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17,054 grants matching “genome editing”
SBIR Phase I: Reversible Introduction of Multiplex Automated Genome Engineering (MAGE) Competence in Yeast
$150,000Jay H Konieczka · Enevolv, Inc. · · FY2013 · TIP
Manganese Transport and Toxicity
$150,000Chih-Hao Lee · Harvard School Of Public Health · R56 · FY2018 · ES
SBIR Phase I: Engineered large-scale genomic deletions with a universal targeted cleavage system
$150,000Rachel E Haurwitz · Caribou Biosciences, Inc. · · FY2013 · TIP
Enhancing CRISPR-based Therapeutic Interventions Via a Targeted Platform Tool
$150,000Douglas A Lappi · Advanced Targeting Systems, Inc. · R43 · FY2017 · TR
CSHL GENOME CENTER-A ROUGH DRAFT OF THE MOUSE GENOME
$150,000Cold Spring Harbor Laboratory · U54 · FY2001 · HG
SBIR Phase I: A novel multicolor cell line engineering platform that enables high-throughput microscopy-based screening of living cells for drug discovery
$150,000Mary J Ludlam · Cairn Biosciences · · FY2015 · TIP
Yeast as a model for understanding gene expression adaptation
$150,000Hunter B Fraser · Stanford University · R01 · FY2018 · GM
SEMI-DWARF WHEAT MADE THE GREEN REVOLUTION A GREAT SUCCESS VIA RESISTANCE TO YIELD-REDUCING LODGING. HOWEVER, THE DWARF GENE ALSO REDUCED NUE, WHICH IS ALSO COMPROMISED DUE TO INCREASED CO2 LEVELS. AN INCREASE IN N FERTILIZER INPUT NOT ONLY INCREASES WHEAT PRODUCTION COSTS, BUT CAN ALSO DAMAGE OUR ENVIRONMENT DUE TO WATER POLLUTION. NEW SEMI-DWARF WHEAT VARIETIES COMBINING HIGH YIELD POTENTIAL AND HIGH NUE ARE URGENTLY NEEDED TO SUSTAINABLY MEET THE INCREASING DEMAND FOR WHEAT GRAINS.THIS PROJECT TAKES THE ADVANTAGE OF THE RECENTLY-DEVELOPED PRECISION GENOME EDITING TECHNOLOGY TO MODIFY THE N MODULATOR GRF4 TO INCREASE NUE AND GRAIN YIELD. THE PROJECT INCLUDES THREE SPECIFIC OBJECTIVES: 1) CREATE SYNONYMOUS MUTATIONS TO OVER-EXPRESS GRF4, 2) EVALUATE THE MUTATION EFFECT ON YIELD COMPONENTS AND NUE, AND 3) DEVELOP BREEDING-READY GERMPLASM. THE COMPLETION OF THIS PROJECT WILL DELIVER A SET OF EDITED MRE MUTATIONS IN THE GRF4 GENES, DETAILED INFORMATION OF THE MUTATION EFFECT ON GRF4 EXPRESSION AND PHENOTYPES, AND A PACKAGE OF COMPLETELY NEW GERMPLASM WITH ENHANCED NUE AND YIELD POTENTIAL. WITH THIS, THE PROJECT IS EXPECTED TO CONTRIBUTE TO A MORE PROFITABLE AND SUSTAINABLE US WHEAT INDUSTRY AND RURAL ECONOMY.
$150,000South Dakota State University · · FY2021 · National Institute of Food and Agriculture
Engineering Targeted Epigenetic Modifiers for Precise Control of Gene Regulation
$149,999Charles A Gersbach · Duke University · R01 · FY2015 · DA
Scalable post-assembly editing software for finishing and annotating personal genomes
$149,981Timothy J Durfee · Dnastar, Inc. · R44 · FY2018 · GM
Scaffolding Conceptually Driven Genomics Education
$149,976Susan R Singer · Carleton College · · FY2008 · EDU
Discovery of new therapeutics for Huntingtons Disease through successive reversal of phenotypic signatures
$149,968Tomomi Haremaki · Rumi Scientific, Inc. · R43 · FY2019 · NS
Unraveling the Role of p53 in Endothelium Homeostasis after Ionizing Radiation Exposure
$149,948Won Suk Jahng · Stanford University · K99 · FY2024 · HL
Unraveling the Role of p53 in Endothelium Homeostasis after Ionizing Radiation Exposure
$149,948Won Suk Jahng · Stanford University · K99 · FY2025 · HL
Comparison of single versus dual vector delivery of AAV-SPY-DYS45-55 for Duchenne muscular dystrophy
$149,919Courtney S Young · Myogene Bio, Llc · R43 · FY2020 · AR
Stem Cell/Organoid and Genome Editing Core
$149,892James M Wells · Cincinnati Childrens Hosp Med Ctr · P30 · FY2025 · DK
Stem Cell/Organoid and Genome Editing Core
$149,892James M Wells · Cincinnati Childrens Hosp Med Ctr · P30 · FY2023 · DK
Stem Cell/Organoid and Genome Editing Core
$149,892James M Wells · Cincinnati Childrens Hosp Med Ctr · P30 · FY2022 · DK
Stem Cell/Organoid and Genome Editing Core
$149,892James M Wells · Cincinnati Childrens Hosp Med Ctr · P30 · FY2024 · DK
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vitro Bioassay and Model Development Resource
$149,648John M Parant · University Of Alabama At Birmingham · U54 · FY2020 · DK
SBIR Phase I: Physical Cellular High Content Screening Using a piggyBac Transposen System
$149,390Anirban Majumder · Aruna Biomedical, Inc. · · FY2013 · TIP
Administrative Supplement for Research on Vitamin B3 Dietary Supplements for Eye Disease
$149,340Val C Sheffield · University Of Iowa · R01 · FY2023 · EY
Virus Production and Manipulation of Protein/Gene Expression Module
$149,305Paul R. Kinchington · University Of Pittsburgh At Pittsburgh · P30 · FY2025 · EY
Core D Genetic Modification
$149,172Michael T McManus · University Of California, San Francisco · P30 · FY2018 · DK
Core D Genetic Modification
$149,172Michael T McManus · University Of California, San Francisco · P30 · FY2016 · DK