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38,696 grants matching “als”
Mechanisms of assembly of photoreceptor G protein complexes
$367,500Barry M Willardson · Brigham Young University · R01 · FY2014 · EY
Computer Supported Design of High Temperature Ti-AI-Nb Alloys for Gas Turbine Applications
$367,500Hans Seifert · University Of Florida · · FY2006 · MPS
Enhancing Glaucoma Medication Adherence Among African Americans
$367,500Laura E Dreer · University Of Alabama At Birmingham · R01 · FY2019 · EY
Enhancing Glaucoma Medication Adherence Among African Americans
$367,500Laura E Dreer · University Of Alabama At Birmingham · R01 · FY2016 · EY
Locus-linked Regulatory Motifs of Globin Gene Switching
$367,500Kenneth R Peterson · University Of Kansas Medical Center · R56 · FY2008 · HL
Enhancing Glaucoma Medication Adherence Among African Americans
$367,500Laura E Dreer · University Of Alabama At Birmingham · R01 · FY2018 · EY
GOALI: Understanding synergies between solute clusters and deformation in Al-Mg-Si-Cu alloys
$367,499Emmanuelle A Marquis · Regents Of The University Of Michigan - Ann Arbor · · FY2024 · MPS
TERT Promoter Mutations in Thyroid Cancer
$367,455Michael Mingzhao Xing · Johns Hopkins University · R01 · FY2017 · CA
Transition Path Theory and Markovian Milestoning for Prediction of Protein-Ligand Binding Kinetics in Molecular Simulations
$367,437Cameron F Abrams · Drexel University · R01 · FY2019 · GM
REMOTE MEASUREMENT OF LUNAR HEAT FLOW FROM EARTH BASED RADIO ASTRONOMYSCIENTIFIC OBJECTIVES: THE PRIMARY OBJECTIVE OF THIS STUDY IS TO BETTER CONSTRAIN THE GEOTHERMAL HEAT FLUX FROM THE LUNAR INTERIOR USING VLA PASSIVE RADIO OBSERVATIONS OF THE LUNAR NEARSIDE. CURRENTLY WE HAVE ONLY TWO VALUES OF LUNAR HEAT FLOW FROM THE APOLLO 15 AND 17 MISSIONS WITH A POTENTIAL 3RD UPPER LIMIT MEASUREMENT FROM DIVINER LUNAR RADIOMETER (DIVINER) MEASUREMENTS NEAR THE LUNAR SOUTH POLE [SIEGLER ET AL. 2014 PAIGE ET AL. 2016]. USING C L AND P BAND (~6 21 AND 90CM WAVELENGTH) PASSIVE RADIO MEASUREMENTS OF THE LUNAR NEARSIDE WE CAN POTENTIALLY CONNECT THESE DATA TO CONSTRAIN THE LUNAR NEAR SIDE AT ~100KM RESOLUTION. AS IN THE APOLLO HEAT FLOW EXPERIMENTS (HFE) [E.G. LANGSETH ET AL. 1976] AND THE UPCOMING INSIGHT MISSION MEASUREMENTS OF THE TEMPERATURE GRADIENT AT DEPTH CAN BE USED TO CHARACTERIZE THE GEOTHERMAL HEAT PRODUCTION OF A PLANET. PASSIVE RADIO-WAVELENGTH MEASUREMENTS HAVE BEEN LONG SUGGESTED [E.G. KEIHM ET AL. 1975] AS A METHOD FOR CONSTRAINING THERMAL EMISSION (AND THEREFORE THE TEMPERATURE GRADIENT) FROM SEVERAL METERS BELOW THE SURFACE. HOWEVER A MAJOR SOURCE OF ERROR ON SUCH A MEASUREMENT IS THE EMISSION FROM THE NEAR SURFACE WHICH VARIES DIURNALLY WITHIN THE UPPER METER. SUCH LIMITATIONS HAVE LED TO LITTLE MORE BEING DONE ON THE TOPIC THAN FULL-DISC OBSERVATIONS IN THE 1960 S AND 70 S. WITH THE VLA AND ARECIBO WE CAN INCREASE THE RESOLUTION BY A FACTOR OF 30 POTENTIALLY MAPPING NEARSIDE HEAT FLOW TO 100KM RESOLUTION. NEW DATA FROM THE DIVINER AND CHANG E 1 AND 2 PASSIVE MICROWAVE RADIOMETERS NOW ALLOWS DETAILED CONSTRAINT ON THIS NEAR SURFACE EMISSION. THESE INSTRUMENTS HAVE REVOLUTIONIZED OUT UNDERSTANDING OF INFRARED AND MICROWAVE BRIGHTNESS TEMPERATURES OF THE UPPER ~1M OF THE LUNAR SURFACE (ASSUMING ~10 WAVELENGTHS PENETRATION). COMBINED WITH THERMAL MODELS DESIGNED TO REPRODUCE DIVINER TEMPERATURES WE SHOULD NOW BE ABLE TO CHARACTERIZE THIS NEAR SURFACE EMISSION PRECISELY ENOUGH TO CONSTRAIN EMISSION FROM DEPTH ALONE. METHODOLOGY: L-BAND(~21CM) AND P-BAND(~90CM) MEASUREMENTS WILL BE USED TO BACK OUT PHYSICAL TEMPERATURE AS A FUNCTION OF DEPTH ON THE MOON IN THE UPPER ~10M. L-BAND WILL COLLECT THERMAL EMISSION WITHIN THE UPPER ~2M P-BAND WITHIN THE UPPER ~9M. FOR A SYNTHESIS IMAGING INSTRUMENT LIKE THE VLA A SPATIAL DYNAMIC RANGE OF ~30-40 BEAMS IS TYPICAL MEANING THAT WE NEED A SPATIAL RESOLUTION OF ~45 . THIS CAN BE ACHIEVED AT P-BAND IN THE C-CONFIGURATION AND AT L-BAND IN THE D-CONFIGURATION. THIS WILL YIELD A PHYSICAL RESOLUTION OF ~100 KM ON THE SURFACE OF THE MOON. VLA IS NOT ABLE TO MAKE FULL LUNAR MAPS AT SHORTER WAVELENGTHS LEADING TO A DESIRE TO MAP C-BAND (~6CM) DATA WITH ARECIBO WHICH COINCIDENTALLY WILL ALSO BE ~30-35 BEAM SPOTS ACROSS THE MOON RESULTING IN A COMPARABLE MAP TO THE VLA LONG WAVELENGTH DATA. THIS WILL REQUIRE TWO SEPARATE OBSERVING CAMPAIGNS AT THE VLA AS THESE CONFIGURATIONS ARE CHANGED EVERY 4 MONTHS AND ONE CAMPAIGN AT ARECIBO. EACH CAMPAIGN WILL IDEALLY INVOLVE MEASUREMENTS AT 3 PHASES WITHIN THE LUNAR MONTH TO AID IN CHARACTERIZATION OF THE DIURNAL COMPONENT OF THERMAL EMISSION. MODELS OF SUBSURFACE TEMPERATURES AND HEAT FLUX WILL BE USED TO PRODUCE FORWARD MODELS OF THERMAL FLUX CONSISTENT WITH THE TELESCOPE(AND EXISTING DIVINER AND CHANG E) OBSERVATIONS. RELEVANCE TO THE NASA SOLAR SYSTEM OBSERVATIONS PROGRAM: SSO SOLICITS OBSERVATIONS AT ALL WAVELENGTHS INCLUDING RADIO THAT CONTRIBUTE TO THE UNDERSTANDING OF THE NATURE AND EVOLUTION OF THE SOLAR SYSTEM BODIES. CONSTRAINING THE INTERNAL HEAT PRODUCTION OF THE MOON WAS A DESIRED GOAL OF THE NASA PLANETARY DECADAL SURVEY AND SUCH A MEASUREMENT MAY BE A VALUABLE PRECURSOR TO THE PROPOSED LUNAR GEOPHYSICAL NETWORK LISTED IN THAT DOCUMENT.
$367,431Planetary Science Institute · · FY2017 · National Aeronautics and Space Administration
Collagen a 1 (v) Epitope-Specific TH17 Cells in Heart and Lung Transplantation
$367,373William J Burlingham · Indiana University Indianapolis · P01 · FY2011 · AI
CORE B- HEART BIOLOGY CORE
$367,349Enrico Stefani · University Of California Los Angeles · P01 · FY2007 · HL
Neurocircuitry Mapping and Genotyping Core
$367,332Robert J Hitzemann · Oregon Health & Science University · U01 · FY2014 · AA
Electrical impedance myography in an animal model
$367,304Seward B Rutkove · Beth Israel Deaconess Medical Center · R01 · FY2013 · NS
Mechanisms of ER-Protein Quality Control in Podocytes
$367,304Ling Qi · University Of Virginia · R01 · FY2025 · DK
End-of-Life in Assisted Living: Links between Structure, Process, and Outcomes
$367,287Molly M Perkins · Emory University · R01 · FY2018 · AG
Raloxifene-Based Therapy in Neuro Degenerative Diseases
$367,264Doris A Germain · Icahn School Of Medicine At Mount Sinai · R01 · FY2023 · NS
Deficits in KCC2 activity and the pathophysiology of Status Epilepticus
$367,244Stephen J Moss · Tufts University Boston · R01 · FY2017 · NS
Deficits in KCC2 activity and the pathophysiology of Status Epilepticus
$367,244Stephen J Moss · Tufts University Boston · R01 · FY2018 · NS
End-of-Life in Assisted Living: Links between Structure, Process, and Outcomes
$367,230Molly M Perkins · Emory University · R01 · FY2016 · AG
Error Detection and Error Awareness in Incarcerated Cocaine Dependent Individuals
$367,220Matthew Shane · The Mind Research Network · R01 · FY2011 · DA
Lymph node-targeted molecular vaccines for mucosal HIV immunity
$367,197Darrell J Irvine · Texas Biomedical Research Institute · P01 · FY2017 · AI
Sensory Science and Metabolism; Molecular and Neuronal Mechanisms
$367,156Paule Joseph · National Institute Of Nursing Research · ZIA · FY2018 · NR
Hypocretin Antagonists as a Novel Approach to Medication Development
$367,153Richard W Foltin · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R01 · FY2013 · DA
WE PROPOSE TO QUANTITATIVELY EVALUATE ONE SPECIFIC MECHANISM FOR THE FORMATION OF LIQUID WATER ON PRESENT-DAY MARS THAT WE CONSIDER PARTICULARLY PROMISING: MELTING OF SEASONAL WATER FROST IN ALCOVES. IN AREAS WITHIN ALCOVES THAT ARE SEASONALLY SHADOWED WATER FROST WILLACCUMULATE AND WHEN THE SUN RISES AGAIN TEMPERATURE INCREASES RAPIDLY AND MAY MELT THE FROST. WE WILL USE HIRISE-STEREO DERIVED DIGITAL ELEVATION MODELS (DEMS) AND THREE-DIMENSIONAL MODELING OF SHADOWS SURFACE TEMPERATURE NEAR-SURFACE TEMPERATURES AND SUBLIMATION IN RSLALCOVES TO TEST THIS HYPOTHESIS. THE GOAL IS TO QUANTITATIVELY ASSESS THE FULL CYCLE OF FROSTACCUMULATION WARMING AND MELTING IN THESE LOCAL ENVIRONMENTS. THE INVESTIGATION WILL ANSWERTHE FOLLOWING PROFOUND QUESTION: CAN LIQUID WATER FORM BY MELTING OF SEASONAL FROST IN ALCOVES AT PRESENT-DAY MARS CONDITIONS? THE MODEL RESULTS WILL BE COMPARED TO A SUITE OF OBSERVATIONAL CONSTRAINTS. WE WILL TAKE THE MODEL SURFACE TEMPERATURE OUTPUT AND COMPARE IT TO 1) MEASURED RSL GROWTH/RETREAT TIMESCALES (AT WHAT TEMPERATURES ARE THE RSL CHANGING?) AND TO 2) FREEZING POINT DEPRESSIONCALCULATIONS FOR CHLORIDE PERCHLORATE AND SULFATE SOLUTIONS AND/OR BRINES. THE RESULTS OF THIS PROJECT WILL YIELD A MORE DETAILED PICTURE OF THE THERMAL STATE OF RSL AND AS A CONSEQUENCE WHAT FLUIDS THEY COULD BE COMPOSED OF. THIS WILL HELP ESTABLISH IF THEY ARE "SPECIAL REGIONS" OR ARE TOO SALTY TO SUPPORT LIFE AS WE KNOW IT (RUMMEL ET AL. 2014). THE PROPOSED RESEARCH FALLS WITHIN THE SCOPE OF THE HABITABLE WORLDS PROGRAM AS IT IDENTIFIES ANDCHARACTERIZES THE DISTRIBUTION OF POTENTIALLY HABITABLE ENVIRONMENTS ON MARS. THE "ASTROBIOLOGICAL POTENTIAL OF PAST OR PRESENT ENVIRONMENTS ON OR IN THE MARTIAN SURFACE ORSUBSURFACE" IS SPECIFICALLY MENTIONED IN THE PROGRAM CALL. ALTHOUGH PRIMARILY A SCIENCE DRIVEN INVESTIGATION THE PROJECT WILL ALSO GENERATE HIGHER-ORDER DATA PRODUCTS FROM NASA MISSIONS TO MARS (HIRISE DEMS) AND IT WILL LEAD TO FURTHER DEVELOPMENT AND DISSEMINATION OF SOFTWARE TOOLS.
$367,103Planetary Science Institute · · FY2017 · National Aeronautics and Space Administration