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17,054 grants matching “genome editing”
Mechanisms Underlying Tissue Fragility in Ectodermal Dysplasias
$70,206Peter J. Koch · University Of Colorado Denver · R01 · FY2019 · AR
Environmentally-modulated cytosine deamination in genome instability and cancer
$70,168Steven A Roberts · Washington State University · R00 · FY2016 · ES
Effect of Pre- and Peri-Implantation Zika Virus Infection on Fetal Development
$70,106Lauretta A. Lacko · Weill Medical Coll Of Cornell Univ · F32 · FY2019 · HD
Determining the Molecular Chain of Causality Through Which Genetic Variants Affect Physiology
$70,082Stefan Zdraljevic · University Of California Los Angeles · F32 · FY2022 · GM
Cancer Molecular Genetics Program
$70,050Jolene J Windle · Virginia Commonwealth University · P30 · FY2019 · CA
Johns Hopkins Retinal Degenerations and Visual Electrophysiology Conference 2023.
$70,000Mandeep Singh · Johns Hopkins University · R13 · FY2023 · EY
Center for functional analysis of human UDN gene homologs in Drosophila and zebrafish
$70,000Hugo J Bellen · Baylor College Of Medicine · U54 · FY2016 · NS
Whole Exome Sequencing for Familial Intracranial Aneurysm (FIA I-II) Study
$70,000David L Valle · Johns Hopkins University · N01 · FY2011 · NS
Clinical Molecular Genetic Diagnosis of Hearing Loss
$70,000Jun Shen · Brigham And Women'S Hospital · R03 · FY2014 · DC
Engineering chimeric gene therapy vectors with enhanced packaging capacity
$69,802Victoria Jane Madigan · Massachusetts Institute Of Technology · F32 · FY2022 · AI
Characterization of the function of gene body DNA methylation
$69,802Colette Lafontaine Picard · University Of California Los Angeles · F32 · FY2022 · GM
Enhancer-targeted correction of haploinsufficient autism risk genes
$69,802George Tsun-Te Chen · University Of California Los Angeles · F32 · FY2022 · MH
Innate cellular responses against Adeno-associated virus in hematopoietic stem and progentitor cells influence cell survival and repopulation capacity
$69,802Amanda M Dudek · Stanford University · F32 · FY2022 · HL
Defining the mechanism of Shieldin complex in DNA end joining
$69,802Joshua Heyza · Michigan State University · F32 · FY2022 · GM
Lysyl oxidases are novel regulators of definitive hematopoiesis
$69,802Elizabeth Coffey · Cincinnati Childrens Hosp Med Ctr · F32 · FY2022 · DK
Natural variation in C. elegans responses to environmental pollution
$69,797Tess Catherine Leuthner · Duke University · F32 · FY2023 · ES
Cancer Molecular Genetics Program
$69,767Seth Joel Corey · Virginia Commonwealth University · P30 · FY2017 · CA
Creation of Knockout Laboratory Opossums
$69,672John L Vandeberg · University Of Texas Rio Grande Valley · R21 · FY2024 · OD
INFLUENZA OR FLU IS ONE OF TOP 3 ECONOMIC DISEASES AFFECTING THE PORK INDUSTRY. IN HUMANS, IT CAUSES UP TO 41,000 HUMAN FATALITIES IN UNITED STATES AND UPWARDS OF 500,000 CASUALTIES WORLDWIDE. PIGS SERVE AS RESERVOIRS FOR SWINE, AVIAN, AND HUMAN VIRUSES AND PRODUCE NOVEL HIGH POTENCY STRAINS, SIMILAR TO THE "SWINE FLU" PANDEMIC H1N1 STRAIN. OUR HYPOTHESIS IS THAT ELIMINATING RECEPTORS FOR VIRAL ENTRY AND INTERFERING WITH VIRAL REPLICATION WILL SERVES AS A DUAL MECHANISM FOR PROTECTING THE PIGS FROM VIRAL INFECTION, AND TRANSMISSION OF FLU TO HUMAN AND PIG HOSTS. THERE ARE THREE OBJECTIVES IN THE PROPOSAL: 1) ASSEMBLE AND VALIDATE GENOME EDITING TOOLS TO DELETE THE RECEPTOR FOR FLU VIRUS ENTRY, AND PREVENT VIRAL PROPAGATION; 2) GENERATE RECOMBINANT PIGS; AND 3) TEST THE RECOMBINANT PIGS FOR SUSCEPTIBILITY TO INFECTION BY SWINE AND HUMAN TYPE ADAPTED VIRUSES TO INFECTION AND DISSEMINATION. WE EXPECT TO DEVELOP A PIG MODEL OF INFLUENZA RESEARCH AND IDENTIFY DRUGGABLE TARGETS. FROM AGRICULTURAL STAND POINT, WE ANTICIPATE ELIMINATION OF FLU FROM COMMERCIAL SWINE HERDS.
$69,646University Of Maryland, College Park · · FY2015 · National Institute of Food and Agriculture
Coupling between circadian rhythms and redox signaling in stem cell differentiation and adult neurogenesis
$69,554Daniel Maxim Iascone · University Of Pennsylvania · F32 · FY2020 · MH
Genomics Core
$69,511Alan R. Shuldiner · University Of Maryland Baltimore · P30 · FY2016 · NR
Genomics Core
$69,511Alan R. Shuldiner · University Of Maryland Baltimore · P30 · FY2012 · NR
Developing Methanosarcina spp. as a model system to study cytochromes c and their role in archaeal methane metabolism
$69,500Dinesh Gupta · University Of California Berkeley · F32 · FY2023 · GM
Nicotine & Nodose: A Neural Basis for Peripheral Control over Nicotine Intake
$69,500Kevin Braunscheidel · Icahn School Of Medicine At Mount Sinai · F32 · FY2023 · DA
Assessing the generality of sexual conflict in new gene evolution in Drosophila
$69,500Deanna Arsala · University Of Chicago · F32 · FY2023 · GM