Sort
20,791 grants matching “optogenetics”
Behavioral Function of Forebrain Projections to Brainstem Gustatory Nuclei Revealed By Optogenetic Control of Cell-Type/Target-Specific Pathways
$225,600Robert F Lundy · University Of Louisville · R21 · FY2018 · DC
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertension
$225,597Annette Diane De Kloet · Georgia State University · R01 · FY2023 · HL
Behavioral Neuroscience Research Core
$225,443Charles Lee Pickens · Kansas State University · P20 · FY2023 · GM
Behavioral Neuroscience Research Core
$225,443Charles Lee Pickens · Kansas State University · P20 · FY2025 · GM
Behavioral Neuroscience Research Core
$225,443Charles Lee Pickens · Kansas State University · P20 · FY2024 · GM
Optogenetic Mapping of Adult Newborn Neuron Projections
$225,438Bret N Smith · University Of Kentucky · R21 · FY2015 · NS
A robust ionotropic activator for brain-wide manipulation of neuronal function
$225,428Andrew D Ellington · University Of Texas At Austin · R21 · FY2016 · EY
c-Myc Targets in the Pathogenesis of Human Cancers
$225,384Chi V. Dang · Wistar Institute · R01 · FY2021 · CA
Optogenetic Dissection of a Neural Circuit Underlying the Extinction of PTSD
$225,258David J Anderson · California Institute Of Technology · · FY2013 · SBE
Molecular and optogenetic tools for studying voltage in the brain
$225,131Evan Walker Miller · University Of California Berkeley · R00 · FY2015 · NS
Circuits Mediationg Emotional Versus Motivational Components of Opioid Action
$225,128Nigel T Maidment · University Of California Los Angeles · P50 · FY2012 · DA
Circuits Mediationg Emotional Versus Motivational Components of Opioid Action
$225,128Nigel T Maidment · University Of California Los Angeles · P50 · FY2014 · DA
CRCNS: The diffusional complexity of the brain's extracellular space
$225,097Fidel Santamaria · University Of Texas San Antonio · R01 · FY2022 · NS
Optogenetic control of neuronal pathways that mediate repetitive behavior
$225,000Mark H Lewis · University Of Florida · R21 · FY2016 · MH
Optogenetic modeling of primary and secondary CNS proteinopathies in Drosophila
$225,000Diego E Rincon-Limas · University Of Florida · R21 · FY2014 · NS
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) for relapse preventionin patients with Opioid Use (OUD)
$225,000William Bradford Lawson · Evon Medics, Llc · R43 · FY2019 · DA
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** SOYBEAN IS A MAJOR CROP IN US AGRICULTURE, AND PRODUCING HIGHER-QUALITY SOYBEAN LINES IS IMPERATIVE TO GROWING THE SOYBEAN INDUSTRY. HYBRID CROPS BENEFIT FROM HYBRID VIGOR, A PHENOMENON IN WHICH THE OFFSPRING OF GENETICALLY UNIQUE PARENTS EXHIBIT INCREASED GROWTH. THE CREATION OF THESE HYBRIDS IS DIFFICULT IN SOYBEAN SINCE IT IS A HERMAPHRODITIC PLANT THAT SELF-POLLINATES BEFORE IT CAN BE POLLINATED BY A DIFFERENT INDIVIDUAL PLANT. THE MAJOR GOAL OF THIS PROJECT IS TO IMPROVE THE EASE WITH WHICH HYBRID SOYBEAN CROSSES CAN BE MADE BY SOYBEAN BREEDERS.SEX CHROMOSOMES HAVE EVOLVED IN PLANTS REPEATEDLY, CONFERRING FEMALENESS OR MALENESS TO INDIVIDUAL PLANTS WITHIN A SPECIES. SUCH PLANTS MUST CROSS-POLLINATE, WHICH LEADS TO THE CREATION OF MORE VIGOROUS HYBRID OFFSPRING. IN THIS PROJECT, I PROPOSE TO ENGINEER SEX CHROMOSOMES IN SOYBEAN, THUS CREATING UNIQUE MALE AND FEMALE SOYBEAN PLANTS. I WILL ACCOMPLISH THIS BY USING MOLECULAR CLONING AND TRANSFORMATION TECHNIQUES TO GENETICALLY MANIPULATE SOYBEAN PLANTS BASED ON OUR KNOWLEDGE OF WHAT CONSTITUTES SEX CHROMOSOMES IN PLANTS. AGAIN USING MOLECULAR CLONING AND TRANSFORMATION TECHNIQUES, I WILL ALSO CREATE A SOYBEAN LINE IN WHICH SEX DETERMINATION WILL BE CONTROLLABLE BY SHINING A RED LIGHT ON THE PLANTS DURING A PARTICULAR DEVELOPMENTAL PHASE--THIS IS A TOOL CALLED OPTOGENETICS. THIS WILL YIELD PLANTS THAT REMAIN HERMAPHRODITES BY DEFAULT, MAKING IT POSSIBLE FOR THEM TO BE DEPLOYED IN FIELDS WITHOUT THE NEED TO BE MONITORED. THIS PROJECT WILL THUS PRODUCE SOYBEAN LINES THAT WILL ENABLE SOYBEAN BREEDERS TO CREATE STRONGER HYBRID LINES, THUS BOLSTERING THE SOYBEAN INDUSTRY.
$225,000Hudsonalpha Institute For Biotechnology · · FY2024 · National Institute of Food and Agriculture
Ambient light activatable opsin based therapy for age-related macular degeneration
$224,925Weldon Wright · Nanoscope Technologies, Llc · R43 · FY2015 · EY
Vagus nerve stimulation as a tool to modulate synaptic plasticity during extinction from drug seeking
$224,910Sven Kroener · University Of Texas Dallas · R21 · FY2017 · DA
Mapping Dynamic Changes in Protein Interactome using Proximity Labeling with High Temporal Resolution
$224,863Andrei V Karginov · University Of Illinois At Chicago · R61 · FY2025 · CA
Compressive Light Field microscopy for optogenetic neural activity tracking
$224,725Laura Waller · University Of California Berkeley · R21 · FY2016 · EY
Integration of gustatory and somatosensory information in the tongue
$224,650Aurelie Vandenbeuch · University Of Colorado Denver · R21 · FY2020 · DC
Thalamo-Prefrontal interactions in cognition: cortical layers
$224,518Christoph Kellendonk · New York State Psychiatric Institute Dba Research Foundation For Mental Hygiene, Inc · R21 · FY2019 · MH
New Approaches to the study of 5-HT1a autoreceptors in the raphe
$224,464Rodrigo Andrade · Wayne State University · R01 · FY2013 · MH
Resource Core 2 - Primate/rodent Optics Core (POC)
$224,462Ailey Crow · Stanford University · U19 · FY2021 · NS