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17,828 grants matching “crispr”
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease
$114,128Mingtao Zhao · Research Inst Nationwide Children'S Hosp · R01 · FY2024 · HL
Development of functional genomic technologies in mice
$114,015Aki Ushiki · University Of California, San Francisco · K99 · FY2024 · HG
Deep learning-based approach to identify non-coding cancer drivers that alter chromatin conformation
$113,967Ekta Khurana · Weill Medical Coll Of Cornell Univ · R01 · FY2019 · CA
Paving the way for bystander T cell immunotherapies
$113,937Nicholas Joseph Maurice · University Of Minnesota · K99 · FY2025 · CA
Development of functional genomic technologies in mice
$113,935Aki Ushiki · University Of California, San Francisco · K99 · FY2023 · HG
Core 012 (797) Proteomics Core
$113,897John M Koomen · H. Lee Moffitt Cancer Ctr & Res Inst · P30 · FY2019 · CA
OBESITY HAS BECOME A HEALTH AND FINANCIAL CRISIS IN AMERICA, SHORTENING LIFE EXPECTANCY FOR THE FIRST TIME IN HISTORY. IT IS EXPECTED THAT 51% OF AMERICANS WILL BE OBESE BY THE YEAR 2030. THE OLFACTORY SYSTEM DRIVES FOOD CHOICE, WHEREBY OLFACTORY SENSITIVITY IS STRONGLY RELATED TO HUNGER AND FULLNESS. HOW OLFACTORY FUNCTION DIRECTLY CONTRIBUTES TO OBESITY IS NOT FULLY UNDERSTOOD. MY PROPOSAL WILL CONTRIBUTE FUNDAMENTAL KNOWLEDGE CONCERNING THE OLFACTION/OBESITY RELATIONSHIP.MICE ARE AN EXCELLENT MODEL FOR OLFACTORY AND METABOLIC STUDIES. USING CRISPR EDITING TECHNOLOGIES, I WILL ALTER THE WAY THAT A SUBSET OF NEURONS WITHIN THE OLFACTORY BULB PASS INFORMATION TO OTHER REGIONS OF THE BRAIN. I WILL MEASURE THE ELECTRICAL ACTIVITY OF THESE NEURONS, THE CHANGE IN OLFACTORY ABILITY OF THE MICE, AND THE CHANGE IN WHOLE-BODY METABOLISM OF THE MICE. DURING THE EXECUTION OF THIS PROJECT I WILL ENGAGE THREE DIFFERENT UNDERGRADUATE AUDIENCES: UNDERGRADUATE RESEARCHERS THAT I MENTOR IN DATA COLLECTION, UNDERGRADUATE WOMEN IN SCIENCE AND ENGINEERING THAT I LEAD ON A TOUR OF OUR FACILITIES, AND UNDERGRADUATE BIOLOGY HONOR STUDENTS WHOM I PROVIDE AN EXPLORATIVE LEARNING LECTURE. THE RESULTS OF THIS PROJECT WILL BE PUBLISHED IN SCIENTIFIC JOURNALS AND PRESENTED AT SCIENTIFIC CONFERENCES IN ORDER TO FURTHER INFORM CLINICIANS AND NUTRITION SCIENTISTS.THIS PROJECT HOPES TO IDENTIFY A SPECIFIC TARGET WITHIN THE OLFACTORY BULB THAT CAN BE MODULATED FOR THE CLINICAL TREATMENT OF OBESITY. THIS MAY LOWER OBESITY-ASSOCIATED HEALTHCARE COSTS AND MORTALITY. THIS PROJECT ALSO HOPES TO PROVIDE UNDERSTANDING OF AN OLFACTION-OBESITY PATHWAY, AFFECTING THE COMMERCIAL PREPARATION OF FOOD TO DECREASE OVERCONSUMPTION. THIS COULD REDUCE THE PROPORTION OF AMERICAN YOUTH WHO ARE OVERWEIGHT AND OBESE.
$113,731Florida State University · · FY2020 · National Institute of Food and Agriculture
Dissecting the cis-regulatory roles of transposable elements in human cancers
$113,716Yanxiao Zhang · Ludwig Institute For Cancer Res Ltd · K99 · FY2020 · CA
Dissecting the cis-regulatory roles of transposable elements in human cancers
$113,716Yanxiao Zhang · Ludwig Institute For Cancer Res Ltd · K99 · FY2021 · CA
Role of DNA sensing pathways in KSHV associated cancers
$113,624Zhe Ma · Univ Of North Carolina Chapel Hill · K99 · FY2018 · CA
Role of DNA sensing pathways in KSHV associated cancers
$113,624Zhe Ma · Univ Of North Carolina Chapel Hill · K99 · FY2019 · CA
Characterization of a novel mouse with deficient calcium flux
$113,605R. Suzanne Zukin · Albert Einstein College Of Medicine · R21 · FY2018 · NS
Host-parasite lipid metabolism in Trypanosoma cruzi-infected cardiac myocytes
$113,519Jeffrey Dominick Whitman · University Of California, San Francisco · K38 · FY2020 · HL
Host-parasite lipid metabolism in Trypanosoma cruzi-infected cardiac myocytes
$113,519Jeffrey Dominick Whitman · University Of California, San Francisco · K38 · FY2021 · HL
Defining macrophage defense during Klebsiella pneumoniae bacteremia
$113,448Caitlyn Leigh Holmes · University Of Michigan At Ann Arbor · K99 · FY2024 · AI
shRNAmir and CRISPR sgRNA Library Construction Core
$112,906Matthew Eugene Pipkin · La Jolla Institute For Immunology · P01 · FY2020 · AI
GLUCOSE BINDS RBPs TO REGULATE EPIDERMAL HOMEOSTASIS
$112,798Weili Miao · Stanford University · K01 · FY2024 · AR
GLUCOSE BINDS RBPs TO REGULATE EPIDERMAL HOMEOSTASIS
$112,798Weili Miao · Stanford University · K01 · FY2025 · AR
Neurobehavioral
$112,776Richard E Paylor · Baylor College Of Medicine · U54 · FY2019 · HD
PD-1 tumor suppressor mechanims in peripheral T-cell lymphoma
$112,613Tim Wartewig · Yale University · K99 · FY2023 · CA
Reactivating regulatory programs for regeneration
$112,350Megan Lee Martik · University Of California Berkeley · DP2 · FY2025 · HL
Functional genomics of hypothetical genes in Gram-positive bacteria
$112,326Julia Willett · University Of Minnesota · K99 · FY2022 · AI
Functional genomics of hypothetical genes in Gram-positive bacteria
$112,326Julia Willett · University Of Minnesota · K99 · FY2021 · AI
Overcoming treatment-resistant gynecological cancers by combination of DNA damage response inhibitors
$112,052Haineng Xu · University Of Pennsylvania · R50 · FY2025 · CA
Overcoming treatment-resistant gynecological cancers by combination of DNA damage response inhibitors
$112,052Haineng Xu · University Of Pennsylvania · R50 · FY2024 · CA