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27,075 grants matching “cholesterol”
Regulatory Roles of Cellular Cholesterol
$300,179Wonhwa Cho · University Of Illinois At Chicago · R01 · FY2016 · GM
Raman Tomography of Musculoskeletal Tissue
$300,164Michael D Morris · University Of Michigan At Ann Arbor · R01 · FY2010 · AR
Biochemical Mechanism of Eicosanoid Synthesizing Enzymes
$300,158Aditi Das · University Of Illinois At Urbana-Champaign · R01 · FY2020 · GM
Insights into skin barrier function: In silico and experimental studies of healthy and diseased stratum corneum lipid models
$300,103Clare McCabe · Vanderbilt University · R01 · FY2020 · AR
Structure and Function of Lens Channels
$300,048Guido A Zampighi · University Of California Los Angeles · R01 · FY2007 · EY
Inflammation and Immunosuppression in Lung Cancer
$300,048Cong Yan · Indiana University Indianapolis · R01 · FY2014 · CA
Racial and Cardiovascular Risk Factor Anomalies in CKD
$300,017Csaba Pal Kovesdy · University Of Tennessee Health Sci Ctr · R01 · FY2015 · DK
Development of antibody drug conjugates as pan-filo antivirals
$300,000Gai Liu · Microbiotix, Inc · R43 · FY2023 · AI
Control of interfacial behavior through lipid domain formation, ligand-receptor binding and their synergetic effect
$300,000Igal G Szleifer · Northwestern University · · FY2008 · ENG
Pregnane X Receptor (PXR) Antagonists for Non-Alcoholic Fatty Liver Disease
$300,000Jay Edward Wrobel · Fox Chase Chemical Diversity Center, Inc · R43 · FY2015 · DK
The Role of Lipid Rafts in Fetal Alcohol Spectrum Disorder
$300,000Cynthia F. Bearer · University Of Maryland Baltimore · R01 · FY2009 · AA
Cholesterol Ester Hydrolysis and Cholesterol Efflux
$300,000Virginia Commonwealth University · R01 · FY2005 · HL
Synergistic panfiloviral entry inhibiting antibody drug conjugates
$300,000Zachary David Aron · Microbiotix, Inc · R43 · FY2019 · AI
Native LDL, Cholesterol and Impaired Vasodilation
$300,000Medical College Of Wisconsin · R01 · FY2005 · HL
GENETIC EPIDEMIOLOGICAL STUDIES OF ALZHEIMERS DISEASE
$300,000Boston University Medical Campus · R01 · FY2001 · AG
Cellular cholesterol movement and homeostasis
$300,000Yvonne Lange · Rush University Medical Center · R01 · FY2012 · HL
Cellular cholesterol movement and homeostasis
$300,000Yvonne Lange · Rush University Medical Center · R01 · FY2011 · HL
APOL1, sickle cell trait and chronic kidney disease in African Americans
$300,000Nora Franceschini · Univ Of North Carolina Chapel Hill · R56 · FY2016 · DK
Native LDL, Cholesterol and Impaired Vasodilation
$300,000Medical College Of Wisconsin · R01 · FY2004 · HL
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE GOALS OF THIS STUDY ARE CONSISTENT WITH THE USDA'S FOOD AND HUMAN HEALTH AREA. CARDIOVASCULAR DISEASE (CVD) IS A LEADING CAUSE OF DEATH, ACCOUNTING FOR 30% OF ANNUAL GLOBAL MORTALITY. AS IS THE CASE FOR MANY CHRONIC DISEASES, INFLAMMATION, OXIDATIVE STRESS, AND CHANGES IN GUT MICROBIOTA ARE KEY CONTRIBUTORS TO CVD. POLYPHENOLS HAVE ANTIOXIDANT, ANTI-INFLAMMATORY, AND LIPID-LOWERING PROPERTIES AFFECTING HOST GUT MICROBIOTA; HOWEVER, THEIR BIOAVAILABILITY IS VERY LOW. AMONG THESE, RED WINE POMACE (RWP) IS A WINE BIO-RESIDUE RICH IN ANTHOCYANIN (ACN), OTHER POLYPHENOLS, AND FIBER WITH HIGH ANTIOXIDANT ACTIVITIES. RECENTLY, WE SUCCESSFULLY SEPARATED AND DETECTED GLYCOL-MACRO-PEPTIDES (GMP) FROM WHEY PROTEIN. WE SHOWED THAT THE RESULTING ENCAPSULATED PRODUCT IMPROVED POLYPHENOL RELEASE INTO THE INTESTINAL TRACT (>80%). FOR THIS PROPOSED STUDY, WE HYPOTHESIZED THAT MICROENCAPSULATION OF RWP WITH GMP USING ELECTROSPINNING WILL ENHANCE ACN BIOAVAILABILITY IN RWP, LEADING TO BENEFICIAL CHANGES IN GUT MICROBIAL DIVERSITY AND IMPROVING CVD IN AN OBESE MOUSE MODEL. SPECIFICALLY, WE WILL OPTIMIZE THE BIOAVAILABILITY OF MICROENCAPSULATED RWP, USING GMP, VIA ELECTROSPINNING AND GASTRIC SIMULATION SYSTEM, FOLLOWED BY EVALUATING THE BIOAVAILABILITY AND GUT MICROBIOTA-MODULATING EFFECTS OF ENCAPSULATED RWP ON CHOLESTEROL EFFLUX (CE) IN DIET-INDUCED OBESE B6 MICE. OUR NOVEL APPROACHES WILL GENERATE NEW KNOWLEDGE BY INTRODUCING A COST-EFFECTIVE, ADDED-VALUE SOURCE OF ACN FROM RWP, WITH HIGH BIOAVAILABILITY AND BENEFICIAL EFFECTS ON GUT MICROBIOTA FOR OPTIMAL HUMAN NUTRITION AND HEALTH. MOREOVER, THIS GRANT IS VERY TIMELY AND A STEPPING STONE FOR THE PD'S CAREER DEVELOPMENT IN NUTRITION, FOODS AND AGRICULTURE AREAS.
$300,000Texas Womans University · · FY2024 · National Institute of Food and Agriculture
Cholesterol Ester Hydrolysis and Cholesterol Efflux
$300,000Virginia Commonwealth University · R01 · FY2004 · HL
Synergistic panfiloviral entry inhibiting antibody drug conjugates
$300,000Zachary David Aron · Microbiotix, Inc · R43 · FY2018 · AI
Cellular cholesterol movement and homeostasis
$300,000Yvonne Lange · Rush University Medical Center · R01 · FY2010 · HL
Develop a rapid, efficient and low cost extracellular vesicles isolation method toward non-invasive non-small cell lung cancer molecular analysis
$300,000Hongzhang He · Captis Diagnostics · R43 · FY2018 · CA
WV Prevention Research Center
$300,000Dina L Maruca · West Virginia University · U48 · FY2017 · DP