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38,696 grants matching “als”
Approaches to ABeta Vaccination in Animal Models
$370,008University Of California Irvine · R01 · FY2001 · AG
LOADING AND UNLOADING AT THE EARTH'S SURFACE IS AN IMPORTANT PROCESS THAT CAUSES DEFORMATION IN THE MANTLE AND CRUST AND TO THE EARTH'S SURFACE AS WELL. BECAUSE THE DEFORMATION IS SENSITIVE TO MANTLE AND LITHOSPHERIC RHEOLOGY OR VISCOSITY THE LOADING PROCESSES HAVE BEEN STUDIED EXTENSIVELY TO LEARN ABOUT THE VISCOSITY THAT IS IMPORTANT FOR DYNAMIC PROCESSES IN THE MANTLE INCLUDING MANTLE CONVECTION [E.G. WATTS 2001J. ONE OF THE BEST-KNOWN SUCH EXAMPLES IS GLACIATION AND DE-GLACIATION FOR THE LAST 100 000 YEARS AND THIS PROCESS HAS CAUSED SIGNIFICANT SURFACE DEFORMATION AND CHANGES IN SEA-LEVEL GRAVITY AND OTHER GEOPHYSICAL OBSERVABLES. STUDIES OF THIS LOADING PROCESS (I.E. GLACIAL ISOSTATIC ADJUSTMENT OR GIA) HAVE PLACED CONSTRAINTS ON THE VISCOSITY OF THE MANTLE AND GLACIATION/ DE-GLACIATION HISTORY AND PROVIDED EXPLANATIONS TO THE GIA OBSERVATIONS [PELTIER ET AL. 2015; SIMONS AND HAGER 1997; MITROVICA AND FORTE 2004J. THE MAIN OBJECTIVES OF THIS PROJECT ARE: 1) TO UNDERSTAND THE EFFECTS OF REALISTIC TEMPERATURE- AND STRESS-DEPENDENT (I.E. 3-D) MANTLE VISCOSITY ON THE GIA PROCESS 2) TO CONSTRUCT REFERENCE GIA MODELS WITH 3-D MANTLE VISCOSITY BY FITTING GEOLOGICAL AND GEODETIC OBSERVATIONS 3) TO UNDERSTAND THE POSSIBLE DYNAMIC INTERACTION BETWEEN SURFACE LOADING PROCESS AND MANTLE PROCESS INCLUDING DISSIPATIVE HEATING. THESE OBJECTIVES ARE CLOSELY RELATED TO THE SOLICITATION OF THIS EARTH SURFACE AND INTERIOR PROGRAM AND NASA GENERAL SCIENCE GOAL. FIVE TASKS ARE PROPOSED TO ACCOMPLISH OUR OBJECTIVES VIA REALISTIC AND SOPHISTICATED ANALYTICAL AND LARGE-SCALE NUMERICAL MODELING. TO EXPLORE THE EFFECTS OF 3-D MANTLE VISCOSITY ON THE GIA PROCESS USING NEW SEISMIC MODELS IN A DEPTH- AND TEMPERATURE-DEPENDENT MANTLE VISCOSITY MODEL AND PARTICULARLY TO TEST THE 1-D AVERAGE VISCOSITY MODEL HYPOTHESIS AND TO EXAMINE THE CHARACTERISTIC 3-D EFFECTS AT FAR-FIELD SITES (E.G. BARBADOS CARIBBEAN) AND IN ANTARCTICA. TO FORMULATE GIA MODELS WITH STRESS-DEPENDENT MANTLE VISCOSITY INCLUDING BOTH ICE-LOAD-INDUCED STRESS AND MANTLE BACKGROUND STRESS DUE TO MANTLE CONVECTION AND TO TEST THE HYPOTHESIS THAT BOTH ICE-LOAD-INDUCED STRESS AND MANTLE BACKGROUND STRESS SIGNIFICANTLY AFFECT THE GIA PROCESS DUE TO STRESS-DEPENDENT VISCOSITY. TO FORMULATE NEW STANDARD GIA MODELS WITH 3-D VISCOSITY STRUCTURE THAT EXPLAIN GIA RELATED OBSERVATIONS AND HELP INTERPRET NON- GIA RELATED GRAVITY CHANGE IN THE GRACE DATA. TO DEVELOP GENERAL UNDERSTANDING ON THE RELATIONSHIP BETWEEN SURFACE LOADING AND INTERNAL DEFORMATION AND DISSIPATIVE ENERGY IN THE MANTLE AND TO ASSESS POSSIBLE DYNAMIC FEEDBACK BETWEEN THE LOADING PROCESS AND MANTLE PROCESS. TO RE-PROGRAM PARALLEL COMPUTING ROUTINES FOR VISCOELASTIC LOADING CODE CITCOMSVE FOR MASSIVELY PARALLEL COMPUTING AND TO MAKE THE CODE PUBLICALLY AVAILABLE TO SCIENCE COMMUNITY.
$370,000The Regents Of The University Of Colorado · · FY2020 · National Aeronautics and Space Administration
Thermodynamics and Kinetics of Deeply Supercooled Multicomponent Metallic Glass Forming Melts
$370,000Ralf Busch · Oregon State University · · FY2002 · MPS
Structure and Function of Ocular Lacritin
$370,000University Of Virginia Charlottesville · R01 · FY2002 · EY
Increasing efficacy of antineoplastic drugs with gap junction enhancers
$370,000Thu Annelise Nguyen · Kansas State University · R15 · FY2010 · CA
Zinc inhibition of endotoxemia in alcoholic liver injury
$370,000Zhanxiang Zhou · University Of Louisville · R01 · FY2009 · AA
Induction of tolerance to FVIII by engineered T regulatory cells in hemophilia
$369,989David William Scott · Henry M. Jackson Fdn For The Adv Mil/Med · R01 · FY2020 · HL
Induction of tolerance to FVIII by engineered T regulatory cells in hemophilia
$369,989David William Scott · Henry M. Jackson Fdn For The Adv Mil/Med · R01 · FY2019 · HL
Induction of tolerance to FVIII by engineered T regulatory cells in hemophilia
$369,989David William Scott · Henry M. Jackson Fdn For The Adv Mil/Med · R01 · FY2021 · HL
Induction of tolerance to FVIII by engineered T regulatory cells in hemophilia
$369,989David William Scott · Henry M. Jackson Fdn For The Adv Mil/Med · R01 · FY2022 · HL
A Direct Brain to Speech Generator for use in Humans
$369,975Philip R Kennedy · Neural Signals, Inc. · R44 · FY2007 · DC
Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTD
$369,956Evangelos Kiskinis · Northwestern University At Chicago · R01 · FY2022 · NS
Fluorescence Anisotropy-based Macromolecule Crystallization Screening
$369,950Marc Lee Pusey · Ixpressgenes, Inc. · R44 · FY2010 · GM
The Activation of ERBB3 Signaling as a Resistance Mechanism to Targeted Therapies
$369,945Jeffrey A Engelman · Massachusetts General Hospital · R01 · FY2009 · CA
Mechanisms of Brain Tumor Stem Cell Growth and Differentiation
$369,930John Park · National Institute Of Neurological Disorders And Stroke · ZIA · FY2011 · NS
Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
$369,923Qing Kenneth Wang · Cleveland Clinic Lerner Com-Cwru · R01 · FY2013 · HL
Function of 9-cis-retinoic acid
$369,894Joseph L Napoli · University Of California Berkeley · R01 · FY2011 · DK
Aging and Varieties of Cognitive Control
$369,862Paul Verhaeghen · Georgia Institute Of Technology · R56 · FY2009 · AG
Intracellular chloride regulation in olfactory neurons.
$369,849Rona J Delay · University Of Vermont & St Agric College · R01 · FY2006 · DC
Neural mechanisms underlying estradiol-enhanced extinction of cocaine seeking
$369,825Devin Mueller · University Of Wisconsin Milwaukee · R01 · FY2014 · DA
Neurotransmitter Mechanisms in the Mammalian Retina
$369,795Stephen C. Massey · University Of Texas Hlth Sci Ctr Houston · R01 · FY2007 · EY
Neurotransmitter Mechanisms in the Mammalian Retina
$369,795Stephen C. Massey · University Of Texas Hlth Sci Ctr Houston · R01 · FY2009 · EY
Treatment of ALS based on transplantation of glial restricted progenitors
$369,795Piotr Walczak · Johns Hopkins University · R01 · FY2015 · NS
Genetic Pathways Contributing to Systemic Lupus Erythematosus Pathogenesis
$369,790Edward K Wakeland · Ut Southwestern Medical Center · R37 · FY2007 · AI
Integrative studies of post-glacial cap carbonates in Namibia and Canada
$369,782Paul F Hoffman · Harvard University · · FY2005 · GEO