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17,054 grants matching “genome editing”
Immunoengineering Durable Control of HIV Replication
$3,643,653James L Riley · University Of Pennsylvania · P01 · FY2025 · AI
Pathogenic Mechanisms in Spondyloarthritis
$3,621,719Robert Colbert · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2016 · AR
Dissection of endosomal trafficking mechanisms in Alzheimer's Disease
$3,613,268Li-Huei Tsai · Massachusetts Institute Of Technology · RF1 · FY2018 · AG
A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes
$3,600,000David A Rasko · University Of Maryland Baltimore · U19 · FY2019 · AI
A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes
$3,600,000David A Rasko · University Of Maryland Baltimore · U19 · FY2020 · AI
Pathogenic Mechanisms in Spondyloarthritis
$3,582,224Robert Colbert · National Institute Of Arthritis And Musculoskeletal And Skin Diseases · ZIA · FY2017 · AR
NCRN-MN: Cornell Census-NSF Research Node: Integrated Research Support, Training and Data Documentation
$3,560,887Lars Vilhuber · Cornell University · · FY2011 · SBE
Genetic epidemiology of complex diseases
$3,555,403Charles Rotimi · National Human Genome Research Institute · ZIA · FY2021 · HG
A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes
$3,548,646David A Rasko · University Of Maryland Baltimore · U19 · FY2021 · AI
Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure
$3,528,529Paula M Cannon · University Of Southern California · U19 · FY2023 · HL
PlanB2CureHIV (the 'PlanB' consortium)
$3,519,835James Even Voss · Scripps Research Institute, The · P01 · FY2025 · HL
Research Project
$3,509,128Isaac S. Kohane · Harvard Medical School · P50 · FY2017 · MH
Cancer Center Support Grant
$3,504,376Steven K. Libutti · Rutgers Biomedical And Health Sciences · P30 · FY2025 · CA
Cancer Center Support Grant
$3,504,376Steven K. Libutti · Rutgers Biomedical And Health Sciences · P30 · FY2024 · CA
Molecular Biology of Mammalian Gametogenesis, Fertilization and Early Development
$3,460,434Jurrien Dean · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2022 · DK
NIDCD Core for Clinical Research and Care
$3,457,090Joshua Levy · National Institute On Deafness And Other Communication Disorders · ZID · FY2025 · DC
Molecular Mechanisms and Genetic Basis of Human Ovarian Aging
$3,445,585Yousin Suh · Columbia University Health Sciences · RF1 · FY2025 · AG
A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes
$3,428,670David A Rasko · University Of Maryland Baltimore · U19 · FY2022 · AI
Center for 3D Structure and Physics of the Genome
$3,427,788Job Dekker · Univ Of Massachusetts Med Sch Worcester · U54 · FY2015 · DK
A germline- and promoter-independent strategy to gain access to all cell types in the brain
$3,418,721Baisong Lu · Wake Forest University Health Sciences · RF1 · FY2023 · MH
Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome
$3,415,011Carol J Bult · Jackson Laboratory · U24 · FY2021 · HG
NIDCD Core for Clinical Research and Care
$3,399,659Joshua Levy · National Institute On Deafness And Other Communication Disorders · ZID · FY2024 · DC
Genetic epidemiology of complex diseases
$3,386,972Charles Rotimi · National Human Genome Research Institute · ZIA · FY2019 · HG
WE PROPOSE TO GENERATE NON-TRANSGENIC HLB RESISTANT CITRUS VARIETIES VIA GENOME EDITING OF CITRUS SUSCEPTIBILITY (S) GENES TO HLB USING CRISPR/CAS9 TECHNOLOGY. OUR CENTRAL HYPOTHESIS IS THAT CANDIDATUS LIBERIBACTER ASIATICUS (LAS), WHICH UTILIZES A SET OF BACTERIAL SECRETED EFFECTOR PROTEINS TO MANIPULATE KEY DISEASE S GENE(S), CAN BE ELIMINATED BY MODIFICATION OF KEY S GENE(S). WE PROPOSE TO CHARACTERIZE THE INTERACTION BETWEEN LAS EFFECTORS AND KEY S GENES OR THEIR PRODUCTS. MULTIPLE CANDIDATE S GENES BASED ON INTERACTIONS WITH KEY EFFECTORS HAVE BEEN IDENTIFIED IN OUR PRELIMINARY STUDY. WE WILL GENERATE MUTATIONS IN THE CANDIDATE S GENES USING CRISPR-CAS9 AND SCREEN THE MUTANTS FOR RESISTANCE TO HLB. THE CONFIRMED S GENE(S) WILL BE MODIFIED IN ADDITIONAL SELECTED CITRUS SCION AND ROOTSTOCK VARIETIES. IN PARALLEL, WE WILL CONSTRUCT MUTATIONS IN THE KEY S GENES TO PINPOINT THE CRITICAL RESIDUES FOR INTERACTIONS WITH LAS EFFECTORS, WHICH WILL ASSIST IN DIRECTING PLANT MODIFICATIONS AND VALIDATION OF IDENTIFIED RESISTANT LINES. THIS PROPOSAL ADDRESSES ONE OF THE SIX AREAS OF HIGHEST PRIORITY DETERMINED BY THE CITRUS DISEASE SUB-COMMITTEE (CDS): DEVELOPMENT OF TOLERANCE OR RESISTANCE TO HLB IN CULTIVARS COMMERCIALLY IMPORTANT IN ALL CITRUS PRODUCTION REGIONS. THE STRATEGY TO BE EMPLOYED AND THE OBJECTIVES ARE DEVELOPED BASED ON INPUT FROM CITRUS INDUSTRY. CITRUS GROWER SPONSORED PROJECTS ESTABLISHED THE FOUNDATION OF THIS APPLICATION, E.G., ADOPTION OF CRISPR TECHNOLOGY ON CITRUS. THE NON-TRANSGENIC PLANTS GENERATED HERE MAY NOT BE REGULATED BY USDA AND COULD BE COMMERCIALIZED IMMEDIATELY, IF PROVEN HLB RESISTANT AND WITH ACCEPTABLE HORTICULTURAL TRAITS.
$3,378,628University Of Florida · · FY2018 · National Institute of Food and Agriculture
Investigations of Methylmalonic Acidemia and Related Disorders
$3,378,385Charles P Venditti · National Human Genome Research Institute · ZIA · FY2025 · HG