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17,054 grants matching “genome editing”
Overcoming barriers to efficient genome editing in HSPCs
$144,349Philip Douglas Gregory · University Of Southern California · U19 · FY2018 · HL
Overcoming barriers to efficient genome editing in HSPCs
$144,349Philip Douglas Gregory · University Of Southern California · U19 · FY2019 · HL
Project 5 - Charcot Marie-Tooth Project
$144,230Robert W Burgess · Jackson Laboratory · U54 · FY2016 · OD
Project 5 - Charcot Marie-Tooth Project
$144,220Robert W Burgess · Jackson Laboratory · U54 · FY2018 · OD
TRANSGENIC AND TARGETED MUTAGENESIS LABORATORY
$144,206Leonidas C Platanias · Northwestern University At Chicago · P30 · FY2015 · CA
Project 5 - Charcot Marie-Tooth Project
$143,922Robert W Burgess · Jackson Laboratory · U54 · FY2019 · OD
Genome Engineering and iPSC Center
$143,863Timothy J Eberlein · Washington University · P30 · FY2015 · CA
Mouse Biology Shared Resource
$143,792Kc Kent Lloyd · University Of California At Davis · P30 · FY2025 · CA
GENOMIC INFORMATION IS RAPIDLY BEING GENERATED NOT ONLY FOR MAJOR CROPS SUCH AS MAIZE, WHEAT AND RICE, BUT ALSO FOR OTHER ECONOMICALLY IMPORTANT CROPS INCLUDING COMMON BEAN, CHILI PEPPER, PAPAYA, GRAPEVINE, ETC. THE INCREASING AMOUNT OF INFORMATION ABOUT PLANT GENOMES HAS ALLOWED THE USE OF DIFFERENT STRATEGIES, SUCH AS GENOME WIDE ASSOCIATION STUDIES, COMPARATIVE GENOMICS AND USE OF MUTANT AND MAPPING POPULATIONS, TO IDENTIFY GENES THAT CONTRIBUTE TO DIFFERENT TRAITS IMPORTANT FOR PLANT PRODUCTIVITY. TO VALIDATE CANDIDATE GENES IN MOST CASES IT IS NECESSARY TO PRODUCE KNOCKOUT OR ALTERED MUTANTS OF THE GENE OF INTEREST. THE DEVELOPMENT OF THE CRISP/CAS9 TECHNOLOGY THAT ALLOWS TO EDIT GENETIC INFORMATION TO PRODUCE KNOCKOUT, POINT MUTATIONS, CHANGES IN PROMOTER STRENGTH (PROMOTER BASHING), DNA INSERTIONS, AND GENE REPLACEMENTS, HAS CHANGED THE WAY WE DO BIOLOGY. SUCCESSFUL APPLICATION OF GENE EDITING HAS BEEN REPORTED FOR MANY CROP PLANTS INCLUDING MAIZE, RICE, SOYBEAN, COTTON, AMONG SEVERAL OTHERS, BUT THE TISSUE CULTURE STEP TO PRODUCE GENE EDITED PLANTS IS TIME CONSUMING AND LIMITED TO THE FEW LABORATORIES THAT HAVE THE EXPERTISE IN CELL CULTURE TO REGENERATE THESE CROP PLANTS. TO OVERCOME THE TISSUE CULTURE HURDLE TO PRODUCE GENE EDITED PLANTS, WE PROPOSE TO DESIGN AND DEVELOP A TISSUE-CULTURE INDEPENDENT GENE EDITING SYSTEM THAT SHOULD BE GENERALLY APPLICABLE TO MOST BROAD LEAVE CROPS, SUCH AS COTTON, SOYBEAN, COMMON BEANS, SUNFLOWERS, ETC., AND SIMPLE ENOUGH THAT COULD BE CARRIED OUT IN A COMMON GREENHOUSE BY PEOPLE WITH BASIC TRAINING IN HORTICULTURE OR OTHER PLANT SCIENCE AREAS. THE RATIONAL OF THIS PROPOSAL IS TO USE NATURAL LONG-DISTANCE RNA MOBILITY TO SUPPLY CELLS IN THE SHOOT APICAL MERISTEM WITH THE RNAS REQUIRED FOR GENE EDITING WITHOUT THE NEED OF THE TARGET CELLS TO BE DIRECTLY SUBJECTED TO THE PROCESS OF DNA, RNA, PROTEIN DELIVERY, OR THE REGENERATION PROCESS. IF WE TRANSFECT LEAF OR COTYLEDON CELLS WITH THE GENES REQUIRED TO PRODUCE THE EDITING MACHINERY AND ONLY THE RNAS MOVE INTO MERISTEMATIC CELLS, WE WILL PREVENT UNDESIRABLE DNA INSERTIONS, GENETIC AND EPIGENETIC ALTERATIONS IN THE GENOME OF THE TARGET CELLS THAT ARE OFTEN ASSOCIATED WITH THE AGROBACTERIUM-MEDIATED TRANSFORMATION PROCESSES OR ABNORMAL DEVELOPMENTAL PROCESSES SUCH AS DE NOVO MERISTEM FORMATION FROM DIFFERENTIATED CELLS. GENE-EDITED CELLS WILL STILL BE PART OF THE NORMAL APICAL MERISTEM, WHICH LATER WILL RISE TO GAMETES THAT WILL PRODUCE GENE EDITED SEED UNDER NORMAL GREENHOUSE CONDITIONS.
$143,748Texas Tech University System · · FY2021 · National Institute of Food and Agriculture
Targeting Hepatocyte Senescence to Improve NAFLD
$143,747Kuo Du · Duke University · K01 · FY2025 · DK
Resource and Service Section
$143,597Cathleen M Lutz · Jackson Laboratory · U54 · FY2023 · OD
Resource and Service Section
$143,597Cathleen M Lutz · Jackson Laboratory · U54 · FY2024 · OD
Resource and Service Section
$143,597Cathleen M Lutz · Jackson Laboratory · U54 · FY2022 · OD
Uncovering novel gene regulatory mechanisms underlying glucocorticoid response phenotypes through targeted mutagenesis of an essential transcription factor
$143,585Graham Johnson · Duke University · K01 · FY2022 · DK
Core-004
$143,538Stephen B Gruber · University Of Southern California · P30 · FY2017 · CA
Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model Services
$143,443Lan Liao · Baylor College Of Medicine · R50 · FY2024 · CA
Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model Services
$143,443Lan Liao · Baylor College Of Medicine · R50 · FY2025 · CA
Optimizing Cancer Immunotherapy Safety and Efficacy using Genome Editing
$143,370Benjamin Peter Kleinstiver · Massachusetts General Hospital · K99 · FY2017 · CA
Genomics Core
$143,366Eugene Wei-Ming Yeo · University Of California, San Diego · U19 · FY2015 · MH
Research Training Program in Vision Science
$143,275Elena V Semina · Medical College Of Wisconsin · T32 · FY2019 · EY
Target Validation Core
$143,124Jing Wang · University Of Nebraska Medical Center · P20 · FY2019 · GM
Core D-Get IN
$143,095Irina V Budunova · Northwestern University At Chicago · P30 · FY2024 · AR
Outreach Core
$142,878Nameer Kirma · University Of Texas Hlth Science Center · U54 · FY2017 · CA
Genetic mechanisms of metformin's pro-longevity and anti-cancer effects
$142,800Alexander A Soukas · Massachusetts General Hospital · R01 · FY2019 · AG
Molecular genetic mechanisms of opioid receptor signaling
$142,776Brock Grill · Seattle Children'S Hospital · R01 · FY2023 · DA