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17,828 grants matching “crispr”
Isoform expression and post-transcriptional regulation of centrosomal plp mRNA
$99,655Junnan Fang · Emory University · K99 · FY2022 · GM
CRISPR therapy in the canine DMD model
$99,608Dongsheng Duan · University Of Missouri-Columbia · R56 · FY2022 · AR
Mechanisms of Myotonic Dystrophy Type 2-causing CCTG DNA Repeat Instability
$99,500Jane C Kim · California State University San Marcos · SC3 · FY2018 · GM
Transgenic & Gene-Targeting Shared Resource
$99,323Jay L Vivian · University Of Kansas Medical Center · P30 · FY2023 · CA
Defining tumor and blood-based immunogenomic signatures predicting response to immunotherapy in ovarian cancer
$99,171Kelsey R Monson · Icahn School Of Medicine At Mount Sinai · K00 · FY2025 · CA
The Role of E2F2 in HER2 Positive Breast Cancer
$99,014Jonathan Rennhack · Dana-Farber Cancer Inst · K00 · FY2020 · CA
Genetic and immunological dissection of coinhibitory crosstalks between human T cells and cancer cells
$98,998Masato Ogishi · Stanford University · K00 · FY2025 · CA
Molecular basis for CRISPR RNA-guided nucleic acid cleavage and DNA transposition
$98,922Leifu Chang · Purdue University · R01 · FY2021 · GM
High resolution dissection of oncogene enhancer networks via CRISPR screening and live-cell imaging.
$98,858Lei Stanley Qi · Stanford University · R01 · FY2024 · CA
MicroRNA Control of Dilated Cardiomyopathy
$98,828Mark Mercola · Stanford University · R01 · FY2025 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROJECT AIMS TO IMPROVE AGRONOMIC TRAITS OF PENNYCRESS TO ENHANCE ITS POTENTIAL AS AN EMERGING CASH COVER CROP THROUGH A UNIQUE ACCELERATED BREEDING APPROACH THAT LEVERAGES COMPUTATIONAL SIMULATIONS AND GENE-EDITING TECHNOLOGIES. COVER CROPS CAN REDUCE SOIL EROSION AND IMPROVE SOIL HEALTH, BUT THEY ADOPTION OF COVER CROPPING AS MANAGEMENT PRACTICE IS HINDERED BY IMPLEMENTATION COST AND POTENTIAL CASH CROP YIELD LOSS. PENNYCRESS HAS THE POTENTIAL TO PROVIDE SOIL HEALTH BENEFITS AND GENERATE 879 LITERS/HA OF SEED OIL THAT CAN BE CONVERTED INTO BIODIESEL AND BIO-JET FUELS. HOWEVER, PENNYCRESS IS ONLY PARTIALLY DOMESTICATED, AND EFFORTS TO IMPROVE AGRONOMIC TRAITS SUCH AS FLOWERING TIME, SEED QUALITY, AND STRESS TOLERANCE ARE ONGOING.TO ACCELERATE THE DEVELOPMENT OF COMMERCIALLY VIABLE PENNYCRESS, THIS PROJECT WILL LEVERAGE COMPUTATIONAL PROTEIN SIMULATION METHODS TO IDENTIFY BENEFICIAL VARIANTS TO THE TARGET GENE, THE E1 COMPONENT OF THE ODGH ENZYME COMPLEX, THAT RESULT IN EARLIER FLOWERING TIMES, LARGER SEED SIZES, AND IMPROVED ROOT SYSTEM ARCHITECTURE. POTENTIAL GENE VARIANTS WILL BE INTRODUCED INTO PENNYCRESS PLANTS USING CRISPR-CAS GENE EDITING TECHNOLOGIES TO GENERATE PLANT VARIETIES WITH THE PRECISE GENE VARIANT OF INTEREST. THESE PLANT VARIETIES WILL THEN BE EVALUATED AT SEEDLING STAGE AND AT MATURITY TO EVALUATE THE IMPACT OF THE GENE EDIT ON PLANT ABOVEGROUND AND BELOWGROUND GROWTH AS WELL AS OIL QUALITY. AGRONOMIC TRAITS SUCH AS FLOWERING TIME AND SEED SIZE WILL ALSO BE MEASURED AND EVALUATED. IMPROVED PENNYCRESS VARIETIES PRODUCED FROM THIS WORK HAS THE POTENTIAL TO BRING PENNYCRESS CLOSER TO MARKET AS A CASH COVER CROP AND ENABLE A CIRCULAR BIOECONOMY FOR SUSTAINABLE ENERGY PRODUCTION.
$98,752Donald Danforth Plant Science Center · · FY2024 · National Institute of Food and Agriculture
Preclinical optimization of a gene therapy for erythromelalgia and chronic pain
$98,701Fernando Aleman Guillen · Navega Therapeutics, Inc. · U44 · FY2024 · NS
Functional evaluation of a new GWAS locus that links visceral adiposity and type 2 diabetes
$98,061Matthew Steinhauser · Brigham And Women'S Hospital · R01 · FY2019 · DK
Multigene knockdown in Mycobacterium tuberculosis by repurposing the endogenous type III CRISPR system
$98,000Christoph Grundner · Seattle Biomedical Research Institute · R03 · FY2017 · AI
Lrp4 signaling in bone metabolism and mechanotransduction
$97,963Alexander G Robling · Indiana University Indianapolis · R01 · FY2019 · AR
Regulation of KSHV replication by N6-methyladenosine (m6A) - Diversity Supplement
$97,654Shou-Jiang Gao · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · CA
Investigating molecular mechanism of immune response during cancer progression
$97,605Zeyu Chen · Dana-Farber Cancer Inst · K00 · FY2024 · CA
Gene Delivery Core
$97,536Jose A. Cancelas · Cincinnati Childrens Hosp Med Ctr · U54 · FY2022 · DK
Gene Delivery Core
$97,526Jose A. Cancelas · Cincinnati Childrens Hosp Med Ctr · U54 · FY2023 · DK
Gene Delivery Core
$97,526Jose A. Cancelas · Cincinnati Childrens Hosp Med Ctr · U54 · FY2021 · DK
Gene Delivery Core
$97,526Jose A. Cancelas · Cincinnati Childrens Hosp Med Ctr · U54 · FY2025 · DK
Gene Delivery Core
$97,526Jose A. Cancelas · Cincinnati Childrens Hosp Med Ctr · U54 · FY2024 · DK
Genomic control of gene regulatory networks governing early human lineagedecisions
$97,511Danwei Huangfu · Sloan-Kettering Inst Can Research · U01 · FY2023 · HG
Specification of Treg cells: FOXP3 functional facets
$97,463Christophe O Benoist · Harvard Medical School · R01 · FY2017 · AI
Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients
$97,357Casey R Dorr · Hennepin Healthcare Research Institute · K01 · FY2019 · AI