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38,696 grants matching “als”
Mechanism of Gp1 mGluR-dependent translation and plasticity
$377,183Nien-Pei Tsai · University Of Illinois At Urbana-Champaign · R01 · FY2022 · MH
Survival Motor Neuron (SMN) function in motoneuron development
$377,161Sharon L Amacher · Ohio State University · R01 · FY2018 · NS
Noise Trauma-Induced Cortical PV Neuron Dysfunction
$377,144Shaowen Bao · University Of Arizona · R01 · FY2023 · DC
A FUNDAMENTAL GOAL IN PLANETARY SCIENCE IS TO UNDERSTAND THE EARLY HISTORY OF THE SOLAR SYSTEM. EFFECTIVE WAYS IN WHICH THIS CAN BE INVESTIGATED INCLUDE THE PETROLOGIC INVESTIGATION OF PRIMITIVE METEORITES; EXPERIMENTS THAT REPRODUCE PROCESSES THAT MAY HAVE OCCURRED IN THE EARLYSOLAR SYSTEM; AND ISOTOPIC ANALYSES OF PRIMITIVE SAMPLES. ALL THREE OF THESE AVENUES OF INQUIRY ARE PURSUED IN THIS PROPOSED STUDY. OVER THE PAST DECADE A LARGE SUITE (OVER 200 SPECIMENS) OF VERY LOW-GRADE CARBONACEOUS CHONDRITES CLASSIFIED AS CO3S HAS BEEN RETURNED FROM ANTARCTICA MAINLY FROM THE MILLER RANGE AND THE DOMINION RANGE. SUCH SAMPLES ARE OF GREAT INTEREST BECAUSE THEY HAVE RELATIVELY HIGH CONTENTS OF PRESOLAR SILICATES (E.G. ALEXANDER ET AL. 2014) BUT THEY ARE ALSO IMPORTANT BECAUSE THEYPROVIDE AN OPPORTUNITY TO STUDY CHONDRULES AND REFRACTORY INCLUSIONS THAT DO NOT HAVE METAMORPHIC OVERPRINTS FROM THEIR PARENT BODIES. WE HAVE BEGUN A PETROLOGIC STUDY OF THE REFRACTORY INCLUSIONS IN SUCH SAMPLES (SIMON AND GROSSMAN 2014; 2015) AND IN TASK 1A WE PROPOSE TO CONTINUE AND EXPAND UPON THAT WORK. IN ADDITION IN A MULTIDISCIPLINARY (MIN-PET/TEM/XANES) STUDY OF LOWGRADECARBONACEOUS AND ORDINARY CHONDRITES TASK 1B WE WILL INVESTIGATE THE EFFECTS OF THE ONSET OF METAMORPHISM ON CHONDRITE PARENT BODIES. THE DISCOVERY OF TRIVALENT TI IN OLIVINE AND PYROXENE IN SEMARKONA CHONDRULES (SIMON ET AL. 2008) INSPIRED AN EXPERIMENTAL STUDY OF THE REDOX KINETICS OF FE AND TI IN CHONDRULE-LIKE SYSTEMS IN WHICH WE BEGAN TO EVALUATE THE RELATIVE RATES OF OXIDATION OF THESE ELEMENTS. PRELIMINARY RESULTS WERE REPORTED BY S. SIMON ET AL. (2011; 2014) AND A SECOND GENERATION OF THESE CHALLENGING EXPERIMENTS TASK 2 IS PROPOSED. OTHER MAJOR TOOLS FOR INVESTIGATION OF EARLY SOLAR SYSTEM PROCESSES ARE APPLICATION OF ISOTOPIC CHRONOMETERS TO CHONDRULES AND INCLUSIONS FOR BOTH RELATIVE AND ABSOLUTE DATING (TASKS 3A AND 3B; AND THE MEASUREMENT OF STABLE ISOTOPIC COMPOSITIONS FOR BOTH IDENTIFICATION OF RESERVOIRS AND EVALUATION OF MASS FRACTIONATION (EVAPORATION) EFFECTS IN RIMS ON REFRACTORY INCLUSIONS (TASK 3C). IN SUCH STUDIES SELECTION OF APPROPRIATE SAMPLES AND DETAILED CHARACTERIZATION OF THEM ARE NECESSARY FOR OBTAINING THE MOST MEANINGFUL RESULTS POSSIBLE. THE PROPOSED WORK WILL INVESTIGATE: THE ORIGINS OF SOME OF THE EARLIEST SOLAR SYSTEM MATERIALS (CHONDRULES AND REFRACTORY INCLUSIONS); PROCESSES THAT OCCURRED DURING CHONDRULE FORMATION; EFFECTS OF THE FIRST STAGES OF CHONDRITE METAMORPHISM; ABSOLUTE AND RELATIVE AGES OF CHONDRULES; AND THE DISTRIBUTION OF 26AL AND 16O RESERVOIRS IN THE EARLY SOLAR SYSTEM AND AS SUCH IS HIGHLY RELEVANT TO THE GOALS OF THE EMERGING WORLDS PROGRAM.
$377,130University Of New Mexico · · FY2017 · National Aeronautics and Space Administration
Therapeutic Expression of Glial Glutamate Transporters
$377,130Johns Hopkins University · R01 · FY2005 · NS
Innate Immune Response in Cardiac Healing and Rejuvenation
$377,125Jeffery D Molkentin · Ut Southwestern Medical Center · P01 · FY2023 · HL
Estrogen: Neuroprotection and Rescue
$377,113R. Suzanne Zukin · Albert Einstein College Of Medicine · R01 · FY2006 · NS
STRUCTURE OF GABA-A RECEPTOR ANION-SELECTIVE CHANNEL
$377,113Myles H Akabas · Albert Einstein College Of Medicine · R01 · FY2006 · NS
AAV capsid-promoter interactions determines CNS cell selective gene expression in vivo
$377,088Thomas J. McCown · Univ Of North Carolina Chapel Hill · R01 · FY2024 · NS
The role of lipid homeostasis in nuclear shape and function
$377,074Orna Cohen Fix · Diabetes, Digestive, Kidney Diseases · Z01 · FY2007 · DK
Cell Cycle Regulation In Budding Yeast
$377,074Orna Cohen Fix · Diabetes, Digestive, Kidney Diseases · Z01 · FY2007 · DK
Role of KMT2D Gene Inactivation in B cell Non Hodgkin Lymphoma
$377,055Laura Pasqualucci · Columbia University Health Sciences · R01 · FY2022 · CA
Molecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetes
$377,034Alexei A Bogdanov · Univ Of Massachusetts Med Sch Worcester · R01 · FY2015 · DK
Molecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetes
$377,034Alexei A Bogdanov · Univ Of Massachusetts Med Sch Worcester · R01 · FY2016 · DK
Molecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetes
$377,034Alexei A Bogdanov · Univ Of Massachusetts Med Sch Worcester · R01 · FY2017 · DK
ALL immunobiology and the bone marrow niche
$377,007Terry Fry · Division Of Basic Sciences - Nci · ZIA · FY2014 · CA
Ameloblastin Function in Periodontal Development
$376,996Xianghong Luan · University Of Illinois At Chicago · R01 · FY2012 · DE
TSP-1 and ROS: CD47 and SIRP-alpha as Mediators of Vascular Dysfunction
$376,993Patrick J Pagano · University Of Pittsburgh At Pittsburgh · R01 · FY2014 · HL
Epitope dynamics of SARS-CoV-2 S protein by cryo-electron tomography and single particle cryo-EM
$376,946Mario Borgnia · National Institute Of Environmental Health Sciences · ZIA · FY2022 · ES
Endocannabinoids And The Control Of Behavior and Cardiovascular Function
$376,928George Kunos · National Institute On Alcohol Abuse And Alcoholism · ZIA · FY2012 · AA
Stress Impaired Microbial Clearance
$376,918Phillip T. Marucha · University Of Illinois At Chicago · R01 · FY2010 · DE
Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTD
$376,893Evangelos Kiskinis · Northwestern University At Chicago · R01 · FY2021 · NS
Coding of action by motor & premotor cortical ensembles
$376,879Nicholas G Hatsopoulos · University Of Chicago · R01 · FY2010 · NS
Electrical impedance myography in an animal model
$376,820Seward B Rutkove · Beth Israel Deaconess Medical Center · R01 · FY2014 · NS
Synaptic FGFs are required and sufficient to maintain and repair aged NMJs
$376,819Gregorio Valdez · Virginia Polytechnic Inst And St Univ · R56 · FY2015 · AG