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141,003 grants matching “cytokine”
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) HAS BEEN DAMAGING THE PORK INDUSTRY FOR OVER THREE DECADES AND IS STILL ONE OF THE MOST ECONOMICALLY SIGNIFICANT SWINE DISEASES. KILLED VACCINES ARE INEFFECTIVE; ONLY LIVE-ATTENUATED VACCINES ARE AVAILABLE, BUT THEY ARE GENERALLY CONSIDERED LESS THAN SATISFACTORY. PRRSV HAS ABILITIES TO MODULATE HOST INNATE IMMUNITY AND STIMULATE INFLAMMATORY CYTOKINE RESPONSES. PRRSV IS KNOWN TO SUPPRESS THE TYPE I IFN PRODUCTION AND DOWNSTREAM SIGNALING RESPONSIBLE FOR ANTIVIRAL PROTEIN PRODUCTION. AS A RESULT, THE DEVELOPMENT OF ADAPTIVE IMMUNE RESPONSES IS NEGATIVELY AFFECTED, AND PRRSV SURVIVES LONGER AND ESTABLISHES A PERSISTENT INFECTION IN PIGS.FURTHERMORE, PRRSV STIMULATES NF-ΚB DURING INFECTION, AND THUS PROINFLAMMATORY CYTOKINES LEVELS ARE ELEVATED, LEADING TO MORE SEVERE CLINICAL OUTCOMES (CYTOKINE STORM-LIKE), ESPECIALLY WHEN PIGS ARE COINFECTED WITH A SECONDARY BACTERIAL PATHOGEN. THE VIRAL IFN ANTAGONISM CAN BE REMOVED FROM PRRSV WITHOUT LOSING THE INFECTIVITY, AND SYNERGISTIC PRODUCTION OF INFLAMMATORY CYTOKINES CAN BE LESSENED BY REMOVING THE NF-ΚB ACTIVATION FUNCTION FROM THE VIRUS. A THIRD PROBLEM IS THE GENOME RECOMBINATION BETWEEN THE VACCINE AND THE VIRULENT VIRUS CIRCULATING IN PIG FARMS.USING THE DOUBLE-DELETION MUTANT AS THE BACKBONE VIRUS, RECOMBINATION-NEGATIVE PRRSV WILL BE GENERATED. PRRSV GENOME CONTAINS A SPECIFIC SEQUENCE ELEMENT FOR VIRAL REPLICATION, AND IT IS POSSIBLE TO REPROGRAM THE SEQUENCE ELEMENT SO THAT ANY RECOMBINATION WITH A FIELD PRRSV WILL NOT BE VIABLE IF OCCURS. THE VACCINE CANDIDATE WILL IMPROVE CLINICAL SEVERITY DURING BACTERIAL CO-INFECTION ON FARMS (ENVIRONMENTAL FACTOR), CONFER BETTER IMMUNE RESPONSES (HOST FACTOR) REGARDLESS OF THE ANTIGENIC HETEROGENEITY (VIRAL FACTORS), AND PREVENT RNA RECOMBINATION (VIRAL FACTOR) BETWEEN THE VACCINE AND VIRULENT PRRSV ON FARMS. OUR STUDY IS A NOVEL APPROACH TO DEVELOPING A FUTURE PRRSV VACCINE CANDIDATE.
$650,000University Of Illinois · · FY2023 · National Institute of Food and Agriculture
**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** LIVER ABSCESSES IN FEEDLOT CATTLE ARE PREVALENT ACROSS THE UNITED STATES COSTING THE INDUSTRY MILLIONS OF DOLLARS IN LIVERS THAT CANNOT BE USED FOR FOOD, INCREASED TIME TO PROCESS CARCASSES, AND CATTLE PRODUCTIVITY LOSSES. THE OCCURRENCE OF LIVER ABSCESSES WILL CONTINUE TO INCREASE AS THE INDUSTRY REDUCES IN-FEED ANTIBIOTIC USE. WE HYPOTHESIZE THAT SOME CATTLE ARE MORE PRONE TO ABSCESS BECAUSE OF THEIR GENETICS, AND THAT CELLULAR MARKERS THAT WILL CORRELATE WITH THE DEVELOPMENT OF LIVER ABSCESSES. OUR FIRST OBJECTIVE IS IDENTIFY GENOMIC MARKERS THAT PREDICT THE LIKELIHOOD OF AN ANIMAL DEVELOPING LIVER ABSCESSES.OUR SECOND OBJECTIVE IS TO EVALUATE CIRCULATING CELL TYPES, CYTOKINES, AND METABOLITES IN THE BLOOD, AND GENE EXPRESSION, LIVER ENZYME FUNCTION, BACTERIAL COMMUNITIES, FEED INTAKE AND BODY WEIGHT GAIN TO IDENTIFY BIOLOGICAL OR CELLULAR PROFILES THAT CORRELATE WITH THE DEVELOPMENT OF LIVER ABSCESSES AND THE TIMING AT WHICH THEY OCCUR DURING THE FEEDING PERIOD. DELIVERABLES WILL INCLUDE GENETIC VARIANTS THAT CORRELATE WITH SUSCEPTIBILITY TO LIVER ABSCESSES TO ALLOW SELECTION OF ANIMALS THAT ARE LESS PRONE TO DEVELOPING THEM, AND DIAGNOSTIC TOOLS TO IDENTIFY ANIMALS THAT ARE DEVELOPING LIVER ABSCESSES AND MAY NEED TO BE MANAGED DIFFERENTLY. THESE DATA WILL BE USEFUL AS A NOVEL APPROACH TO REDUCE THE INCIDENCE OF LIVER ABSCESSES IN THE US WITHOUT THE USE OF ANTIBIOTICS AND PROVIDE AN OPPORTUNITY TO IMPROVE FEED EFFICIENCY AND BEEF PRODUCTION.
$650,000Agricultural Research Service · · FY2023 · National Institute of Food and Agriculture
A Randomized Study of Maternal Donor Derived CMV Cytotoxic T-Lymphocytes (CTLs) and Valganciclovir vs Valganciclovir in Neonates With Moderate/Severe Maternal Acquired CMV Infection
$649,999Mitchell S. Cairo · New York Medical College · R01 · FY2023 · FD
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INFLAMMATORY STIMULI SUCH AS INFECTIOUS DISEASE INCUR SIGNIFICANT COSTS TO SWINE PRODUCTION. ONE IMPORTANT CONSEQUENCE OF INFLAMMATION IS THE REDIRECTION OF METABOLIC RESOURCES AWAY FROM WEIGHT GAIN RESULTING IN SIGNIFICANT PRODUCTION LOSSES. CD163 AN IMPORTANT RECEPTOR FOR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) ALSO PARTICIPATES IN THE REGULATION OF INFLAMMATION. IN PRELIMINARY WORK WE SHOWED THAT CD163 KNOCKOUT (KO) PIGS INFECTED WITH A PORCINE CIRCOVIRUS TYPE 2D (PCV2D) ANOTHER IMPORTANT PIG PATHOGEN SHOWED RESISTANCE TO INFECTION. WE PROPOSE THAT THE ABSENCE OF CD163 PROTECTS PIGS BY DOWNREGULATING PATHOGEN-MEDIATED INFLAMMATORY RESPONSES. THE PROPOSED RESEARCH PROJECT TESTS THIS HYPOTHESIS BY MEASURING INFLAMMATORY RESPONSES IN CD163 WILD-TYPE (WT) AND KO PIGS DURING INFECTION WITH PCV2D. THE EXPERIMENTAL APPROACH IS THE APPLICATION OF NOVEL GENE PROFILING AND PATHWAY ANALYSIS METHODS TO MAP INFLAMMATORY RESPONSES IN INDIVIDUAL IMMUNE CELL POPULATIONS. OBJECTIVE 1 IS TO COMPARE GENE PROFILES IN MACROPHAGES FROM CD163 WT AND KO PIGS. MACROPHAGES ARE CHOSEN FOR STUDY BECAUSE THEY EXPRESS CD163 AND AS A RESULT ARE KEY MEDIATORS IN THE INITIATION AND REGULATION OF INFLAMMATION. THE METHODS AND RESULTS FROM OBJECTIVE 1 WILL BE APPLIED TO SUBSEQUENT OBJECTIVES. OBJECTIVE 2 IS TO EVALUATE GENE EXPRESSION IN CD163 WT AND KO MACROPHAGES DURING INFECTION WITH PCV2D AND OTHER MACROPHAGE-TROPIC VIRUSES. GENE PROFILES WILL BE CONSTRUCTED IN MACROPHAGES DURING INFECTION WITH PCV2D AND A VARIETY OF IMPORTANT PIG CORONAVIRUSES. THE RESULTS WILL BE USED TO UNDERSTAND THE EFFECT OF PCV2D INFECTION ON THE INFLAMMATORY RESPONSE OF MACROPHAGES AND TO DETERMINE IF THE RESPONSE IS A GENERAL PROPERTY THAT CAN BE APPLIED TO OTHER PATHOGENS. OBJECTIVE 3 IS TO CONSTRUCT GENE PROFILES OF IMMUNE CELL POPULATIONS IN WT AND KO PIGS DURING PCV2D INFECTION. GENE PROFILES AND INFLAMMATORY RESPONSE PATHWAYS WILL BE MAPPED IN IMPORTANT CELL POPULATIONS SORTED FROM THE BLOOD OF PIGS. IMPORTANT IMMUNE CELL POPULATIONS INVESTIGATED INCLUDE MONOCYTES B CELLS AND T CELLS. BLOCKING CD163 FUNCTION MAY PROTECT PIGS FROM INFLAMMATION CAUSED BY NON-INFECTIOUS STRESSORS SUCH AS WEANING ENVIRONMENTAL CHANGES AND INFLAMMATORY CYTOKINES PRODUCED IN RESPONSE TO FAST-GROWTH DIETS. ALTOGETHER THE REGULATION OF CD163 FUNCTION WOULD RESULT IN A PIG THAT IS BETTER ADAPTED TO THE MODERN PRODUCTION SYSTEM.
$649,991University Of Illinois · · FY2025 · National Institute of Food and Agriculture
TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies
$649,938David R Boulware · University Of Minnesota · R01 · FY2024 · AI
RNA-Mediated Mechanisms of Motor System Dysfunction in Spinal Muscular Atrophy
$649,910Livio Pellizzoni · Columbia University Health Sciences · R01 · FY2024 · NS
Immune Protection Against Pulmonary Tularemia
$649,877Dennis W. Metzger · Albany Medical College · P01 · FY2016 · AI
Heart failure and atrial arrhythmias in CKD
$649,833Nisha Bansal · University Of Washington · R01 · FY2016 · DK
Discovery of Novel TLR Ligands with Adjuvant Properties
$649,771Vaxinnate Corporation · R43 · FY2004 · AI
Neuropeptide-mediated regulation of antihelminth immunity
$649,739Mark Christopher Siracusa · Rutgers Biomedical And Health Sciences · R01 · FY2022 · AI
The effect of inflammation and damage to lymph node structures on durable protective immunity following vaccination
$649,719Timothy W Schacker · University Of Minnesota · U01 · FY2023 · AI
Efflux proteins and insulin resistance in atherogenesis
$649,713David P Hajjar · Weill Medical Coll Of Cornell Univ · P01 · FY2007 · HL
Unpacking the Mechanisms of Disparities for HIV-related Hypertension in African American and Asian Pacific American MSM
$649,694Frank Y. Wong · Florida State University · R01 · FY2022 · MD
Genotype-Phenotype Relationships in Fragile X Families
$649,652Randi J Hagerman · University Of California At Davis · R01 · FY2023 · HD
Mechanisms of Alcoholic Liver Disease
$649,597Bin Gao · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2009 · AA
The role of Chlamydia pneumoniae infection in Alzheimer's Disease
$649,583Timothy Robert Crother · Cedars-Sinai Medical Center · R01 · FY2025 · AG
Targeting renal inflammatory pathways of SLE nephritis in mouse and man
$649,579Anne Davidson · Feinstein Institute For Medical Research · R01 · FY2010 · DK
B cell receptor dependent infection as a mechanism of immune-mediated enhancement of dengue virus infection and pathogenesis
$649,530Adam T Waickman · Upstate Medical University · R01 · FY2025 · AI
Immune Regulation in Mycobacterial and Fungal Infections
$649,507Daniel Barber · National Institute Of Allergy And Infectious Diseases · ZIA · FY2013 · AI
A Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor Immunity
$649,506Benjamin Greenbaum · Sloan-Kettering Inst Can Research · U01 · FY2021 · CA
Atherosclerosis, Prostaglandin Inhibition and Checkpoint Blockade
$649,492Garret A Fitzgerald · University Of Pennsylvania · R01 · FY2020 · HL
Multivalent Toxoid Vaccine for recurrent Staphylococccus aureus disease
$649,379M. Javad Aman · Abvacc, Inc. · R01 · FY2024 · AI
Molecular Determinants of Social Factors in Prostate Cancer
$649,342Deepak Kumar · North Carolina Central University · R01 · FY2017 · MD
Cardioprotective Effect of Growth Hormone Releasing Hormone
$649,300Joshua M Hare · University Of Miami School Of Medicine · R01 · FY2013 · HL
New Paradigms in Gene Regulation During Influenza Virus Infections
$649,247Curt M Horvath · Northwestern University · U01 · FY2013 · AI