLY IN LIFE; AND 3) TEST THE EFFICACY OF A NOVEL DEVICE TO FILTER OUT AIR POLLUTANTS FROM WILDFIRE SMOKE. WE ANTICIPATE THAT WILDFIRE SMOKE WILL CONTRIBUTE TO INFLAMMATION IN COWS THAT CONTINUES AFTER WILDFIRE SMOKE EXPOSURE, CULMINATING IN DECREASED LUNG FUNCTION AND OVERALL ANIMAL HEALTH. THESE EFFECTS ARE EXPECTED TO BE DIMINISHED WHEN THE AIR COWS ARE BREATHING IS PURIFIED. FURTHER, WE EXPECT THAT CALVES EXPOSED TO WILDFIRE SMOKE EARLY IN LIFE WILL EXPERIENCE MORE SEVERE SYMPTOMS AND HEALTH EFFECTS THAN COWS SINCE THEIR IMMUNE AND ORGAN SYSTEMS ARE STILL DEVELOPING AND MATURING. WE ALSO ANTICIPATE THAT THESE EARLY LIFE EFFECTS WILL PERSIST INTO LATER LIFE STAGES. OUR RESEARCH WILL FILL A GAP IN KNOWLEDGE OF THE IMPACTS OF WILDFIRE SMOKE ON DAIRY CATTLE ACROSS MULTIPLE LIFE STAGES AND WILL PROVIDE NEEDED INFORMATION TO DEVELOP TOOLS AND STRATEGIES PRODUCERS CAN EMPLOY TO IMPROVE CATTLE HEALTH AND PERFORMANCE UNDER RAPIDLY CHANGING ENVIRONMENTAL CONDITIONS.
$771,596Regents Of The University Of Idaho · · FY2023 · National Institute of Food and Agriculture
Mechanisms of Susceptibility of Excitatory Neurons to Tau Pathology and Neurodegeneration in Alzheimer's disease
$771,576Ana C. Pereira · Icahn School Of Medicine At Mount Sinai · R01 · FY2024 · AG
Probing the role of adenosine pathway in SIV pathogenesis
$771,534Ivona Pandrea · University Of Pittsburgh At Pittsburgh · R01 · FY2025 · AI
Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip
$771,525Arum Han · Texas Engineering Experiment Station · UH3 · FY2023 · TR
Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence
$771,519Howard C Hang · Scripps Research Institute, The · R01 · FY2023 · AI
Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence
$771,519Howard C Hang · Scripps Research Institute, The · R01 · FY2024 · AI
Impact of Gender Affirming Hormone Therapy on HIV Viral Dynamics and Immune Responses in Transgender Women
$771,490Eileen Patricia Scully · Johns Hopkins University · R01 · FY2025 · AI
Innate immune responses to tissue infection by intestinal fungi inhibit wound repair
$771,486Thaddeus S Stappenbeck · Cleveland Clinic Lerner Com-Cwru · R01 · FY2025 · AI
HIV Persistence During Suppressive Antiretroviral Therapy
$771,465Frank Maldarelli · Division Of Basic Sciences - Nci · ZIA · FY2017 · CA
Preclinical Studies and Mucosal Responses
$771,455Rama Rao Amara · Geovax, Inc. · U19 · FY2008 · AI
Integrated analysis of coronary anatomy and biology with 18F-fluoride PET and CT angiography
$771,431Piotr J Slomka · Cedars-Sinai Medical Center · R01 · FY2017 · HL
Cervicovaginal microbiome, mucosal immunity, and pathogen factors that contribute to spontaneous clearance of Chlamydia trachomatis
$771,416Rebecca M. Brotman · University Of Maryland Baltimore · R01 · FY2024 · AI
Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
$771,376Sogol Mostoufi-Moab · Children'S Hosp Of Philadelphia · R01 · FY2021 · CA
Clinical translation of targeted intracoronary imaging for inflammatory activity
$771,347Guillermo J. Tearney · Massachusetts General Hospital · R01 · FY2023 · HL
Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
$771,295Brian Richard Lindman · Vanderbilt University Medical Center · R01 · FY2024 · HL