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84,503 grants matching “bioinformatics”
EMERGE PHASE III CLINICAL CENTER AT PARTNERS HEALTHCARE
$800,708Scott T Weiss · Brigham And Women'S Hospital · U01 · FY2019 · HG
Functional Genomics of Atrial Fibrillation in Human Atria
$800,640Mina Kay Chung · Cleveland Clinic Lerner Com-Cwru · R01 · FY2015 · HL
Longitudinal SARS-CoV-2 mRNA vaccine-induced mucosal, serological, and cellular immunity in children and human milk
$800,605Pia S Pannaraj · Children'S Hospital Of Los Angeles · R01 · FY2022 · AI
Data Management Core: Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity
$800,481Alexander Ozonoff · Boston Children'S Hospital · U19 · FY2021 · AI
IMPACC convalescent data collection, including Patient Reported Outcomes (PROs) and home visit sampling
$800,481Ofer Levy · Boston Children'S Hospital · U19 · FY2021 · AI
Understanding Unconventional CD8+ T cell Responses in Protection from HIV
$800,450Jonah B. Sacha · Oregon Health & Science University · R01 · FY2021 · AI
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems
$800,329Jonathan Himmelfarb · University Of Washington · UG3 · FY2021 · TR
The genetic basis of Dandy-Walker and other mid-hindbrain malformations
$800,250William B Dobyns · Seattle Children'S Hospital · R01 · FY2015 · NS
Biorepository of iPSC lines from diverse rat strains for regenerative medicine research
$800,146Kwang-Soo Kim · Mclean Hospital · R24 · FY2019 · OD
The construction and utility of reference pan-genome graphs
$800,001Heng Li · Dana-Farber Cancer Inst · U01 · FY2022 · HG
Collaborative Research:ITR/AP: Enabling Microscopic Simulators to Perform System-Level Analysis
$800,000Yannis Kevrekidis · Princeton University · · FY2002 · ENG
Decoding endocrine and paracrine communication through mammokines
$800,000Prashant Rajbhandari · Icahn School Of Medicine At Mount Sinai · DP1 · FY2024 · DK
International TB Portals Program
$800,000National Institute Of Allergy And Infectious Diseases · Y01 · FY2017 · AI
Amino acid networks in enzyme catalysis
$800,000David D Boehr · Pennsylvania State Univ University Park · · FY2016 · BIO
The construction and utility of reference pan-genome graphs
$800,000Heng Li · Dana-Farber Cancer Inst · U01 · FY2020 · HG
PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS
$800,000Stephen K Burley · Rutgers, The State Univ Of N.J. · R01 · FY2022 · GM
Stanford Center for Undiagnosed Diseases
$800,000Euan A Ashley · Stanford University · U01 · FY2014 · HG
The effects of holoparasitism on plant organellar translation and tRNA metabolism
$800,000Daniel B Sloan · Colorado State University · · FY2023 · BIO
UCLA clinical site for the investigation of undiagnosed disorders
$800,000Eric J Vilain · University Of California Los Angeles · U01 · FY2014 · HG
Functional RNA elements in the human genome
$800,000Xiang-Dong Fu · University Of California, San Diego · R01 · FY2008 · HG
THE DOMINANT ENVIRONMENTAL STRESSORS THAT MAY AFFECT CARDIAC BIOLOGY DURING SPACE EXPLORATION ARE SPACE RADIATION AND WEIGHTLESSNESS. THE KEY CENTRAL OBJECTIVE OF THIS PROPOSAL IS TO OBTAIN A MULTI OMICS AND PHYSIOLOGICAL UNDERSTANDING OF THE IMPACT OF SPACE RADIATION AND WEIGHTLESSNESS INDIVIDUALLY AND TOGETHER ON THE CARDIOVASCULAR SYSTEM USING TWO RODENT MODELS: RAT NEONATAL CARDIOMYOCYTES (RNNC) AND C57BL/6 MICE. IN STUDIES EVALUATING THE EFFECT OF MICROGRAVITY ON THE PROTEIN CONTENT OF RNNC WE WERE ABLE TO DEMONSTRATE THAT PROTEIN TURNOVER DIMINISHES GLOBALLY IN THESE CELLS. MOREOVER WE WERE ABLE TO PINPOINT MOLECULAR PATHWAYS POTENTIALLY RESPONSIBLE AND POSSIBLY TARGETABLE FOR THIS EFFECT. WE HAVE AN ONGOING STUDY EVALUATING THE CARDIAC PHENOME AND CARDIAC PROTEOME IN C57BL/6 MICE EXPOSED TO GALACTIC COSMIC RAYS (GCR). OUR DATA SUGGESTS THAT IN CONTRAST TO OTHER FORMS OF RADIATION A SINGLE EXPOSURE TO GCR RESULT IN A SIGNIFICANT DETERIORATION OF CARDIAC FUNCTION THAT BECOMES APPARENT LONG AFTER EXPOSURE (9-12 MONTHS POST GCR). BIOINFORMATICS ANALYSES OF THE CARDIAC PROTEOME OF THESE MICE HAVE IDENTIFIED THAT KERATINIZATION AND CORNIFICATION PATHWAYS ARE UP REGULATED IN HEARTS FROM GCR IRRADIATED MICE. THESE PATHWAYS ARE PRESUMABLY UPREGULATED AS A RESPONSE TO SUSTAINED INFLAMMATION AND PERSISTENT OXIDATIVE DAMAGE POST RADIATION. THE IMPACT OF BOTH STRESSORS SIMULTANEOUSLY (GCR AND WEIGHTLESSNESS) ON CARDIAC PHYSIOLOGY AND CARDIAC PROTEOMICS HAS NOT BEEN EXPLORED AT ALL. WE WILL LEVERAGE OUR EXPERTISE USING THESE MODELS FROM TWO SPECIES (MOUSE AND RAT) AS WELL AS ACCUMULATED DATA SETS AND BIOSPECIMENS ACCRUED FROM OTHER STUDIES TO ADDRESS THE FOLLOWING TWO AIMS: AIM 1. TEST THE HYPOTHESIS THAT THE COMBINATION OF GCR EXPOSURE AND WEIGHTLESSNESS WILL RESULT IN ADDITIVE OR EVEN SYNERGISTIC ENHANCEMENTS IN CELL DEATH INCREASES IN REACTIVE OXYGEN SPECIES PROTEIN TURNOVER AND MITOCHONDRIAL DYSFUNCTION OVER THAT OBSERVED WITH EITHER STRESSOR ALONE. THIS AIM WILL UTILIZE THE RNNC MODEL AND THE SYNTHECON ROTARY CELL CULTURE SYSTEM FOR WEIGHTLESSNESS. GCR WITH AND WITHOUT WEIGHTLESS WILL BE ADMINISTERED TO RNNC AT NSRL. FUNCTIONAL READOUTS WILL INCLUDE ASSESSMENTS OF CELL VIABILITY CELL DEATH (APOPTOSIS) MITOCHONDRIAL INTEGRITY AND FUNCTIONALITY AS WELL AS MULTI OMICS COMPARATIVE ASSESSMENTS (TRANSCRIPTOMICS AND MASS SPECTROMETRY-BASED PROTEOMICS).
$800,000Duke University · · FY2022 · National Aeronautics and Space Administration
BCM CLINICAL SITE FOR AN UNDIAGNOSED DISEASES NETWORK (UDN)
$800,000Brendan Hl Lee · Baylor College Of Medicine · U01 · FY2014 · HG
Integrative Omics of HepB Vaccine Response in Co-Infection with Parasites
$800,000Elias K Haddad · Drexel University · U19 · FY2017 · AI
The construction and utility of reference pan-genome graphs
$800,000Heng Li · Dana-Farber Cancer Inst · U01 · FY2021 · HG
SPX: Scalable In-Memory Processing Using Spintronics
$800,000Ulya R Karpuzcu · University Of Minnesota-Twin Cities · · FY2017 · CSE