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17,828 grants matching “crispr”
Investigating epigenetic mechanisms of cancer
$162,115Richard L Bennett · University Of Florida · R50 · FY2025 · CA
Developing inducible CRISPR to identify molecular targets in melanoma
$162,038Matthew Wayne Vanbrocklin · University Of Utah · R21 · FY2016 · CA
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2021 · HL
Role of Nrf Proteins in Embryonic Development and the Response to Developmental Toxicants
$162,000Mark E Hahn · Woods Hole Oceanographic Institution · R56 · FY2018 · ES
Off-the-shelf engineered NK cells for the treatment of AML
$162,000Katy Rezvani · University Of Tx Md Anderson Can Ctr · R01 · FY2020 · CA
Non-conventional regulation of essential apicomplexan guanylate cyclases
$162,000Kevin Michael Brown · University Of Oklahoma Hlth Sciences Ctr · K22 · FY2019 · AI
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2020 · HL
Identification of Key Regulators in Pancreatic Cancer Metastasis
$162,000Chang-Il Hwang · University Of California At Davis · K22 · FY2019 · CA
Identification of Key Regulators in Pancreatic Cancer Metastasis
$162,000Chang-Il Hwang · University Of California At Davis · K22 · FY2020 · CA
CRISPR-based Functional Genomics in Pathogenic Bacteria
$162,000Jason M. Peters · University Of Wisconsin-Madison · K22 · FY2018 · AI
The biochemical basis of immune cell reprogramming: how cellular metabolism regulates epigenetic remodeling during T cell differentiation
$162,000Will H. Bailis · Children'S Hosp Of Philadelphia · K22 · FY2019 · AI
Non-Invasive Monitoring of CRISPR/Cas-Edited Chimeric Antigen Receptor T (CAR-T) Cells with Reporter Gene-Based Magnetic Resonance Imaging and Positron Emission Tomography
$162,000John Andrew Ronald · University Of Western Ontario · UH2 · FY2020 · EB
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2024 · HL
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2022 · HL
Prioritizing and Characterizing T Cell-Relevant Genetic Variants Associated with Autoimmune Diseases
$162,000John Philip Ray · Benaroya Research Inst At Virginia Mason · K22 · FY2021 · AI
Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia
$162,000Deepthi Alapati · Nemours Children'S Hospital, Delaware · K08 · FY2023 · HL
Discovering protein networks underlying regulated exocytosis
$161,967Jingshi Shen · University Of Colorado · R35 · FY2024 · GM
AMERICANS LEAD THE WORLD IN FOOD WASTE. THOUGH IT MAY NOT BE A STATISTIC TO BE PROUD OF THERE IS A WAY TO TURN THINGS AROUND! EACH YEAR WE THROW AWAY 60 MILLION TONS OF FOOD, ALMOST HALF OF ALL PRODUCE SOLD. WHILE A SMALL PORTION OF THE FOOD WASTE IS USED AS ANIMAL FEED MOST OF IT ENDS UP IN LANDFILLS, CONTRIBUTING TO GLOBAL WARMING ANDGASSES THAT ARE 25 TIMES MORE POWERFUL THEN FUMES FROM MOTORIZED VEHICLES (CARBON DIOXIDE). ONE POSSIBLE SOLUTION IS TO TURN THIS FOOD WASTE INTO SOMETHING WE CAN ALL BENEFIT FROM. THROUGH THE USE OF A SPECIAL WASTE EATING BACTERIUM, BACILLUS LICHENIFORMIS YNP5-TSU, WE CAN CONVERT WASTE INTO A USEFUL BIOFUEL CALLED BUTANEDIOL (BDL).OUR GOAL FOR THIS PROJECT IS TO DETERMINE THE BEST FERMENTATION SETTINGS AND GENETIC MODIFICATIONS FOR B. LICHENIFORMIS YNP5-TSU SO THE MAXIMUM AMOUNT OF BIOFUEL CAN BE PRODUCED. MANY FERMENTATION PARAMETERS SUCH AS; PH, TEMPERATURE, DISSOLVED OXYGEN CONTENT, AND FEEDSTOCK COMPOSITION HAVE SIGNIFICANT EFFECTS ON BDL OUTPUT AND WILL BE CALCULATED THROUGH USE OF 2-LITER NEW BRUNSWICK® FERMENTERS AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC). IN ORDER TO REMOVE OTHER UNWANTED FERMENTATION END-PRODUCTS, GENETIC MODIFICATIONS TO B. LICHENIFORMIS YNP5-TSU THROUGH THE NEWLY DISCOVERED CRISPR-CAS9 GENOME EDITING TOOL WILL ALSO BE PERFORMED.THROUGH THESE TECHNIQUES MENTIONED WE WILL BE ABLE TO PROVIDE VALUABLE DATA ON HOW THIS UNIQUE MICROORGANISM DEGRADES FOOD WASTE AND CONVERTS IT INTO BIOFUEL. COMPLETION OF THIS PROJECT WILL ALSO GIVE INSIGHT TOWARDS THE NEXT STEP; IMPLEMENTATION OF B. LICHENIFORMIS YNP5-TSU INTO LARGE SCALE PRODUCTION AND ULTIMATELY LEAD TO A NEW SUSTAINABLE ENERGY RESOURCE FROM FOOD WASTE.
$161,917Virginia Polytechnic Institute & State University · · FY2019 · National Institute of Food and Agriculture
Hippo Signaling Mediates the Development of Liver Fibrosis
$161,892Dean Yimlamai · University Of Pittsburgh At Pittsburgh · K08 · FY2019 · DK
Hippo Signaling Mediates the Development of Liver Fibrosis
$161,892Dean Yimlamai · University Of Pittsburgh At Pittsburgh · K08 · FY2018 · DK
Core E: Organoids Core
$161,778Yu Chen · Sloan-Kettering Inst Can Research · P50 · FY2020 · CA
Cancer and stromal metabolic reprogramming drives chemotherapy resistance in human models of pancreatic cancer
$161,750Pankaj Kumar Singh · University Of Oklahoma Hlth Sciences Ctr · U54 · FY2024 · CA
Purinergic Signaling in Intestinal Inflammation
$161,695Kristen Engevik · Medical University Of South Carolina · K01 · FY2025 · DK
Spatiotemporal Control of T cell Synapse Stabilization and Signaling
$161,649Matthew F Krummel · University Of California, San Francisco · R01 · FY2021 · AI
Host Factors That Restrict HIV mRNA With Retained Introns
$161,500Marie-Louise Hammarskjold · University Of Virginia · R21 · FY2023 · AI