antimicrobial resistance — grants

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15,273 grants matching “antimicrobial resistance”

Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent Infections

Adrian Marcelo Zelazny · Clinical Center · ZIA · FY2020 · CL

Big Data- Epidemiology of Antimicrobial Resistance

Sameer Kadri · Clinical Center · ZIA · FY2020 · CL

Development and Evaluation of Novel Applied Diagnostic Platforms for Clinical Microbiology

Anna Lau · Clinical Center · ZIA · FY2015 · CL

Big Data - Epidemiology of Critical Illness and Sepsis

Sameer Kadri · Clinical Center · ZIA · FY2020 · CL

Research Initiation Award: Green-Synthesized Silver Nanoparticles using Citrus fruit and their evaluation on the Bacterial Stability of Streptococcus pneumoniae.

Ronda K Bibbs · Johnson C. Smith University · · FY2024 · EDU

BIOFILM FORMATION AND ITS CONCOMITANT RISK OF CAUSING EQUIPMENT MALFUNCTION AND HUMAN ILLNESSES IS A PROBLEM THAT NEEDS TO BE ADDRESSED TO ENABLE SAFE LONG TERM HUMAN SPACE EXPLORATION. WITH THAT OBJECTIVE THIS PROPOSAL AIMS TO CHARACTERIZE BIOFILM GROWTH DURING ONE ISS INCREMENT IN TERMS OF MASS THICKNESS MORPHOLOGY AND ASSOCIATED GENE EXPRESSION USING DIFFERENT SPACEFLIGHT RELEVANT MICROBIAL SPECIES AND MATERIAL SUBSTRATA. THIS PROJECT ALSO AIMS TO ELUCIDATE THE BIOMECHANICAL AND TRANSCRIPTOMIC MECHANISMS INVOLVED IN THE FORMATION OF THE COLUMN AND CANOPY BIOFILM ARCHITECTURE OBSERVED IN SPACE. THE EXPERIMENT IS DESIGNED TO ASSESS THE EXPRESSION OF GENES ASSOCIATED WITH CONFERRING MICROORGANISMS WITH RESISTANCE TO OXIDATIVE STRESS ACIDITY AND ANTIMICROBIALS IN BIOFILMS FORMED IN SPACE AND TO DETERMINE PHYSICAL MECHANISMS OF MATERIAL/MICROORGANISMS INTERACTION IN BIOFILMS. THE EXPERIMENT WILL BE CONDUCTED USING BIOSERVES BIOCELLS HOUSING SUBSTRATA COUPONS EXPOSED TO DIFFERENT MICROORGANISMS AND MEDIA. POST FLIGHT ANALYSES OF FIXED SAMPLES INCLUDE CONFOCAL LASER SCANNING MICROSCOPY AND RNA SEQUENCING. THE SIGNIFICANCE OF THIS PROJECT STEMS FROM GAINING VALUABLE NEW KNOWLEDGE THAT MAY LEAD TO IMPROVED METHODS AND/OR MATERIAL PROPERTIES FOR CONTROLLING BIOFILM FORMATION DURING LONG DURATION SPACE MISSIONS. THE SELECTION OF BACTERIAL SPECIES GROWTH MEDIA AND SUBSTRATA MATERIAL MAKE THE RESULTS APPLICABLE TO A) THE SAFETY AND MAINTENANCE OF CREWED SPACECRAFT B) PLANETARY PROTECTION C) MITIGATION OF BIOFILM ASSOCIATED ILLNESSES ON THE CREW AND D) BIOFILM ASSOCIATED ILLNESSES ON EARTH THUS MAKING IT RELEVANT NOT ONLY TO THIS RESEARCH ANNOUNCEMENT BUT ALSO TO NASAS HUMAN EXPLORATION AND OPERATIONS DIRECTORATE SPACE BIOLOGY PROGRAM AND HUMAN RESEARCH ROADMAP.

The Regents Of The University Of Colorado · · FY2017 · National Aeronautics and Space Administration

Novel Applications of Mass Spectrometry and Proteomics to Infectious Disease Diagnostics

John Dekker · Clinical Center · ZIA · FY2015 · CL

Antifungal Resistance and Novel Mycology Diagnostics

Amir Seyedmousavi · Clinical Center · ZIA · FY2022 · CL

Big Data - Epidemiology of Critical Illness and Sepsis

Sameer Kadri · Clinical Center · ZIA · FY2025 · CL

Global initiative to characterize antiretroviral pharmacokinetics

Henry Masur · Clinical Center · Z01 · FY2008 · CL

Investigation of Horizontal Transfer of Carbapenemase Gene in Gram Negative Bacteria

Karen Frank · Clinical Center · ZIA · FY2022 · CL

NSF Postdoctoral Fellowship in Biology FY 2022: Determining functional correlates to the emergence and maintenance of antibiotic resistance genes in host-associated microbiomes

Taylor E Reiter · Reiter, Taylor E · · FY2023 · BIO

Development and Evaluation of Novel Applied Diagnostic Platforms for Clinical Microbiology

Anna Lau · Clinical Center · ZIA · FY2017 · CL

Big Data Epidemiology of Critical Illness and Sepsis

Sameer Kadri · Clinical Center · ZIA · FY2018 · CL

Big Data- Epidemiology of Antimicrobial Resistance

Sameer Kadri · Clinical Center · ZIA · FY2019 · CL

Granulocyte Donation with GCSF

Susan F Leitman · Clinical Center · ZIA · FY2012 · CL

EVALUATING DIFFERENT MANURE MANAGEMENT PRACTICES IN CONTROLLING SPREAD OF ANTIMICROBIAL RESISTANCE FROM DAIRY FARMS

$-41

The Research Foundation For The State University Of New York · · FY2021 · National Institute of Food and Agriculture

IMPROVING OUR UNDERSTANDING OF THE ECOLOGY OF ANTIMICROBIAL RESISTANCE IN FOOD PRODUCTION USING BAYESIAN MODEL AND MACHINE LEARNING APPROACH

$-67

Colorado State University · · FY2018 · National Institute of Food and Agriculture

ANTIMICROBIAL DRUG RESISTANCE (AMR) HAS REACHED A CRITICAL LEVEL OF IMPORTANCE; IF UNCHECKED, IT WILL REVERSE DECADES OF ADVANCES IN HUMAN AND ANIMAL HEALTH. THE CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) ESTIMATES THAT AMR BACTERIA KILL APPROXIMATELY 23,000 PEOPLE IN THE U.S. EACH YEAR AND 2 MILLION ARE CLINICALLY INFECTED. AS A RESULT, AMR COSTS THE U.S. ECONOMY APPROXIMATELY $70 BILLION ANNUALLY. IN ADDITION TO CLEAR THREATS TO PUBLIC HEALTH, AMR POSES IMMEDIATE CHALLENGES TO THE SECURITY OF OUR AGRICULTURAL ECONOMY BECAUSE AMR CAN ALSO DECREASE THE EFFECTIVENESS AND DIMINISH THE AVAILABILITY OF ANTIMICROBIALS USEFUL AGAINST BACTERIA THAT CAUSE SIGNIFICANT FOOD-ANIMAL DISEASE. VIBRANT AND EFFECTIVE PUBLIC AND ANIMAL-HEALTH SYSTEMS DEPEND ON APPROACHES TO PREVENT AND CURE INFECTIOUS DISEASES. SOLUTIONS TO AMR ARE OF PARAMOUNT IMPORTANCE TO THE U.S.WORLDWIDE, MANY HAVE CALLED FOR A WHOLESALE REDUCTION IN THE USE OF ANTIMICROBIALS, CITING EVIDENCE THAT THERE IS EITHER OVERUSE ORMISUSE OF THESE PRODUCTS. IN MULTIPLE JURISDICTIONS, REGULATORY APPROACHES TO REDUCE 'OVERUSE' OR 'MISUSE' PROCEED EITHER ON THE BASIS OF DEFINING WHAT IS NOT CONSIDERED JUDICIOUS USE, POINT TO SCIENTIFIC DATA SUPPORTING A PROHIBITION ORDER FOR A SPECIFIED PRODUCT (SOMETIMES, A CHANGE IN NEW DRUG APPROVAL PROCESSES, OR ELSE INVOKE THE USE OF THE PRECAUTIONARY PRINCIPLE TO PROTECT THE EFFICACY OF A PRODUCT IN THE ABSENCE OF FIRM SCIENTIFIC EVIDENCE.IN THE UNITED STATES, SEVERAL RECENT FOOD AND DRUG ADMINISTRATION (FDA) DOCUMENTS OF NOTE, WHOSE MAJOR PURPOSE IS TO ENSURE THE PRUDENT APPROVAL AND USE OF ANTIMICROBIALS IN VETERINARY MEDICINE AND ANIMAL AGRICULTURE, HAVE BEEN PUBLISHED (E.G., GUIDANCE FOR INDUSTRY (GFI) #152, #159, #209, AND #213; TO A MAJOR EXTENT, THESE CONSIST OF NON-BINDING RECOMMENDATIONS). IN 2003, GFI #152 ESTABLISHED THE RISK ASSESSMENT FRAMEWORK UNDER WHICH NEW ANIMAL DRUG APPROVALS WOULD PROCEED. THIS PROCESS INCLUDED GUIDANCE TO DRUG SPONSORS THAT QUALITATIVELY CATEGORIZED ANTIMICROBIALS AS TO CRITICALITY, BUT ALSO ESTABLISHED ASPECTS OF HAZARD, RELEASE, EXPOSURE, AND CONSEQUENCE ASSESSMENT THAT WERE PREVIOUSLY LESS WELL DEFINED FOR MICROBIAL HAZARDS. A SIMPLIFIED FRAMEWORK FOR EXAMINING THE RISK OF RELEASE OF RESISTANT BACTERIA AND THEIR DETERMINANTS FROM AGRICULTURAL FACILITIES AS PART OF A BROADER QUANTITATIVE RISK ASSESSMENT FRAMEWORK PRESENTS A COMPELLING OPPORTUNITY TO AIM TO ACHIEVE 'ZERO' RELEASE OF RESISTANT BACTERIA (OR DETERMINANTS) ABOVE BASELINE OR BACKGROUND RISK LEVELS. SINCE ANIMAL PRODUCTION CAN ONLY TAKE OWNERSHIP OF WHAT IS UNDER ITS CONTROL THIS SEEMS THE LOGICAL PLACE TO START A DISCUSSION OF WHAT CONSTITUTES ANTIMICROBIAL STEWARDSHIP, AND HOW THIS CAN BE PROMOTED INTO THE FUTURE.OUR OVERALL LONG TERM GOAL IS TO IDENTIFY, EVALUATE, AND IMPLEMENT PRACTICAL, EFFECTIVE AND WIDELY ADOPTABLE INTERVENTIONS FOR MANAGING ANTIMICROBIAL RESISTANCE (AMR) AMONG ENTERIC BACTERIA; IN THIS PROJECT, OUR FOCUS IS ON,DEVELOPING - THROUGH A SYSTEMS-BASED STAKEHOLDER-CENTERED PROCESS - SCIENCE-BASED VOLUNTARY STEWARDSHIP PROGRAMS SUITED TO ANIMAL PRODUCTION. IN PURSUIT OF THIS OVERALL GOAL WE FOCUS OUR EFFORTS - HEREIN ON BEEF AND DAIRY CATTLE PRODUCTION SYSTEMS - AND DIRECTLY ADDRESS THE FOLLOWING SUPPORTING OBJECTIVES IN THIS PROPOSAL: 1) RECRUIT KEY STAKEHOLDERS TO QUALITATIVELY EXPLORE THE ESSENTIAL COMPONENTS AND SYSTEMS FRAMEWORK TO MAXIMIZE VOLUNTARY COMPLIANCE WITH HIGHLY EFFECTIVE ANTIMICROBIAL STEWARDSHIP PROGRAMS, 2) CONDUCT EMPIRICAL FIELD STUDIES TO PROVIDE KEY MICROBIOLOGICAL, PRODUCTION, ECONOMIC, AND SOCIAL SCIENCE DECISION SUPPORT DATA, 3) PERFORM QUALITATIVE AND QUANTITATIVE MODELING NEEDED TO DESIGN, TEST, AND IMPROVE ESSENTIAL DECISION SUPPORT TOOLS, AND 4) ENGAGE KEY STAKEHOLDERS TO FURTHER DEVELOP, REFINE AND COMMUNICATE HIGHLY EFFECTIVE DECISION SUPPORT TOOLS TO ENHANCE THEIR VOLUNTARY ADOPTION AND DIFFUSION AND TO MAXIMIZE ANTIMICROBIAL STEWARDSHIP.BOTH AMR AND THE LIKELIHOOD OF UNINTENDED CONSEQUENCES OF UNINFORMED, BROAD-SWEEPING ATTEMPTS TO CONTROL IT POSE A DIRECT THREAT TO THE SUSTAINABILITY OF U.S. AGRICULTURE. IN OUR INTEGRATED STANDARD GRANT PROJECT, WE WILL DESIGN, EVALUATE AND DELIVER EFFICACIOUS AND IMPLEMENTABLE INTERVENTIONS TO MITIGATE AMR, BASED ON VOLUNTARY STEWARDSHIP PRINCIPLES AND GUIDELINES, FACILITATED BY SCIENCE-BASED DECISION TOOLS AND MULTIPLE AND BROAD STAKEHOLDER INPUT AND SUPPORT.

$-1,802

Texas A&M Agrilife Research · · FY2023 · National Institute of Food and Agriculture

ENGINEERING BACTERIOPHAGE ENDOLYSINS: ANTIMICROBIALS FOR MASTITIS PATHOGENS THAT ARE REFRACTORY TO RESISTANCE DEVELOPMENT

$-3,699

Agricultural Research Service · · FY2016 · National Institute of Food and Agriculture