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46,585 grants matching “heart failure”
Angiotensin-Converting Enzyme2 in Vascular Endothelial Function
$460,573Mohan K. Raizada · University Of Florida · R01 · FY2011 · HL
Teens with Type 1 Diabetes: A Focus on Friendship
$460,554Vicki S Helgeson · Carnegie-Mellon University · R01 · FY2019 · DK
STRESS REDUCTION AND CVD MORBIDITY AND MORTALITY-II
$460,543Maharishi University Of Management · R01 · FY2003 · HL
Cyclosporine Inhalation Solution (CIS) treatment of Bronchiolitis Obliterans
$460,500Richard Childs · National Heart, Lung, And Blood Institute · ZIA · FY2012 · HL
Novel Cardioprotective Mechanisms Myoglobin null Mice
$460,473University Of Texas Sw Med Ctr/Dallas · R01 · FY2004 · HL
Bioactive injectable blends for cardiac stem cell recruitment
$460,449Yi Hong · University Of Texas Arlington · R15 · FY2018 · HL
Novel exosomal niches for alveolar stem cell-bassed repair of ARDS
$460,415Hong-Long Ji · Loyola University Chicago · R01 · FY2025 · HL
Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)
$460,337Gabor D Kelen · Johns Hopkins University · U24 · FY2023 · NS
Genetic testing to guide pediatric cancer care and follow up: using anthracycline-associated cardiac toxicity as a model for the future
$460,299Jennifer M. Yeh · Boston Children'S Hospital · R01 · FY2018 · CA
Pediatric Heart Network Prairieland Consortium
$460,250James Cnota · Cincinnati Childrens Hosp Med Ctr · U10 · FY2013 · HL
Pediatric Heart Network Prairieland Consortium
$460,250James Cnota · Cincinnati Childrens Hosp Med Ctr · U10 · FY2012 · HL
Pediatric Heart Network Prairieland Consortium
$460,250James Cnota · Cincinnati Childrens Hosp Med Ctr · U10 · FY2014 · HL
Pediatric Heart Network Prairieland Consortium
$460,250James Cnota · Cincinnati Childrens Hosp Med Ctr · U10 · FY2015 · HL
CARDIAC MAST CELL--ROLE IN PATHOGENESIS OF HEART FAILURE
$460,195Auburn University At Auburn · R01 · FY2002 · HL
Role of Depression in Medicare New Chronic Care Improvement Program
$460,190Jurgen Unutzer · University Of Washington · U01 · FY2008 · MH
Home-based videoplethysmographic detection of atrial fibrillation
$460,176Jean-Philippe Y Couderc · University Of Rochester · R01 · FY2020 · HL
Depression and Biobehavioral Processes in Heart Failure
$460,124Willem Johan Kop · University Of Maryland Baltimore · R01 · FY2009 · HL
Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure
$460,116Livia Agnes Veress · University Of Colorado Denver · R01 · FY2025 · ES
Biomarkers for Outcomes In Late-life Depression (BOLD)
$460,089Ian A Cook · University Of California Los Angeles · RC1 · FY2009 · MH
Preclinical Validation of PPARg Acetylation Inhibitors for Diabetes Prevention and Treatment
$460,068Weidong Wang · University Of Oklahoma Hlth Sciences Ctr · R01 · FY2023 · DK
COMMON MILKWEED IS A PERENNIAL PLANT WITH A WIDE DISTRIBUTION IN THE CENTRAL AND EASTERN UNITED STATES. POTENTIAL USES OF MILKWEED INCLUDE THE HARVEST OF FIBER, HYPOALLERGENIC FLOSS, AND MEDICALLY RELEVANT METABOLITES. CARDENOLIDES, A CLASS OF COMPOUNDS THAT IS ABUNDANT IN MILKWEED, HAVE BEEN USED FOR CENTURIES TO TREAT HEART FAILURE, ARRHYTHMIAS, AND OTHER HUMAN DISEASES. CARDENOLIDE PRODUCTION FOR PHARMACEUTICAL APPLICATIONS AND CLINICAL RESEARCH HAS BEEN LIMITED BY THEIR UNKNOWN BIOSYNTHETIC PATHWAYS AND SOMETIMES LIMITED ABUNDANCE IN A COMPLEX MIXTURE OF PLANT METABOLITES. BASED ON PRELIMINARY RESULTS THAT INCLUDE A MILKWEED GENOME SEQUENCE, GENE EXPRESSION DATA, AND METABOLITE PROFILING DATA, FURTHER EXPERIMENTS WILL BE CONDUCTED TO IDENTIFY PATHWAYS FOR THE BIOSYNTHESIS OF CARDENOLIDES IN MILKWEED. TOGETHER, THESE EXPERIMENTS WILL PROVIDE NEW INSIGHT INTO AN IMPORTANT METABOLIC PATHWAY WHOSE ENZYMATIC STEPS HAVE NOT BEEN DETERMINED IN ANY PLANT SPECIES. PRIOR WORK HAS DEMONSTRATED THAT MILKWEED CAN BE GROWN IN CONVENTIONAL AGRICULTURAL ENVIRONMENTS, AND THEREFORE HAS POTENTIAL AN AGRICULTURAL CROP. BY ELUCIDATING BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF PLANT-BASED CHEMICALS, IT WILL BE POSSIBLE TO USE SELECTIVE BREEDING TO IMPROVE THE ECONOMIC VALUE OF MILKWEED. RESOURCES DEVELOPED THROUGH THIS PROJECT WILL LEAD TO THE MORE TARGETED PRODUCTION OF PHARMACEUTICAL COMPOUNDS IN MILKWEED AND CAN BE USED TO IMPROVE THE AGRONOMIC PROPERTIES THIS SPECIES AS A NEW PERENNIAL FIELD CROP FOR AMERICAN FARMERS.
$460,000Boyce Thompson Institute For Plant Research Inc · · FY2020 · National Institute of Food and Agriculture
Reinforce Cell Sheets with Acellular Porcine Myocardial Scaffolds: Application in Cardiac Repair
$459,992Ge Zhang · University Of Akron · R15 · FY2015 · HL
Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart
$459,979Miguel Antonio Aon · Johns Hopkins University · R01 · FY2011 · HL
Effects of maternal cortisol on perinatal cardiac metabolism and function
$459,929Maureen Keller-Wood · University Of Florida · R01 · FY2019 · HD
Autophagy, cardioprotection and metabolic syndrome
$459,914Robert M Mentzer · Cedars-Sinai Medical Center · P01 · FY2015 · HL