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172,184 grants matching “inflammation”
Animal Core
$800,140David A Stoltz · University Of Iowa · P01 · FY2016 · HL
Endothelial-to-mesenchyma transition and atherosclerosis
$800,131Martin A. Schwartz · Yale University · R01 · FY2020 · HL
Defining Mechanisms of Viral Persistence in Situ at the Single-Cell Level
$800,128Jacob D Estes · Oregon Health & Science University · R01 · FY2021 · AI
A systems immunology approach for predicting poor responses to Hepatitis B vaccination
$800,116Ramin Herati · New York University School Of Medicine · R01 · FY2023 · AI
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSIS
$800,095Shabaana A. Khader · Washington University · R01 · FY2019 · AI
Progesterone induced immune modulation during pregnancy
$800,085Sing Sing Way · Cincinnati Childrens Hosp Med Ctr · R01 · FY2019 · AI
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSIS
$800,058Shabaana A. Khader · Washington University · R01 · FY2018 · AI
Stem Cell Bioreactor for Cardiac Care
$800,030Arno W Tilles · Sentien Biotechnologies, Inc. · R44 · FY2017 · HL
Natural History of C. trachomatis urogenital and rectal infections
$800,015Deborah Anne Dean · University Of California, San Francisco · R01 · FY2022 · AI
GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of disease
$800,005Ramnik J Xavier · Massachusetts General Hospital · R01 · FY2025 · AI
Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure
$800,001Kurt Lu · Case Western Reserve University · U01 · FY2017 · AR
FREEDOM - Frequent Dialysis Outcomes &Markers Study
$800,000University Of California San Francisco · U01 · FY2004 · DK
Collaborative Research: Statistical Methods for RNA-seq Based Transcriptomic Analysis of Macrophage Function in Spinal Cord Injury
$800,000Jianqing Fan · Princeton University · · FY2017 · MPS
How Cyclophilins both Regulate and are Regulated by RNA
$800,000Deborah S Wuttke · University Of Colorado At Boulder · · FY2017 · BIO
INFLAMMATORY BOWEL DISEASE IS A DEVASTATING CONDITION THAT AFFECTS OVER A MILLION AMERICANS, BOTH YOUNG AND OLD, AND IS CHARACTERIZED BY CHRONIC INFLAMMATION WITHIN THE DIGESTIVE SYSTEM. PATIENTS WITH INFLAMMATORY BOWEL DISEASE HAVE SYMPTOMS OF ABDOMINAL PAIN, DIARRHEA, AND RECTAL BLEEDING THAT CAN SIGNIFICANTLY IMPACT THEIR QUALITY OF LIFE AS WELL AS INCREASE THEIR RISK OF DEVELOPING LIFE-THREATENING CONDITIONS, INCLUDING COLORECTAL CANCER. EVEN THOUGH SIGNIFICANT ADVANCES HAVE BEEN MADE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE, THERE IS STILL A NEED FOR ADDITIONAL THERAPEUTIC STRATEGIES TO INDUCE LONG-LASTING REMISSIONS WHILE MINIMIZING SIDE EFFECTS. ONE SUCH STRATEGY IS THE INCORPORATION OF DIETARY INTERVENTIONS. THERE IS INCREASING EVIDENCE THAT DIET AND THE MICROBES THAT LIVE IN OUR GUT, THAT IS,THE GUT MICROBIOTA,HAVE SIGNIFICANT IMPACT ON HUMAN HEALTH AND ONTHE DEVELOPMENTOF DISEASE, INCLUDINGINFLAMMATORY BOWEL DISEASE.INDEED, A WESTERNIZED DIET HAS BEEN ASSOCIATED WITH AHIGHER RISK FOR DEVELOPING INFLAMMATORY BOWEL DISEASE WHILE A DIET RICH IN FRUITS AND VEGETABLES TENDS TO REDUCE RISK. WORK FROM OUR LABORATORY SUGGESTS THAT A SPECIFICPREPARATION OF BROCCOLI SPROUTSREDUCES INFLAMMATION IN THE GUT AND THAT BROCCOLI-DERIVED METABOLITES CAN ALTER THE COMPOSITION OF THE GUT MICROBIOTA. THUS, THE PRIMARY GOAL OF THE PROJECT IS TO DETERMINE THE FEASIBILITY OF INCREASING THE NUMBER OF BROCCOLI SPROUTS CONSUMED ON A DAILY BASIS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE AND TO DETERMINE THE NUMBER OF SERVINGS NEEDED TO INCREASE THE LEVELS OF BENEFICIAL, ANTI-INFLAMMATORY BROCCOLI-DERIVED METABOLITES IN THE BLOOD AND STOOL. IN ADDITION, WE WILL DETERMINE WHETHER CONSUMPTION OF BROCCOLI SPROUTSCHANGES THE GUT MICROBIOTA IN A BENEFICIAL WAY AND REDUCE INFLAMMATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. OUR LONG-TERM GOAL IS TO DEVELOP AWHOLE FOOD APPROACH IN REDUCING SYMPTOMS,PREVENTING WORSENING DISEASE, AND IMPROVING HEALTH IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
$800,000Regents Of The University Of Michigan · · FY2022 · National Institute of Food and Agriculture
THE DOMINANT ENVIRONMENTAL STRESSORS THAT MAY AFFECT CARDIAC BIOLOGY DURING SPACE EXPLORATION ARE SPACE RADIATION AND WEIGHTLESSNESS. THE KEY CENTRAL OBJECTIVE OF THIS PROPOSAL IS TO OBTAIN A MULTI OMICS AND PHYSIOLOGICAL UNDERSTANDING OF THE IMPACT OF SPACE RADIATION AND WEIGHTLESSNESS INDIVIDUALLY AND TOGETHER ON THE CARDIOVASCULAR SYSTEM USING TWO RODENT MODELS: RAT NEONATAL CARDIOMYOCYTES (RNNC) AND C57BL/6 MICE. IN STUDIES EVALUATING THE EFFECT OF MICROGRAVITY ON THE PROTEIN CONTENT OF RNNC WE WERE ABLE TO DEMONSTRATE THAT PROTEIN TURNOVER DIMINISHES GLOBALLY IN THESE CELLS. MOREOVER WE WERE ABLE TO PINPOINT MOLECULAR PATHWAYS POTENTIALLY RESPONSIBLE AND POSSIBLY TARGETABLE FOR THIS EFFECT. WE HAVE AN ONGOING STUDY EVALUATING THE CARDIAC PHENOME AND CARDIAC PROTEOME IN C57BL/6 MICE EXPOSED TO GALACTIC COSMIC RAYS (GCR). OUR DATA SUGGESTS THAT IN CONTRAST TO OTHER FORMS OF RADIATION A SINGLE EXPOSURE TO GCR RESULT IN A SIGNIFICANT DETERIORATION OF CARDIAC FUNCTION THAT BECOMES APPARENT LONG AFTER EXPOSURE (9-12 MONTHS POST GCR). BIOINFORMATICS ANALYSES OF THE CARDIAC PROTEOME OF THESE MICE HAVE IDENTIFIED THAT KERATINIZATION AND CORNIFICATION PATHWAYS ARE UP REGULATED IN HEARTS FROM GCR IRRADIATED MICE. THESE PATHWAYS ARE PRESUMABLY UPREGULATED AS A RESPONSE TO SUSTAINED INFLAMMATION AND PERSISTENT OXIDATIVE DAMAGE POST RADIATION. THE IMPACT OF BOTH STRESSORS SIMULTANEOUSLY (GCR AND WEIGHTLESSNESS) ON CARDIAC PHYSIOLOGY AND CARDIAC PROTEOMICS HAS NOT BEEN EXPLORED AT ALL. WE WILL LEVERAGE OUR EXPERTISE USING THESE MODELS FROM TWO SPECIES (MOUSE AND RAT) AS WELL AS ACCUMULATED DATA SETS AND BIOSPECIMENS ACCRUED FROM OTHER STUDIES TO ADDRESS THE FOLLOWING TWO AIMS: AIM 1. TEST THE HYPOTHESIS THAT THE COMBINATION OF GCR EXPOSURE AND WEIGHTLESSNESS WILL RESULT IN ADDITIVE OR EVEN SYNERGISTIC ENHANCEMENTS IN CELL DEATH INCREASES IN REACTIVE OXYGEN SPECIES PROTEIN TURNOVER AND MITOCHONDRIAL DYSFUNCTION OVER THAT OBSERVED WITH EITHER STRESSOR ALONE. THIS AIM WILL UTILIZE THE RNNC MODEL AND THE SYNTHECON ROTARY CELL CULTURE SYSTEM FOR WEIGHTLESSNESS. GCR WITH AND WITHOUT WEIGHTLESS WILL BE ADMINISTERED TO RNNC AT NSRL. FUNCTIONAL READOUTS WILL INCLUDE ASSESSMENTS OF CELL VIABILITY CELL DEATH (APOPTOSIS) MITOCHONDRIAL INTEGRITY AND FUNCTIONALITY AS WELL AS MULTI OMICS COMPARATIVE ASSESSMENTS (TRANSCRIPTOMICS AND MASS SPECTROMETRY-BASED PROTEOMICS).
$800,000Duke University · · FY2022 · National Aeronautics and Space Administration
Defining the role of BPA in promoting obesity and associated metabolic complicati
$800,000Beverly S Rubin · Tufts University Boston · RC2 · FY2009 · ES
Collaborative Research: Statistical Methods for RNA-seq Based Transcriptomic Analysis of Macrophage Function in Spinal Cord Injury
$800,000Yi Ren · Florida State University · · FY2017 · MPS
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** POLYPHENOL-RICH HASKAP BERRIES (HASKAP) HAVE UNTAPPED THERAPEUTIC POTENTIAL TO IMPROVE HUMANHEALTH, AND AGRICULTURAL PRODUCERS IN NORTHERN U.S. STATES ARE POISED TO INCREASE PRODUCTION IFCONSUMER DEMAND INCREASES. A CRITICAL KNOWLEDGE GAP IS THAT LITTLE IS KNOWN ABOUT THE INTERACTIONSBETWEEN GUT MICROBES AND HASKAP POLYPHENOLS TO PRODUCE BIOACTIVE METABOLITES LINKED TODOWNSTREAM HEALTH IMPACTS. ADDITIONALLY, WE NEED TO KNOW WHICH HASKAP VARIETIES AND HARVESTTIMING WILL YIELD THE GREATEST BIOACTIVE POTENTIAL. THE LONG-TERM GOAL OF THIS PROJECT IS TO FORM APARTNERSHIP LINKING THE HEALTH IMPACTS OF HASKAP VARIETIES AND MANAGEMENT PRACTICES THAT MAXIMIZEHEALTH-PROMOTING COMPOUNDS TO BENEFIT BOTH CONSUMERS AND PRODUCERS. OUR OBJECTIVES ARE TODETERMINE 1) THE IMPACT OF HASKAP ON THE GUT MICROBIOME AND METABOLOME, 2) HOW GUT MICROBIOMECOMPOSITION AND PRODUCTION OF BIOACTIVE METABOLITES FROM HASKAP IMPACTS HEALTH AND INFLAMMATIONBIOMARKERS, AND 3) WHICH HASKAP VARIETIES AND GROWING PRACTICES INCREASE PRODUCTION OF HEALTH-PROMOTING COMPOUNDS. A FOUR-ARMED, RANDOMIZED, TRIPLE-BLIND, PLACEBO CONTROLLED CLINICAL TRIAL OFHASKAP VERSUS PLACEBO FOR TWO SEPARATE GROUPS WITH DISTINCTLY LOW AND HIGH METABOLIC SYNDROMESTATUS WILL BE COMPLETED. PARTICIPANTS WILL BE ASSESSED FOR HEALTH BIOMETRICS, GUT MICROBIOMECOMPOSITION, INFLAMMATION, AND BOTH THE GUT AND SERUM METABOLOME BEFORE AND AFTER 8 WEEKS OFINTERVENTION. HASKAP FRUIT FROM TWENTY VARIETIES WILL PRIMARILY COME FROM THE RANDOMIZED BLOCKDESIGN FIELD TRIAL AND FRUIT WILL BE HARVESTED AT FOUR STAGES OF FRUIT MATURITY, THEN ANALYZED FORPOLYPHENOL CONTENT. THIS PART OF THE STUDY WILL BE REPLICATED OVER THREE GROWING SEASONS.
$800,000Montana State University · · FY2024 · National Institute of Food and Agriculture
Frequent Hemodialysis Network - West Coast Consortium
$799,999Glenn Matthew Chertow · Stanford University · U01 · FY2008 · DK
Effects of Inhaled Florida Red Tide Brevetoxins
$799,999Daniel G Baden · University Of North Carolina Wilmington · P01 · FY2009 · ES
Detrimental Effects of B-Cell-Th17 Axis in Antiviral Immunity in Smokers.
$799,998Farrah Kheradmand · Baylor College Of Medicine · R01 · FY2025 · HL
Human nasal epithelial organoids as a non-invasive, personalized model for predicting effectiveness of CFTR modulators in cystic fibrosis patients
$799,995John Mellnik · Path Bioanalytics, Inc. · R44 · FY2017 · HL
Periodontitis Exposure and Risk of Incident Dementia
$799,992James McCallum Noble · Columbia University Health Sciences · R56 · FY2013 · DE
The Role of Complement Inhibition in Expanded Criteria Kidney Transplantation
$799,989Dixon B Kaufman · University Of Wisconsin-Madison · R01 · FY2019 · AI