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17,828 grants matching “crispr”
Elucidating Thiol Reductive Stress in Lung Cancer Growth and Metastasis
$140,130Maolin Ge · Massachusetts General Hospital · K99 · FY2025 · CA
Core 1: Viral Vector Core
$140,118Kristine E Yoder · Ohio State University · P01 · FY2024 · CA
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
$140,093Sanchita Bhatnagar · University Of Virginia · R01 · FY2021 · CA
Target Validation Core
$140,074Jing Wang · University Of Nebraska Medical Center · P20 · FY2020 · GM
STAPHYLOCOCCUS EPIDERMIDIS IS AN OPPORTUNISTIC HUMAN PATHOGEN CONSISTENTLY ISOLATED AND DETECTED BY MOLECULAR ANALYSIS ON BOARD THE INTERNATIONAL SPACE STATION. THE FORMATION OF BIOFILMS IS A SIGNIFICANT PROCESS FOR S. EPIDERMIDIS TO ESTABLISH PATHOGENICITY AND FIVE DISTINCT BIOFILM MORPHOTYPES HAVE BEEN RECENTLY IDENTIFIED. THE GOAL OF THIS STUDY IS TO CHARACTERIZE THE BIOFILM FORMING CAPACITY OF ISS ISOLATED S. EPIDERMIDIS STRAINS AND TO INVESTIGATE THEIR PATHOGENICITY IN THE MODEL ORGANISM CAENORHABDITIS ELEGANS. FIRST WE SHALL PROVIDE THE FIRST COMPARATIVE GENOMIC INFORMATION OF S. EPIDERMIDIS STRAINS TO CHARACTERIZE STRAIN-SPECIFIC SEQUENCE VARIANTS AND THE IDENTIFICATION OF MUTATIONS IN BIOFILM-ASSOCIATED GENES THAT MAY HAVE BEEN INCURRED DURING SPACEFLIGHT. WE WILL ALSO EXAMINE THE PRESENCE OF THE CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS-CRISPR-ASSOCIATED PROTEINS (CRISPR-CAS) THAT CONFER BACTERIAL RESISTANCE TO FOREIGN DNA AND MAY PROVIDE AN ADDITIONAL METHOD OF PERSISTENCE TO SPACE FLIGHT CONDITIONS. USING QUANTITATIVE MICROSCOPIC ANALYSES CONFOCAL SCANNING LASER MICROSCOPY WILL BE USED TO CHARACTERIZE BIOFILM MORPHOTYPES AND EACH MORPHOTYPE WILL BE EVALUATED FOR ANTIBIOTIC RESISTANCE. TRANSCRIPTIONAL ANALYSIS AND PROTEOMIC DATA WILL DETERMINE HOW BIOFILM-ASSOCIATED GENE EXPRESSION AND PROTEIN PRODUCTION VARY AND HOW THESE VARIATIONS RELATE TO THE BIOFILM MORPHOTYPE PRODUCED. IN VIVO PATHOGENICITY TESTS WILL CULMINATE OUR INVESTIGATION INTO THE EFFECT OF S. EPIDERMIDIS BIOFILM MORPHOTYPES ON THE ABILITY TO ESTABLISH INFECTION IN THE MODEL ORGANISM CAENORHABDITIS ELEGANS. THIS WORK WILL HELP TO DETERMINE GENOMIC PHENOTYPIC AND PHYSIOLOGICAL BASIS FOR VARIOUS BIOFILM MORPHOTYPES FORMED BY ISS ISOLATED S. EPIDERMIDIS AND PROVIDE INSIGHT TO PATHOGENI ITY OF SPACE FLIGHT ISOLATED MICROORGANISMS WHERE ASTRONAUT IMMUNITY IS DECREASED AND THE AVAILABILITY OF ANTIBIOTICS IS LIMITED.
$140,000Massachusetts Institute Of Technology · · FY2020 · National Aeronautics and Space Administration
Nicotinic receptor gene editing vectors
$139,944Ryan Michael Drenan · Northwestern University At Chicago · R21 · FY2018 · DA
Urgent Supplement: Correcting genetic disorders using predictable CRISPR/Cas9-induced exon skipping
$139,773Richard I Sherwood · Brigham And Women'S Hospital · R21 · FY2020 · HG
Exploring Integrative Conjugative Elements in the Biology and Ecology of Oral Streptococci
$139,730Robert Colquhoun Shields · Arkansas State University · R03 · FY2022 · DE
Structural Biology
$139,665Steven C. Almo · Albert Einstein College Of Medicine · P30 · FY2019 · CA
Structural Biology
$139,665Steven C. Almo · Albert Einstein College Of Medicine · P30 · FY2020 · CA
Identification of novel safe harbors to be used in a gene editing strategy for the treatment of hemophilia A
$139,586Jennifer Marie Johnston · San Jose State University · SC2 · FY2020 · GM
Elucidating KRAS-specific vulnerabilities in pancreatic cancer
$139,563Mandar Deepak Muzumdar · Yale University · K08 · FY2017 · CA
Identification of pathogenic mechanisms important in multiple system atrophy
$139,500Matt Huentelman · Translational Genomics Research Inst · R21 · FY2016 · NS
"Core C" Recombinant Virus Core
$139,481Rolf F Renne · University Of Florida · P01 · FY2024 · CA
Gene Modulation in Cancer Cellular Models
$139,379Dan Liu · Baylor College Of Medicine · P30 · FY2021 · CA
Structure and Function of ATP-Dependent Chromatin Remodeling Complexes in Human Cancer
$139,190Nazar Mashtalir · Dana-Farber Cancer Inst · K99 · FY2019 · CA
Structure and Function of ATP-Dependent Chromatin Remodeling Complexes in Human Cancer
$139,190Nazar Mashtalir · Dana-Farber Cancer Inst · K99 · FY2020 · CA
The RNA components of the translation apparatus in prostate cancer plasticity and therapy response
$139,184Yeon Soo Kim · Fred Hutchinson Cancer Center · K99 · FY2025 · CA
Systematic Discovery and Characterization of Novel Cancer Anti-Phagocytic Mechanisms
$139,109Roarke Alexander Kamber · University Of California, San Francisco · R00 · FY2024 · CA
Implications of Driver Mutations for Progression of Hepatocellular Carcinoma
$139,053Ron C Gaba · University Of Illinois At Chicago · R21 · FY2019 · CA
Novel target deconvolution in cGAS-STING pathway
$139,009Jingxin Wang · University Of Kansas Lawrence · P20 · FY2020 · GM
Germline transmission of epigenetic alterations to offspring
$138,885Ramji Kumar Bhandari · University Of North Carolina Greensboro · R01 · FY2023 · ES
Gene Modulation inCancer Cellular Models
$138,871Jun Xu · Baylor College Of Medicine · P30 · FY2023 · CA
Gene Modulation inCancer Cellular Models
$138,871Jun Xu · Baylor College Of Medicine · P30 · FY2024 · CA
Gene Modulation inCancer Cellular Models
$138,871Jun Xu · Baylor College Of Medicine · P30 · FY2022 · CA