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59,101 grants matching “hypertension”
MIND the Kidneys
$499,769Manjula Kurella Tamura · Stanford University · R01 · FY2013 · DK
HYPERTENSION OR HIGH BLOOD PRESSURE IS A MAJOR, YET PREVENTABLE, MODIFIABLE RISK FACTOR FOR CARDIOVASCULAR DISEASE, THE LEADING CAUSE OF MORBIDITY AND MORTALITY IN THE WORLD. ACCORDING TO THE 2018 REPORT FROM THE AMERICAN HEART ASSOCIATION ON HEART DISEASE STATISTICS, IT IS CURRENTLY ESTIMATED THAT 85 MILLION IN THE US HAVE HYPERTENSION. THE REPORT ALSO INDICATES THAT IN 2015, 37.5% OF DEATHS WERE ATTRIBUTED TO HYPERTENSION AND THE DIRECT AND INDIRECT COST TO TREAT HYPERTENSION IN 2014 WAS $53.2 BILLION. ADDITIONALLY, THE REPORT REVEALS THAT HYPERTENSION IS LINKED TO OVERALL SHORTER LIFE EXPECTANCY AND A GREATER NUMBER OF YEARS WITH CARDIOVASCULAR DISEASE.A NUMBER OF ANTI-HYPERTENSIVE DRUGS ARE AVAILABLE TO TREAT HYPERTENSION; HOWEVER, THESE DRUGS HAVE VARIOUS SIDE EFFECTS, INCLUDING FATIGUE, DIZZINESS, HEADACHES, CONSTIPATION, NAUSEA, COUGH AND EDEMA. ADDITIONALLY, MULTIPLE ANTI-HYPERTENSIVE MEDICATIONS ARE OFTEN NEEDED TO DECREASE BP, INCREASING POTENTIAL SIDE EFFECTS AND DECREASING ADHERENCE. THEREFORE, ALTERNATIVE OR COMPLEMENTARY THERAPEUTIC APPROACHES, INCLUDING NUTRITIONAL STRATEGIES, THAT ARE SAFE AND EFFECTIVE ARE NEEDED TO PREVENT AND/OR TREAT HYPERTENSION AND DECREASE THE RISK OF CARDIOVASCULAR EVENTS.RECOMMENDATIONS FROM THE AMERICAN HEART ASSOCIATION AND AMERICAN COLLEGE OF CARDIOLOGY IN THE PRIMARY TREATMENT OF HYPERTENSION CONSIST OF LIFESTYLE CHANGES, INCLUDING WEIGHT LOSS, EXERCISE AND DIETARY MODIFICATIONS, E.G. INCREASING THE CONSUMPTION OF FRUIT AND VEGETABLES. IN FACT, POPULATION STUDIES INDICATE THAT CONSUMPTION OF FRUITS AND VEGETABLES IS ASSOCIATED WITH DECREASED INFLAMMATION AND INCIDENCE OF CARDIOVASCULAR DISEASE. BLACKBERRIES AND RASPBERRIES ARE MAJOR FRUIT CROPS THAT ARE NATIVE TO NORTH AMERICA AND ARE WIDELY CONSUMED IN THE US. THESE BERRIES HAVE STRONG ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES. SCIENTIFIC EVIDENCE INDICATES THAT CONSUMPTION OF BERRIES MAY PRODUCE BENEFICIAL EFFECTS ON BLOOD PRESSURE. HOWEVER, THEIR APPLICABILITY ISDIMINISHED BY THE LACK OF MECHANISTIC EXPLANATIONS ABOUT THEIR MODE OF ACTION WHICH INCREASES UNCERTAINTY ABOUT THEIR POTENTIAL BENEFITS AND POTENTIAL SIDE EFFECTS. FURTHER, THE IDEAL TYPE AND/OR COMBINATION OF BERRY THAT WILL ELICIT THE GREATEST BENEFITS TO CARDIOMETABOLIC HEALTH HAS NOT BEEN IDENTIFIED.THEREFORE, LONG TERM-GOAL OF THESE STUDIES IS TO IDENTIFY AND DEVELOP SAFE AND EFFECTIVE ALTERNATIVE OR COMPLEMENTARY NUTRITIONAL STRATEGIES THAT CAN IMPROVE CARDIOVASCULAR AND GUT HEALTH. THE OVERALL GOAL OF OUR PROJECT IS TO USE A PRECLINICAL RAT MODEL TO INVESTIGATE THE EFFICACY OF BLACKBERRY AND RASPBERRY, ALONE OR IN COMBINATION, IN ATTENUATING HYPERTENSION AND THE ASSOCIATED CARDIAC DAMAGE. WE ALSO AIM TO DETERMINE WHETHER THE PROTECTIVE EFFECTS OF BERRIES ON BLOOD PRESSURE AND CARDIAC FUNCTION ARE MEDIATED BY FAVORABLE ALTERATIONS IN GUT HEALTH AND DECREASES IN OXIDATIVE STRESS AND INFLAMMATION. DATA GENERATED BY THESE STUDIES WILL BE MADE AVAILABLE TO THE PUBLIC AND SCIENTIFICCOMMUNITIES IN PEER-REVIEWED SCIENTIFIC JOURNALS, PRESENTATIONS AT SCIENTIFIC MEETINGS, AND PRESS-RELEASES. BY CONDUCTING THESE STUDIES, WE WILL PROVIDE EVIDENCE TO INFORM THE PUBLIC OF DIETARY STRATEGIES THAT THEY CAN EMPLOY TO REDUCE THEIR RISK OF HYPERTENSION AND IMPROVE THEIR CARDIOVASCULAR HEALTH. FURTHER, IDENTIFYING THE MECHANISMS MEDIATING THE PROTECTIVE EFFECTS OF BERRIES PROVIDES POTENTIAL NEW THERAPEUTIC TARGETS FOR THE TREATMENT OF HYPERTENSION. THIS IS OF SIGNIFICANCE AS IT CAN HAVE A GREAT IMPACT ON THE QUALITY OF LIFE, PRODUCTIVITY, AND ECONOMIC BURDEN FOR THE AFFECTED POPULATIONS. LASTLY, THIS CAN LEAD TO ADDITIONAL DEMAND FOR BLACKBERRY AND RASPBERRY DUE TO THEIR HEALTH BENEFITS RESULTING IN AGRICULTURAL EXPANSION IN PRODUCTION OF THESE BERRIES.
$499,745Georgia State University Research Foundation Inc · · FY2019 · National Institute of Food and Agriculture
Comprehensive Pediatric Hypertension Diagnosis and Management
$499,685Michael L Rinke · Albert Einstein College Of Medicine, Inc · R01 · FY2018 · HS
Jigsawdio: an AudioVisual Jigsaw Puzzle for People with Alzheimer's Disease and Alzheimer's-Disease-Related Dementias
$499,670Amy Young · Callahan-Young Llc · R41 · FY2022 · AG
PATHWAY AND EXCEPTIONAL LONGEVITY
$499,666Nir J Barzilai · Albert Einstein College Of Medicine · P01 · FY2010 · AG
Defective PKA Signaling in Cushing's Syndrome
$499,648John D Scott · University Of Washington · R01 · FY2023 · DK
Tracking Disparities In The Effective Delivery Of Health Services
$499,616Christopher J.l. Murray · University Of Washington · RC1 · FY2009 · AG
The Role of Neighborhood Greenspace in reducing Risk of Hypertensive Disorders of Pregnancy, Chronic Hypertension, and Racial Disparities in Maternal Morbidity
$499,609Eugenia C South · University Of Pennsylvania · R01 · FY2023 · HL
Mechanisms of Hypertension and Cardiovascular Diseases
$499,594Suzanne Oparil · University Of Alabama At Birmingham · T32 · FY2022 · HL
RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
$499,588Robert Schneider · Institute For Prevention Research · RC1 · FY2010 · HL
MobileMedMinder: A Networked Aide for Medication Compliance
$499,582 · N01 · FY2010 · AA
MIF: A novel CNS regulator of cardiovascular function
$499,579Colin Sumners · University Of Florida · R01 · FY2008 · HL
Role of Vascular Oxidative Stress in Obesity
$499,562Hua Linda Cai · University Of California Los Angeles · R01 · FY2012 · HL
Analysis of five year follow-up data from the Weight Loss Maintenance Trial
$499,546Victor J Stevens · Kaiser Foundation Research Institute · RC1 · FY2009 · HL
Safety of Anti-CGRP Migraine Therapeutics in Ischemic Stroke
$499,509Cenk Ayata · Massachusetts General Hospital · R01 · FY2025 · NS
GENETICS OF SALT SENSITIVITY IN AFRICAN AMERICANS
$499,496Case Western Reserve University · R01 · FY2001 · HL
Treatment of Heart Disease with an Intraventricular Sac
$499,487Mc3, Inc. · R44 · FY2005 · HL
TeleHealth & Remote Measurement Technologies to Improve Med Adherence in HTN
$499,478Robert H Friedman · Boston Medical Center · RC1 · FY2010 · HL
Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
$499,432Robert S Schwartz · University Of Colorado Denver · R01 · FY2009 · AG
Adherence Improvement and Measurement- AIM- System. Challenge Topic 10-MH-101
$499,428James O Kahn · University Of California, San Francisco · RC1 · FY2009 · MH
Comparative Safety of Atypical Antipsychotics in High-Risk US Children with ADHD
$499,396David M Rubin · Children'S Hosp Of Philadelphia · R01 · FY2012 · HS
Genetic Determinants of Susceptibility to Kidney Disease in African Americans
$499,385Thomas M Coffman · Duke University · RC1 · FY2010 · DK
STRESS, BLOOD PRESSURE AND ETHNICITY
$499,376University Of California San Diego · R01 · FY2003 · HL
Cohort Study of Medication Adherence Among Older Adults
$499,345Marie A Krousel-Wood · Ochsner Clinic Foundation · R01 · FY2006 · AG
Decompressive craniotomy versus medical therapy for refractory intracranial hyper
$499,315Raminder Nirula · University Of Utah · RC1 · FY2009 · NS