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172,184 grants matching “inflammation”
Regulatory B10 Cells in Autoimmune Arthritis
$776,116Thomas F Tedder · Duke University · U19 · FY2010 · AI
Inflammatory Triggers in B Cell Autoimmunity
$776,115Garnett H Kelsoe · Duke University · U19 · FY2010 · AI
Changes in Bone Quality, Sarcopenia and Fat Distribution in HIV/HCV Patients after HCV Therapy
$776,106Vincent Lo Re · University Of Pennsylvania · R01 · FY2022 · AI
Alcohol Metabolism, Functional Consequences and Apoptosis Signaling Mechanism
$776,088Byoung-Joon Song · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2011 · AA
A randomized double-blind, placebo-controlled phase 2 clinical trial of intravenous citrulline for vaso-occlusive crisis in sickle cell disease
$776,011Suvankar Majumdar · Children'S Research Institute · R61 · FY2024 · HL
DNA Repair Capacity Assays for Lung Disease Risk Assessment
$776,004Steven A Belinsky · Lovelace Biomedical Research Institute · U01 · FY2020 · CA
The effect of endogenous and exogenous glucocorticoids acting through regulatory T cells on resolution of ALI and the contribution of host genetic variability.
$775,992Jason Robert Mock · Univ Of North Carolina Chapel Hill · R01 · FY2025 · HL
Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults
$775,988John F Alcorn · University Of Pittsburgh At Pittsburgh · R01 · FY2023 · AI
Cannabinoid modulation of EV composition and function in HIV/SIV infection
$775,988Chioma M Okeoma · New York Medical College · R01 · FY2022 · DA
Quantitative cerebral blood vessel imaging biomarkers for AD and VCID
$775,949Lirong Yan · Northwestern University At Chicago · R01 · FY2025 · AG
The Role Of Innate Immunity Genes In Viral Infection and Disease Progression
$775,944Steven R Kleeberger · National Institute Of Environmental Health Sciences · ZIA · FY2014 · ES
OBESITY AFFECTS A SIGNIFICANT PROPORTION OF THE U.S. POPULATION AND IS CHARACTERIZED BY ALTERED GUT MICROBIOMES, IMPAIRED CARDIO- AND IMMUNOPROTECTIVE HDL FUNCTIONS, AND PRO-INFLAMMATORY IMMUNE PROFILES, THEREBY INCREASING CHRONIC DISEASE RISK WHILE IMPAIRING IMMUNE DEFENSES. THE GUT MICROBIOME AND ASSOCIATED METABOLOME REGULATE HDL AND IMMUNE PATHWAYS THAT DIFFER BY SEX, AND REPRESENT PROMISING TARGETS TO MITIGATE OBESITY-ASSOCIATED DISEASE. OUR PREVIOUS WORK DEMONSTRATES THAT, COMPARED TO EGG WHITES, WHOLE EGGS IMPROVE HDL, INFLAMMATORY, AND IMMUNE PROFILES TO VARYING DEGREES IN HEALTHY AND METABOLIC SYNDROME POPULATIONS; HOWEVER, IT IS UNKNOWN WHETHER GUT MICROBIOME CHANGES ARE MEDIATING THESE EFFECTS, OR WHETHER THESE EFFECTS ARE SEX-SPECIFIC. THEREFORE, THE LONG-TERM GOAL OF THIS PROJECT IS TO EVALUATE THE GUT MICROBIOME ROLE IN MEDIATING WHOLE EGG EFFECTS ON HDL AND IMMUNE PROFILES BY SEX AND METABOLIC PHENOTYPE. WE WILL CONDUCT A RANDOMIZED CROSSOVER INTERVENTION TRIAL WITH HEALTHY WEIGHT AND OBESITY GROUPS TO TEST OUR HYPOTHESIS THAT, COMPARED TO EGG WHITE INTAKE, WHOLE EGGS WILL PROVIDE GREATER GUT HEALTH-PROMOTING COMPONENTS TO IMPROVE GUT MICROBIOTA COMPOSITION, FECAL AND SERUM METABOLOMES, AND MEASURES OF GUT INFLAMMATION AND INTEGRITY (OBJECTIVE 1); HDL COMPOSITION, EFFLUX AND ANTIOXIDANT CAPACITY, AND IMMUNOMODULATORY FUNCTIONS (OBJECTIVE 2); AND CLINICAL, FUNCTIONAL, AND OMICS-BASED IMMUNE PROFILES (OBJECTIVE 3); AND THAT SEX, METABOLIC PHENOTYPE, AND GUT MICROBIOME PROFILES WILL DICTATE HDL AND IMMUNE RESPONSES TO EGG INTAKE. THIS STUDY DIRECTLY ADDRESSES USDA NIFA FOOD AND HUMAN HEALTH PRIORITIES BY INVESTIGATING THE INTERRELATIONSHIP OF EGGS (AND IMPORTANT U.S. AGRICULTURAL PRODUCT), THE GUT MICROBIOME, AND CHRONIC DISEASE PATHWAYS TO INFORM PERSONALIZED NUTRITION RECOMMENDATIONS THAT SUPPORT HUMAN HEALTH.
$775,934University Of Connecticut · · FY2025 · National Institute of Food and Agriculture
Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults
$775,914John F Alcorn · University Of Pittsburgh At Pittsburgh · R01 · FY2022 · AI
Cookstove air pollution: Emission profiles and subclinical effects of exposure
$775,910Jennifer L Peel · Colorado State University · R01 · FY2017 · ES
Placental Vascular Compromise and Preterm Delivery
$775,898University Of North Carolina Chapel Hill · R01 · FY2005 · HD
Project 2 Pharmacokinetics and Pharmacodynamics of C60 and MWCNTs in non-pregnant
$775,877Susan J Sumner · Research Triangle Institute · U19 · FY2014 · ES
Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent Girls
$775,867Mitchell J Prinstein · Univ Of North Carolina Chapel Hill · R01 · FY2019 · MH
Characterization of cardiovascular diseases (CVD) in people with long duration Type 1 diabetes
$775,846George L King · Joslin Diabetes Center · R01 · FY2023 · HL
Dissecting the pathogenesis of HIV-TB Immune reconstitution inflammatory syndrome
$775,815Philana Ling Lin · University Of Pittsburgh At Pittsburgh · R01 · FY2020 · AI
Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence
$775,779Howard C Hang · Scripps Research Institute, The · R01 · FY2025 · AI
Elucidating the Role of Adipokines in Mediating and Predicting HF Associated with Obesity
$775,761Chiadi E Ndumele · Johns Hopkins University · R01 · FY2023 · HL
Macrophage Ontogeny and Polarization in HIV/SIV Infection
$775,742Janice Ellen Clements · Johns Hopkins University · R01 · FY2016 · AI
Endothelial protocadherins in vascular development and disease
$775,720Martin A. Schwartz · Yale University · R01 · FY2025 · HL
Role of Th17 in Severe and Recurrent C. difficile Infection
$775,719William A Petri · University Of Virginia · R01 · FY2024 · AI
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and Prognosis
$775,696Viola Vaccarino Vaccarino · Emory University · R01 · FY2020 · HL