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91,797 grants matching “obesity”
Effects of early vs. late time restricted eating vs. daily caloric restriction on weight loss and metabolic outcomes in adults with obesity
$645,523Elizabeth Anne Thomas · University Of Colorado Denver · R01 · FY2024 · DK
Foundational studies for precision nutrition
$645,512David W. Threadgill · Texas A&M Agrilife Research · R01 · FY2023 · DK
Predictors of Early Menopause
$645,481Elizabeth R Bertone-Johnson · University Of Massachusetts Amherst · R01 · FY2016 · HD
Jump Start+:COVID Support to improve resiliency and mitigate risks in childcare centers serving children from low-income ethnic minority backgrounds.
$645,468Ruby Ann Natale · University Of Miami School Of Medicine · R01 · FY2023 · HD
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** OBESITY AND ASSOCIATED DISEASES SUCH AS NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) HAVE REACHED EPIDEMIC LEVEL.NAFLD'S GLOBAL PREVALENCE IS 20-30% IN GENERAL POPULATION AND 80% IN OBESE PEOPLE.EPIDEMIOLOGICAL DATA SUGGEST THAT DIETS THAT EMPHASIZE FRUITS AND VEGETABLE (F&V) REDUCE RISK FOR OBESITY-ASSOCIATED DISEASES INCLUDING NAFLD. HOWEVER, ONLY A FEW STUDIES USING SINGLE F&V OR THEIR EXTRACTS HAVE TESTED THIS HYPOTHESIS. OUR PRELIMINARY STUDIES SHOW THAT FEEDING MICE A DIET SUPPLEMENTED WITH 15% (W/W) OF A MIXTURE OF F&V COMMONLY CONSUMED BY AMERICANS PROTECTS AGAINST NAFLD IN OBESE AND LEAN MICE BY 48.4% AND 28.5%. THE MECHANISM FOR F&V-INDUCED PROTECTION AGAINST NAFLD IS NOT UNDERSTOOD, YET, IS URGENTLY NEEDED TO EXPAND EVIDENCE-BASED SUPPORT FOR DIETARY GUIDELINES OF INCREASE F&V CONSUMPTION TO PREVENT CHRONIC DISEASES. WHILE DIETARY INTERVENTIONS TO PREVENT NAFLD HAVE FOCUSED ON WEIGHT LOSS, LITERATURE AND OUR PRELIMINARY DATA SUGGEST THAT OTHER FACTORS THAN MAINTAINING ENERGY BALANCE CONTRIBUTE TO NAFLD DEVELOPMENT. IDENTIFYING THESE FACTORS THROUGH INVESTIGATING THE UNDERLYING MECHANISMS OF F&V-INDUCED PREVENTION OF NAFLD WILL HELP DEVELOP MORE EFFICIENT STRATEGIES TO COMBAT NAFLD. WE HAVE IDENTIFIED NOVEL PATHWAYS (CERAMIDE AND GUT MICROBIOME) THROUGH WHICH F&V MAY EXERT THEIR BENEFICIAL EFFECTS IN PREVENTING NAFLD, HOWEVER, THEIR CAUSAL ROLE AND RELATIVE CONTRIBUTION TO THE PROTECTIVE EFFECT OF F&V ARE NOT KNOWN. THUS, IN THIS PROPOSAL WE AIM TO ADDRESS THIS GAP IN KNOWLEDGE. RESULTS FROM THE PROPOSED STUDIES WILL EXPAND THE KNOWLEDGE BASE TO SUPPORT AND IMPLEMENT THE CURRENT DIETARY GUIDELINES AND HELP DEVELOP EFFECTIVE DIETARY INTERVENTIONS TO COMBAT NAFLD.
$645,464Trustees Of Tufts College · · FY2022 · National Institute of Food and Agriculture
Prevention and Control of Diabetes in Families
$645,440University Of Southern California · R18 · FY2005 · DK
Health Professionals Education Partnership Initiative Ethiopia
$645,432Miliard Derbew · Addis Ababa University · R25 · FY2020 · TW
Behavioral Weight Management for Pregnant and Postpartum Women in the Military
$645,432Marion Hare · University Of Tennessee Health Sci Ctr · R01 · FY2020 · DK
Gut microbiota and metabolite interactions in atherosclerosis
$645,424Aldons Jake Lusis · University Of California Los Angeles · R01 · FY2020 · HL
Time-restricted feeding to mitigate metabolic impairments during circadian misalignment
$645,424Josiane Broussard · Colorado State University · R01 · FY2021 · DK
Vervet Research Colony as a Biomedical Resource
$645,420Jay R Kaplan · Wake Forest University Health Sciences · P40 · FY2013 · OD
Magnetic Resonance of Cardiac C13 Flux & Metabolism Rate
$645,405E Douglas Lewandowski · Ohio State University · R01 · FY2018 · HL
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
$645,399Janelle Wilder Coughlin · Johns Hopkins University · R01 · FY2024 · CA
The Origin, Dynamics, and Function of Postnatal Beige Adipocytes
$645,378Paul Cohen · Rockefeller University · R01 · FY2024 · DK
The Origin, Dynamics, and Function of Postnatal Beige Adipocytes
$645,378Paul Cohen · Rockefeller University · R01 · FY2025 · DK
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
$645,365Rinku Majumder · Lsu Health Sciences Center · R01 · FY2022 · HL
CRISPR-enhanced adipocyte browning to improve glucose tolerance in obesity and diabetes
$645,361Michael P Czech · Univ Of Massachusetts Med Sch Worcester · R01 · FY2023 · DK
Factors which predict variance in weight change
$645,359Jonathan Krakoff · National Institute Of Diabetes And Digestive And Kidney Diseases · ZIA · FY2019 · DK
Examining the Role of Sleep Disturbances in Contributing to Health Risk Behaviors and Cardiometabolic Outcomes in Urban Native American Youth
$645,349Wendy M Troxel · Rand Corporation · R01 · FY2021 · MD
Bile acid-mediated control of lipid absorption and fatty liver disease
$645,340Thomas A Vallim · University Of California Los Angeles · R01 · FY2025 · DK
LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS
$645,335Medical College Of Georgia (Mcg) · R01 · FY2003 · HL
Institute for Integration of Medicine & Science: A Partnership to Improve Health
$645,300Robert A Clark · University Of Texas Hlth Science Center · KL2 · FY2016 · TR
3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammation
$645,276Jorge Henao-Mejia · University Of Pennsylvania · R01 · FY2024 · AI
3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammation
$645,276Jorge Henao-Mejia · University Of Pennsylvania · R01 · FY2022 · AI
3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammation
$645,276Jorge Henao-Mejia · University Of Pennsylvania · R01 · FY2023 · AI